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| 1 | Adaptive Fuzzy Dynamic Surface Control of Flexible-Joint Robot Systems With Input Saturation显示文摘In this paper, we propose an adaptive fuzzy dynamic surface control(DSC) scheme for single-link flexible-joint robotic systems with input saturation. A smooth function is utilized with the mean-value theorem to deal with the difficulties associated with input saturation. An adaptive DSC design with an auxiliary first-order filter is used to solve the 'explosion of complexity'problem. It is proved that all the signals in the closed-loop system are semi-globally uniformly ultimately bounded, and the tracking error eventually converges to a small neighborhood around zero. The main advantage of the proposed method is that only one adaptation parameter needs to be updated,which reduces the computational burden significantly. Simulation results demonstrate the feasibility of the proposed scheme and the comparison results show that the improved DSC method can reduce the computational burden by almost two thirds in comparison with the standard DSC method. | Song Ling Huanqing Wang Peter X.Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 22 |
| 2 | Approximation-based adaptive fuzzy control for a class of non-strict-feedback stochastic nonlinear systems显示文摘This paper considers the problem of adaptive fuzzy control of a class of single-input/single-output(SISO)nonlinear stochastic systems in non-strict-feedback form.Fuzzy logic systems are used to approximate the uncertain nonlinearities and backstepping technique is utilized to construct an adaptive fuzzy controller.The proposed controller guarantees that all the signals in the resulting closed-loop system are bounded in probability.The main contribution of this note lies in providing a control strategy for a class of nonlinear systems in non-strict-feedback form.Simulation result is used to test the efectiveness of the suggested approach. | WANG HuanQing CHEN Bing LIN Chong | 2014 | Science China(Information Sciences)2014，57，3： | 12 |
| 3 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 4 | Finite-time Adaptive Fault-tolerant Control for Nonlinear Systems With Multiple Faults显示文摘This paper focuses on the problem of adaptive finitetime fault-tolerant control for a class of non-lower-triangular nonlinear systems.The faults encountered in the control system include the actuator faults and the abrupt system fault.By applying backstepping design and neural networks approximation,an adaptive finite-time fault-tolerant control scheme is developed.It is shown that the proposed controller ensures that all signals in the closed-loop system are semi-globally practically finite-time stable and the track-ing error converges to a small neighborhood around the origin within finite time.The simulation is carried out to explain the validity of the developed strategy. | Huanqing Wang Wen Bai Peter Xiaoping Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 3 |
| 5 | Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls显示文摘Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD. | Huanqing Yang Hua Xu Qingfeng Li Yan Jin Weixiong Jiang Jinghua Wang Yina Wu Wei Li Cece Yang Xia Li Shifu Xiao Feng Shi Tao Wang | 2019 | General Psychiatry2019，32，2： | 3 |
| 6 | A stage-specific cell-manipulation platform for inducing endothelialization on demand显示文摘Endothelialization is of great significance for vascular remodeling,as well as for the success of implanted vascular grafts/stents in cardiovascular disease treatment.However,desirable endothelialization on synthetic biomaterials remains greatly challenging owing to extreme difficulty in offering dynamic guidance on endothelial cell(EC)functions resembling the native extracellular matrix-mediated effects.Here,we demonstrate a bilayer platform with near-infrared-triggered transformable topographies,which can alter the geometries and functions of human ECs by tunable topographical cues in a remote-controlled manner,yet cause no damage to the cell viability.The migration and the adhesion/spreading of human ECs are respectively promoted by the temporary anisotropic and permanent isotropic topographies of the platform in turn,which appropriately meet the requirements of stage-specific EC manipulation for endothelialization.In addition to the potential of promoting the development of a new generation of vascular grafts/stents enabling rapid endothelialization,this stage-specific cell-manipulation platform also holds promise in various biomedical fields,since the needs for stepwise control over different cell functions are common in wound healing and various tissue-regeneration processes. | Qilong Zhao Juan Wang Yunlong Wang Huanqing Cui Xuemin Du | 2020 | National Science Review2020，7，3： | 3 |
| 7 | Interfacial characteristics and mechanical properties of additive manufacturing martensite stainless steel on the Cu-Cr alloy substrate by directed energy deposition显示文摘Copper/steel is a typical bimetal functional material,combining the excellent electrical and thermal conductivity of copper alloy and the high strength and hardness of stainless steel.There has been recent interest in manufacturing copper/steel bimetal by directed energy deposition(DED)due to its layer-bylayer method.However,cracks tend to form on the copper/steel interface because of the great difference in thermal expansion coefficient and crystal structure between copper and steel.In this work,interfacial characteristics and mechanical properties of the copper/steel bimetal were studied from one layer to multilayers.The laser power has a great influence on the Cu element distribution of the molten pool,affecting the crack formation dramatically on the solidification stage.Cracks tend to form along columnar grain boundaries because of the Cu-rich liquid films and spherical particles in the cracks.Crack-free and good metallurgical bonding copper/steel interface is formed at a scanning velocity of 800 mm/min and the laser power of 3000 W.The ultimate tensile strength(UTS)and the break elongation(EL)of the vertically combined crack-free copper/steel bimetal are 238.2±4.4 MPa and 20.6±0.7%,respectively.The fracture occurs on the copper side instead of the copper/steel interface,indicating that the bonding strength is higher than that of the Cu-Cr alloy.The UTS of the horizontally combined crack-free copper/steel bimetal is 746.7±22.6 MPa,which is 200%higher than that of the Cu-Cr alloy substrate.The microhardness is 398.6±5.4 HV at the steel side and is 235.3±64.1 HV at the interface,which is400%higher than that of the Cu-Cr alloy substrate.This paper advances the understanding of the interfacial characteristics of heterogeneous materials and provides guidance and reference for the fabrication of multi-material components by DED. | Wenqi Zhang Hailong Liao Zhiheng Hu Shasha Zhang Baijin Chen Huanqing Yang Yun Wang Haihong Zhu | 2021 | Journal of Materials Science & Technology2021，，31： | 2 |
| 8 | Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to α-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor显示文摘 | Yanjun Dong Jing Cao Haidong Wang Jie Zhang Zhiwei Zhu Rui Bai HuanQing Hao Xiaoyan He Ruiwen Fan Changsheng Dong | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 9 | Adaptive Neural Control for Strict-Feedback Stochastic Nonlinear Systems with Time-Delay显示文摘 | Wang Huanqing Chen Bing Lin Chong | | 0，，01： | 1 |
| 10 | Adaptive neural control for strict-feedback stochastic nonlinear systemswith time-delay显示文摘 | WANG Huanqing CHEN Bing LIN Chong | 2012 | Neuroeomputing2012，77，1： | 1 |
| 11 | Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer显示文摘Objective: To investigate the expression of fragile histidine triad (FHIT) protein in normal colorectal tissue, colorectal adenoma and colorectal cancer (CRC), and to study the relationships between the expression of FHIT protein and the clinical pathology, the apoptosis-associated protein (Bcl-2, Bax, Survivin), apoptosis in colorectal cancer. Methods: Tissue microarray (TMA) and immunohistochemistry SP were used to detect the expression of FHIT gene, Bcl-2, Bax and Survivin in 16 cases of the normal colorectal tissue, 16 cases of colorectal adenoma and 80 cases of the colorectal cancer. TUNEL was used to detect the apoptosis index (AI) in 80 cases of the colorectal cancer. Results: (1) The positive rates of FHIT gene expression in normal colorectal tissue, colorectal adenoma and adenocancer were 93.75%, 68.75% and 46.25% respectively. There were no significant differences in the relationships between the FHIT gene expression and histological types, the gender as well as the age (P>0.05). There were significant relationships between FHIT gene expression and lymph node metastasis, histological grades, Duke’s system as well as the 5-year survival rate after operation. (2) The positive rates of Bax, Bcl-2 and Survivin in colorectal adenocancer were 72.50%, 51.25%, 77.50% respectively. The expression of FHIT gene was positively correlated with that of Bcl-2, Bax and Survivin. (3) The mean AI in FHIT negative tumors was significantly lower than that in FHIT positive tumors (P<0.01). Conclusion: FHIT gene may play a role in the oncogenesis and progression of colorectal cancer. The abnormal regulation of apoptosis may play an important role in the pathogenesis of colorectal cancer. | Jie Cao Xiaoping Chen Wanglin Li Jie Xia Hong Du Weibiao Tang Hui Wang Xiwen Chen Huanqing Xiao Yuyuan Li | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 1 |
| 12 | Almost Disturbance Decoupling for HOFA Nonlinear Systems with Strict-Feedback Form显示文摘The article is devoted to the almost disturbance decoupling problem for high-order fully actuated(HOFA)nonlinear systems with strict-feedback form.Using the full-actuation feature of high-order fully actuated systems and Lyapunov stability theory,a state feedback control law and virtual control laws are designed.The unknown disturbances are handled by almost disturbance decoupling(ADD)method.Finally,the effectiveness of the control strategy is verified by stability analysis and simulation. | WANG Na LIU Xiaoping LIU Cungen WANG Huanqing ZHOU Yucheng | 2022 | Journal of Systems Science & Complexity2022，35，2： | 1 |
| 13 | Acute Symptomatic Seizure disorders in young children--a population study in southern Taiwan 显示文摘 | Huanq CC ChangYC Wang ST | 1998 | Epilepsia1998，39，9： | 1 |
| 14 | Individual eye model based on wavefront aberration显示文摘 | Zhaoqi Wang Qiuling Zhao Wei Quan Yan Wang | 2004 | Optik2004，116，2： | 1 |
| 15 | Planning the obstacle-avoidance trajectory of mobile anchor in 3D sensor networks显示文摘Localization plays an important role in many applications of wireless sensor networks. Recently,mobile anchor assisted localization methods become promising, and the moving trajectory planning of anchor is an interesting and basic issue in these methods. In this paper, an obstacle-avoidance trajectory planning method for three-dimensional wireless sensor networks is proposed. After dividing the network into grids, a depth-firstsearch algorithm with greedy strategy is proposed to get the approximately shortest path, and a trigonal function based localization method is presented to estimate the positions of the sensor nodes. Simulations show that this method can obtain almost the optimal path and localize almost all the sensor nodes. | SHU MingLei CUI HuanQing WANG YingLong WANG Cheng-Xiang | 2015 | Science China(Information Sciences)2015，58，10： | 1 |
| 16 | Weight Selection and PSO based Three-Dimensional Localization forWireless Sensor Networks显示文摘 | LvJialiang Wang Yinglong Cui Huanqing Wei Nuo | 2013 | International Conference on Computer Science Electronics Technology and Automation2013，427，429： | 1 |
| 17 | Clinical Effects of the COVID-19 Pandemic Among the Uninfected Pregnant Women—6 PLADs,China,2019−2020显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic potentially affected prenatal care quality and maternal and fetal outcomes globally.What is added by this report?During COVID-19 pandemic period,the rates of caesarean sections(CS)and preterm birth for uninfected pregnant women increased slightly in areas that were relatively severely impacted by the pandemic in China. | Bin Wang Hang An Huanqing Hu Wei Zhao Bahabaike Jiangtulu Shuo Wang Jiamei Wang Junxi Chen Manman Long Zewu Li Yu Jin Yuhuan Li Huiting Chen Tao Xue Xiqing Li Kexin Li Wei Du Suhong Gao Jiangli Di Xiaohong Liu Rongwei Ye Zhiwen Li | 2021 | China CDC weekly2021，3，10： | 0 |
| 18 | Adaptive Tracking Control for Output-Constrained Switched MIMO Pure-Feedback Nonlinear Systems with Input Saturation显示文摘In this paper,an adaptive neural tracking control scheme for a class of uncertain switched multi-input multi-output(MIMO)pure-feedback nonlinear systems is proposed.The considered MIMO pure-feedback nonlinear system contains input and output constraints,completely unknown nonlinear functions and time-varying external disturbances.The unknown nonlinear functions representing system uncertainties are identified via radial basis function neural networks(RBFNNs).Then,the Nussbaum function is utilized to deal with the nonlinearity issue caused by the input saturation.To prevent system outputs from violating prescribed constraints,the barrier Lyapunov functions(BLFs)are introduced.Also,a switched disturbance observer is designed to make the time-varying external disturbances estimable.Based on the backstepping recursive design technique and the Lyapunov stability theory,the developed control method is verified applicable to ensure the boundedness of all signals in the closed-loop system and make the system output track given reference signals well.Finally,a numerical simulation is given to demonstrate the effectiveness of the proposed control method. | ZHANG Haoyan ZHAO Xudong WANG Huanqing NIU Ben XU Ning | 2023 | Journal of Systems Science & Complexity2023，36，3： | 0 |
| 19 | Cu-substitution P2-Na_(0.66)Mn_(1-x)Cu_(x)O_(2) sodium-ion cathode with enhanced interlayer stability显示文摘P2-type Mn-based layered oxides are viewed as promising cathode materials for sodium ion battery by virtue of their high theoretical capacity.Considering that pure Na_(2/3)MnO_(2)suffers from poor cycling performances,Cu-substitution strategy is proposed to effectively alleviate this issue.However,the structural evolution mechanism of the Cu-containing samples still remains unclear.Herein,we propose that CuSubstitution P2-type Na_(0.66)Mn_(1-x)Cu_(x)O_(2)with enlarged lattice parameters are conducive to improving the interlayer structure stability through mitigating TMO_(2)slabs distortion.Proved by synchrotron XAS spectra and ex/in situ XRD,the expansion/contraction of MnO_6 octahedron is dramatically reduced with the increased Cu content,showing the facilitated Na ion diffusion.Furthermore,when the ratio of Cu to Mn reaches 1:4,the phase transition from P2 to P'2 type at the end of discharge can be suppressed,resulting in the improved interlayer skeleton stability.The Cu-containing samples with stable interlayer structure exhibit high capacity retention and outstanding rate performances(a capacity of 79.9 m Ah g^(-1)at 5C).This Cu-substitution strategy provides a promising approach to designing highly stable cathodes. | Huanqing Liu Xu Gao Jun Chen Jinqiang Gao Haoji Wang Yu Mei Huan Liu Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 20 | Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer显示文摘The fragile histidine triad(FHIT)gene,a candidate tumor suppressor gene located at 3p14.2,has been shown to be involved in the carcinogenesis of many human tissues,including digestive tract tissues.However,the expression and the role of the FHIT in the initiation and the development of the colorectal cancer(CRC)are poorly understood.We have shown that the FHIT gene exhibits significantly decreased expression in human CRC compared to colorectal adenoma and normal colorectal tissue by tissue microarray(TMA).The positive rate of FHIT gene expression in normal colorectal tissue,adenoma and adenocarcinoma were 93.75%,68.75%and 46.25%,respectively.We show this decreased expression to be significantly correlated with the progression of colorectal carcinoma(P<0.05)as well as with differentiation and lymph node metastasis(P<0.05).We detected two somatic alterations in the FHIT gene in human CRC.The presence of this mutation correlated significantly with decreased FHIT expression in the human CRC.In our present study we tested the hypothesis that the decreased FHIT expression resulted in apoptosis inhibition associated with abnormal expression of apoptosis related proteins.To test this hypothesis we did a series of experiments.In the first test,we assessed apoptosis status using a standard TUNEL(terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling)assay by comparing FHIT-positive CRC vs.FHIT-negative CRC.In the second experiment,the protein expression of the FHIT and other apoptosis related proteins(Bax,Bcl-2 and Survivin)were measured in human CRC by TMA.Our combined results demonstrate the mutation in the FHIT gene significantly reduced FHIT expression in human CRC.Both TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax and the up-regulation of Survivin and Bcl-2.Collectively,these studies identify the mechanism by which an important tumor suppressor gene,FHIT is inactivated specifically in human CRC contributing to our understanding of the mechanism of colorectal carcinogenesis. | CAO Jie CHEN Xiaoping LI Wanglin XIA Jie DU Hong TANG Weibiao CHEN Shanming WANG Hui CHEN Xiwen XIAO Huanqing LI Yuyuan | 2007 | Frontiers of Medicine2007，1，2： | 0 |
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