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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Incidence and in-hospital mortality of acute aortic dissection in China: analysis of China Health Insurance Research (CHIRA) Data 2011显示文摘ObjectiveAcute 大动脉的解剖(AAD ) 是有高早的死亡率的一个灾难的事件,但是迄今为止,在大陆中国的 AAD 的发生上的数据都不是可得到的。这研究试图在中国估计 AAD 的发生并且描绘临床的侧面,这脉管的 event.MethodsWe 的管理和在里面医院结果使用了中国健康保险研究数据( CHIRA 数据) 2011 它从 25 个城市在到 3,335,000 个随机取样的受益人( 1,718,500 个男人和 1,616,500 个女人)的2011年12月31日的1月一日 2011 的经期期间包括所有住院病人医院记录( 300,886 )并且在大陆中国的不同经济地理的区域的县。有尖锐大动脉的解剖的病人根据疾病 10 I71.0 的 th 修订(ICD-10 ) 。AAD 的估计的发生用方程被计算:估计的发生 = 2.0 ×( 40%×医院承认率)+60%×医院承认 rate.ResultsThe 医院承认率是 2.0/100,000 (65/3,325,000, 95% CI:1.2-2.8 ) 。AAD 的估计的年度发生是 2.8/100,000 (95% CI:1.9-3.6 ) 并且比在女性在男性是更高的(3.7 对 1.5, P <0.001 ) 。吝啬的年龄是 58.9 ±13.4 年。在 23 ± 的吝啬的医院停留期间;6 天,全面在里面医院死亡是 13.9%(9/65 ).ConclusionsOur 学习在中国的大陆显示出相对更低然而并非可以忽略的发生和 AAD 的在里面医院死亡。有用汉语的 AAD 的病人的吝啬的年龄比从西方国家由研究报导了的年轻,当到女发生比率的男性类似于另外的研究报导的那些时。 | Lei XIA Jing-Hu LI Kun ZHAO Hai-Yun WU | 2015 | Journal of Geriatric Cardiology2015，12，5： | 49 |
| 3 | Multivariate analysis of surface water quality in the Three Gorges area of China and implications for water management显示文摘Multivariate statistical techniques,cluster analysis,non-parametric tests,and factor analysis were applied to analyze a water quality dataset including 13 parameters at 37 sites of the Three Gorges area,China,from 2003–2008 to investigate spatio-temporal variations and identify potential pollution sources.Using cluster analysis,the twelve months of the year were classified into three periods of lowflow (LF),normal-flow (NF),and high-flow (HF);and the 37 monitoring sites were divided into low pollution (LP),moderate pollution (MP),and high pollution (HP).Dissolved oxygen (DO),potassium permanganate index (COD Mn ),and ammonia-nitrogen (NH 4 +-N) were identified as significant variables affecting temporal and spatial variations by non-parametric tests.Factor analysis identified that the major pollutants in the HP region were organic matters and nutrients during NF,heavy metals during LF,and petroleum during HF.In the MP region,the identified pollutants primarily included organic matter and heavy metals year-around,while in the LP region,organic pollution was significant during both NF and HF,and nutrient and heavy metal levels were high during both LF and HF.The main sources of pollution came from domestic wastewater and agricultural activities and runoff;however,they contributed differently to each region in regards to pollution levels.For the HP region,inputs from wastewater treatment plants were significant;but for MP and LP regions,water pollution was more likely from the combined effects of agriculture,domestic wastewater,and chemical industry.These results provide fundamental information for developing better water pollution control strategies for the Three Gorges area. | Jian Zhao Guo Fu Kun Lei Yanwu Li | 2011 | Journal of Environmental Sciences2011，23，9： | 25 |
| 4 | Assessment and sequencing of air target threat based on intuitionistic fuzzy entropy and dynamic VIKOR显示文摘In view of the fact that traditional air target threat assessment methods are difficult to reflect the combat characteristics of uncertain, dynamic and hybrid formation, an algorithm is proposed to solve the multi-target threat assessment problems. The target attribute weight is calculated by the intuitionistic fuzzy entropy(IFE) algorithm and the time series weight is gained by the Poisson distribution method based on multi-times data. Finally,assessment and sequencing of the air multi-target threat model based on IFE and dynamic Vlse Kriterijumska Optimizacija I Kompromisno Resenje(VIKOR) is established with an example which indicates that the method is reasonable and effective. | ZHANG Kun KONG Weiren LIU Peipei SHI Jiao LEI Yu ZOU Jie | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 24 |
| 5 | Early nasogastric enteral nutrition for severe acute pancreatitis: A systematic review显示文摘AIM: To evaluate the effectiveness and safety of early nasogastric enteral nutrition (NGEN) for patients with severe acute pancreatitis (SAP). METHODS: We searched Cochrane Central Register of Controlled Trials (Issue 2, 2006), Pub-Medline (1966-2006), and references from relevant articles. We included randomized controlled trials (RCTs) only, which reported the mortality of SAP patients at least. Two reviewers assessed the quality of each trial and collected data independently. The Cochrane Collaboration’s RevMan 4.2.9 software was used for statistical analysis. RESULTS: Three RCTs were included, involving 131 patients. The baselines of each trial were comparable. Meta-analysis showed no significant differences in mortality rate of SAP patients between nasogastric and conventional routes (RR = 0.76, 95% CI = 0.37 and 1.55, P = 0.45), and in other outcomes, including time of hospital stay (weighted mean difference = -5.87, 95% CI = -20.58 and 8.84, P = 0.43), complication rate of infection (RR = 1.41, 95% CI = 0.62 and 3.23, P = 0.41) or multiple organ defi ciency syndrome (RR = 0.97, 95% CI = 0.27 and 3.47, P = 0.97), rate of admission to ICU (RR = 1.00, 95% CI = 0.48 and 2.09, P = 0.99) or conversion to surgery (RR = 0.66, 95% CI = 0.12 and 3.69, P = 0.64), as well as recurrence of re-feeding pain and adverse events associated with nutrition. CONCLUSION: Early NGEN is a breakthrough in the management of SAP. Based on current studies, early NGEN appears effective and safe. Since the available evidence is poor in quantity, it is hard to make an accurate evaluation of the role of early NGEN in SAP.Before recommendation to clinical practice, further high qualified, large scale, randomized controlled trials are needed. | Kun Jiang Xin-Zu Chen Qing Xia Wen-Fu Tang Lei Wang | 2007 | World Journal of Gastroenterology2007，13，39： | 21 |
| 6 | Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway显示文摘Background: Pancreatic ductal adenocarcinoma(PDAC) is the most deadly type of tumor, and its pathogenesis remains unknown. Circular RNAs(circRNAs) may be functional and bind to micro RNAs and consequently, influence the activity of targeted mRNAs. Recent researches indicate that one circRNA, ciRS-7, acts as a sponge of miR-7 and thus, inhibits its activity. It is well known that miR-7 is a cancer suppressor in many cancers. However, the relationship between ciRS-7 and miR-7, and the role of ciRS-7 in PDAC, remains to be elucidated. Methods: miR-7 and ciRS-7 expression in 41 pairs of PDAC tumors and their paracancerous tissues were detected by quantitative reverse transcription polymerase chain reaction(qRT-PCR). The relationships between their expression levels and clinicopathological features in PDAC tissues were assessed. The relationship between miR-7 and ciRS-7 was also assessed by Spearman’s correlation. We also used cell lines to evaluate the role of ciRS-7 in cell line behavior. The ciRS-7 interfere RNA(si RNA) and its empty vector were transfected into PDAC cells. PDAC cells proliferation and invasion abilities were detected by MTT assay and invasion analysis. The expression of proteins was assessed by Western blotting. Results: ciRS-7 expression was significantly higher in PDAC tissues than paracancerous tissues( P = 0.002). However, miR-7 expression showed the opposite trend( P = 0.048). Moreover, ciRS-7 expression was inversely correlated with miR-7 in PDAC( r s =-0.353, P = 0.023). ciRS-7 expression was also significantly elevated in venous invasion(3.72 ± 2.93 vs. 2.14 ± 1.26;P = 0.028) and lymph node metastasis(4.19 ± 2.75 vs. 2.32 ± 1.90;P = 0.016) in PDAC patients. Furthermore, ciRS-7 knockdown suppressed cell proliferation and invasion of PDAC cells( P < 0.05), and the downregulation of ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of epidermal growth factor receptor(EGFR) and signal transducer and activator of transcription 3(STAT3). Conclusions: Circular RNA ciRS-7 plays an oncogene role in PDAC, partly by targeting miR-7 and regulating the EGFR/STAT3 signaling pathway. | Lei Liu Fu-Bao Liu Mei Huang Kun Xie Qing-Song Xie Chen-Hai Liu Min-Jing Shen Qiang Huang | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 21 |
| 7 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 8 | Temporal and spatial changes in nutrients and chlorophyll-a in a shallow lake,Lake Chaohu, China: An 11-year investigation显示文摘Temporal and spatial changes of total nitrogen(TN),total phosphorus(TP) and chlorophyll-a(Chl-a) in a shallow lake,Lake Chaohu,China,were investigated using monthly monitoring data from 2001 through 2011.The results showed that the annual mean concentration ranges of TN,TP,and Chl-a were 0.08-14.60 mg/L,0.02-1.08 mg/L,and 0.10-465.90 μg/L,respectively.Our data showed that Lake Chaohu was highly eutrophic and that water quality showed no substantial improvement during 2001 through 2011.The mean concentrations of TP,TN and Chl-a in the western lake were significantly higher than in the eastern lake,which indicates a spatial distribution of the three water parameters.The annual mean ratio of TN:TP by weight ranged from 10 to 20,indicating that phosphorus was the limiting nutrient in this lake.A similar seasonality variation for TP and Chl-a was observed.Riverine TP and NH4+ loading from eight major tributaries were in the range of 1.56 × 104-5.47 × 104 and 0.19 × 104-0.51 × 104 tons/yr over 2002-2011,respectively,and exceeded the water environmental capability of the two nutrients in the lake by a factor of 3-6.Thus reduction of nutrient loading in the sub-watershed and tributaries would be essential for the restoration of Lake Chaohu. | Libiao Yang Kun Lei Wei Meng Guo Fu Weijin Yan | 2013 | Journal of Environmental Sciences2013，25，6： | 19 |
| 9 | Enhanced bioremediation of oil contaminated soil by graded modified Fenton oxidation显示文摘Graded modified Fenton's (MF) oxidation is a strategy in which H 2 O 2 is added intermittently to prevent a sharp temperature increase and undesired soil sterilization at soil circumneutral pH versus adding the same amount of H 2 O 2 continuously.The primary objective of the present study was to investigate whether a mild MF pre-oxidation such as a stepwise addition of H 2 O 2 can prevent sterilization and achieve a maximum degradation of tank oil in soil.Optimization experiments of graded MF oxidation were conducted using citric acid,oxalic acid and SOLV-X as iron chelators under different frequencies of H 2 O 2 addition.The results indicated that the activity order of iron chelates decreased as:citric acid (51%) > SOLV-X (44%) > oxalic acid (9%),and citric acid was found to be an optimized iron chelating agent of graded MF oxidation.Three-time addition of H 2 O 2 was found to be favorable and economical due to decreasing total petroleum hydrocarbon removal from three time addition (51%) to five time addition (59%).Biological experiments were conducted after graded MF oxidation of tank oil completed under optimum conditions mentioned above.After graded oxidation,substantially higher increase (31%) in microbial activity was observed with excessive H 2 O 2 (1470 mmol/L,the mol ratio of H 2 O 2:Fe 2+ was 210:1) than that of non-oxidized soil.Removal efficiency of tank oil was up to 93% after four weeks.Especially,the oil fraction (C 10 -C 40 ) became more biodagradable after graded MF oxidation than its absence.Therefore,graded MF oxidation is a mild pretreatment to achieve an effective bioremediation of oil contaminated soil. | Jinlan Xu Lei Xin Tinglin Huang Kun Chang | 2011 | Journal of Environmental Sciences2011，23，11： | 17 |
| 10 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 11 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 12 | Transplantation of VEGF165-gene-transfected endothelial progenitor cells in the treatment of chronic venous thrombosis in rats显示文摘背景血栓症的组织和开运河是一个动态、复杂的过程。研究是在我们构造了的长期的静脉的 thrombosis.Methods 上学习干细胞移植和基因 transfection 的 cotherapeutic 效果的这的目的带脉管的 endothelial 生长因素的 recombinant adenoviral 向量 165 (VEGF165 ) 由使用 pAdEasy 系统的基因,它是随后识别了并且放大。同时, endothelial 祖先房间(EPC ) 用 Ficoll 从老鼠骨头髓被孤立,在 EBM-2MV 媒介有教养,并且识别。然后,房间是有 recombinant Ad-VEGF165 的 transfected。EPC 在移植前用 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine (Dil ) 被标记。长期的静脉血栓的一个老鼠模型被劣等的静脉 cava 的部分结扎开发。老鼠随机被划分成 4 个组(n=25,每) :一, Ad-VEGF165/EPC-transplantation 组收到了 1 ml (10 ~ 6 ) Ad-VEGF165/EPCs;B, EPC-transpiantation 组收到了 1 ml (10 ~ 6 ) EPC;C, Ad/EPC-transplantation 组收到了 1 ml (10 ~ 6 ) Ad/EPCs;D,控制组收到了移植媒介的 1 ml。血栓症和邻近的 ceval 墙被收获在移植以后的 28 天;即时量的聚合酶链反应被用来检测脉管的 endothelial 生长的表示水平因素(VEGF ) Mrna;并且西方的弄污被用来在染色的 VEGF 蛋白质 expression.Hematoxylin 曙红测量变化,染色的 immunohistochemical 被执行检测开运河。Neovascularization 被为 von Willebrand 因素(Vwf ) 用抗体染色的 immunohistochemical 检测,它是份量上由在高力量的 microscope.Results 下面数 capillaries 决定了的毛状的密度是的 endothelial cells.The 的一个部件 Ad-VEGF165 被构造,并且 bone-marrow-derived EPC 被栽培并且成功地识别了。我们决定了支持了 EPC 的生长的最佳 transfection 比率。在 transfection 以后, EPC 分泌了 VEGF 蛋白质。在移植以后,在里面进 endothelial 房间的 EPC 和他们的区别的 vivo 幸存被检测与 Dil 污点联系的荧光决定。VEGF Mrna 在组 A 在移植,和 VEGF Mrna 水平以后在组 A, B, C 和 D 被表示比在组 B, C 和 D 的那些显著地高(P < 0.05 ) ;在组 B 和 C 的 VEGF Mrna 层次比在组 D 的那些显著地高(P < 0.05 ) ,并且在在组 B 和 C 的 VEGF Mrna 层次之间没有统计意义。开运河在组 A 的毛状的密度比在组 B 的那些显著地高, C (P < 0.05 ) 并且 D (P < 0.01 ) ;开运河在组 B 和 C 的毛状的密度在组 D 比那显著地高(P < 0.05 ) 。而且,为 EPC 是的组 B 和 C.Conclusions 的价值之间没有统计重要差别成功地由 Ad-VEGF165 的 transfected。合适的 transfection 比率能在移植以后改进 EPC 和 angiogenesis 的提升的可能性的效率。Transfected EPC 引起了静脉血栓症的加速的组织和开运河。 | MENG Qing-you LI Xiao-qiang YU Xiao-bin LEI Feng-rui JIANG Kun LI Chuan-yong | 2010 | Chinese Medical Journal2010，，4： | 14 |
| 13 | Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG显示文摘Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a 'factory' to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG. | Chun-Yuan Chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie Huang Yin Hu Zhong-Wei Luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang Chen Wei Du Jiang-Hua Liu Yan Zhang Tuan-Hui Chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie | 2019 | Bone Research2019，7，3： | 14 |
| 14 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 15 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 16 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 17 | The positive function of selenium supplementation on reducing nitrate accumulation in hydroponic lettuce(Lactuca sativa L.)显示文摘High nitrate(NO_3^- ) in vegetables, especially in leaf vegetables poses threaten to human health. Selenium(Se) is an important element for maintaining human health, and exogenous Se application during vegetable and crop production is an effective way to prevent Se deficiency in human bodies. Exogenous Se shows positive function on plant growth and nutrition uptake under abiotic and/or biotic stresses. However, the influence of exogenous Se on NO_3^- accumulation in hydroponic vegetables is still not clear. In the present study, hydroponic lettuce plants were subjected to six different concentrations(0, 0.1, 0.5, 5, 10 and 50 μmol L–1) of Se as Na2 Se O3. The effects of Se on NO_3^- content, plant growth, and photosynthetic capacity of lettuce(Lactuca sativa L.) were investigated. The results showed that exogenous Se positively decreased NO_3^- content and this effect was concentration-dependent. The lowest NO_3^- content was obtained under 0.5 μmol L–1 Se treatment. The application of Se enhanced photosynthetic capacity by increasing the photosynthesis rate(Pn), stomatal conductance(Cs) and the transpiration efficiency(Tr) of lettuce. The transportation and assimilation of NO_3^- and activities of nitrogen metabolism enzymes in lettuce were also analysed. The NO_3^- efflux in the lettuce roots was markedly increased, but the efflux of NO_3^- from the root to the shoot was decreased after treated with exogenous Se. Moreover, Se application stimulated NO_3^- assimilation by enhancing nitrate reductase(NR), nitrite reductase(Ni R), glutamine synthetase(GS) and glutamate synthase enzyme(GOGAT) activities. These results provide direct evidence that exogenous Se shows positive function on decreasing NO_3^- accumulation via regulating the transport and enhancing activities of nitrogen metabolism enzyme in lettuce. We suggested that 0.5 μmol L–1 Se can be used to reduce NO_3^- content and increase hydroponic lettuce yield. | LEI Bo BIAN Zhong-hua YANG Qi-chang WANG Jun CHENG Rui-feng LI Kun LIU Wen-ke ZHANG Yi FANG Hui TONG Yun-xin | 2018 | Journal of Integrative Agriculture2018，17，4： | 9 |
| 18 | High-speed image reconstruction for optically sectioned,super-resolution structured illumination microscopy显示文摘Super-resolution structured illumination microscopy(SR-SIM)is an outstanding method for visualizing the subcellular dynamics in living cells.To date,by using elaborately designed systems and algorithms,SR-SIM can achieve rapid,optically sectioned,SR observation with hundreds to thousands of time points.However,real-time observation is still out of reach for most SIM setups as conventional algorithms for image reconstruction involve a heavy computing burden.To address this limitation,an accelerated reconstruction algorithm was developed by implementing a simplified workflow for SR-SIM,termed joint space and frequency reconstruction.This algorithm results in an 80-fold improvement in reconstruction speed relative to the widely used Wiener-SIM.Critically,the increased processing speed does not come at the expense of spatial resolution or sectioning capability,as demonstrated by live imaging of microtubule dynamics and mitochondrial tubulation. | Zhaojun Wang Tianyu Zhao Huiwen Hao Yanan Cai Kun Feng Xue Yun Yansheng Liang Shaowei Wang Yujie Sun Piero RBianco Kwangsung Oh Ming Lei | 2022 | Advanced Photonics2022，4，2： | 9 |
| 19 | Construction of TiO2/silane nanofilm on AZ31 magnesium alloy for controlled degradability and enhanced biocompatibility显示文摘A TiO2 nanofilm was prepared on the surface of AZ31 magnesium alloy with controllable thickness through atomic layer deposition(ALD) technique, which can adjust the corrosion behaviors of AZ31 Mg alloy.Compared with the untreated Mg alloys, corrosion current densities(icorr)can decline by 58% in the 200-cycles TiO2-covered Mg alloy and further decline by up to 74% with the thickness of nanofilm up to 63 nm(400 cycles).The subsequent modification with a cross-linked conversion layer of 3-aminopropyltriethoxysilane(APTES) by a dipping method can produce a compact silane coating on TiO2 nanofilm, which can seal pinholes of TiO2 nanofilm and serve as a barrier to further adjust the corrosion behavior of the substrate.The icorrcan decline about two orders of magnitude in the TiO2/silane composite coating.Making the adjustable corrosion rate come true, which can be attributed to the precise control on the thickness of metal oxide nanofilm and additional protection from the compact silane coating.In vitro study discloses that the TiO2/silane hybrid coating shows higher expression of alkaline phosphatase(ALP)and can promote cellular adhesion and proliferation with better cytocompatibility than untreated Mg alloy. | Lei Huang Kun Su Yu-Feng Zheng Kelvin Wai-Kwok Yeung Xiang-Mei Liu | 2019 | Rare Metals2019，38，6： | 9 |
| 20 | Machine learning in materials science显示文摘Traditional methods of discovering new materials,such as the empirical trial and error method and the density functional theory(DFT)-based method,are unable to keep pace with the development of materials science today due to their long development cycles,low efficiency,and high costs.Accordingly,due to its low computational cost and short development cycle,machine learning is coupled with powerful data processing and high prediction performance and is being widely used in material detection,material analysis,and material design.In this article,we discuss the basic operational procedures in analyzing material properties via machine learning,summarize recent applications of machine learning algorithms to several mature fields in materials science,and discuss the improvements that are required for wide-ranging application. | Jing Wei Xuan Chu Xiang-Yu Sun Kun Xu Hui-Xiong Deng Jigen Chen Zhongming Wei Ming Lei | 2019 | InfoMat2019，1，3： | 9 |
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