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| 1 | The calcium sensing receptor: from calcium sensing to signaling显示文摘The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic hypercalciuria.Compelling evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological processes.In this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated mutations.This systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling. | ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 2 | Saposhnikoviae divaricata:a phytochemical,pharmacological,and pharmacokinetic review显示文摘Saposhnikoviae divaricata(Turcz.) Schischk(SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine. | Jenny Kreiner Edwin Pang George Binh Lenon Angela Wei Hong Yang | 2017 | Chinese Journal of Natural Medicines2017，15，4： | 12 |
| 3 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 4 | P68 RNA helicase is a nucleocytoplasmic shuttling protein显示文摘P68 RNA helicase 是原型的死了的盒子 RNA helicase。蛋白质在早机关开发和成熟起一个很重要的作用。与在 transcriptional 规定并且 pre-mRNA 拼接的蛋白质的功能一致, p68 被发现主要在房间原子核本地化。然而,最近的实验表明蛋白质的短暂细胞质的本地化。我们这里报导那 p68 在原子核和细胞质之间的梭。p68 的 nucleocytoplasmic shuttling 被二个原子本地化信号和二个原子出口信号顺序元素调停。我们的实验揭示那 p68 经由一条古典 RanGTPase 依赖的小径的梭。 | Haizhen Wang Xueliang Gao Yun Huang Jenny Yang Zhi-Ren Liu | 2009 | Cell Research2009，19，12： | 3 |
| 5 | Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase显示文摘 | Xueliang Gao Haizhen Wang Jenny J. Yang Xiaowei Liu Zhi-Ren Liu | 2012 | Molecular Cell2012，，5： | 2 |
| 6 | A novel real-time cell electronic analysis technology for the authentication and quality control of natural medicines显示文摘The study was designed to explore the potential applications of the real-time cell electronic analysis technology in the quality evaluation of natural medicines.The natural medicinal Flos Carthami was discussed as a methodological example and the specifc time/dose-dependent cell response profles(TCRPs)were produced by the real-time cell electronic analysis technology.The similarity and bioactivity were obtained by analyzing all TCRPs.Meanwhile,an HPLC method according to the Chinese Pharmacopeia(edition 2010)was used to evaluate the quality of Flos Carthami.The correlation was obtained by comparing the results produced by the two different approaches.By analyzing the data,fve different samples of Flos Carthami can produce remarkably similar TCRPs.The quality of Flos Carthami was evaluated by both the HPLC and the TCRPs analysis-based approaches and similar results were obtained.The results suggest that the same natural medicine from different locations could produce similar TCRPs.By analyzing the TCRPs,the bioactivity and quality evaluation of natural medicines can be obtained.This technology is a physiologically relevant approach for the quality evaluation of natural medicines.The ultimate aim of our study is to establish a new standard for quality evaluation. | Guo-Jun Yan Xin Mei Jin Yang Jenny Zhu Jie-Ying Wu Jin-Huo Pan | 2013 | Chinese Chemical Letters2013，24，12： | 2 |
| 7 | Comparing community birdwatching and professional bird monitoring with implications for avian diversity research: a case study of Suzhou, China显示文摘Background:In the past decades,birdwatching as a hobby developed rapidly and produced ample scientific records that have aided conservation efforts.Therefore,it is increasingly attractive to promote avian research by providing data from birdwatching.Methods:We compared records from 16 years of community birdwatching and a 1-year formalized bird monitoring in Suzhou,China to study the similarities and differences between the two monitoring methods.Results:We showed that within the 325 bird species recorded by the two methods,an annual average of 108 species were documented by community science and 223 bird species were recorded by 1-year formalized monitoring.Measured by the number of bird species recorded per survey trip,the bird monitoring activity of community birdwatchers was significantly lower.Furthermore,the monitoring intensity of community birdwatching measured as the average survey trips per site each survey year was also lower than that of formalized bird monitoring.In addition,community birdwatchers preferred urban landscapes to rural areas.Conclusions:Community birdwatching could record the majority of local birds and complements the professional surveys in avian research.Well designed and coordinated community science can be used to expand the knowledge about avian distribution and population dynamics.These findings are critical for the development of conservation science with regard to community involvement. | Yan Zhou Anping Chen Jenny QOuyang Yanlin Liu Aiyu Zheng Zaixi Yang Yong Zhang Bin Wang Yifei Jia Shengwu Jiao Qing Zeng Changhu Lu | 2020 | Avian Research2020，11，2： | 2 |
| 8 | Calciomics:prediction and analysis of EF-hand calcium binding proteins by protein engineering显示文摘Ca2+ plays a pivotal role in the physiology and biochemistry of prokaryotic and mammalian organisms.Viruses also utilize the universal Ca2+ signal to create a specific cellular environment to achieve coexistence with the host,and to propagate.In this paper we first describe our development of a grafting approach to understand site-specific Ca2+ binding properties of EF-hand proteins with a helix-loop-helix Ca2+ binding motif,then summarize our prediction and identification of EF-hand Ca2+ binding sites on a genome-wide scale in bacteria and virus,and next report the application of the grafting approach to probe the metal binding capability of predicted EF-hand motifs within the streptococcal hemoprotein receptor(Shr) of Streptococcus pyrogenes and the nonstructural protein 1(nsP1) of Sindbis virus.When methods such as the grafting approach are developed in conjunction with prediction algorithms we are better able to probe continuous Ca2+-binding sites that have been previously underrepresented due to the limitation of conventional methodology. | YANG Jenny Jie | 2010 | Science China Chemistry2010，53，1： | 1 |
| 9 | Endoscopic submucosal dissection of gastric lesions by using a Master and Slave Transluminal Endoscopic Robot (MASTER)显示文摘 | Khek-Yu Ho Soo Jay Phee Asim Shabbir Soon Chiang Low Van An Huynh Andy Prima Kencana Kai Yang Davide Lomanto Bok Yan Jimmy So Y.Y. Jennie Wong S.C. Sydney Chung | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 10 | Per- formance evaluation of direct heuristic dynamic programming u- sing control-theoretic measures 显示文摘 | YANG Lei SI Jennie TSAKALIS Konstantinos S | 2009 | Journal of Intelligent and Ro- botic Systems : Theory and Applications2009，55，23： | 1 |
| 11 | Characterization of CIAE developed double-sided silicon strip detector for charged particles显示文摘A double-sided silicon strip detector(DSSD)with active area of 48 mm x 48 mm and thickness of300μm has been developed. Each side of DSSD consists of48 strips, each with width of 0.9 mm and inter-strip separation of 0.1 mm. Electrical properties and detection performances including full depletion bias voltage, reverse leakage current, rise time, energy resolution and cross talk have been studied. At a bias of 80 V, leakage current in each strip is less than 15 nA, and rise time for alpha particle at 5157 keV is approximately 15 ns on both sides.Good energy resolutions have been achieved with0.65-0.80% for the junction strips and 0.85-1.00% for the ohmic strips. The cross talk is found to be negligible on both sides. The overall good performance of DSSD indicates its readiness for various nuclear physics experiments. | Xin-Xing Xu Fanurs C.E.Teh Cheng-Jian Lin Jenny Lee Feng Yang Zhao-Qiao Guo Tian-Shu Guo Li-Jie Sun Xin-Zhi Teng Jia-Jian Liu Peng-Jie Li Peng-Fei Liang Lei Yang Nan-Ru Ma Hui-Ming Jia Dong-Xi Wang Sylvain Leblond Taras Lokotko Qing-Qing Zhao Huan-Qiao Zhang | 2018 | Nuclear Science and Techniques2018，29，5： | 1 |
| 12 | N-glycosylation is required for the surface localization of MUC17 mucin显示文摘 | Jenny Ho Reena Jaituni Suzanne Crawley Stacey Yang James Gum Young Kim | 2003 | International Journal of Oncology2003，，3： | 1 |
| 13 | Hypoxia Preconditioning Enhances the Viability of ADSCs to Increase the Survival Rate of Ischemic Skin Flaps in Rats显示文摘 | Yeli Yue Peipei Zhang Dan Liu Jenny F. Yang Chunlei Nie Daping Yang | 2013 | Aesthetic Plastic Surgery2013，，1： | 1 |
| 14 | Diseases Caused by Enterovirus 71 Infection显示文摘 | Ta-Chung Lee How-Ran Guo Huey-Jen Jenny Su Yi-Ching Yang Hsiao-Ling Chang Kow-Tong Chen | 2009 | The Pediatric Infectious Disease Journal2009，，10： | 1 |
| 15 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 16 | Earthy odor compounds production and loss in three cyanobacterial cultures显示文摘 | Zonglai Li Peter Hobson Wei An Michael D. Burch Jenny House Min Yang | 2012 | Water Research2012，，16： | 1 |
| 17 | Deletion of a C–terminal intrinsically disordered region of WRINKLED 1 affects its stability and enhances oil accumulation in Arabidopsis显示文摘 | Wei Ma Que Kong Michael Grix Jenny J. Mantyla Yang Yang Christoph Benning John B. Ohlrogge | 2015 | Plant J2015，，5： | 1 |
| 18 | A simple cellulose acetate membrane-based small lanes technique for protein electrophoresis显示文摘 | Na Na Tingting Liu Xiaojun Yang Binjie Sun Jenny Ouyang Jin Ouyang | 2012 | Analytical and Bioanalytical Chemistry2012，，3： | 1 |
| 19 | A comparison of foliage profiles in the Sierra National Forest obtained with a full-waveform under-canopy EVI lidar system with the foliage profiles obtained with an airborne full-waveform LVIS lidar system显示文摘 | Feng Zhao Xiaoyuan Yang Alan H. Strahler Crystal L. Schaaf Tian Yao Zhuosen Wang Miguel O. Román Curtis E. Woodcock Wenge Ni-Meister David L.B. Jupp Jenny L. Lovell Darius S. Culvenor Glenn J. Newnham Hao Tang Ralph O. Dubayah | 2013 | Remote Sensing of Environment2013，，： | 1 |
| 20 | Hypoxia Preconditioning Enhances the Viability of ADSCs to Increase the Survival Rate of Ischemic Skin Flaps in Rats显示文摘 | Yeli Yue Peipei Zhang Dan Liu Jenny F. Yang Chunlei Nie Daping Yang | 2013 | Aesthetic Plastic Surgery2013，，1： | 1 |
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