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| 1 | Sulfur-containing amino acid methionine as the precursor of volatile organic sulfur compounds in algea-induced black bloom显示文摘After the application of methionine, a progressive and significant increase occurred in five volatile organic sulfur compounds (VOSCs): methanethiol (MeSH), dimethyl sulfide (DMS), dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS) and dimethyl tetrasulfide (DMTeS). Even in the untreated control without a methionine addition, methionine and its catabolites (VOSCs, mainly DMDS) were found in considerable amounts that were high enough to account for the water's offensive odor. However, blackening only occurred in two methionine-amended treatments. The VOSCs production was observed to precede black color development, and the reaching of a peak value for total VOSCs was often followed by water blackening. The presence of glucose stimulated the degradation of methionine while postponing the occurrence of the black color and inhibiting the production of VOSCs. In addition, DMDS was found to be the most abundant species produced after the addition of methionine alone, and DMTeS appeared to be the most important compound produced after the addition of methionine+glucose. These results suggest that methionine acted as an important precursor of the VOSCs in lakes suffering from algea-induced black bloom. The existence of glucose may change the transformation pathway of methionine into VOSCs to form larger molecular weight compounds, such as DMTS and DMTeS. | Xin Lu Chengxin Fan Wei He Jiancai Deng Hongbin Yin | 2013 | Journal of Environmental Sciences2013，25，1： | 27 |
| 2 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 3 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 4 | Investigation on thermophysical properties of reactive powder concrete显示文摘The thermophysical properties,such as thermal conductivity,thermal diffusivity,specific heat capacity and linear thermal expansion of reactive powder concrete(RPC) with different steel fiber volumetric fractions are investigated by means of high temperature tests. The thermophysical characteristics of RPC with different fiber volumes under different temperatures are analyzed and compared with those of the common high-strength concrete and high-performance concrete. The empirical relationships of thermophysical properties with temperature and fiber volume are identified. By the heat transfer and solid physics methods,the microscopic physical mechanism of heat transfer process and heat conduction properties of RPC are investigated,and the theoretical formulas of specific heat capacity and thermal expansion coefficient are derived,respectively. The effects of temperature and steel fibers on the specific heat capacity and the thermal expansion coefficient are quantitatively analyzed and the discriminant conditions are provided. It is shown that the experimental results are consistent with the theoretical prediction. | JU Yang LIU HongBin LIU JinHui TIAN KaiPei WEI Song HAO Song | 2011 | Science China(Technological Sciences)2011，54，12： | 13 |
| 5 | Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas显示文摘Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been described.To determine how EBV miRNAs control the expression of host genes,and to understand their potential role in NPC tumorigenesis,we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues.We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC.Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC.A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated,suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis.An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis. | ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan | 2014 | Science China(Life Sciences)2014，57，3： | 10 |
| 6 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 7 | Cooling mechanism of embankment with block stone interlayer in Qinghai-Tibet railway显示文摘In order to study the cooling mechanism of embankment with block stone interlayer under open and closed conditions,an experimental railway section was built and data within one freeze-thaw cycle were collected. The results explain well the cooling mechanism of embankment with block stone interlayer. Under the open condition in cold seasons,the enforced convection effect occurs within block stone interlayer when the wind speed is large;however,the weak air convection occurs within the block stone interlayer near the bottom of the embankment when the wind speed is slow. Under the open condition in warm seasons,heat conduc-tion occurs within block stone interlayer due to the change in wind speed and di-rection. Under the closed condition,however,the enforced convection within block stone interlayer is so weak that heat conduction is dominant in the whole year be-cause wind is blocked. Therefore,the cooling effect of embankment with a block stone interlayer to the soil beneath it is produced by enforced convection and weak free air convection;both its process and the cooling intensity are controlled by the local wind speed and direction. Because of the difference in the cooling effects,the soil temperature beneath the embankment has a temperature difference of 2℃―4℃ between the open and closed conditions. | WU QingBai CHENG HongBin JIANG GuanLi MA Wei LIU YongZhi | 2007 | Science China(Technological Sciences)2007，50，3： | 8 |
| 8 | Distribution of green algae micro-propagules and their function in the formation of the green tides in the coast of Qinhuangdao,the Bohai Sea, China显示文摘Since 2015, a novel green tide has been recurring in the coastal areas of Qinhuangdao at the western coast of the Bohai Sea in China, threatening the environment and ecosystem of the Beidaihe seaside holiday resort along the coast. Micro-propagules of the green algae including gametes, spores, micro-germlings and micro-vegetative fragments play an important role in the formation of green tides. They serve as a 'seed source' of green macroalgae, and their distributions could reflect and influence the 'algae source' of green tides. In this study,monthly surveys in the inshore and offshore areas of the Qinhuangdao coast were conducted from April to September 2016 and in January 2017 to investigate the tempo-spatial distribution patterns and the biomass variations of the green algae micro-propagules. The obtained results show that micro-propagules were mainly distributed in the inshore areas with a significantly decreasing abundance towards offshore areas. Their biomass was highest in July and August, and lowest in winter. The areas that were affected by the green tides showed a remarkably higher abundance of micro-propagules compared to other areas. These micro-propagules could serve as the 'seed' source of green tides. Their distribution patterns indicate that the green tide in the coastal areas of Qinhuangdao originated locally. | Hongbin Han Wei Song Zongling Wang Dewen Ding Chao Yuan Xuelei Zhang Yan Li | 2019 | Acta Oceanologica Sinica2019，38，8： | 8 |
| 9 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 10 | RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor显示文摘The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory,metabolic and neurodegenerative diseases,but medications targeting the NLRP3 inflammasome are not available for clinical use.RRx-001 is a well-tolerated anticancer agent currently being investigated in phase III clinical trials,but its effects on inflammatory diseases are not known.Here,we show that RRx-001 is a highly selective and potent NLRP3 inhibitor that has strong beneficial effects on NLRP3-driven inflammatory diseases.RRx-001 inhibits the activation of the canonical,noncanonical,and alternative NLRP3 inflammasomes but not the AIM2,NLRC4 or Pyrin inflammasomes.Mechanistically,RRx-001 covalently binds to cysteine 409 of NLRP3 via its bromoacetyl group and therefore blocks the NLRP3-NEK7 interaction,which is critical for the assembly and activation of the NLRP3 inflammasome.More importantly,RRx-001 treatment attenuates the symptoms of lipopolysaccharide(LPS)-induced systemic inflammation,dextran sulfate sodium(DSS)-induced colitis and experimental autoimmune encephalomyelitis(EAE)in mice.Thus,our study identifies RRx-001 as a new potential therapeutic agent for NLRP3-driven diseases. | Yun Chen Hongbin He Bolong Lin Yun Chen Xianming Deng Wei Jiang Rongbin Zhou | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 11 | Microstructure and Tribological Properties of Fe-Cr-B-Si-based Alloy Coating on the Surface of Scraper Conveyor Middle Trough NM450显示文摘This paper aims to develop a surface modification process to improve the surface properties of the middle trough.The coatings were prepared by plasma cladding with Fe-Cr-B-Si-based alloy powders (Ig 6 and Ig7).The organizational structure and micro-hardness of the coatings were analyzed by laboratory equipments.The friction and wear tests were performed to investigate the friction-wear properties of middle trough.The coatings have higher hardness and good friction-wear properties than the substrate.The hardness and friction wear properties of the coating with Ig7 powder are better than those with Ig6 powder.The experimental results show that the surface properties of the middle trough are improved by Fe-Cr-B-Si-based alloy coating,which can improve the middle trough service life.The plasma cladding can be widely used in the surface-modification of middle trough to reduce the waste of resources. | 李军霞 张弘玉 ZHANG Hongbin YANG Xiaobing ZHANG Wei LIU Libo | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 5 |
| 12 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 13 | Production of gasoline range hydrocarbons from methanol on hierarchical ZSM-5 and Zn/ZSM-5 catalyst prepared with soft second template显示文摘Nano hierarchical mesoporous ZSM-5 catalysts were prepared with cationic dimethyldiallyl ammonium chloride acrylamide copolymer(PDDA) as a soft second template. Using ZSM-5 catalyst as a matrix,Zn/ZSM-5 catalysts were also obtained by the wet impregnation method. The effect of the PDDA amount and Zn loadings on the properties of the catalysts,including crystallinity,morphology,textural properties,acid nature and catalytic activity in MTG reaction,was investigated by XRD,FESEM,TEM,Nitrogen adsorption–desorption isotherms and NH3-TPD method,respectively. The MTG reaction was performed in a fixed bed reactor,and the result revealed that the nano hierarchical ZSM-5 catalyst prepared with a PDDA/Si molar ratio of 0.070 possesses longer stable phase of 70 h with a liquid hydrocarbon selectivity of 29.8%.Zn/ZSM-5 catalyst with a Zn/ZSM-5 ratio of 0.07 wt.% shows the highest liquid hydrocarbon selectivity,reaching 62.5%. | Xiaodong Wang Xiaoxia Gao Mei Dong Hongbin Zhao Wei Huang | 2015 | Journal of Energy Chemistry2015，24，4： | 4 |
| 14 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
| 15 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 16 | Highly efficient pure white polymer light-emitting devices based on poly(N-vinylcarbazole) doped with blue and red phosphorescent dyes显示文摘Efficient white-polymer-light-emitting devices (WPLEDs) have been fabricated with a single emitting layer containing a hole-transporting host polymer,poly(N-vinylcarbzole),and an electron-transporting auxiliary,1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl]-phenylene,codoped with two phosphorescent dyes:Iridium(III)bis (2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate (FIrpic) and home-made Ir-G2 for blue and red emission,respectively.With the structure of ITO/PEDOT:PSS 4083(40 nm)/emission layer(80 nm)/Ba(4 nm)/Al(120 nm),the device showed a maximal luminous efficiency (LE) of 13.5 cd A-1(corresponding to an external quantum efficiency (EQE) of 6.8%),and a peak power efficiency (PE) of 6.5 lm W-1 at 6.0 V.Meanwhile,the device exhibited pure white emission with Commission Internationale de l'Eclairage (CIE) coordinates of (0.34,0.35) at a current density of 12 mA cm-2,which is very close to the equi-energy white point with CIE coordinates of (0.33,0.33).The device performance can be further optimized when more balanced hole/electron injection is achieved by incorporating a lower conducting type anode buffer layer (PEDOT:PSS) and incorporating poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorenene)-alt-2,7-(9,9-dioctyfluorene)] (PFN) as an electron injection layer at the cathode.The optimized device showed an LE of 24.6 cd A-1 (with an EQE of 14.1%),while the peak power efficiency reached 12.66 lm W-1.Moreover,the WPLEDs showed good electroluminescence (EL) stability over a wide range of operating current density and luminance. | HU SuJun ZOU JianHua ZHOU GuiJiang LI DongYun WU HongBin SU ShiJian WONG Wai-Yeung YANG Wei PENG JunBiao CAO Yong | 2011 | Science China Chemistry2011，54，4： | 4 |
| 17 | Light Regulation of Stomatal Development and Patterning: Shifting the Paradigm from Arabidopsis to Grasses显示文摘The stomatal pores of plant leaves control gas exchange with the environment.Stomatal development is prevised regulated by both internal genetic programs and environmental cues.Among various environmental factors,light regulation of stomata formation has been extensively studied in Arabidopsis.In this review,we summarize recent advances in the genetic control of stomata development and its regulation by light.We also present a comparative analysis of the conserved and diverged stomatal regulatory networks between Arabidopsis and cereal grasses.Lastly,we provide our perspectives on manipulation of the stomata density on plant leaves for the purpose of breeding crops that are better adapted to the adverse environment and high-density planting conditions. | Hongbin Wei Dexin Kong Juan Yang Haiyang Wang | 2020 | Plant Communications2020，1，2： | 4 |
| 18 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 19 | Electrochemistry during efficient copper recovery from complex electronic waste using ammonia based solutions显示文摘 | Zhi Sun Hongbin Cao Prakash Venkatesan Wei Jin Yanping Xiao Jilt Sietsma Yongxiang Yang | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 3 |
| 20 | Modeling plants with sensor data显示文摘Sensor data, typically images and laser data, are essential to modeling real plants. However, due to the complex geometry of the plants, the measurement data are generally limited, thereby bringing great difficulties in classifying and constructing plant organs, comprising leaves and branches. The paper presents an approach to modeling plants with the sensor data by detecting reliable sharp features, i.e. the leaf apexes of the plants with leaves and the branch tips of the plants without leaves, on volumes recovered from the raw data. The extracted features provide good estimations of correct positions of the organs. Thereafter, the leaves are reconstructed separately by simply fitting and optimizing a generic leaf model. One advantage of the method is that it involves limited manual intervention. For plants without leaves, we develop an efficient strategy for decomposition-based skeletonization by using the tip features to reconstruct the 3D models from noisy laser data. Experiments show that the sharp feature detection algorithm is effective, and the proposed plant modeling approach is competent in constructing realistic models with sensor data. | MA Wei XIANG Bo ZHA HongBin LIU Jia ZHANG XiaoPeng | 2009 | Science in China(Series F)2009，52，3： | 3 |
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