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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Preparation and properties of low cost porous titanium by using rice husk as hold space显示文摘The present study demonstrates an effective low cost effective process for the production of porous titanium with 50-60 vol% porosity using 20 wt% rice husk(RH) with the hold spaces in the size ranges of 100-180,180-250,250-380,and 380-550 μm.The analysis of the samples revealed an interconnected pore microstructure consisting of a mixture of coarse channel pores,created during burnout of RH.The compressive strength of the developed samples was in the range of 17-70 MPa and depended strongly on their porosity and pore size.Large amounts of cleavage steps appeared on the brittle fracture surface after compression of the samples.The 3D morphology of porous titanium surface with rice husk sizes of 100-180μm and 380-550μm can be characterized by the micro-hole surface of pore size,and the size of the hole diameter and husk.The developed porous titanium is considered potentially useful in future medical or industrial application of biomass. | Xinsheng Wang Zhenlin Lu Lei Jia Feizhou Li | 2017 | Progress in Natural Science:Materials International2017，27，3： | 2 |
| 3 | Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1显示文摘As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of TNBC.This study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of invadopodia.ITSN can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling pathway.Moreover,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβR1.Furthermore,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβR1.Additionally,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor microenvironment.Our findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC metastasis.Moreover,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor. | Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 1 |
| 4 | A multichannel neural signal detecting module:Its design and test in animal experiments显示文摘A four-channel neural signal detecting module with an implantable 12-contact cuff electrode was designed for real-time neural signal recording on peripheral and central nerves. The mathematic coupling model between nerve and electronic system was analyzed. Electrode connection configurations were considered. The detecting circuit included an input coupling network, a pre-amplifier, and some filtering and notching stages. Shield guarding and the right-leg-driven circuit were developed for further elimination of common mode interference. By electrode switches, the module could cooperate with a nerve functional electrical stimulation circuit, building a neural channel bridge-connection system. It was tested by recording experiments on rat’s sciatic and spine nerves. The signals in spontaneous and evoked conditions have been captured successfully. In addition, an implantable neural signal detecting CMOS IC has been introduced. | Wang Yufeng Wang Zhigong Lu Xiaoying Gu Xiaosong Li Wenyuan Wang Huiling Jiang Zhenlin Lu Guangming K. P. Koch | 2007 | Progress in Natural Science:Materials International2007，17，6： | 1 |
| 5 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 6 | Microstructure and solidification behavior of Cu-Ni-Si alloys 显示文摘 | Hui Xie Lei Jia Zhenlin Lu | 2009 | Materials Characterization2009，60，： | 1 |
| 7 | Drug discovery of sclerostin inhibitors显示文摘Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy. | Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 8 | Suggestion of EFS-small satellite system for impending earthquake forecast显示文摘In the IAF Congress ’92 a multiple small satellite Earth observation system was put forward with sensors of visible and infrared spectrums. The system could shorten the revisiting period so that any place on the world could be observed twice a day Now we extend the idea to the microwave remote sensing satellite system. The main purpose of the system is the impending forecast of earthquakes. According to the theory and long-time concrete practice of Qiang Zuji through the observation of temperature increase of the low layer of atmosphere and its moving trend caused by some sorts of radiation and gases released from Earth interior, an impending strong earthquake could be predicted in time. As the temperature increase is detected by thermo-infrared spectrum sensors on the meteorological satellites. the observation may be sometimes obstructed by cloud or rain. In the suggested system, mm-wave radiometers are used and those obstructions could be generally overcome. Besides, radiometers of some other microwave frequencies are also included so as to make the small satellite system useful for observation of atmosphere. soil and crops. The plattorm construction and the altitude control system of the satellites suitable to the sweeping radiometer antennas are stressfully implemented. The orbit of the satellites in the system is well designed so that any place in the world could be observed twice a day in accordance with the optical small satellite system. | QIANG Zuji MA Ainar CHEN Fangyun ZHANG Junrong LIN Laixing LU Zhenlin | 2000 | Chinese Science Bulletin2000，45，2： | 1 |
| 9 | A study on the cycling oxidation behavior of mullite-coated silicon carbide显示文摘 | LI Shibin LU Zhenlin GAO Jiqiang | 2003 | Mater Chem Phys2003，78，： | 1 |
| 10 | An investigation of the corrosion-abrasion wear behavior of 6 % chromium martensitic cast steel 显示文摘 | LU Zhenlin RAO Qichang JIN Zhihao | 1999 | Journal of Materials Processing Technology1999，95，： | 1 |
| 11 | An investigation of the abrasive wear behavior of ductile cast iron显示文摘 | Lu Zhenlin Zhou Yongxin Rao Qichang | 2001 | Journal of Materials Processing Technology2001，116，： | 1 |
| 12 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 13 | Electrical resistivity and microstructure of pressureless reactive sintered MoSi2-SiC composite显示文摘 | Xiaoli Zhang Zhenlin Lu Zhinhao Jin | 2004 | Material Chemistry and Physics2004，，86： | 1 |
| 14 | NHC-gold(Ⅰ)-alkyne complexes induced hepatocellular carcinoma cell death through bioorthogonal activation by palladium complex in living system显示文摘Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene(NHC)-gold(Ⅰ)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase(TrxR)and exhibit significant anticancer bioactivity in hepatocellular carcinoma(HCC). | Yunlong Lu Yuanhao Liu Zhenlin Liang Xiaoyan Ma Lijuan Liu Zhenfan Wen Iogann Tolbatov Alessandro Marrone Wukun Liu | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 15 | Optimal Design of 850nm 2 × 2 Multimode Interference Polymer Waveguide Coupler by Imprint Technique显示文摘2 | Yuchen SHAO Xiuyou HAN Xiaonan HAN Zhili LU Zhenlin WU Jie TENG Jinyan WANG Geert MORTHIER Mingshan ZHAO | 2016 | Photonic Sensors2016，6，3： | 0 |
| 16 | Meta-Analysis of the Clinical Effect of Acupuncture on Postherpetic Neuralgia显示文摘Objective:To systematically evaluate the safety and efficacy of acupuncture on patients with postherpetic neuralgia.Methods:Based on the heyword retrieval method,China National Knowledge Infrastructure(CNKI,1978-2020),China Biomedical Literature database(CBM,1979-2020),VIP database(WEIPU,1989-2020),Wanfang database(1989-2020),Cochrane Library,PubMed,and Embase were searched;randomized controlled trials of the use of acupuncture in the treatment of postherpetic neuralgia were screened out;the quality of the included literatures was evaluated based on the evaluation criteria in the Cochrane Handbook,and meta-analysis was performed using RevMan 5.3.Results:Twenty-six literatures that met the criteria,involving 2,174 patients,were included;the meta-analysis showed that compared with western medicine,the use of acupuncture can improve the overall effective rate(RR=1.24,95%CI[1.17,1.32],P<0.00001)and reduce the VAS score(MD=-1.43,95%CI[-1.97,-0.89],P<0.00001).Conclusion:The use of acupuncture can further improve the clinical effect of patients with postherpetic neuralgia. | Lu Wang Zhenlin Chen Shuo Zhang Wenjing Ma Tiantian Gao | 2022 | Proceedings of Anticancer Research2022，6，1： | 0 |
| 17 | Plasmonic evolution of atomically size-selected Au clusters by electron energy loss spectrum显示文摘The plasmonic response of gold clusters with atom number(N)=100–70000 was investigated using scanning transmission electron microscopy-electron energy loss spectroscopy.For decreasing N,the bulk plasmon remains unchanged above N=887 but then disappears,while the surface plasmon firstly redshifts from 2.4 to 2.3 e V above N=887 before blueshifting towards 2.6 e V down to N=300,and finally splitting into three fine features.The surface plasmon’s excitation ratio is found to follow N^(0.669),which is essentially R^(2).An atomically precise evolution picture of plasmon physics is thus demonstrated according to three regimes:classical plasmon(N=887–70000),quantum confinement corrected plasmon(N=300–887)and molecule related plasmon(N<300). | Siqi Lu Lin Xie Kang Lai Runkun Chen Lu Cao Kuojuei Hu Xuefeng Wang Jinsen Han Xiangang Wan Jianguo Wan Qing Dai Fengqi Song Jiaqing He Jiayu Dai Jianing Chen Zhenlin Wang Guanghou Wang | 2021 | National Science Review2021，8，12： | 0 |
| 18 | Investigations of structural phase transformation and THz properties across metal–insulator transition in VO_2/Al_2O_3epitaxial films显示文摘Vanadium dioxide(VO2) epitaxial thin films on(0001)-oriented Al2O3 substrates were prepared using radio frequency(RF) magnetron sputtering techniques.To study the metal-insulator-transition(MIT) mechanism and extend the applications of VO2 epitaxial films at terahertz(THz) band,temperature-dependent X-ray diffraction(XRD) and THz time domain spectroscopy of the VO2 epitaxial films were performed.Both the lattice constants and THz transmission exhibited a similar and sharp transition that was similar to that observed for the electrical resistance.Consequently,the MIT of the VO2/Al2O3 epitaxial films should be co-triggered by the structural phase transition and electronic transition.Moreover,the very large resistance change(on the order of 103) and THz response(with a transmission modulation ratio of 87%) in the VO2/Al2O3 epitaxial heterostructures are promising for electrical switch and electro-optical device applications. | Mengmeng Yang Yuanjun Yang Bin Hong Yi Zhao Xiaoguang Li Yalin Lu Zhenlin Luo Chen Gao | 2015 | Progress in Natural Science:Materials International2015，25，5： | 0 |
| 19 | Synergistic modulation of spin and fluorescence signals in a nano-Saturn assembled by a metallofullerene and cycloparaphenylene nanohoop显示文摘Spin-based interdisciplinary research has attracted considerable attention,and various applications in magnetic memory,quantum science,and precision measuring technology have been reported.In this study,we induced a fluorescence property in a spin-active molecule by supramolecular assembly and realized a synergistic modulation of its spin and fluorescence properties.A Saturn-shaped supramolecular complex was synthesized using a spin-active metallofullerene Sc_(3)C_(2)@C80 with a fluorescent nanohoop of tetra-benzothiadiazole-based[12]cycloparaphenylene(TB[12]CPP),and its spin and fluorescence properties were comprehensively investigated.Temperature-dependent electron paramagnetic resonance(EPR)spectroscopy and fluorescence analyses were conducted.Synchronous changes in the EPR signals and fluorescence peaks were discovered in the temperature range of 170–290 K.Based on nuclear magnetic resonance observations and theoretical calculations,a temperature-dependent host–guest interaction between Sc_(3)C_(2)@C_(80)and a nanohoop was demonstrated,which explained the synchronous changes in the EPR signals and fluorescence peaks for Sc_(3)C_(2)@C_(80)⊂TB[12]CPP.The application of Sc_(3)C_(2)@C_(80)as a molecular spin system to probe the host–guest interaction was also evaluated.These results show that the supramolecular assembly can be used to design advanced spin systems coupled with optical and magnetic behaviors based on paramagnetic and luminescent molecules. | Jie Zhang Zhenlin Qiu Chong Zhao Yuxi Lu Wang Li Linshan Liu Chunru Wang Yuanzhi Tan Taishan Wang | 2023 | Nano Research2023，16，2： | 0 |
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