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| 1 | Double-shell structure of Al_3(Zr,Sc) precipitate induced by thermomechanical treatment of Al-Zr-Sc alloy cable显示文摘A spheroidal Al_3(Zr,Sc) precipitate with a double-shell structure, comprising a Sc-enriched core enveloped by a Zr-enriched inner shell and a Sc-enriched outer shell(~9 nm in thickness), appears in an Al-0.2 Zr-0.1 Sc alloy cable after thermomechanical treatment. The average diameter of the spheroidal Al_3(Zr,Sc) precipitate is approximately 80 nm. The double-shelled Al_3(Zr,Sc) precipitate presents three different interfaces and is semi-coherent with the Al matrix. Atom probe tomography(APT) analyses further show that the outer shell of Al_3(Zr,Sc) precipitate is Sc element enrichment. The electrical conductivity of Al-0.2 Zr-0.1 Sc alloy cable increases by 6.5 MS/m within the aging time from 0.2 to 100 h at 350 ℃, with double-shelled Al_3(Zr,Sc)precipitate. | Jiayi Zhang Tao Hu Danqing Yi Hongxuan Wang Bin Wang | 2019 | Journal of Rare Earths2019，37，6： | 8 |
| 2 | Vegetation pattern in Shell Ridge Island in China's Yellow River Delta显示文摘 | Yanyun ZHAO Xiangming HU Jingtao LIU Zhaohua LU Jiangbao XIA Jiayi TIAN JunshengMA | 2015 | Frontiers of Earth Science2015，9，3： | 5 |
| 3 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 4 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 5 | PKC inhibition of sotrastaurin hasantitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1显示文摘MCT-1 (在 T 房间 lymphoma-1 的多重拷贝) ,新奇 oncogene,原来在 T 房间淋巴瘤被识别。最近的研究证明了 MCT-1 高度在 85% 弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示。PKC (蛋白质 kinase C ) 为激活细胞的功能和增长为多重生物学上活跃的物质在信号 transduction 起一个必要作用。在这研究,我们发现 MCT-1 的 mRNA 和蛋白质表示层次显然在在 SUDHL-4 和 OCI-LY8 DLBCL 房间线由 siRNA 将 PKC 击倒以后被减少。在一个剂量依赖者和时间依赖者举止的一个选择 PKC 禁止者, sotrastaurin,有效地禁止的房间增长和导致的房间 apoptosis。同时,我们也观察到房间周期在对待 sotrastaurin 的房间在 G1 阶段被逮捕。另外, MCT-1 在在 vivo 的 sotrastaurin 处理组是下面调整的。而且,我们证明 PKC 禁止者 sotrastaurin 通过调整 MCT-1 的表示潜在地在 DLBCL 房间导致了房间 apoptosis 和房间周期拘捕。我们的数据建议那指向的 PKC 可以是为展出 MCT-1 的高水平的淋巴瘤和相关恶意的一条潜在的治疗学的途径蛋白质。 | Gaomei Chang Jiayi Zheng Wenqin Xiao Shuaikang Chang Qing Wei Huiqun Wu Yi Tao Guang Yang Bingqian Xie Xiucai Lan Yingcong Wang Dandan Yu Liangning Hu Yongsheng Xie Wenxuan Bu Yuanyuan Kong Bojie Dai Jun Hou Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 2 |
| 6 | Organic-rich formation and hydrocarbon enrichment of lacustrine shale strata:A case study of Chang 7 Member显示文摘Lacustrine shale is an important target for the exploration of unconventional oil and gas in China beyond marine shale gas.However,the formation environment of lacustrine shale differs from that of marine shale,resulting in a different reservoir composition,organic matter,oil and gas content,and hydrocarbon mobility.In this study,the Chang 7 shale of the Yanchang Formation in the Ordos Basin was used to analyze the effect of volcanic activity on the paleoproductivity and preservation conditions during the formation of lacustrine shale.The results show that algae and bacteria were developed before the eruption.After the eruption,the number of bacteria declined,but the increased prosperity of algae reflects that the volcanic activity enhanced ancient productivity.The sulfate generated by volcanic activity promotes bacterial sulfate reduction,and the produced H_(2)S leads to a strong reducing environment in the waterbody,which is conducive to the preservation of organic matter.Organic geochemical analysis shows that the black shale in the shale strata has a high total organic carbon(TOC)content and strong hydrocarbon generation potential,whereas the tuff has a low TOC content and can scarcely generate hydrocarbons,indicating that the tuff deposited by volcanic activity cannot be considered as effective source rock.In terms of storage space,shale is mainly laminar and dispersed,and it includes organic and inorganic pores.The development of organic pores is affected by thermal maturity,whereas inorganic pores mainly occur between detrital particles and crystals.Tuff is mainly supported by heterogeneous matrix and associated with alteration.Its pores include inter-and intragranular mineral pores.The development of tight sandstone pores is affected by compaction,cementation,and dissolution,which mainly consist of intra-and intergranular pores.The Chang 7 lacustrine shale generally contains oil,but different lithologies have different oil drainage efficiencies.Sandstone and shale exhibit the best and worst oil drainage efficiency,respectively.It is mainly affected by the pore size distribution,fluid properties,and rock wettability.Therefore,the development of shale oil should mainly focus on lacustrine shale formations with interbeds.The mutual dissolution of organic matter and hydrocarbons in the shale section leads to the poor mobility and difficult development of hydrocarbons. | Quanyou LIU Peng LI Zhijun JIN Yuewu SUN Guang HU Dongya ZHU Zhenkai HUANG Xinping LIANG Rui ZHANG Jiayi LIU | 2022 | Science China Earth Sciences2022，65，1： | 2 |
| 7 | Influence of Deposition Temperature and Pressure on Microstructure and Tribological Properties of Arc Ion Plated Ag Films显示文摘The films deposited at low temperature(LT-films) have increasingly attracted theoretical and technical interests since such films exhibit obvious difference in structure and performances compared to those deposited at room temperature.Studies on the tribological properties of LT-films are rarely reported in available literatures.In this paper,the structure,morphology and tribological properties of Ag films,deposited at LT(166 K) under various Ar pressures on AISI 440C steel substrates by arc ion plating(AIP),are studied by X-ray diffraction(XRD),atomic force microscopy(AFM) and a vacuum ball-on-disk tribometer,and compared with the Ag films deposited at RT(300 K).XRD results show that(200) preferred orientation of the films is promoted at LT and low Ar pressure.The Crystallite sizes are 70 nm-80 nm for LT-Ag films deposited at 0.2 Pa and 0.8 Pa and larger than 100 nm for LT-Ag films deposited at 0.4 Pa and 0.6 Pa,while they are 55 nm-60 nm for RT-Ag films deposited at 0.2 Pa-0.6 Pa and 37 nm for RT-Ag films deposited at 0.8 Pa.The surfaces of LT-Ag films are fibre-like at 0.6 Pa and 0.8 Pa,terrace-like at 0.4 Pa,and sphere-like at 0.2 Pa,while the surfaces of RT-Ag films are composed of sphere-like grains separated by voids.Wear tests reveal that,due to the compact microstructure LT-Ag films have better wear resistances than RT-Ag film.These results indicate that the microstructure and wear resistance of Ag films deposited by AIP can be improved by low temperature deposition. | HU Ming GAO Xiaoming SUN Jiayi WENG Lijun ZHOU Feng LIU Weimin | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 2 |
| 8 | Parallel induction of cell proliferation and inhibition of cell differentiationin hepatic progenitor cells by hepatitis B virus X gene显示文摘 | Jiayi Huang Lihong Shen Yongliang Lu Hongli Li Xifeng Zhang Daixi Hu Tao Feng Fangzhou Song | 2012 | International Journal of Molecular Medicine2012，，4： | 1 |
| 9 | Simultaneous enhancement of coercivity and electric resistivity of Nd-Fe-B magnets by Pr-Tb-Al-Cu synergistic grain boundary diffusion toward high-temperature motor rotors显示文摘To high-power permanent magnetic motors,it is critical for Nd-Fe-B magnets to maintain the desirable coercivity at high-temperature operating conditions.To address this,two approaches have been proven effective:(1)enhancing the room temperature coercivity;(2)reducing the eddy current loss.However,these two items are difficult to be simultaneously achieved.Here,the grain boundary diffusion(GBD)of the Pr-Tb-Al-Cu-based source is applied to enhance the coercivity and electric resistivity at room temperature from 1101 kA m-1 and 2.13×10–6Ωm to 1917 kA m-1 and 2.60×10–6Ωm,and those at 120°C from 384 kA m-1 and 4.31×10–6Ωm to 783 kA m-1 and 4.86×10–6Ωm,respectively.Such optimization is ascribed to the improved formation depth of Tb-rich 2:14:1 shells with large magnetocrystalline anisotropy and the increased intergranular Pr-based oxides with high electric resistivity,induced by the coordination effects of Tb and Pr,as proven by the atomic-scale observations and the first principles calculations.It thus results in the simultaneously improved output power and energy efficiency of the motor because of the combination of magnetic thermal stability enhancement and eddy current loss reduction,as theoretically confirmed by electromagnetic simulation. | Jiayi He Jinwen Hu Bang Zhou Haoyang Jia Xiaolian Liu Zhenhua Zhang Lin Wen Lizhong Zhao Hongya Yu Xichun Zhong Xuefeng Zhang Zhongwu Liu | 2023 | Journal of Materials Science & Technology2023，，23： | 1 |
| 10 | Proteomic analysis of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention显示文摘Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one subjects were enrolled in the study.We assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine clinician.Of the participants,we included healthy participants with normal weight(NW,n=23),overweight/obese participants with normal metabolism(ONM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the ONM,OPD,and OML groups were diagnosed with phlegmdampness pattern.The data-independent acquisition(DIA)method was first used to analyze the plasma protein expression of each group,and the relevant differential proteins of each group were screened.The co-expressed proteins were evaluated by Venn analysis.The pathway analyses of the differential proteins were analyzed using Ingenuity Pathway Analysis(IPA)software.Parallel reaction monitoring(PRM)was used to verify the differential and common proteins in each group.Results:After comparing ONM,OPD,and OML groups with NW group,we identified the differentially expressed proteins(DEPs).Next,we determined the DEPs among OPD,OML,and ONM groups.Using Venn analysis of the DEPs in each group,24 co-expressed proteins were screened.Two co-expressed proteins were verified by PRM.IPA analysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity participants.However,the activation or inhibition of these pathways was different among the three groups.Conclusion:Participants with overweight/obesity have similar proteomic characteristics,though each type shows specific proteomic characteristics.Two co-expressed proteins,VTN and ORM1,are potential biomarkers for glucose and lipid metabolism diseases with overweight/obesity caused by phlegmdampness retention. | Jiayi Ma Shuxian Sun Cheng Ni Lingru Li Jing Xia Houqin Li Huirong Song Xujun Heng Dandan Hu Yuanyuan Li | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 1 |
| 11 | Link level performance comparison between LTE V2X and DSRC显示文摘Applications of VANETs(Vehicular Ad hoc Networks)have their own requirements and challenges in wireless communication technology.Although regarded as the rst standard for VANETs,IEEE 802.11p is still in the eld-trial stage.Recently,LTE V2X(Long-Term Evolution Vehicular to X)appeared as a systematic V2X solution based on TD-LTE(Time Division Long-Term Evolution)4G.It is regarded as the most powerful competitor to 802.11p.We conduct link level simulations of LTE V2X and DSRC(Dedicated Short-Range Communication)for several di erent types of scenarios.Simulation results show that LTE V2X can achieve the same BLER(Block Error Ratio)with a lower SNR(Signal Noise Ratio)than DSRC.A more reliable link can be guaranteed by LTE V2X,which can achieve the same BLER with lower receiving power than DSRC.The coverage area of LTE V2X is larger than that of DSRC. | Jinling Hu Shanzhi Chen Li Zhao Yuanyuan Li Jiayi Fang Baozhu Li Yan Shi | 2017 | Journal of Communications and Information Networks2017，2，2： | 1 |
| 12 | Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential显示文摘Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array of regulators,including the multi-functional protein Rif1,has been reported to influence the switch of fate potential,how they act in concert to achieve this cellular plasticity remains elusive.Here,by modularizing the known totipotency regulatory factors,we identify an unprecedented functional connection between Rif1 and the non-canonical polycomb repres-sive complex PRC1.6.Downregulation of the expression of either Rif1 or PRC1.6 subunits imposes similar impacts on the transcriptome of mESCs.The LacO-LacI induced ectopic colocalization assay detects a specific interaction between Rif1 and Pcgf6,bolstering the intactness of the PRC1.6 complex.Chromatin immunoprecipitation followed by sequencing(ChIP-seq)analysis further reveals that Rif1 is required for the accurate targeting of Pcgf6 to a group of genomic loci encompassing many genes involved in the regulation of the 2C-like state.Depletion of Rif1 or Pcgf6 not only activates 2C genes such as Zscan4 and Zfp352,but also derepresses a group of the endogenous retroviral element MERVL,a key marker for totipotency.Collectively,our findings discover that Rif1 can serve as a novel auxiliary component in the PRC1.6 complex to restrain the genetic circuit underlying totipotent fate potential,shedding new mechanistic insights into its function in regulating the cellular plasticity of embryonic stem cells. | Lu Li Pishun Li Jiale Chen Li Li Yunfan Shen Yangzixuan Zhu Jiayi Liu Lu Lv Song Mao Fang Chen Guang Hu Kai Yuan | 2022 | Cell Regeneration2022，11，1： | 1 |
| 13 | Establishment of a Real-time Fluorescent Quantita- tive RT-PCR Method for Pineapple mealybug wilt as. sociated virus-2显示文摘Pineapple mealybug wilt associated virus-2 (PMWaV-2) is an important pathogen causing Mealybug wilt of pineapple (MWP). We established a realtime quantitative RT-PCR( RT-qPCR) method with Taq Man probe based on specific primers of conserved nucleotide sequence of PMWaV-2 coat protein gene. The results showed that the method was highly sensitive to positive sample,but had no fluorescence signal to health sample and blank control. The sensitivity of RT-qPCR was about 100 times higher than general PCR. Reproducibility test revealed that the coefficients of variation between intra-and inter-assay were both within 1.85%,indicating it was a quantitative detection method for PMWaV-2 with simple operation,strong specificity,high sensitivity,and reliable reproducibility. | Fan Hongyan Hu Jiayi Luo Zhiwen Guo Lijun He Shu Hu Fuchu Li Xianghong He Fan Zhang Zhiyi | 2016 | Plant Diseases and Pests2016，7，1： | 1 |
| 14 | Research Progress on the Pathogenesis of Hemorrhagic Fever with Renal Syndrome显示文摘Hemorrhagic fever with renal syndrome(HFRS)is an acute natural focus epidemic disease characterized by fever,shock,hemorrhage and kidney injury caused by hantavirus infection.Hantavirus mainly infects human vascular endothelial cells,and induces extensive damage to small blood vessels and capillaries.Increased vascular permeability is the pathological basis for clinical manifestations of HFRS.Although domestic and foreign scholars have carried out many studies on the hantavirus pathogenesis,such as the immune pathological response induced by hantavirus,host genetics and apoptosis,thrombocytopenia,coagulation and fibrinolysis dysfunction,and the vascular endothelial damage,the pathogenesis of HFRS has not been fully elucidated and there is no effective drug yet.In-depth discussion of the molecular mechanism of HFRS and finding effective therapeutic drugs are still the research hotspots on the field of hantavirus/HFRS.This review will elaborate the research progress on the pathogenesis of HFRS in recent years. | Hong Du Pingzhong Wang Xuefan Bai Jing Li Xiaoyan Wang Haifeng Hu Ying Zhang Hong Jiang Huanjun Shen Jiayi Zhan Jianqi Lian | 2022 | Infectious Diseases & Immunity2022，2，4： | 1 |
| 15 | Pan-cancer analysis of DNA epigenetic modifications by hydrophilic interaction liquid chromatography-tandem mass spectrometry显示文摘Accumulating evidence in recent years indicates that DNA methylation(5-methyl-2-deoxycytidine,5-mdC) and hydroxymethylation(5-hydroxymethyl-2-deoxycytidine, 5-hmd C) have been implicated in various biological processes, and the aberrations of these DNA cytosine modifications is tightly associated with cancer. N6-methyl-2-deoxyadenosine(m~6dA), as a newly discovered epigenetic modification in genome of mammals, has been demonstrated to play vital regulatory roles in tumorigenesis. However, the content information of m~6dA in human tumor tissues is still limited and pan-cancer analysis of these DNA epigenetic modifications is lacked. Herein, we developed a sensitive and robust stable isotopediluted hydrophilic interaction liquid chromatography-tandem mass spectrometry(HILIC-MS/MS) method for accurate quantification of m~6dA, 5-mdC and 5-hmdC in genomic DNA from 82 pairs of human tumor tissues and matched tumor-adjacent normal tissues. The types of tumors included esophagus cancer, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, stromal tumor and colorectal cancer.Compared to the normal tissues, we revealed the level of m6dA was increased in tumor tissues of esophagus cancer, lung cancer and liver cancer, whereas the level of m~6dA was diminished in tumor tissues of pancreatic cancer and gastric cancer;while the contents of 5-mdC and 5-hmdC exhibited significant decrease in tumor tissues of most types of cancer. It is worth noting that we revealed, for the first time,the content of genomic m~6dA in pancreatic cancer, stromal tumor and colorectal cancer. The significant changes of these DNA epigenetic modifications indicate they may serve as indicators of cancers. In addition, this study will benefit for better understanding of the regulatory roles of these DNA epigenetic modifications in cancers. | Yiqiu Hu Xiujuan Hong Zhijun Yuan Jiayi Mu Xiaoxiao Zhang Zhihao Fang Ying Yuan Shu Zheng Cheng Guo | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 16 | Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system显示文摘Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging.For conventional tissue clearing methods,loss of resolution and quality in deep regions is inevitable due to limited transparency.Here we describe the Transparent Embedding Solvent System(TESOS)method,which combines tissue clearing,transparent embedding,sectioning and block-face imaging.We used TESOS to acquire volumetric images of uniform resolution for an adult mouse whole-body sample.The TESOS method is highly versatile and can be combined with different microscopy systems to achieve uniformly high resolution.With a light sheet microscope,we imaged the whole body of an adult mouse,including skin,at a uniform 0.8×0.8×3.5μm^(3) voxel resolution within 120 h.With a confocal microscope and a 40×/1.3 numerical aperture objective,we achieved a uniform sub-micron resolution in the whole sample to reveal a complete projection of individual nerve axons within the central or peripheral nervous system.Furthermore,TESOS allowed the first mesoscale connectome mapping of individual sensory neuron axons spanning 5 cm from adult mouse digits to the spinal cord at a uniform sub-micron resolution. | Yating Yi Youqi Li Shiwen Zhang Yi Men Yuhong Wang Dian Jing Jiayi Ding Qingjie Zhu Zexi Chen Xingjun Chen Jun-Liszt Li Yilong Wang Jun Wang Hanchuan Peng Li Zhang Wenjing Luo Jian Q.Feng Yongwen He Woo-Ping Ge Hu Zhao | 2024 | Cell Research2024，34，2： | 0 |
| 17 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 18 | Personalized surgical recommendations and quantitative therapeutic insights for patients with metastatic breast cancer: Insights from deep learning显示文摘Background:The role of surgery in metastatic breast cancer(MBC)is currently controversial.Several novel statistical and deep learning(DL)methods promise to infer the suitability of surgery at the individual level.Objective:The objective of this study was to identify the most applicable DL model for determining patients with MBC who could benefit from surgery and the type of surgery required.Methods:We introduced the deep survival regression with mixture effects(DSME),a semi-parametric DL model integrating three causal inference methods.Six models were trained to make individualized treatment recommendations.Patients who received treatments in line with the DL models'recommendations were compared with those who underwent treatments divergent from the recommendations.Inverse probability weighting(IPW)was used to minimize bias.The effects of various features on surgery selection were visualized and quantified using multivariate linear regression and causal inference.Results:In total,5269 female patients with MBC were included.DSME was an independent protective factor,outperforming other models in recommending surgery(IPW-adjusted hazard ratio[HR]=0.39,95%confidence interval[CI]:0.19–0.78)and type of surgery(IPW-adjusted HR=0.66,95%CI:0.48–0.93).DSME was superior to other models and traditional guidelines,suggesting a higher proportion of patients benefiting from surgery,especially breast-conserving surgery.The debiased effect of patient characteristics,including age,tumor size,metastatic sites,lymph node status,and breast cancer subtypes,on surgery decision was also quantified.Conclusions:Our findings suggested that DSME could effectively identify patients with MBC likely to benefit from surgery and the specific type of surgery needed.This method can facilitate the development of efficient,reliable treatment recommendation systems and provide quantifiable evidence for decision-making. | Enzhao Zhu Linmei Zhang Jiayi Wang Chunyu Hu Qi Jing Weizhong Shi Ziqin Xu Pu Ai Zhihao Dai Dan Shan Zisheng Ai | 2024 | Cancer Innovation2024，3，3： | 0 |
| 19 | Correction To: Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsxnobfu009ucw6vcx.ffgz.tsg.suse.edu.cn/10.1038/S41392-021-00795-x,published online 19 November 2021 In this article^(1) Qing Wei should have been denoted as a corresponding author along with Huanlong Qin,but was inadvertently removed during the production process.The original article has been corrected. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 20 | Macro-superlubricity in sputtered MoS_(2)-based films by decreasing edge pinning effect显示文摘To date,MoS_(2) can only be achieved at microscale.Edge pinning effect caused by structure defects is the most obvious barrier to expand the size of structural superlubricity to macroscale.Herein,we plan to pin edge planes of MoS_(2) with nanospheres,and then the incommensurate structure can be formed between adjacent rolling nanoparticles to reduce friction.The sputtered MoS_(2) film was prepared by the physical vapor deposition(PVD)in advance.Then enough Cu_(2)O nanospheres(~40 nm)were generated in situ at the edge plane of MoS_(2) layers by liquid phase synthesis.An incommensurate structure(mismatch angle(θ)=8°)caused by MoS_(2) layers was formed before friction.The friction coefficient of the films(5 N,1,000 r/min)was~6.0×10^(−3) at the most.During friction,MoS_(2) layers pinned on numerous of Cu_(2)O nanoparticles reduced its edge pinning effect and decreased friction.Moreover,much more incommensurate was formed,developing macro-superlubricity. | Chunmeng DONG Dong JIANG Yanlong FU Desheng WANG Qinqin WANG Lijun WENG Ming HU Xiaoming GAO Jiayi SUN | 2024 | Friction2024，12，1： | 0 |
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