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| 1 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 2 | Sedimentary Characteristics of the Pleistocene Outwash Accumulation and their Implications for Paleoclimate Change in the Midstream of Dadu River,Southwestern China显示文摘古老的冰川边碛外的沉积累积,与复杂沉积特征在更新世扔了,在 Dadu 河的中流山谷被发现,西南的中国。他们的沉积特征为在这个区域获得深卓见进古气候变化的相关性被调查。这为二代表性的冰川边碛外的沉积累积借助于详细地点调查,采样和实验室测试(谷物尺寸分发和标明日期测试的电子旋转回声) 被完成。基于现在的学习,几个主要结论是如下外面淹死:1 ) 累积主要由粗糙的土壤组成(粗糙的部分是超过 50%) 并且很粗糙的土壤(粗糙的部分关于 20%35% ,并且很粗糙的部分是超过 55%) ;2 ) 粗糙的土壤是排序得好的亚回合和亚 stratified 到成层得好,当粗糙的土壤展出亚回合到亚 angular 时并且糟糕排序;3 ) 累积被要求到间歇地在三个次时期被扔了。这被天气 / 剩余的泥土的二层证实,紫色到在颜色的砖红;并且 4 )在学习区域的温度增加了超过三个次时期,这被推断,即, 280 ka B.P 到 120 ka B.P ,到 80 ka B.P 的 110 ka B.P 和到 25 ka B.P 的 70 ka B.P ,并且分别地在 120 ka B.P 和 77 ka B.P 衰退了两次。 | TU Guoxiang HUANG Runqiu DENG Hui LI Yanrong | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 3 | Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway显示文摘Neuritin is a member of the neurotrophic factor family,which plays an important role in the promotion and development of the nervous system.Neuritin is also involved in angiogenesis.Neuritin was recently found to be a negative regulatory factor of the Notch 1 signaling pathway.Notch signaling pathway is known as a regulatory pathway of angiogenesis.Thus,neuritin may play a role in angiogenesis through the Notch signaling pathway.In the present study,we investigated the expressions of neuritin and Notch signaling pathway factors in the pulmonary vascular tissue.The results showed that neuritin expression was increased in the paraneoplastic vascular tissue and decreased in the lung cancer vascular tissue.The neuritin expression was increased with the increase of vascular tissue density,and a negative correlation between neuritin expression and delta-like ligand 4(DLL4)was identified in vascular tissues of lung cancer.Overexpression of neuritin in human umbilical vein endothelial cells(HUVECs)inhibited the expressions of Notch signaling pathway-associated factors,including DLL4,NICD,and Hes-1,and promoted the migration and tubular formation of HUVECs.In conclusion,our results indicated that neuritin is involved in angiogenesis and may play a role in angiogenesis through the Notch signaling pathway.This study provides a theoretical basis for clinical anti-angiogenesis therapy. | Li Yang Xuhui Wang Jiawei Sun Chunyan Liu Guoxiang Li Jingling Zhu Jin Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 4 |
| 4 | Circadian clock gene expression regulates cancer cell growth through glutaminase显示文摘夫酸安是为恶意的肿瘤房间的必要氨基酸。使夫酸安产生代射变化的 Glutaminase 到达肿瘤立即在最大的增长前评估的最大的 expressionin。肿瘤房间在日子期间以不同的率成长。我们 postulatedthat 在肿瘤房间的 glutaminase 的活动服从于生理节奏的钟基因的规定。我们测量了由在在六 equispaced 时间的肝和 tumorcells 的即时聚合酶链反应的西方的污点分析和生理节奏的钟基因表示削尖的 glutaminaseby 在一张 12/12 h 光 / 黑暗时间表的单个鼠标今日。结果显示出 thatthe 忍受肿瘤的鼠标,在正常下面日报条件,生理节奏地被乘火车,由正常主机 locomotoractivity 节奏和有韵律的肝钟基因表示思考了。在这些老鼠以内的肿瘤生理节奏地也被组织,由生理节奏的钟基因(Bmal1 ) 的 asreflected 表示。是很显著的的,是肾类型 glutaminase 也在一样的模式 withtumor 显示出生理节奏的节奏在肝癌症异种皮移植模型的生理节奏的钟基因表示,有条件地显示那禁止 glutaminaseactivity 可以为癌症提供一个新目标治疗。 | Aixia Huang Bingbo Bao H Rex Gaskins Haijun Liu Xueli Zhang Liwen Lu Shan Gao Yihai Shi Ming Zhang Yuanzhou Shan Jing Feng Guoxiang Yao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 3 |
| 5 | Macro-Experimental Observation of the Staggered Mode in Lattice System显示文摘The staggered mode of solitons in polyacetylene which is first discovered by Sun et al.is one of the typical gap soliton studied in lattice system.Using a one dimensional damped and parametrically driven pendulum lattice,we have observed a stable staggered mode which can be explained successfully by a nonlinear Schrödinger equation under the multiple scale approximation. | LOU Senyue YU Jun LIN Ji HUANG Guoxiang | 1995 | Chinese Physics Letters1995，12，7： | 3 |
| 6 | A novel Z-scheme CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst for degradation of Bisphenol A and hydrogen evolution and insight of the photocatalysis mechanism显示文摘CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst had been successfully fabricated through a one-step in-situ pyrolysis formation of 3D hollow CeO_(2)mesoporous nanospheres and 2D g-C_(3)N_(4)nanosheets together with simultaneous removal of carbon sphere templates after heat treatment.The sample shows high catalytic performances for photocatalytic hydrogen generation and photocatalytic oxidation of Bisphenol A(BPA)under visible light irradiation,and the catalytic degradation route of BPA was suggested by the degradation products determined by GC-MS.The enhancing catalytic activity was attributed to the effective interfacial charge migration and separation.Finally,it was proposed that the CeO_(2)/g-C_(3)N_(4)heterojunction photocatalyst could follow a more appropriate Z-scheme charge transfer mechanism,which was confirmed by the analysis of experiment and theoretical calculation results. | Wei Zhao Tiantian She Jingyi Zhang Guoxiang Wang Sujuan Zhang Wei Wei Gang Yang Lili Zhang Dehua Xia Zhipeng Cheng Haibao Huang Dennis Y.C.Leung | 2021 | Journal of Materials Science & Technology2021，，26： | 3 |
| 7 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 8 | Determination of lysozyme at the nanograrn level in chicken egg white using Resonance Rayleigh-scattering method with Cd-doped ZnSe quantum dots as probe显示文摘 | CAI Zhaoxia CHEN Guoxiang HUANG Xi | 2011 | Sensors and Actuators B: Chemical2011，157，2： | 1 |
| 9 | Microstructures and thermochromic characteristics of low-cost vanadium–tungsten co-sputtered thin films显示文摘 | Sheng Zhou Yi Li Huiqun Zhu Ruoxi Sun Yuming Zhang Yize Huang Liu Li Yujian Shen Qiuxin Zhen Guoxiang Tong Baoying Fang | 2011 | Surface & Coatings Technology (-)2011，，11： | 1 |
| 10 | Distribution, prevalence, molecular typing, and virulence of Vibrio parahaemolyticus isolated from different sources in coastal province Jiangsu, China显示文摘 | Guoxiang Chao Xinan Jiao Xiaohui Zhou Zhenquan Yang Jinlin Huang Lipin Zhou Xiaoqin Qian | 2009 | Food Control2009，，10： | 1 |
| 11 | Kinks and Solitons in Coupled Pendulum Lattices显示文摘Self-localized structures in nonlinear coupled pendulum lattices are investigated by use of the method of multiple-scales under quasi-discreteness approximation.The upper cutoff and noncutoff kinks observed by Denardo et al.recently are theoretically explained qualitatively and a lower cutoff standing soliton is also predicated. | HUANG Guoxiang XU Zaixin | 1992 | Chinese Physics Letters1992，9，12： | 1 |
| 12 | Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells 显示文摘 | Liyong HUANG Ye XU Guoxiang CAI | 2012 | Oncology reports2012，27，4： | 1 |
| 13 | Guiding ultraslow weak-light bullets with Airy beams in a coherent atomic system 显示文摘 | HANG Chao HUANG Guoxiang | 2014 | Physreva2014，89，1： | 1 |
| 14 | CYLINDRICAL ENVELOPE SOLITARY WAVES显示文摘The method of multiple-scales is used to investigate the nonlinear modulation of capillary-gravity waves with cylindrical symmetry.We find that the evolution of wave-packets is described by a nonlinear schrödinger-like equation i(U+U/2r)+αUξξ+β|U|2U=0.Some exact and explicit cylindrical envelope solitary wave solutions are also obtained by means of variable transformations. | HUANG Guoxiang LOU senyue DAI xianxi | 1990 | Chinese Physics Letters1990，7，9： | 0 |
| 15 | Influence of Urea Uneven Injection on the Performances of a Diesel Engine显示文摘The influence of heterogeneous flow injection of urea at different velocities and temperatures on NO x conversion efficiency,ammonia storage and ammonia leakage is investigated experimentally.A diesel engine employing a selective catalytic reduction(SCR)technology is considered.It is found that for a fixed injection velocity,the degree of ammonia leakage changes depending on the temperature.The higher the temperature,the faster the catalytic reduction reaction and the smaller the degree of ammonia leakage.The temperature has a great influence on the catalytic reduction reaction rate.At an injection velocity of 10000/h,the average reaction rate at 420℃ is 12 times higher than that at 180℃.The injection velocity has a weak influence on the reaction rate.When the injection velocity changes from 10000/h to 40000/h at the same temperature,the average reaction rate does not change appreciably.However,increasing the space velocity can accelerate the leakage of ammonia,thereby miti-gating the benefits associated with the NO_(x) conversion. | Chang Huang Shuzhan Bai Guoxiang Li Ke Sun | 2023 | Fluid Dynamics & Materials Processing2023，19，1： | 0 |
| 16 | GENERALIZATION TO CYLINDRICAL COORDINATE SYSTEM FOR THE HIGHER ORDER KDV AND KP EQUATION显示文摘Two new model equations which we call a higher order cylindrical KdV equation and a higher order cylindrical KP equation are proposed when we consider the 2-dimensional modulation of water waves with surface tension in cylindrical coordinate system.Some exact (2+1)-dimensional solitary wave solutions have been obtained by relating them to the higher order KdV equation through an appropriate variable transformation. | HUANG Guoxiang DAI Xianxi LOU Senyue | 1990 | Chinese Physics Letters1990，7，2： | 0 |
| 17 | Analyses of gene effects and inheritance of resistance to bacterial blight in rice显示文摘<正> We analyzed the resistant inheritance of a japonica variety, Jia23, to two bacterial blight pathogen strains, KS—6—6 and Zhe 173, representing respectively the two predominant pathogenic types (Ⅱ and Ⅳ) in the rice cropping area along the Yangtze River Valley. Jla23 was crossed with susceptible varieties, Ewan8 and 7416. F_1 plants were backcrossed with both resistant and susceptible parents to produce B_1 (F_1×P_1) and B_2 (F_2×P_2). All generations were planted during the late—season on an isolated field from Jun to Oct in 1994. Thirty—day—old seedlings were transplanted individually with a spacing of 13cm between plants and 17cm between rows. Concentration of inoculum was adjusted to 10~9 cells/ml. Three fully expanded leaves per plant were inoculated with each type of strains by | ZHANG Xianguang GONG Guoxiang and HUANG Yongkai Food Crops Res Inst,Hubei Acad of Agri Sci,Wuhan 430064,China | 1995 | Chinese Rice Research Newsletter1995，3，4： | 0 |
| 18 | LARRAZA-PUTTERMAN EQUATION INCLUDING VISCOSITY AND EXTERNAL DRIVE显示文摘The weak nonlinear modulation of the surface wave of a three-dimensional imcompressible fluidwithout rotation,which is contained in a rectangular trough is studied by using the method of multi-ple scales perturbation theory.The effects of viscid and external drive on the motion,which modifiesthe Larraza-Putterman equation,are considered.The results are consistent with that of Miles. | YAN Jiaren, HUANG Guoxiang and LI Hong(Xiangtan University) | 1989 | Chinese Journal of Acoustics1989，8，2： | 0 |
| 19 | Development of Energy-Saving Devices for a 20,000DWT River–Sea Bulk Carrier显示文摘A reduction of fuel consumption and an increase in efficiency are currently required for river–sea bulk carriers.Pre-swirl and ducted stators are widely used devices in the industry and efficiency gains can be obtained for single-screw and twin-screw vessels.Based on the hydrodynamic characteristics of the 20,000DWT river–sea bulk carrier,in this study,we proposed,designed,and tested a series of pre-swirl energy-saving devices(ESDs).The experimental results demonstrate that the proposed ESDs improved the propulsive efficiency and reduced the delivered power.The results confirm the success of our ESD for the 20,000DWT river–sea bulk carrier.We validated the role of Reynolds-averaged Navier–Stokes(RANS)computational fluid dynamics(CFD)in the twin-skeg river–sea vessel ESD design and found the circumferential arrangement and number of stators to be important factors in the design process. | Kunpeng Chen Yuling Gao Zhenping Huang Guoxiang Dong | 2018 | Journal of Marine Science and Application2018，17，1： | 0 |
| 20 | Executive summary of Chinese expert consensus for topical application of anti-microbial agents for lower respiratory tract infection in adults显示文摘In recent years,with the increased prevalence of multi-drug resistant(MDR)bacterial infection and chronic pulmonary infection,the topical application of anti-microbial agents,mainly inhaled antibiotics,has come back to clinical practice.Several formulations for nebulization and dry powder inhaler(DPI)have been approved for inhaled anti-infective therapy.Meanwhile,evidence and experience have been accumulated in the use of anti-microbial agents delivered via airway.However,the available studies in this field are heterogenous in the study population,drug delivery route and dosages.The efficacy and safety of inhaled anti-infective therapy in various types of lower respiratory tract infections(LRTIs)need to be evaluated.Moreover. | Jing Zhang Qijian Cheng Yi Huang Hong Fan Guoxiang Lai Xiangdong Mu Wei Sha Danyang She Ning Shen Xin Su Jinfu Xu Feng Ye Xinlun Tian Tiantuo Zhang Hua Zhou Youning Liu Lixian He Heping Xiao Bei He Yi Shi Xiangyan Zhang Bin Cao Jieming Qu on behalf of Pulmonary Infection Assembly of Chinese Thoracic Society | 2022 | Chinese Medical Journal2022，135，22： | 0 |
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