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| 1 | The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis显示文摘上皮间充质的转变(EMT ) 把上皮的肿瘤房间变换成侵略、变形的癌症房间,导致在癌症病人的死亡。尽管扭曲为胸和另外的癌症是 EMT 和转移的一个主人管理者,为调停扭曲的基因抄写负责的机制仍然保持未知。在这研究, TWIST 蛋白质建筑群的纯化和描述表明那扭曲与改变的 Mi2/nucleosome 和 deacetylase (Mi2/NuRD ) 的几个部件交往建筑群, MTA2, RbAp46, Mi2 和 HDAC2,和成员他们到为 transcriptional 压抑的 E-cadherin 倡导者的近似区域。从取决于的房间线高效地为转移扭曲的癌症的这些扭曲建筑群部件的弄空在老鼠在文化和肺转移压制房间移植和侵略。这些调查结果不仅提供在扭曲和 Mi2/NuRD 建筑群之间的新奇机械学、功能的连接而且为在癌症复杂的 Mi2/NuRD 的部件建立新必要角色转移。 | Junjiang Fu Li Qin Tao He Jun Qin Jun Hong Jiemin Wong Lan Liao Jianming XU | 2011 | Cell Research2011，21，2： | 51 |
| 2 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 3 | Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma显示文摘Objective:This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods:The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes:clear cell carcinoma(CCC),giant cell carcinoma(GCC),sarcomatoid carcinoma(SC),and combined hepatocellular-cholangiocarcinoma(CHC)between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma(HCC)(early-and advanced-stage HCC)during the same period.Results:The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions:CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis. | Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang Haizhen Lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai | 2018 | Chinese Journal of Cancer Research2018，30，3： | 6 |
| 4 | Enhanced piezo-response in copper halide perovskites based PVDF composite films显示文摘In-situ fabricated perovskite nanocrystals in polymeric matrix provide new generation composite materials for plenty of cutting edge technology. In this work, we report the in-situ fabrication of copper halide perovskite(MA_2CuCl_4, MA:CH_3NH_3^+) embedded poly(vinylidene fluoride)(PVDF) composite films. The optimized MA_2CuCl_4/PVDF composite films exhibit greatly enhanced piezo-response in comparasion with pure PVDF films. The enhancements were invesitgated and explained by applying piezo-response force microscopy(PFM) measurements and density functional theory(DFT) caculations. We proposed that the high piezoelectric properties of MA_2CuCl_4/PVDF composite films could be related to the large Cu off-centering displacement, the strong interactions between MA_2CuCl_4 and PVDF as well as large stress concentration around the MA_2CuCl_4 particles in the films. These piezoelectric composite films are expected to be suitable functional materials for flexible and/or wearable piezoelectrics. | Sheng Huang Gang Tang Hailong Huang Xian-gang Wu Puming Zhou Lin Zou Lei Xie Jianming Deng Xueyun Wang Haizheng Zhong Jiawang Hong | 2018 | Science Bulletin2018，63，19： | 4 |
| 5 | Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis显示文摘天门冬素(Asn/N ) 连接了 glycans 为蛋白质合拢, trafficking,和 endoplasmic 是重要的在优核质的联系蜂窝胃的降级。glycoproteins 的成熟包含在 Golgi 由另外的糖分子的 mannosidases 和三分支的 N-glycans 的增加整修 mannosyl 残余。然而,调停 Golgi 的甘露糖整修的生物重要性充分没被理解。这里,我们显示出二机能上地冗余的 mannosidases, MNS1 和 MNS2 的那废除,为在 A 和工厂 N-glycans 的 C 分支上整修的 -1,2-mannose 负责在 Arabidopsis 在盐压力条件下面导致严重的根生长抑制。相反,有在 oligosaccharide 先锋的生合成的缺点的异种当甘露糖整修不在时显示了提高的盐忍耐。然而,在 EBS3 的变化,为分叉的 N-glycan 先锋的形成被要求,压制了 mns1 mns2 的盐敏感的显型两倍异种。有趣地,我们观察了那 ? 纤维素生合成在高咸度下面在 mns1 mns2 根被损害。一致地, ? 许多膜抛锚了 endo -- 在纤维素生合成起一个关键作用的 1,4-endoglucanase (RSW2/KOR ) 和它的变异的变体 rsw2-1 ? 被调制由 ? 在盐应力下面整修的 -1,2-mannose。RSW2 的 Overexpression 能部分救 mns1 mns2 的盐敏感的显型。一起拿,这些结果建议 N-glycans 整修的那 MNS1/2-mediated 甘露糖在 modulating glycoprotein 丰富是关键的在植物承受盐应力。 | Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu Yonghua Yang Jianming Li Zhi Hong | 2018 | Molecular Plant2018，11，5： | 3 |
| 6 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h9wof0ok5696v6pf5.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 7 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 8 | Function of Agricultural Land Use and Its Evolvement in Peri-urban Area: A Case Study of Beijing显示文摘Rapid urbanization in Beijing stimulates the urban land expansion and diminishes available agricultural land. Monofunctional agricultural land use can not meet the demand of the devel- opment of the multifunctional agriculture and urbanization any more, so multifunctional agricultural land use is going to be promoted in the city. This article proposes the evolvement of the land use change from 1992 to 2004 and discusses some evolvement views. | Yuan Hong, Cai Jianming, Jiang Fang, Liu Shenghe Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China | 2007 | Chinese Journal of Population,Resources and Environment2007，5，2： | 1 |
| 9 | Fabrication of cobalt nanostructures with different shapes in alumina template显示文摘 | Bao Jianchun Xu Zheng Hong Jianming | 2004 | Scripta Materialia2004，50，： | 1 |
| 10 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 11 | A hybrid bound- ary node method 显示文摘 | Zhang Jianming Yao Zhenhan Hong Li | 2002 | International Journal for Numerical Methods in Engineering2002，53，4： | 1 |
| 12 | Atomic-scale structural and chemical evolution of Li3V2(PO4)3 cathode cycled at high voltage window显示文摘Here,by using atomically resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we investigate the structural and chemical evolution of Li3V2(PO4)3 (LVP) upon the high-voltage window (3.0-4.8 V).We find that the valence of vanadium gradually increases towards the core corresponding to the formation of electrochemically inactive Li3-xV2(PO4)3 (L3-xVP) phases.These Li-deficient phases exhibit structure distortion with superstructure stripes,likely caused by the migration of the vanadium,which can slow down the lithium ion diffusion or even block the diffusion channels.Such kinetic limitations lead to the formation of Li-deficient phase along with capacity loss.Thus,the LVP continuously losses of electrochemical activity and Li-deficient phases gradually grow from the particle core towards the surface during cycling.After 500 cycles,the thickness of active LVP layer decreases to be - 5-20 nm.Moreover,the micromorphology and chemical composition of solid electrolyte interphase (SEI) have been investigated,indicating the thick SEI film also contributes to the capacity loss.The present work reveals the structural and chemical evolution in the cycled electrode materials at an atomic scale,which is essential to understand the voltage fading and capacity decaying of LVP cathode. | Shulin Chen Jian Zou Yuehui Li Ning Li Mei Wu Jinghuang Lin Jingmin Zhang Jian Cao Jicai Feng Xiaobin Niu Jianming Bai Junlei Qi Peng Gao Liping Wang Hong Li | 2019 | Nano Research2019，12，7： | 1 |
| 13 | Ultrasonic assisted synthesis, characterization and influence factors of monodispersed dumbbell-like YF3 nanostructures 显示文摘 | Ni Yonghong Li Guoyan Hong Jianming | 2010 | Ultrasonics Sonochemistry2010，17，3： | 1 |
| 14 | A hybrid boundary node method显示文摘 | ZHNANG Jianming YAO Zhenhan LI Hong | 2002 | International Journal for Numerical Methods in Engineering2002，53，： | 1 |
| 15 | Preparation and characterization of MgTiO3 thin films by atmospheric pressure metalorganic chemical vapor deposition显示文摘 | Zeng Jianming Wang Hong Song Shigeng | 1997 | Journal of Crystal Growth1997，178，3： | 1 |
| 16 | ControUed synthesis of different morphological YF3 crystalline particles at room temperature 显示文摘 | Wang Miao Huang Qingli Hong Jianming | 2007 | Materials Letters2007，61，10： | 1 |
| 17 | Characterization of copper oxide supported on ceria-modified anatase显示文摘 | Haiyang Zhu Mingmin Shen Yan Kong Jianming Hong Yuhai Hu Tiandong Liu Lin Dong Yi Chen Can Jian Zhong Liu | 2004 | A, Chemical2004，，1： | 1 |
| 18 | Revealing the correlation between structure evolution and electrochemical performance of high-voltage lithium cobalt oxide显示文摘Lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(LIBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical performances.The constantly increasing demands of higher energy density urge to develop high-voltage LCO via a variety of strategies.However,the corresponding modification mechanism,especially the influence of the long-and short-range structural transitions at high-voltage on electrochemical performance,is still not well understood and needs further exploration.Based on ss-NMR,in-situ X-ray diffraction,and electrochemical performance results,it is revealed that the H3 to H1-3 phase transition dictates the structural reversibility and stability of LCO,thereby determining the electrochemical performance.The introduction of La and Al ions could postpone the appearance of H1-3 phase and induce various types of local environments to alleviate the volume variation at the atomic level,leading to better reversibility of the H1-3 phase and smaller lattice strain,and significantly improved cycle performance.Such a comprehensive long-range,local,and electronic structure characterization enables an in-depth understanding of the structural evolution of LCO,providing a guiding principle for developing high-voltage LCO for high energy density LIBs. | Jiajia Wan Jianping Zhu Yuxuan Xiang Guiming Zhong Xiangsi Liu Yixiao Li Kelvin H.L.Zhang Chaoyu Hong Jianming Zheng Kai Wang Yong Yang | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 19 | Ensemble-based uncertainty quantification for coordination and control of thermostatically controlled loads显示文摘This work investigates an uncertainty quantification(UQ)framework that analyses the uncertainty involved in modelling control systems to improve control strategy performance.The framework involves solving four problems:identifying uncertain parameters,propagating uncertainty to the quantity of interest,data assimilation and making decisions under quantified uncertainties.A specific group of UQ approaches,known as the ensemble-based methods,are adopted to solve these problems.This UQ framework is applied to coordinating a group of thermostatically controlled loads,which relies on simulating a second-order equivalent thermal parameter model with some uncertain parameters.How this uncertainty affects the prediction and the control of total power is examined.The study shows that uncertainty can be effectively reduced using the measurement of air temperatures.Also,the control objective is achieved fairly accurately with a quantification of the uncertainty. | Weixuan Li Jianming Lian Dave Engel Hong Wang | 2018 | Journal of Control and Decision2018，5，2： | 1 |
| 20 | 显示文摘 | Zeng Jianming Wang Hong Wang Ming | 1998 | Thin Solid Films1998，322，： | 1 |
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