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| 1 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 2 | Combined prednisone and levothyroxine improve treatment of severe thrombocytopenia in hepatitis B with compensatory cirrhosis accompanied by subclinical and overt hypothyroidism显示文摘The aim of the present study was to investigate the relationship between hypothyroidism and thrombocytopenia in hepatitis Brelated compensatory liver cirrhosis and to determine whether treatment with levothyroxine and prednisone is superior in a multicenter, open-label, observational study in China. In total, 125 consecutive hepatitis B-related compensated liver cirrhosis patients with severe thrombocytopenia accompanied by hypothyroidism were included. The patients were divided into four groups according to treatment strategy: a control group(n=29), a prednisone group(n=25), a levothyroxine group(n=32) and a prednisone plus levothyroxine group(n=39). Severe thrombocytopenia was more prevalent in hepatitis B-associated compensatory liver cirrhosis patients with hypothyroidism than in euthyroid patients(29.6% vs. 14.7%, P<0.05). Combination treatment with prednisone and levothyroxine decreased the risk of bleeding and improved platelet recovery compared to control treatment and treatment with either prednisone or levothyroxine alone. The platelet count before therapy, serum thyroid stimulating hormone and combination treatment with prednisone and levothyroxine were associated with bleeding events. Therefore, the present study suggests that hypothyroidism is associated with severe thrombocytopenia in hepatitis B-associated compensatory liver cirrhosis. Treatment with prednisone plus levothyroxine may present a novel approach in these patients. | Jing Xue Ru Feng Haixia Fu Qian Jiang Hao Jiang Jing Lu Hui Liu Jingwen Wang Ting Niu Xin Wang YANDi Xie Hao Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 8 |
| 3 | Preparation of cross-linked enzyme aggregates of nitrile hydratase ES-NHT-118 from E.coli by macromolecular cross-linking agent显示文摘Cross-linked enzyme aggregates(CLEAs) of nitrile hydratase(NHase) ES-NHT-118 from Escherichia coli were prepared by using ammonium sulfate as precipitating agent followed by cross-linking with dextran polyaldehyde for the first time. In this process, egg white was added as protein feeder for facilitating the formation of CLEAs. The optimal conditions of the immobilization process were determined. Michaelis constants(Km) of free NHase and NHase CLEAs were also determined. The NHase CLEAs exhibited increased stability at varied pH and temperature conditions compared to its free counterpart. When exposed to high concentrations of acrylamide, NHase CLEAs also exhibited effective catalytic activity. | Liya Zhou Haixia Mou Jing Gao Li Ma Ying He Yanjun Jiang | 2017 | Chinese Journal of Chemical Engineering2017，25，4： | 5 |
| 4 | Fluid-Structure Interaction Simulation of Aqueous Outflow System in Response to Juxtacanalicular Meshwork Permeability Changes with a Two-Way Coupled Method显示文摘Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system(AOS).However,there is still no consensus about exact location of the increased outflow resistance of aqueous humor,and the mechanism is not perfect.In addition,it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology.In this paper,a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork,juxtacanalicular meshwork(JCM)and Schlemm’s canal in response to JCM permeability changes.We obtained the JCM permeability of normal intraocular pressure varied between 1×10?15 m2 and 10×10?15 m2 while permeability of the JCM ranged from 2×10?16 m2 and 3×10?16 m2 under conditions of high intraocular pressure.The study indicated that the fluid dynamics parameters in trabecular meshwork and Schlemm’s canal are most significantly affected by the changes of JCM permeability.Moreover,the study demonstrates that the finite element modeling of AOS provides a practical means for studying the outflow dynamics and the biomechanical environment of the AOS. | Jing Zhang Xiuqing Qian Haixia Zhang Zhicheng Liu | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 3 |
| 5 | Correlation between the genetic variants of base excision repair (BER) pathway genes and neuroblastoma susceptibility in eastern Chinese children显示文摘Dear Editor,Neuroblastoma is the most common non-central nerve system(CNS)solid tumor in pediatrics[1].Neuroblastoma accounts for approximately 8%of all pediatric cancers but disproportionally causes a high cancer mortality(15%)in children[2].Pediatric patients with low-risk neuroblastoma witness a 5-year overall survival rate>90%,whereas the 5-year overall survival rate in high-risk neuroblastoma pediatric patients is<40%[3]. | Zhenjian Zhuo Chunlei Zhou Yuan Fang Jinhong Zhu Hongting Lu Haixia Zhou Haiyan Wu Yizhen Wang Jing He | 2020 | Cancer Communications2020，40，11： | 2 |
| 6 | Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China显示文摘Dear Editor,Chikungunya virus(CHIKV)is a mosquito-borne virus belonging to the family Togaviridae,genus Alphavirus,and was first isolated in Tanzania in the 1950s(Silva and Dermody 2017;Weaver and Lecuit 2015).Human infections with CHIKV typically result in a rapid-onset febrile disease,with symptoms that include fever,headache,rash,severe joint and muscle pain,as well as prolonged periods of disability in some patients(Weaver and Lecuit 2015;Silva and Dermody 2017). | Yang Yang Zhixiang Xu Haixia Zheng Jingdong Song Ying Wu Zhou Tong Jing Yuan Gary Wong William J.Liu Yuhai Bi Yingxia Liu George F.Gao | 2020 | Virologica Sinica2020，35，1： | 2 |
| 7 | Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-κBpathway in BV-2 murine microglial cells显示文摘 | Haixia Hu Zuanfang Li Xiaoqin Zhu Ruhui Lin Jiumao Lin Jun Peng Jing Tao Lidian Chen | 2013 | International Journal of Molecular Medicine2013，，6： | 2 |
| 8 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hbc6wkwck0nuq6kw6.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 9 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells显示文摘Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.In this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular endothelium.Results show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated apoptosis.These effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,BAPTA-AM.Blockade of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]i.Comparing to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell apoptosis.Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD.In summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and Orai1.Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases. | Kai Yang Shiyun Liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 2 |
| 10 | ZFX modulates the growth of human leukemic cells via B4GALT1显示文摘锌手指蛋白质 X 连接(ZFX ) 是胚胎的干细胞(转换字符) 和造血的干细胞(HSC ) 的一个关键管理者,它被要求因为两个都槽口细胞内部的领域(NotchIC ) 在鼠标模型导致了尖锐 T 房间白血病和 MLL-AF9-induced myeloid 白血病。然而, ZFX 的角色和它在人的白血病的房间的内在的机制还仍然保持不清楚,尽管积累的数据证明了 ZFX 异常地在各种各样的人的肿瘤被表示并且起一个重要作用。此处,我们发现 ZFX 异常地与控制房间相比从白血病病人在各种各样的人的白血病的房间线和主要房间被表示。ZFX 的沉默包括 K562, Jurkat, Namalwa,和 THP-1 房间在各种各样的房间通过 deregulated 房间周期或 apoptosis 的正式就职导致了生长抑制。基因表示分析揭示了那 UDP 女郎: GlcNAc 1,4-galactosyltransferase,(B4GALT1 ) 多肽 1 在 ZFX silencing 之上是显著地下面调整的,它在对 imatinib mesylate (IM ) 的治疗的 K562 房间的反应被含有。另外, lectin 污点试金证明在 K562 房间的 glycoproteins 的 galactosylation 在 ZFX silencing 之上被压制。有趣地, B4GALT1 的 overexpression 恢复了生长并且授与药抵抗到沉默 ZFX 的细胞。一起拿,我们证明了 ZFX 异常地在多重人的白血病的房间被表示,它经由 B4GALT1 部分调制生长和白血病的房间的药反应,它建议 ZFX 是白血病的房间的一个新管理者并且在这些致命的疾病在这个 stemness 管理者上保证集中的调查。 | Jie Wu Lun Xiao Haixia Zhou Hong Liu Yue Ge Jing Yang Yuanyuan Li Depei Wu Yun Zhao Xiuyan Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 2 |
| 11 | Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes显示文摘 | Benchun Miao Meiyu Geng Jing Li Fuchuan Li Haixia Chen Huashi Guan Jian Ding | 2004 | Biochemical Pharmacology2004，，4： | 1 |
| 12 | Imaging of skin microvessels with optical coherence tomography: potentialuses in port wine stains显示文摘 | Yang Zhou Daiqiang Yin Ping Xue Naiyan Huang Haixia Qiu Ying Wang Jing Zeng Zhihua Ding Ying Gu | 2012 | Experimental and Therapeutic Medicine2012，，6： | 1 |
| 13 | HighThyroglobulin Antibody Levels Increase the Risk ofDifferentiated Thyroid Carcinoma 显示文摘 | Qin Jing Yu Zhenqian Guan Haixia | 2015 | Disease markers2015，8，15： | 1 |
| 14 | Incomplete Fingerprint Recognition Based on Inproved GA-PSO显示文摘 | Jing XJ (Jing Xiaojun) Zhang J (Zhang Jie) Jiang.HX (Jiang Haixia) Zhong ML (ZhongMingliang) Tao L (Tao Lei) | | 0，，04： | 1 |
| 15 | Primary malignant tumours and malignant transformation of cysts in the retrorectal space:MRI diagnosis and treatment outcomes显示文摘Background:There are no clear guidelines for the diagnosis and treatment of malignant retrorectal tumours.The purpose of this study was to increase preoperative diagnostic knowledge and to describe the outcomes of treatment for these patients.Methods:This retrospective study was conducted on patients who underwent complete retrorectal tumour resection between May 2006 and July 2018,and had confirmed post-operative pathology reports.Demographic and clinical data(including imaging,perioperative,pathological,and prognostic data)were collected and analysed.Results:Malignant lesions were identified in 15(9[60%],female)patients.The median age of the patients was 59 years(range,34–72 years).Primary malignant tumours were identified in seven patients with solid tumours,in which gastrointestinal stromal tumours accounted for 71.4%(five of seven)and the remainder were chordoma or mucinous adenocarcinoma.Malignant transformation of cysts occurred in another eight patients with heterogeneous tumours,while histopathological features were present in 75%(six of eight)of patients with mucinous adenocarcinoma,and the remainder were squamouscell carcinoma or neuroendocrine tumour(Grade 2).The malignant characteristics of the solid portions observed using magnetic resonance imaging(MRI)were as follows:the cyst wall of the tumour was irregularly thickened;the surface was convex or lobed;the solid tumour had no capsule,or the capsule was destroyed;and the surface had a gyrus-like morphology.At a median follow-up time of 52 months(range,13–100 months),the overall recurrence-free survival rate was 40.0%and the survival rate was 46.7%.Conclusion:Some MRI features can be used to distinguish malignant retrorectal tumours from benign retrorectal tumours.The survival rate of patients with malignant retrorectal tumours is poor. | Jing Gong Yumeng Xu Yan Zhang Lichao Qiao Haixia Xu Ping Zhu Bolin Yang | 2022 | Gastroenterology Report2022，10，1： | 1 |
| 16 | Immune response induced by hematoporphyrin derivatives mediated photodynamic therapy:Immunogenic cell death and elevated costimulatory molecules显示文摘Photodynamic therapy(PDT)not only destroys tumor cells directly but also induced anti-tumor immune response through damage-associated molecular patterns(DAMPs).It is reported that anti-tumor response was associated with light dose and photosensitizer used in PDT.In this study,4T1 tumor cells were implanted on both the right and left flanks of mice.Only the right tumor was treated by HpD-PDT,while the left tumor was not irradiated.The anti-tumor immune response induced by HpD-PDT was investigated.The expression of DAMPs and costimulatory molecules induced by HpD-PDT were tested by immuno fluorescence and flow cytometry in vivo.Different light doses of PDT were designed to treat 4T1 cells.The killing effect was assessed by CCK-8 kit and apoptosis kit.The expression of DAMPs on 4T1 cells after HpDPDT were evaluated by flow cytometry,western blot and ATP kit.This study showed that CD4^(+)T,CD8^(+)T and the production of IFN-γwere increased significantly on day 10 in righttumor after PDT treatment compared with control group.HpD-PDT enhanced the expression of calreticulin(CRT)on tumor tissue.Importantly,co-stimulatory molecular OX-40 and 4-1BB were elevated on CD8^(+)T cells.In vitro,immunogenic death of 4T1 cells was induced after PDT.Besides,the expression of DAMPs increased with the increasing of energy density.This study indicates that anti-tumor immune effect was induced by HpD-PDT.The knowledge of the involvement of CRT,ATP and co-stimulatory molecules uncovers important mechanistic insight into the anti-tumor immunogenicity.It was the first time that co-stimulatory molecules were investigated and found to elevate after PDT. | Shan Long Yibing Zhao Yuanyuan Xu Hui Li Hongyou Zhao Defu Chen Jing Zeng Haixia Qiu Xiaosong Li Ying Gu | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 1 |
| 17 | Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection显示文摘The worldwide epidemic of coronavirus disease 2019(COVID-19)is ongoing.Rapid and accurate detection of the causative virus SARSCoV-2 is vital for the treatment and control of COVID-19.In this study,the comparative sensitivity of different respiratory specimen types were retrospectively analyzed using 3,552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC(Center for Disease Control and Prevention).Except for bronchoalveolar lavage fluid(BALF),the sputum possessed the highest positive rate(73.4%–87.5%),followed by nasal swabs(53.1%–85.3%)for both severe and mild cases during the first 14 days after illness onset(d.a.o.).Viral RNA could be detected in all BALF samples collected from the severe group within 14 d.a.o.and lasted up to 46 d.a.o.Moreover,although viral RNA was negative in the upper respiratory samples,it was also positive in BALF samples in most cases from the severe group during treatment.Notably,no viral RNA was detected in BALF samples from the mild group.Despite typical ground-glass opacity observed via computed tomographic scans,no viral RNA was detected in the first three or all upper respiratory tract specimens from some COVID-19 patients.In conclusion,sputum is most sensitive for routine laboratory diagnosis of COVID-19,followed by nasal swabs.Detection of viral RNA in BALF improves diagnostic accuracy in severe COVID-19 patients. | Yang Yang Minghui Yang Jing Yuan Fuxiang Wang Zhaoqin Wang Jinxiu Li Mingxia Zhang Jinli Wei Ling Peng Gary Wong Haixia Zheng Weibo Wu Chenguang Shen Mingfeng Liao Kai Feng Jianming Li Qianting Yang Juanjuan Zhao Lei Liu Yingxia Liu | 2020 | The Innovation2020，1，3： | 1 |
| 18 | Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer显示文摘 | Ying Li Haixia Zhao Yuzhong Wang Hao Zheng Wei Yu Hongyan Chai Jing Zhang John R. Falck Austin M. Guo Jiang Yue Renxiu Peng Jing Yang | 2013 | Toxicology and Applied Pharmacology2013，，： | 1 |
| 19 | Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population显示文摘 | Bo Wang Haixia Zhou Jing Yang et a1 | 2013 | Gene2013，531，： | 1 |
| 20 | Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice显示文摘 | Haixia Zhao Ying Li Yuzhong Wang Jing Zhang Xiaoming Ouyang Renxiu Peng Jing Yang | 2012 | Food and Chemical Toxicology2012，，8： | 1 |
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