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| 1 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 2 | Finite-time Adaptive Fault-tolerant Control for Nonlinear Systems With Multiple Faults显示文摘This paper focuses on the problem of adaptive finitetime fault-tolerant control for a class of non-lower-triangular nonlinear systems.The faults encountered in the control system include the actuator faults and the abrupt system fault.By applying backstepping design and neural networks approximation,an adaptive finite-time fault-tolerant control scheme is developed.It is shown that the proposed controller ensures that all signals in the closed-loop system are semi-globally practically finite-time stable and the track-ing error converges to a small neighborhood around the origin within finite time.The simulation is carried out to explain the validity of the developed strategy. | Huanqing Wang Wen Bai Peter Xiaoping Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 3 |
| 3 | A novel fuzzy classification entropy approach to image threshol- ding显示文摘 | Liu Dong Jiang Zhaohui Feng Huanqing | 2006 | Pattern Recognition Letters2006，27，16： | 1 |
| 4 | HWM: a hybrid workload migration mechanism of metadata server cluster in data center显示文摘 | Jian LU Huanqing DONG Junwei ZHANG Zhenjun LIU Lu XU | 2017 | Frontiers of Computer Science2017，11，1： | 1 |
| 5 | The dual-special binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection 显示文摘 | Huanq KJ Yang YC Lin YS Huang JH Liu HS Yeh TM Chen SH Liu CC Lei HY | 2006 | Immunl2006，176，5： | 1 |
| 6 | Almost Disturbance Decoupling for HOFA Nonlinear Systems with Strict-Feedback Form显示文摘The article is devoted to the almost disturbance decoupling problem for high-order fully actuated(HOFA)nonlinear systems with strict-feedback form.Using the full-actuation feature of high-order fully actuated systems and Lyapunov stability theory,a state feedback control law and virtual control laws are designed.The unknown disturbances are handled by almost disturbance decoupling(ADD)method.Finally,the effectiveness of the control strategy is verified by stability analysis and simulation. | WANG Na LIU Xiaoping LIU Cungen WANG Huanqing ZHOU Yucheng | 2022 | Journal of Systems Science & Complexity2022，35，2： | 1 |
| 7 | A novel fuzzy classification entropy approach to image thresholding显示文摘 | Liu Dong Jiang Zhaohui Feng Huanqing | 2006 | Pattern Recognition Letters2006，27，7： | 1 |
| 8 | Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice显示文摘Osteoporosis(OP)is a systemic skeletal disease that primarily affects the elderly population,which greatly increases the risk of fractures.Here we report that Kindlin-2 expression in adipose tissue increases during aging and high-fat diet fed and is accompanied by decreased bone mass.Kindlin-2 specific deletion(K2KO)controlled by Adipoq-Cre mice or adipose tissue-targeting AAV(AAV-Rec2-CasRx-sgK2)significantly increases bone mass.Mechanistically,Kindlin-2 promotes peroxisome proliferator-activated receptor gamma(PPARγ)activation and downstream fatty acid binding protein 4(FABP4)expression through stabilizing fatty acid synthase(FAS),and increased FABP4 inhibits insulin expression and decreases bone mass.Kindlin-2 inhibition results in accelerated FAS degradation,decreased PPARγactivation and FABP4 expression,and therefore increased insulin expression and bone mass.Interestingly,we find that FABP4 is increased while insulin is decreased in serum of OP patients.Increased FABP4 expression through PPARγactivation by rosiglitazone reverses the high bone mass phenotype of K2KO mice.Inhibition of FAS by C75 phenocopies the high bone mass phenotype of K2KO mice.Collectively,our study establishes a novel Kindlin-2/FAS/PPARγ/FABP4/insulin axis in adipose tissue modulating bone mass and strongly indicates that FAS and Kindlin-2 are new potential targets and C75 or AAV-Rec2-CasRx-sgK2 treatment are potential strategies for OP treatment. | Wanze Tang Zhen Ding Huanqing Gao Qinnan Yan Jingping Liu Yingying Han Xiaoting Hou Zhengwei Liu Litong Chen Dazhi Yang Guixing Ma Huiling Cao | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 9 | Clinical Effects of the COVID-19 Pandemic Among the Uninfected Pregnant Women—6 PLADs,China,2019−2020显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic potentially affected prenatal care quality and maternal and fetal outcomes globally.What is added by this report?During COVID-19 pandemic period,the rates of caesarean sections(CS)and preterm birth for uninfected pregnant women increased slightly in areas that were relatively severely impacted by the pandemic in China. | Bin Wang Hang An Huanqing Hu Wei Zhao Bahabaike Jiangtulu Shuo Wang Jiamei Wang Junxi Chen Manman Long Zewu Li Yu Jin Yuhuan Li Huiting Chen Tao Xue Xiqing Li Kexin Li Wei Du Suhong Gao Jiangli Di Xiaohong Liu Rongwei Ye Zhiwen Li | 2021 | China CDC weekly2021，3，10： | 0 |
| 10 | Characterization of two halophilic adenylate cyclases from Thermobifida halotolerans and Haloactinopolyspora alba显示文摘Adenylate cyclase(AC)is the key enzyme that catalyzes the formation of cAMP from ATP.In this study,we discovered two novel class Ⅲ ACs with a halophilic property from Thermobifida halotolerans DSM 44931(ThAC)and Haloactinopolyspora alba DSM 45211(HaAC),respectively.The recombinant ThAC and HaAC were expressed in Escherichia coli with molecular weights of 36.1 and 36.0 kDa respectively.The presence of 2500 and 2200 mmolL^(-1)1 NaCl significantly enhanced the enzyme activities of ThAC and HaAC,with 22-fold and 7.4-fold higher activities compared to those without NaCl,respectively.Several divalent metal ions were found to activate the recombinant ACs to different extents,and the optimal metal ion was Mg^(2+)for both ThAC and HaAC with concentrations of 80 mmol·L^(-1) and 40 mmol·L^(-1) respectively.Purified ThAC and HaAC had the optimal specific activities((4.59±0.35)×10^(4) and(7.76±0.52)×10^(4) U·mg^(-1))and catalytic efficiency(4.47 and 5.30 L·mmol^(-1)·s^(-1))at 45℃ and 40℃ respectively,while the optimum pH of both two recombinant ACs was 10.0.This is the first report of the halophilic Class III ACs,which could make new contributions to explore and study ACs for further associated investigations. | Dahai Jiang Zhidi Min Jing Leng Huanqing Niu Yong Chen Dong Liu Chenjie Zhu Ming Li Wei Zhuang Hanjie Ying | 2023 | Chinese Journal of Chemical Engineering2023，53，1： | 0 |
| 11 | Cu-substitution P2-Na_(0.66)Mn_(1-x)Cu_(x)O_(2) sodium-ion cathode with enhanced interlayer stability显示文摘P2-type Mn-based layered oxides are viewed as promising cathode materials for sodium ion battery by virtue of their high theoretical capacity.Considering that pure Na_(2/3)MnO_(2)suffers from poor cycling performances,Cu-substitution strategy is proposed to effectively alleviate this issue.However,the structural evolution mechanism of the Cu-containing samples still remains unclear.Herein,we propose that CuSubstitution P2-type Na_(0.66)Mn_(1-x)Cu_(x)O_(2)with enlarged lattice parameters are conducive to improving the interlayer structure stability through mitigating TMO_(2)slabs distortion.Proved by synchrotron XAS spectra and ex/in situ XRD,the expansion/contraction of MnO_6 octahedron is dramatically reduced with the increased Cu content,showing the facilitated Na ion diffusion.Furthermore,when the ratio of Cu to Mn reaches 1:4,the phase transition from P2 to P'2 type at the end of discharge can be suppressed,resulting in the improved interlayer skeleton stability.The Cu-containing samples with stable interlayer structure exhibit high capacity retention and outstanding rate performances(a capacity of 79.9 m Ah g^(-1)at 5C).This Cu-substitution strategy provides a promising approach to designing highly stable cathodes. | Huanqing Liu Xu Gao Jun Chen Jinqiang Gao Haoji Wang Yu Mei Huan Liu Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 12 | Adaptive Decentralized Asymptotic Tracking Control for Large-Scale Nonlinear Systems With Unknown Strong Interconnections显示文摘An adaptive decentralized asymptotic tracking control scheme is developed in this paper for a class of large-scale nonlinear systems with unknown strong interconnections,unknown time-varying parameters,and disturbances.First,by employing the intrinsic properties of Gaussian functions for the interconnection terms for the first time,all extra signals in the framework of decentralized control are filtered out,thereby removing all additional assumptions imposed on the interconnec-tions,such as upper bounding functions and matching conditions.Second,by introducing two integral bounded functions,asymptotic tracking control is realized.Moreover,the nonlinear filters with the compensation terms are introduced to circumvent the issue of“explosion of complexity”.It is shown that all the closed-loop signals are bounded and the tracking errors converge to zero asymptotically.In the end,a simulation example is carried out to demonstrate the effectiveness of the proposed approach. | Ben Niu Jidong Liu Ding Wang Xudong Zhao Huanqing Wang | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，1： | 0 |
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