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| 1 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 2 | Application of Neural network PID Controller in Constant Temper-ature and Constant Liquid-level System显示文摘Guided by the principle of neural network, an intelligent PID controller based on neural network is devised and applied to control of constant temperature and constant liquidlevel system. The experiment results show that this controller has high accuracy and strong robustness and good characters. | (College of information and control engineering, University of Petroleum, Dongying 257061, China) Chen Guochu Hao Ninmei Liu Xianguang(College of electricity engineering, University of Xi ’ an Communication, Xi’ an 710049, China) Zhang Lin (Workshop of Instrument of Plastic Plant, Qilu Petrochemical Corp., Zibo 255411, China) Wang Junhong | 2003 | 微计算机信息2003，19，1： | 11 |
| 3 | Spaceborne GPS receiver antenna phase center offset and variation estimation for the Shiyan 3 satellite显示文摘In determining the orbits of low Earth orbit(LEO) satellites using spaceborne GPS, the errors caused by receiver antenna phase center offset(PCO) and phase center variations(PCVs) are gradually becoming a major limiting factor for continued improvements to accuracy. Shiyan 3, a small satellite mission for space technology experimentation and climate exploration, was developed by China and launched on November 5, 2008. The dual-frequency GPS receiver payload delivers1 Hz data and provides the basis for precise orbit determination within the range of a few centimeters. The antenna PCO and PCV error characteristics and the principles influencing orbit determination are analyzed. The feasibility of PCO and PCV estimation and compensation in different directions is demonstrated through simulation and in-flight tests. The values of receiver antenna PCO and PCVs for Gravity Recovery and Climate Experiment(GRACE) and Shiyan 3 satellites are estimated from one month of data. A large and stable antenna PCO error, reaching up to10.34 cm in the z-direction, is found with the Shiyan 3 satellite. The PCVs on the Shiyan 3 satellite are estimated and reach up to 3.0 cm, which is slightly larger than that of GRACE satellites. Orbit validation clearly improved with independent k-band ranging(KBR) and satellite laser ranging(SLR) measurements. For GRACE satellites, the average root mean square(RMS) of KBR residuals improved from 1.01 cm to 0.88 cm. For the Shiyan 3 satellite, the average RMS of SLR residuals improved from 4.95 cm to 4.06 cm. | Gu Defeng Lai Yuwang Liu Junhong Ju Bing Tu Jia | 2016 | Chinese Journal of Aeronautics2016，29，5： | 11 |
| 4 | Basic performance of BeiDou-2 navigation satellite system used in LEO satellites precise orbit determination显示文摘The visibility for low earth orbit(LEO) satellites provided by the BeiDou-2 system is analyzed and compared with the global positioning system(GPS). In addition, the spaceborne receivers' observations are simulated by the BeiDou satellites broadcast ephemeris and LEO satellites orbits. The precise orbit determination(POD) results show that the along-track component accuracy is much better over the service area than the non-service area, while the accuracy of the other two directions keeps at the same level over different areas. However, the 3-dimensional(3D) accuracy over the two areas shows almost no difference. Only taking into consideration the observation noise and navigation satellite ephemeris errors, the 3D accuracy of the POD is about30 cm. As for the precise relative orbit determination(PROD), the 3D accuracy is much better over the eastern hemisphere than that of the western hemisphere. The baseline length accuracy is 3.4 mm over the service area, and it is still better than 1 cm over the non-service area. This paper demonstrates that the BeiDou regional constellation could provide global service to LEO satellites for the POD and the PROD. Finally, the benefit of geostationary earth orbit(GEO) satellites is illustrated for POD. | Liu Junhong Gu Defeng Ju Bing Yao Jing Duan Xiaojun Yi Dongyun | 2014 | Chinese Journal of Aeronautics2014，27，5： | 9 |
| 5 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 6 | Precession–nutation correction for star tracker attitude measurement of STECE satellite显示文摘Space Technology Experiment and Climate Exploration(STECE) is a small satellite mission of China for space technology experiment and climate exploration. A new test star tracker and one ASTRO 10 star tracker have been loaded on the STECE satellite to test the new star tracker's measurement performance. However,there is no autonomous precession–nutation correction function for the test star tracker,which causes an apparent periodic deflection in the inter-boresight angle between the two star trackers with respect to each other of up to ±500 arcsec,so the precession and nutation effect needs to be considered while assessing the test star tracker. This paper researches on the precession–nutation correction for the test star tracker's attitude measurement and presents a precession–nutation correction method based on attitude quaternion data. The periodic deflection of the inter-boresight angle between the two star trackers has been greatly eliminated after the precession and nutation of the test star tracker's attitude data have been corrected by the proposed method and the validity of the proposed algorithm has been demonstrated. The in-flight accuracy of the test star tracker has been assessed like attitude noise and low-frequency errors after the precession–nutation correction. | Lai Yuwang Liu Junhong Ding Yonghe Gu Defeng Yi Dongyun | 2014 | Chinese Journal of Aeronautics2014，27，1： | 7 |
| 7 | Composition Dependence of the Thermal Behavior,Morphology and Properties of Biodegradable PBS/PTMO Segment Block Copolymer显示文摘A series of aliphatic biodegradable poly(ether-ester)s based on poly(butylene succinate)(PBS)as hard segment and poly(tetramethylene oxide)(PTMO,M_n=1 000 g/mol) as soft segment were synthesized.The composition dependence of thermal behavior,morphology and mechanical properties was investigated by differential scanning calorimetry(DSC),atomic force microscopy(AFM),and tensile testing.The crystallization temperature(T_c) and melting temperature(T_m) of the PBS block within poly(ether-ester)s decrease steadily at first,but decrease sharply with PTMO content above 50 wt%.Two crystallization peaks were detected for PTMO in PBSPTMO60 sample,suggesting the occurrence of fractionated crystallization.The crystallization enthalpies(△H_c) and melting enthalpies(△H_m) of PBS block decrease at first,then increase as PTMO content increases further.AFM has demonstrated that phase-separated morphology transforms from a phase of continuous hard matrix to one of continuous soft matrix containing isolated hard domain as PTMO content is increased.Finally,the results of tensile testing show that the poly(ether-ester)s present the behavior of plastics when PTMO content is below 40 wt%,and of thermoplastic elastomers with PTMO content above 50 wt%.By varying the composition of copolymer,the aliphatic poly(ether-ester)s plastics,or especially biodegradable aliphatic poly(ether-ester)s thermoplastic elastomers can be obtained. | 黄勇 LIU Junhong 周涛 张爱民 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，1： | 6 |
| 8 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 9 | NF-κB and FosB mediate inflammation and oxidative stress in the blast lung injury of rats exposed to shock waves显示文摘Blast lung injury(BLI)is the major cause of death in explosion-derived shock waves;however,the mechanisms of BLI are not well understood.To identify the time-dependent manner of BLI,a model of lung injury of rats induced by shock waves was established by a fuel air explosive.The model was evaluated by hematoxylin and eosin staining and pathological score.The inflammation and oxidative stress of lung injury were also investigated.The pathological scores of rats’lung injury at 2 h,24 h,3 days,and 7 days post-blast were 9.75±2.96,13.00±1.85,8.50±1.51,and 4.00±1.41,respectively,which were significantly increased compared with those in the control group(1.13±0.64;P<0.05).The respiratory frequency and pause were increased significantly,while minute expiratory volume,inspiratory time,and inspiratory peak flow rate were decreased in a time-dependent manner at 2 and 24 h post-blast compared with those in the control group.In addition,the expressions of inflammatory factors such as interleukin(IL)-6,IL-8,FosB,and NF-κB were increased significantly at 2 h and peaked at 24 h,which gradually decreased after 3 days and returned to normal in 2 weeks.The levels of total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase were significantly decreased 24 h after the shock wave blast.Conversely,the malondialdehyde level reached the peak at 24 h.These results indicated that inflammatory and oxidative stress induced by shock waves changed significantly in a time-dependent manner,which may be the important factors and novel therapeutic targets for the treatment of BLI. | Hong Wang Wenjuan Zhang Jinren Liu Junhong Gao Le Fang Zhiyong Liu Baoqing Xia Xiaolin Fan Cunzhi Li Qing Lu Airong Qian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 4 |
| 10 | Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer显示文摘Eight new water-soluble amino acid conjugates 6 a-h of chlorin p6 ethers(5 a-d) were synthesized and preliminarily investigated for their in vitro PDT antitumor activity and structure-activity relationship(SAR). The results showed that all compounds exhibited much higher phototoxicity against tumor cells than talaporfin. SAR analysis indicated that PDT antitumor effect enhanced with the increase of carbon chain length of alkoxyl ether bonds at 3~1-position, and L-aspartic acid was superior to L-glutamic acid. In particular, the IC_50 values of most phototoxic compound 6 d were 0.20 mmol/L against A549 cell and0.41υmmol/L against B16-F10 cell, which individually represented 31-and 24-fold increase of antitumor potency compared to talaporfin, suggesting that it was a promising candidate photosensitizer(PS) for PDT applications due to its strong absorption at long wavelength, high phototoxicity, low dark cytotoxicity and good water-solubility. | Xingjie Zhang Zhi Meng Zhiqiang Ma Junhong Liu Guiyan Han Fujia Ma Ningyang Jia Zhenyuan Miao Wannian Zhang Chunquan Sheng Jianzhong Yao | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 11 | Pingwei capsules improve gastrointestinal motility in rats with functional dyspepsia显示文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC. | Liang Qiankun Mao Lanfang Du Xiaojuan Li Yunxia Yan Yuan Liang Jingjing Liu Junhong Wang Longde Li Hongfang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 12 | Psychoacoustic Study on Contribution of Fan Noise to Engine Noise显示文摘There are more researches on engine fan noise control focusing on reducing fan noise level through optimizing fan structure,and a lot of research achievements have been obtained.However,researches on the effect of fan noise to engine noise quality are lacking.The influences of the effects of fan structure optimization on the engine noise quality are unclear.Thus,there will be a decline in fan noise level,but the deterioration of engine noise quality.Aiming at the above problems,in consideration of fan structure design and engine noise quality,an innovative method to analyze the contribution of fan noise to engine noise quality using psychoacoustic theory is proposed.The noises of diesel engine installing different cooling fans are measured by using the acoustic pressure method.The experiment results are regarded as analysis samples.The model of sensory pleasantness is used to analyze the sound quality of a diesel engine with different cooling fans.Results show that after installing 10-blade fan in medium diameter the sensory pleasantness at each test point is increased,and the increase is 13.53% on average,which indicate the improvement of the engine noise quality.In order to verify the psychoacoustical analysis,the subjective assessment is carried out.The test result shows the noise quality of engine installed10-blade fan in medium diameter is most superior.1/3 octave frequency spectrum analysis is used to study the reason of the improvement of engine noise quality.It is found that after installing proper cooling fan the sound pressure level below 400 Hz are obviously increased,the frequency assignment and spectral envelope are more reasonable and a proper cooling fan can optimize the spectrum structure of the engine noise.The psychoacoustic study is applied in the contribution of fan noise to engine noise,and the idea of engine sound quality improvement through the structure optimization is proposed. | ZHANG Junhong LIU Hai BI Fengrong NI Guangjian ZHANG Guichang LIN Jiewei YU Hanzhengnan | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 3 |
| 13 | Influence of high overload on the collimating lenses of laser ranging systems显示文摘Collimating lenses are an important component of laser ranging systems,and high overload environments severely affect the beam shaping effect of such lenses.This study proposes a buffer isolation method on the basis of impact stress wave attenuation theory for collimating lens spacers,ANSYS finite element software was applied to simulate the high load dynamics of collimating lenses,and the buffer isolation performance of different materials and composite structures was compared and analysed.Optical simulation analysis of the collimating lenses under different buffer conditions was performed using ZEMAX software to study the mechanism by which a high overload affects the collimating lenses.High overload and optical shaping experiments based on theoretical analysis were further conducted.Results showed the superiority of butadiene rubber to polytetrafluoroethylene after application of 70000 g impact acceleration.The combination-gasket method was superior to the single-gasket method,and the sandwich combination-gasket method was superior to the double-layer combination-gasket method. | Lin Gan He Zhang Bin Liu Junhong Wang | 2020 | Defence Technology(防务技术)2020，16，2： | 3 |
| 14 | Assessment of heavy metal pollution in wetland soils from the young and old reclaimed regions in the Pearl River Estuary, South China显示文摘 | Junhong Bai Rong Xiao Baoshan Cui Kejiang Zhang Qinggai Wang Xinhui Liu Haifeng Gao Laibin Huang | 2010 | Environmental Pollution2010，，3： | 3 |
| 15 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 16 | Analysis of Oil Consumption in Cylinder of Diesel Engine for Optimization of Piston Rings显示文摘The performance and particulate emission of a diesel engine are affected by the consumption of lubricating oil.Most studies on oil consumption mechanism of the cylinder have been done by using the experimental method,however they are very costly.Therefore,it is very necessary to study oil consumption mechanism of the cylinder and obtain the accurate results by the calculation method.Firstly,four main modes of lubricating oil consumption in cylinder are analyzed and then the oil consumption rate under common working conditions are calculated for the four modes based on an engine.Then,the factors that affect the lubricating oil consumption such as working conditions,the second ring closed gap,the elastic force of the piston rings are also investigated for the four modes.The calculation results show that most of the lubricating oil is consumed by evaporation on the liner surface.Besides,there are three other findings:(1) The oil evaporation from the liner is determined by the working condition of an engine;(2) The increase of the ring closed gap reduces the oil blow through the top ring end gap but increases blow-by;(3) With the increase of the elastic force of the ring,both the left oil film thickness and the oil throw-off at the top ring decrease.The oil scraping of the piston top edge is consequently reduced while the friction loss between the rings and the liner increases.A neural network prediction model of the lubricating oil consumption in cylinder is established based on the BP neural network theory,and then the model is trained and validated.The main piston rings parameters which affect the oil consumption are optimized by using the BP neural network prediction model and the prediction accuracy of this BP neural network is within 8%,which is acceptable for normal engineering applications.The oil consumption is also measured experimentally.The relative errors of the calculated and experimental values are less than 10%,verifying the validity of the simulation results.Applying the established simulation model and the validated BP network model is able to generate numerical results with sufficient accuracy,which significantly reduces experimental work and provides guidance for the optimal design of the piston rings diesel engines. | ZHANG Junhong ZHANG Guichang HE Zhenpeng LIN Jiewei LIU Hai | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 3 |
| 17 | Tumor Suppressor Functions of miR-133a in Colorectal Cancer显示文摘 | Yujuan Dong Junhong Zhao Chung-Wah Wu Lijing Zhang Xiaodong Liu Wei Kang Wing-Wah Leung Ning Zhang Francis K.L. Chan Joseph J.Y. Sung Simon S.M. Ng Jun Yu | 2013 | Molecular Cancer Research2013，，9： | 3 |
| 18 | Analysis of sensitivity and specificity:precise recognition of neutrophils during regeneration of contused skeletal muscle in rats显示文摘In this report,we applied the TissueFAXS 200 digital pathological analysis system to rapidly and accurately identify neutrophils during regeneration of contused skeletal muscle,and to provide information for follow-up studies on neutrophils to estimate wound age.Rat injury model was established,and skeletal muscle samples were obtained from the control group and contusion groups at 1,1.5,2,3,4,and 6 h,as well as at 1,3,5,and 15 d post-injury(n紏5 per group).The expression of nuclei and neutrophils was detected by hematoxylin and eosin(HE)staining and immunohistochemical(IHC)staining.A total of 20 injury site areas of 0.25mm^(2)(0.5mm0.5mm)were then randomly selected at all time points.A TissueFAXS 200 digital pathological analysis system was used to identify the positive and negative numbers.Knowledge of five professional medical workers were considered the gold standard to measure the false positive rate(FPR),false negative rate(FNR),sensitivity,specificity,and area under the curve(AUC)of receiver operating characteristic(ROC)curves.As a result,with a staining area of neutrophils from 8 μm^(2) to 15 μm^(2),the FPR was 4.28%–12.14%,the FNR was 12.42%–64.08%,the sensitivity was 35.92%–87.58%,the specificity was 87.86%–95.72%,the Youden index was 0.316–0.754,the accuracy was 82.80%–88.30%,and the AUC was 0.771–0.826.The AUC was largest when the cut-off value of the staining area was 12 mm^(2).Our results show that this software-based method is more accurate than the human eye in evaluating neutrophil infiltration.Based on the sensitivity and specificity,neutrophils can be accurately identified during regeneration of contused skeletal muscle.The TissueFAXS 200 digital pathological analysis system can also be used to optimize conditions for different cell types under various injury conditions to determine the optimal cut-off value of the staining area and provide optimal conditions for further study.Furthermore,it will provide evidence for forensic pathology cases. | Jiajia Niu Guoshuai An Zhen Gu Peng Li Qiqing Liu Rufeng Bai Junhong Sun Qiuxiang Du | 2022 | Forensic Sciences Research2022，7，2： | 2 |
| 19 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 20 | Mechanical quality factor of high-overtone bulk acoustic resonator显示文摘Mechanical quality factor Qm is a key characteristic parameter of High-overtone bulk acoustic resonator(HBAR). The effects of structure parameter(thickness) and perfor?mance parameters(characteristic impedance and mechanical attenuation factor) of substrate,piezoelectric film and electrode constituting HBAR on Qm are carried out. The relationships between Qm and these parameters are obtained by a lumped parameter equivalent circuit instead of distributed parameter equivalent circuit near the resonance frequency, and the an?alytical expressions oi Qm are given. The results show that Qm increases non-monotonically with the continuous increase of the substrate thickness for HBAR with certain piezoelectric film thickness, and it approaches to the substrate material mechanical quality factor as the substrate thickness is large. Qm decreases wavily with the continuous increase of the piezoelectric film thickness for HBAR with certain substrate thickness. Sapphire and YAG with low mechanical loss are appropriate as the substrate to get a larger Qm- The electrode loss must be considered since it can reduce Qm- Compared with Au electrode, A1 electrode with lower loss can obtain higher Qm when the appropriate electrode thickness is selected. In addition, Qm decreases with the increase of frequency. These results provide the theoretical basis for optimizing the parameters of HBAR and show that trade-oflFs between Qm and must be considered in the design because their changes are often inconsistent. | LI Jian LIU Mengwei LI Junhong MA Jun WANG Chenghao | 2016 | Chinese Journal of Acoustics2016，35，3： | 2 |
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