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| 1 | Phytolith records of the climate change since the past 15000 years in the middle reach of the Yangtze River in China显示文摘基于 ^ 啜 14 ^ C 标明日期和核心沉积调查, phytolith 记录被采用重建在在中间的 Jianghan 平原的 paleovegetation 和古气候长江到达。识别的 Phytoliths 被分配进 21 描述得好的 morphotypes 并且把组划分了成四(Poaceae,蕨纲植物,具球果、阔叶) 。和温暖索引的 phytolith 集合(我 ^ 潜水艇 w ^) 被划分成 18 个生态的地区,它在过去的 15000 年期间在长江的中间的活动范围反映与气候变化有关的完全的植被历史。根据有从石笋, peatland ,诺思大西洋深海的沉积,华中的黄土高原,和阿拉伯语海的 paleoclimatic 指示物的 phytolith 记录的关联沉积,八个气候的阶段被识别包括的上次冰川的最大值( LGM )( 20-14.8 cal kaBP ),持续冰川的消失( LDG )( 14.8-11.9 cal kaBP ),在早 Holocene ( 11.9-8 cal kaBP )的低温度的阶段, Holocene 最佳( 8-4.9 cal kaBP ), Holocene Katathermal ( 4.9-1.1 cal kaBP ),中世纪的温暖时期( M 自从 LDG,象 Bolling-Allerod 温暖的间隔,更旧的 Dryas, Inter-Allerod 冷时期,和更年轻的 Dryas 那样的气候的事件,和八个霍洛辛·邦德事件(B1-8 ) 被识别了。我们的结果证明在研究区域的气候的进化与印度夏天有一个强壮的连接季风( SW 季风),亚洲夏天季风( SE 季风),和在诺思大西洋的 Holocene 事件同时,它可能显示太阳的可变性在一百年、千年的规模影响地球表面气候系统[出版摘要] | Yansheng GU Hanlin WANG Xianyu HUANG Hongxia PENG Junhua HUANG | 2012 | Frontiers of Earth Science2012，6，1： | 14 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Apoptosis of Spodoptera litura larval hemocytes induced byheavy metal zinc显示文摘By adding different amount of zinc into the artificial medium of the insect larvae, the zinc-induced apoptosis of the larvae haemocytes of the herbivorous insect Spodoptera litura Fabricius was investigated with flow cy- tometer. The results showed that the increase of zinc dose in the artificial feed led to the accumulations of zinc in the lar- val hemolymph and fat body, and more zinc was accumu- lated in fat body than in hemolymph. The apoptosis of hemocytes was significantly induced at high zinc concentra- tion (1000 mg·kg?1) in the insect diet, and the apoptosis rate was 63.63%, which was remarkably higher than that at con- trol and lower concentrations (50―500 mg·kg?1). This sug- gests that the high dose of zinc in the artificial diet of S. litura larvae could induce the apoptosis of the larval hemocytes of S. litura. | XIA Qiang SUN Hongxia HU Xinjun SHU Yinghua GU Dexiang ZHANG Guren | 2005 | Chinese Science Bulletin2005，50，24： | 9 |
| 4 | A general powder dusting method for latent fingerprint development based on AIEgens显示文摘Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images. | Zijie Qiu Bin Hao Xinggui Gu Zhaoyu Wang Ni Xie Jacky W.Y.Lam Hongxia Hao Ben Zhong Tang | 2018 | Science China Chemistry2018，61，8： | 6 |
| 5 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 6 | Effect of Jianpiyiqi granule on ocular myasthenia gravis in children prepared with a formula from Traditional Chinese Medicine显示文摘OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at the neuromuscular junction.METHODS: A total of 155 children with ocular MG were recruited from January 2008 to January 2015.All individuals received ineffective glucocorticoid treatment prior to admission, and were given Jianpiyiqi granules(two doses per day) for 12 months.Plasma levels of acetylcholine receptor autoantibodies(ACh R-Ab), cytokines, immune parameters and clinical score were analyzed.RESULTS: After intervention with Jianpiyiqi granule for 12 months, the levels of cytokines [including interleukin(IL)-6, IL-12, IL-17], immune parameters[including immunoglobulin G(Ig G), Ig M, free triiodothyronine, free thyroxine] and ACh R-Ab were sig-nificantly decreased(P = 0.042, P = 0.049, P = 0.011,P = 0.02, P = 0.04, P = 0.03, P = 0.01; F = 21.60, P =0.000). In contrast, IL-4 levels were significantly increased(P = 0.049). The absolute clinical score after treatment declined significantly compared with before treatment(F = 33.24, P = 0.000). The effective cure rate and the total effective rate gradually increased to a maximum of 149(96.2%) and 151(97.4%) in MG patients after 12 months of treatment, respectively.CONCLUSION: The Jianpiyiqi granule treatment lowered ACh R-Ab levels and improved cytokine and other immune parameter levels, which suggests that the granule could be an ancillary treatment for ocular MG in children caused by a defect in synaptic transmission at the neuromuscular junction. | Qi Guoyan Liu Peng Gu Shanshan Yang Hongxia Dong Huimin Xue Yinping | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 4 |
| 7 | Synergistic effects of ginseng stem and leaf-extracted ginsenoside and choline on improving learning and memory in rats Association verification experiment in animals with multiple learning and memory disorders显示文摘BACKGROUND: Ginsenoside extracted from the stem and leaf of ginseng (GSL) and choline have both been shown to improve learning and memory functions; however,further studies are needed to understand the synergistic effects of a combination of both. OBJECTIVE: To verify the combined improved synergistic effects of GSL and choline on learning and memory disorders in rats. DESIGN: Control observation. SETTING: Taishan Medical College. MATERIALS: A total of 150 male Kunming mice weighing (20±2) g and 40 healthy male Wistar rats weighing (220±20) g were provided by the Experimental Animal Department of Jilin University. Animal experimentation received confirmed consent from the local ethic committee. GSL was provided by the Department of Chemistry,Norman Bethune Medical University,and choline was provided by the Third Experiment Factory,Shanghai. METHODS: This study was performed at the Life Science Institute,Taishan Medical College from October 2006 to February 2007. ① Scopolamine-induced learning and memory disorders in rats: Forty rats were randomly divided into control group,model group,combination group (400 mg/kg GSL + 200 mg/kg choline),GSL (400 mg/kg) group,and choline (200 mg/kg) group,8 rats/group. Rats were perfused and administrated in the morning,once a day for 14 successive days. Rats in the control group and model group were perfused with 20 mL/kg distilled water and underwent Morris water maze spatial resolution test 1 hour after perfusion on the 10th,11th,and 12th days after administration. Rats also underwent passive step-down avoidance test 1 hour after reperfusion on the 13th and 14th days after administration. Thirty minutes prior to experimentation,rats in the remaining three groups were intraperitoneally (i.p) injected with 2 mg/kg scopolamine,and rats in the control group were i.p. injected with 2 mL/kg saline. ② Scopolamine-induced learning disorder and memory acquired disorder in mice: Fifty mice were randomly divided into control group,model group,combination group (400 mg/kg GSL +200 mg/kg choline),GSL (400 mg/kg) group,and choline (200 mg/kg) group,with 10 mice/group. Mice were perfused and administrated in the morning,once a day for 9 successive days. Mice in the control group and model group were perfused with 20 mL/kg distilled water and underwent passive step down avoidance test 1 hour after reperfusion on the 8th and 9th day after administration. Twenty minutes prior to training,mice in the remaining three groups were i.p. injected with 2 mg/kg scopolamine,and mice in the control group were i.p. injected with 10 mL/kg saline. ③ Sodium nitrite-induced memory consolidation disorder in mice: Grouping,administration,and testing were the same as mentioned above. After training,mice in the remaining three groups were immediately subcutaneously injected with 120 mg/kg sodium nitrite,and mice in the control group were subcutaneously injected with 20 mL/kg saline. ④ Ethanol-induced memory reconsolidation disorder in mice: Grouping,administration,and testing were the same as mentioned above. At 24 hours after training and 20 minutes before retraining,mice in the remaining four groups were perfused with 10 mL/kg ethanol (0.3 volume fraction),and mice in the control group were perfused with 10 mL/kg saline. MAIN OUTCOME MEASURES: Synergistic effects of GSL and choline on learning and memory deficits induced by scopolamine,sodium nitrite,and ethanol in experimental animals. RESULTS: All 40 rats and 150 mice were included in the final analysis. ① Synergistic effects of GSL and choline on learning and memory disorders induced by scopolamine in rats: During passive step-down avoidance and Morris water maze spatial resolution tests,the number of error responses and length of maze training in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses and length of maze training in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combining administration,which suggests that the combination of GSL and choline had synergistic effects. ② Synergistic effects of GSL and choline on learning disorder and memory-acquired disorder induced by scopolamine in mice: During passive step-down avoidance test,the number of error responses in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combining administration,which suggests GSL and choline had synergistic effects. ③ Synergistic effects of GSL and choline on memory sodium nitrate-induced consolidation disorder in mice: During passive step down avoidance test,the number of error responses in the model group were significantly less than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combined administration,which suggests GSL and choline had synergistic effects. ④ Synergistic effects of GSL and choline on ethanol-induced memory reconsolidation disorder in mice: During passive step down avoidance test,the number of error responses in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combined administration,which suggests GSL and choline had synergistic effects. CONCLUSION: GSL and choline have synergistic effects on learning and memory functions. | Xiaomin Zhao Hongxia GU Qing Li Xianglin Xie Zuoli Xia Hongxin Cai Ling Zhang Dawei Li Xinnong Wang | 2008 | Neural Regeneration Research2008，3，2： | 3 |
| 8 | Holocene palaeoflood events recorded by slackwater deposits along the lower Jinghe River valley, middle Yellow River basin, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Hongxia Su Yuzhu Zhang Hengsong Wang Hongliang Gu | 2012 | J Quaternary Sci2012，，5： | 2 |
| 9 | TEMPO-Mediated Oxidation of Primary Alcohols to Aldehydes under Visible Light and Air显示文摘A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant.Ru(bpy)_(3)(PF_(6))_(2)(bpy:bipyridyl)and Ir(dtb-bpy)(ppy)_(2)(PF_(6))(dtb-bpy:4,4'-di-tert-butyl-2,2'-bipyridyl;ppy:2-phenylpyridine)were used as the sensitizers. | Dongwang Liu Hongxia Zhou Xiangyong Gu Xiaoqin Shen Pixu Li | 2014 | Chinese Journal of Chemistry2014，32，2： | 2 |
| 10 | Effect of carboxylic acid groups on the supercapacitive performance of functional carbon frameworks derived from bacterial cellulose显示文摘Three-dimensional(3D) carbonaceous materials derived from bacterial cellulose(BC) has been introduced as electrode for supercapacitors in recent. Here, we report a simple strategy for the synthesis of functional carbon frameworks through 2,2,6,6-tetramethylpilperidine 1-oxyl radical(TEMPO)-mediated oxidation of bacterial cellulose(BC) followed by carbonization. TEMPO-mediated oxidation can efficiently convert the hydroxyls on the surface of BC to carboxylate groups to improve electrochemical activity. Because of its high porosity, good hydrophilicity, rich oxygen groups, and continuous ion transport in-between sheet-like porous network, the TEMPO-oxidized BC delivers a much higher gravimetric capacitance(137.3 F/g) at low annealing temperature of 500℃ than that of pyrolysis BC(31 F/g) at the same annealing temperature. The pyrolysis modified BC obtained at 900℃ shows specific capacitance(160.2 F/g), large current stability and long-term stability(84.2% of its initial capacitance retention after 10,000 cycles). | Tianyun Zhang Junwei Lang Li Liu Lingyang Liu Hongxia Li Yipeng Gu Xingbin Yan Xin Ding | 2017 | Chinese Chemical Letters2017，28，12： | 2 |
| 11 | The cancer-testis gene,MEIOB,sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency显示文摘Objective:The newly defined cancer-testis(CT)gene,MEIOB,was previously found to play key roles in DNA double-strand break(DSB)repair.In this study,we aimed to investigate the effects and mechanisms of MEIOB in the carcinogenesis of triple-negative breast cancers(TNBCs).Methods:The Cancer Genome Atlas database was used to quantify the expression of MEIOB.Cox regression analysis was used to evaluate the association between MEIOB expression and the prognosis of human TNBC.The effects of MEIOB on cell proliferation and migration in TNBCs were also assessed in vitro.Patient-derived xenograft(PDX)models were used to assess the sensitivity of breast cancers with active MEIOB to PARP1 inhibitors.Results:We confirmed MEIOB as a CT gene whose expression was restricted to the testes and breast tumors,especially TNBCs.Its activation was significantly associated with poor survival in breast cancer patients[overall,hazard ratio(HR)=1.90(1.16–2.06);TNBCs:HR=7.05(1.16–41.80)].In addition,we found that MEIOB was oncogenic and significantly promoted the proliferation of TNBC cells.Further analysis showed that MEIOB participated in DSB repair in TNBCs.However,in contrast to its function in meiosis,it mediated homologous recombination deficiency(HRD)through the activation of poly ADP-ribose polymerase(PARP)1 by interacting with YBX1.Furthermore,activated MEIOB was shown to confer sensitivity to PARP inhibitors,which was confirmed in PDX models.Conclusions:MEIOB played an oncogenic role in TNBC through its involvement in HRD.In addition,dysregulation of MEIOB sensitized TNBC cells to PARP inhibitors,so MEIOB may be a therapeutic target of PARP1 inhibitors in TNBC. | Yayun Gu Cheng Wang Rongxuan Zhu Jianshui Yang Wenwen Yuan Yanhui Zhu Yan Zhou Na Qin Hongbing Shen Hongxia Ma Hongxia Wang Xiaoan Liu Zhibin Hu | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 12 | Genetic variants of miRNA sequences and non-small cell lung cancer survival显示文摘 | Hu Zhibin Chen Jiaping Tian Tian Zhou Xiaoyi Gu Haiyong Xu Lin Zeng Yi Miao Ruifen Jin Guangfu Ma Hongxia Chen Yijiang Shen Hongbing | 2008 | Journal of Clinical Investigation2008，，7： | 1 |
| 13 | Release of myocardial noradrenaline during acute hibernation in the isolated rat heart显示文摘Objective: To explore the release of myocardial noradrenaline during acute hibernation. Methods: The hearts were gained from rats and set up as modified Langendorf preparations beating isometrically. They were perfused with modified Krebs-Henseleit buffer under controlled pressure. Mechanical measurements and coronary effluent were recorded simultaneously at 30 min intervals for 150 min. Lactate dehydrogenase in coronary effluent was assayed at the beginning, 60 min and 120 min low-flow ischemia. Noradrenaline in coronary effluent was determined at the beginning of low-flow and 120 min of low-flow ischemia and also in control, during hibernation and after 30 min reperfusion during stimulation, myocardial noradrenaline response on tyramine was investigated in absence or presence of desipramine after 30 min reperfusion. Results: In the control, there was nosignificant chant in noradrenaline overflow during 120 min perfusion; In the acute myocardial hibernation group, there was also nosignificant difference in noradrenaline overflow between the beginning and 120 min low-flow ischemia. The electrical field stimulation-induced overflow of noradrenaline during hibernation myocardium was significantly less than preischemia or after reperfusion, but there was nosignificant difference between preischemia and reperfusion group. Tyramine induced significant noradrenaline release in absence of desipramine after 30 min reperfusion, but this increase in noradrenaline release had nosignificant in the presence of desipramine. These studies indicated that there was not significant spontaneous noadrenaline overflow during acute myocardial hibernation in isolated rat hearts, the stimulation-induced noradrenaline overflow decreased during hibernation and restored to the level of preischemia after reperfusion, myocardial noradrenaline response to tyramine remained after 30 min reperfusion. Conclusion: Myocardial noradrenaline overflow may not contribute to the development of acute myocardial hibernation and the function of sympathetic nerve may also maintain in hibernation as myocardium does during acute myocardial hibernation, reperfusion of myocardium may contribute to restoring the function of sympathetic nerve. | Zuolin Fu Yibai Feng Hongxia Xu Jiang Xie Xinping Zhang Chunzhi Shi Xiang Gu Ming Li | 2005 | Journal of Nanjing Medical University2005，19，5： | 1 |
| 14 | Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals—A 5-year follow-up study显示文摘 | Shimin Jiang Xuefeng Sun Hongxia Gu Yunshuang Chen Chunsheng Xi Xi Qiao Xiangmei Chen | 2012 | Maturitas2012，，3： | 1 |
| 15 | Small moving infrared space target tracking algorithm based on probabilistic data association filter显示文摘 | Zhengzhou Li Jing Chen Yuanshan Gu Lan Tang Zhen Dai Hongxia Fu Ruzhang Li Changju Liu Gang Jin | 2014 | Infrared Physics and Technology2014，，： | 1 |
| 16 | Effects of ginsenoside of stem and leaf combined with choline on learning and memory ability of rat models with Alzheimer diseases显示文摘BACKGROUND: Central adrenergic nerve and 5-serotonergic nerve can influence central cholinergic nerve on learning and memory and make easy for study; however, ginsenoside of stem and leaf (GSL) can improve functions of central adrenergic nerve; moreover, 5-serotonergic nerve and the combination with choline can produce synergistic effect and enhance learning and memory ability so as to improve learning and memory disorder of patients with Alzheimer disease (AD). OBJECTIVE: To observe the effects of GSL combining with choline on learning and memory of AD model rats.DESIGN: Randomized grouping design and controlled animal study.SETTING: Department of Pharmacology, Taishan Medical College. MATERIALS: The experiment was carried out in the Pharmacological Department of Medical College of Jilin University from October 1996 to January 1997. Forty healthy male Wistar rats of clean grade were randomly divided into 5 groups, including sham-injury group, model group, GSL group, choline group and combination group, with 8 rats in each group. Main medications: GSL with the volume more than 92.8% was provided by Department of Chemistry, Norman Bethune Medical College of Jilin University. Panaxatriol, the main component, was detected with thin layer scanning technique and regarded as the index of GSL quality [(55±1)%, CV = 2%, n = 5]. Choline was provided by the Third Shanghai Laboratory Factory. METHODS: 150 nmol quinolinic acid was used to damage bilateral Meynert basal nuclei of adult rats so as to establish AD models. Rats in GSL, choline and combination groups were intragastric administrated with 400 mg/kg GSL, 200 mg/kg choline (20 mL/kg), and both respectively last for 17 days starting from two days before operation. Rats in sham-injury group and model group were perfused with the same volume of distilled water once in each morning for the same days. ① Passive avoidance step-down test: Five minutes later, rats jumped up safe platform when they were shocked with 36 V alternating current. If rats jumped down from the platform and the feet touched railings, the response was wrong. Numbers of wrong response were recorded within 3 minutes, and then the test was redone after 24 hours. ② Morris water-maze spatial localization task: Swimming from jumping-off to platform directly was regarded as right response. Additionally, 4 successively right responses were regarded as the standard. Each rat was trained 10 times a day with 120 s per time for 3 successive days. The interval was 30 s. Three days later, numbers of right response were recorded. The training times were increased to 30 for unlearned rats. ③ Measurement of activity of choilne acetylase in cerebral cortex: Rats were sacrificed at 17 days after operation to obtain cerebral cortex to measure activity of choilne acetylase with radiochemistry technique. ④ Synergistic effect: It was expressed as Q value: Q value = factual incorporative effect/anticipant incorporative effect; Q ≥ 1 was regarded as synergistic effect. Anticipant incorporative effect = (EA+EB-EA·EB), EA and EB were single timing effect, respectively in GSL group and choline group. E (step-down test and Morris water maze test) = (x in model group - factual value in medicine groups)/x in model group; E (activity of choilne acetylase) = (factual value in medicine groups -x in model group)/x in model group. MAIN OUTCOME MEASURES: ① Passive avoidance step-down test and Morris water-maze spatial localization task in the study of learning and memory; ② activity of choilne acetylase. RESULTS: All 40 rats were involved in the final analysis. ① Passive avoidance response: At learning phase on first day and retesting phase on the next day, numbers of wrong responses within 3 minutes were more in model group than sham operation group, and there was significant difference [(5.88±1.46), (2.25±0.87) times; (2.63±1.06), (0.50±0.53) times; P < 0.01]; numbers of wrong responses within 3 minutes were less in combination group than model group, and there was significant difference [learning phase: (1.12±0.83), (5.88±1.46) times; retesting phase: (0.38±0.74), (2.63±1.06) times, P < 0.01]; moreover, effect was stronger than that in GSL group and choline group. The Q value was 1.07 and 1.59, respectively and it showed synergistic effect. ② Spatial localization task: Training times were more in model group than sham operation group, and there was significant difference [(2.9±2.5), (12.6±3.5) times; P < 0.01]. Training times were less in combination group than model group, and there was significant difference [(11.8±2.4), (27.9±2.5) times, P < 0.01]; moreover, effect was stronger than that in GSL group and choline group. The Q value was 1.07 and it showed synergistic effect. ③ Activity of choilne acetylase: Activity was lower in model group than sham operation group, and there was significant difference [(30.56±8.33), (61.11±8.33) nkat/g; P < 0.01]. Activity was higher in combination group than model group and there was significant difference [(50.00±8.33), (30.56±8.33) nkat/g, P < 0.01]; moreover, effect was stronger than that in GSL group and choline group. The Q value was 1.5 and it showed synergistic effect. CONCLUSION: GSL in combination with choline can synergically improve the disorder of learning and memory of AD model rats. Its mechanism may be involved in enhancing the function of central cholinergic system. | Xiaomin Zhao Xianglin Xie Zuoli Xia Yunsheng Gao Yuyun Zhu Hongxia Gu | 2006 | Neural Regeneration Research2006，1，4： | 1 |
| 17 | Effects of acute low temperature stress on the endocrine reactions of the Qinghai toad-headed lizard显示文摘 | Chunwang LI Yuan GU Songhua TANG Hongxia FANG Guohua JIANG Zhigang JIANG | 2011 | Current Zoology2011，57，6： | 1 |
| 18 | Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population显示文摘 | Yong Gao Yisha He Jing Xu Lin Xu Jiangbo Du Chen Zhu Haiyong Gu Hongxia Ma Zhibin Hu Guangfu Jin Xiaofei Chen Hongbing Shen | 2013 | Human Genetics2013，，6： | 1 |
| 19 | Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population显示文摘 | Jiangbo Du Jian Ji Yong Gao Lin Xu Jing Xu Chen Zhu Haiyong Gu Jie Jiang Huizhang Li Hongxia Ma Zhibin Hu Guangfu Jin Wei Guo Xiaofei Chen Hongbing Shen | 2013 | Int J Cancer2013，，2： | 1 |
| 20 | Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population显示文摘 | Jiangbo Du Jian Ji Yong Gao Lin Xu Jing Xu Chen Zhu Haiyong Gu Jie Jiang Huizhang Li Hongxia Ma Zhibin Hu Guangfu Jin Wei Guo Xiaofei Chen Hongbing Shen | 2013 | Cancer2013，，2： | 1 |
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