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| 1 | Lead?Free Halide Double Perovskite Materials: A New Superstar Toward Green and Stable Optoelectronic Applications显示文摘Lead-based halide perovskites have emerged as excellent semiconductors for a broad range of optoelectronic applications, such as photovoltaics, lighting, lasing and photon detection. However, toxicity of lead and poor stability still represent significant challenges. Fortunately, halide double perovskite materials with formula of A_2M(I)M(III)X_6 or A_2M(IV)X_6 could be potentially regarded as stable and green alternatives for optoelectronic applications, where two divalent lead ions are substituted by combining one monovalent and one trivalent ions, or one tetravalent ion. Here, the article provides an up-to-date review on the developments of halide double perovskite materials and their related optoelectronic applications including photodetectors, X-ray detectors, photocatalyst, light-emitting diodes and solar cells. The synthesized halide double perovskite materials exhibit exceptional stability, and a few possess superior optoelectronic properties. However, the number of synthesized halide double perovskites is limited, and more limited materials have been developed for optoelectronic applications to date. In addition, the band structures and carrier transport properties of the materials are still not desired, and the films still manifest low quality for photovoltaic applications. Therefore, we propose that continuing e orts are needed to develop more halide double perovskites, modulate the properties and grow high-quality films, with the aim of opening the wild practical applications. | Liang Chu Waqar Ahmad Wei Liu Jian Yang Rui Zhang Yan Sun Jianping Yang Xing'ao Li | 2019 | Nano-Micro Letters2019，11，1： | 8 |
| 2 | Dynamic Expression of MicroRNA-127 During Porcine Prenatal and Postnatal Skeletal Muscle Development显示文摘MicroRNAs(miRNAs), evolutionarily conserved non-coding RNAs in length 21-24 bp, play a critical role in skeletal muscle development. In this study, to explore the function of mircoRNA-127 in porcine skeletal muscle development, eight tissue samples from adult pigs and longissimus muscle samples at 26 developmental stages were collected from Tongcheng and Landrace pigs. The spatial-temporal expression profiles of miRNA-127 were carried out using step-loop quantitative real-time PCR(stemloop RT-PCR). To explore the molecular functions of miRNA-127, we predicted its target genes and performed functional annotation using bioinformatics methods. Results suggested that miRNA-127 was abundantly expressed in heart, ovary, uterus and spleen tissues and was weakly expressed in liver, lung, kidney and small intestine in both Tongcheng and Landrace pigs. And miRNA-127 showed significant expression differences in heart, ovary, spleen and uterus tissues between these two breeds. miRNA-127 basically kept at a relatively stable high level in middle and later embryonic stages and a low expression level in early embryonic stages and postnatal stages, but the expression levels of miRNA-127 were higher in Tongcheng pigs than in Landrace at most developmental stages. miRNA-127 potentially regulated 240 candidate genes. Results of Gene Ontology and KEGG pathway analysis indicated that these genes could be involved in many molecular functions and mechanisms, such as regulation of the force of heart contraction, regulation of transcription, regulation of T cell differentiation, MAPK signaling pathway and GnRH signaling pathway. Many significantly enriched GO terms and KEGG pathways were related to skeletal muscle development. This study will be helpful to understand the biological function for miRNA-127 and identify candidate gene associated with meat production traits in pigs. | YANG Ya-lan LI Yan LIANG Ru-yi ZHOU Rong AO Hong MU Yu-lian YANG Shu-lin LI Kui TANG Zhong-lin | 2014 | Journal of Integrative Agriculture2014，13，6： | 6 |
| 3 | Application of fish index of biological integrity(FIBI) in the Sanmenxia Wetland with water quality implications显示文摘Long-term changes of fish biotic integrity in the Sanmenxia Wetland,North China,since the 1950 s were assessed using the fish index of biological integrity(FIBI). The water and sediment quality was evaluated by the water quality index(WQI) and sediment pollution index(SPI). The results showed that FIBI continuously decreased from 46 to 20 during the past 5 decades,which indicated that the fish community state shifted from fair to very poor conditions,and damming by itself did not affect the fish biotic integrity. At the same time,WQI fell from 83 to 44.1,and SPI increased from 0.99 to 2.14 since the 1960 s,resulting from fast regional socio-economic development and insufficient wastewater treatment. Correlation analysis suggested that water quality significantly affected biotic integrity(r = 0.867,p < 0.05) through direct effects on the fish community. As a representative example of many wetlands in North China,our study clearly demonstrated that the biological integrity was degraded,induced both by water quality deterioration and sediment pollution,further driven by the contradiction between rapid development of regional economy and lagging development of sewage treatment facilities,which were thought to be the main factor responsible for the degradation of biological integrity. | Hong Zhang Baoqing Shan Liang Ao | 2014 | Journal of Environmental Sciences2014，26，8： | 6 |
| 4 | Effectiveness of vegetation on phosphorus removal from reclaimed water by a subsurface flow wetland in a coastal area显示文摘This work was conducted to evaluate the effectiveness and influence factors of vegetation on phosphorus (P) removal from reclaimed water in constructed wetlands.Comparisons were conducted between one pilot scale subsurface flow wetland (P-SSFW) and two demonstration subsurface flow wetlands,which were series-wound and named as first subsurface flow wetland (F-SSFW),and second subsurface flow wetland (S-SSFW),respectively.The three wetlands had the same vegetation and substrate,but different pH values,total dissolved solids (TDS) and P loads.Results showed that the P content in the vegetation shoots of the F-SSFW was 2.16 mg/g,while 2.31 mg/g in the S-SSFW and 2.69 mg/g in the P-SSFW.These differences were likely caused by the higher pH and TDS in the reclaimed water.The P content also differed among the tissues of the plant,which were 5.94-6.44 mg/g,2.20-2.77 mg/g,1.31-1.46 mg/g and 1.53-1.88 mg/g in the flowers,leaves,stems,and roots,respectively.The greatest discrepancy was observed in the leaves,indicating that the environment of the wetlands had the greatest influence on the leaves.When the total phosphorus (TP) load was lower,the proportion of P removed by vegetation assimilation was 16.17% in the P-SSFW,12.90% in the F-SSFW and 13.29% in the S-SSFW.However,the relative removal efficiency by vegetation among the three wetlands did not vary greatly from that observed in other studies.Moreover,the influence of pH,TDS and TP load was not as great as the influence of the vegetation species,type of substrate,influent style or climate. | Baoqing Shan Liang Ao Chunming Hu Jiayu Song | 2011 | Journal of Environmental Sciences2011，23，10： | 6 |
| 5 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 6 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 7 | Blockchain-Based Secure Distributed Control for Software Defined Optical Networking显示文摘Software defined optical networking(SDON)is a critical technology for the next generation network with the advantages of programmable control and etc.As one of the key issues of SDON,the security of control plane has also received extensive attention,especially in certain network scenarios with high security requirement.Due to the existence of vulnerabilities and heavy overhead,the existing firewalls and distributed control technologies cannot solve the control plane security problem well.In this paper,we propose a distributed control architecture for SDON using the blockchain technique(BlockCtrl).The proposed BlockCtrl model introduces the advantages of blockchain into SDON to achieve a high-efficiency fault tolerant control.We have evaluated the performance of our proposed architecture and compared it to the existing models with respect to various metrics including processing rate,recovery latency and etc.The numerical results show that the BlockCtrl is capable of attacks detection and fault tolerant control in SDON with high performance on resource utilization and service correlation. | Hui Yang Yongshen Liang Qiuyan Yao Shaoyong Guo Ao Yu Jie Zhang | 2019 | China Communications2019，16，6： | 5 |
| 8 | Perfection of Perovskite Grain Boundary Passivation by Rhodium Incorporation for Efficient and Stable Solar Cells显示文摘Organic cation and halide anion defects are omnipresent in the perovskite films,which will destroy perovskite electronic structure and downgrade the properties of devices.Defect passivation in halide perovskites is crucial to the application of solar cells.Herein,tiny amounts of trivalent rhodium ion incorporation can help the nucleation of perovskite grain and passivate the defects in the grain boundaries,which can improve efficiency and stability of perovskite solar cells.Through first-principle calculations,rhodium ion incorporation into the perovskite structure can induce ordered arrangement and tune bandgap.In experiment,rhodium ion incorporation with perovskite can contribute to preparing larger crystalline and uniform film,reducing trap-state density and enlarging charge carrier lifetime.After optimizing the content of 1% rhodium,the devices achieved an efficiency up to 20.71% without obvious hysteresis,from 19.09% of that pristine perovskite.In addition,the unencapsulated solar cells maintain 92% of its initial efficiency after 500 h in dry air.This work highlights the advantages of trivalent rhodium ion incorporation in the characteristics of perovskite solar cells,which will promote the future industrial application. | Wei Liu Nanjing Liu Shilei Ji Hongfeng Hua Yuhui Ma Ruiyuan Hu Jian Zhang Liang Chu Xing’ao Li Wei Huang | 2020 | Nano-Micro Letters2020，12，9： | 4 |
| 9 | Memristive Artificial Synapses for Neuromorphic Computing显示文摘Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary units.Mimicking synaptic functions with these devices is critical in neuromorphic systems.In the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic functions.In this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical signals.The working mechanisms of the devices are analyzed in detail.This is followed by a discussion of the progress in mimicking synaptic functions.In addition,existing application scenarios of various synaptic devices are outlined.Furthermore,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected. | Wen Huang Xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang Chu Xing’ao Li | 2021 | Nano-Micro Letters2021，13，5： | 4 |
| 10 | An Inverse Power Generation Mechanism Based Fruit Fly Algorithm for Function Optimization显示文摘As a novel population-based optimization algorithm, fruit fly optimization(FFO) algorithm is inspired by the foraging behavior of fruit flies and possesses the advantages of simple search operations and easy implementation. Just like most population-based evolutionary algorithms, the basic FFO also suffers from being trapped in local optima for function optimization due to premature convergence.In this paper, an improved FFO, named IPGS-FFO, is proposed in which two novel strategies are incorporated into the conventional FFO. Specifically, a smell sensitivity parameter together with an inverse power generation mechanism(IPGS) is introduced to enhance local exploitation. Moreover,a dynamic shrinking search radius strategy is incorporated so as to enhance the global exploration over search space by adaptively adjusting the searching area in the problem domain. The statistical performance of FFO, the proposed IPGS-FFO, three state-of-the-art FFO variants, and six metaheuristics are tested on twenty-six well-known unimodal and multimodal benchmark functions with dimension 30, respectively. Experimental results and comparisons show that the proposed IPGS-FFO achieves better performance than three FFO variants and competitive performance against six other meta-heuristics in terms of the solution accuracy and convergence rate. | LIU Ao DENG Xudong REN Liang LIU Ying LIU Bo | 2019 | Journal of Systems Science & Complexity2019，32，2： | 3 |
| 11 | Clinical effect of ultrasound-guided nerve block and dexmedetomidine anesthesia on lower extremity operative fracture reduction显示文摘BACKGROUND Lower extremity fractures are mainly treated by surgical reduction,but this operation is often affected by the patient’s level of agitation and the type of anesthesia used.The main treatment for lower-extremity fractures is operative reduction.However,operations can often be affected by both agitation and the degree of anesthesia.Therefore,it is of great importance to develop an effective anesthesia program to effectively ensure the progress of surgery.AIM To discuss the effect of ultrasound-guided nerve block combined with dexmedetomidine anesthesia in lower extremity fracture surgery.METHODS A total of 120 hospital patients with lower extremity fractures were selected for this retrospective study and divided into an observation group(n=60)and a control group(n=60)according to the anesthesia scheme;the control group received ultrasound-guided nerve block;the observation group was treated with dextromethomidine on the basis of the control group,and the mean arterial pressure,heart rate(HR),and blood oxygen saturation were observed in the two groups.RESULTS The mean arterial pressure of T1,T2 and T3 in the observation group were 94.40±7.10,90.84±7.21 and 91.03±6.84 mmHg,significantly higher than that of the control group(P<0.05).The observation group’s HR at T1 was 76.60±7.52 times/min,significantly lower than that of the control group(P<0.05);The observation group’s HR at T2 and T3 was 75.40±8.03 times/min and 76.64±7.11 times/min,significantly higher than that of the control group(P<0.05).The observation group’s visual analog score at 2 h,6 h and 12 h after operation was 3.55±0.87,2.84±0.65 and 2.05±0.40.the recovery time was 15.51±4.21 min,significantly lower than that of the control group(P<0.05).Six hours post-anesthesia,epinephrine and norepinephrine in the observation group were 81.10±21.19 pg/mL and 510.20±98.27 pg/mL,significantly lower than that of the control group(P<0.05),and the mini-mental state exam score of the observation group was 25.51±1.15,significantly higher than that in the control group(P<0.05).CONCLUSION Ultrasound-guided nerve block combined with dexmedetomidine has a good anesthetic effect in the operation of lower limb fractures and has little effect on the hemodynamics of patients. | Cheng-Bin Ao Ping-Lei Wu Liang Shao Jian-Ying Yu Wei-Guo Wu | 2022 | World Journal of Clinical Cases2022，10，13： | 3 |
| 12 | An Outbreak of SARS in a Diabetes Room of a General Hospital without Infected Medical Staff显示文摘Objective To investigate the epidemiologic features of an outbreak of SARS that occurred in a single diabetes room of a general hospital in Beijing in late March 2003.Methods Field investigation was carried out in the ward,the nursing log and the hospitalization medical record of correlative patients were consulted.SARS-CoV in serum specimen from SARS patient was detected by PCR.Results The room where SARS outbreak occurred was on the 13th floor of the 16-story main ward building.There were 6 beds in the room,living with 6 female patients(aged 45-67)who were all hospitalized due to type2 diabetes.On March 24,2003,Patient 1 began to have a fever and cough,chest X-ray showed pneumonia.Five and six days later,Patient 2 and Patient 3 began to have a fever,respectively.Finally,all of these 3 patients died.Their beds were all at the same side of the room,and the other 3 patients at the opposite side were not infected.Serum SARS CoV-RNA of the Patient 3 was positive by nest-PCR.The daughter-in-law of Patient 1who accompanied Patient 1 by the bedside several days,mainly near the window,upwind of Patient 1,was not infected.Medical staff,family members and visitors of the 6 patients were not infected.Conclusions This outbreak was not transmitted by aerosol.The distance droplets travels could be up to 3.43 meters.Droplet spread has direction,and the droplets direction of propagation is closely related with the wind direction and speed.Those at the downwind position of SARS patients were susceptible to be infected.Medical staff wore face masks and good natural ventilation of this ward building may be important reasons for the prevention of infection. | Chun-ling Liu Jun Cheng He Gao Bo Zhang Qun Yuan Ao Tong Yi-an Liang Hong Tang Xiao-hong Guan | 2013 | 国际感染病学(电子版)2013，2，4： | 3 |
| 13 | Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients显示文摘Summary:The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease.Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic.In this study,we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia(FOP)patients who underwent lung surgery and served as controls.We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients.In contrast to the FOP patients,Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients.This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients.In summary,our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity.Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic. | Ya-qi DUAN Ming-hui XIA Liang REN Yan-fang ZHANG Qi-lin AO San-peng XU Dong KUANG Qian LIU Bing YAN Yi-wu ZHOU Qian CHU Liang LIU Xiang-Ping YANG Guo-ping WANG | 2020 | Current Medical Science2020，40，4： | 2 |
| 14 | High birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children显示文摘Background High birth weight(HBW)is associated with childhood obesity,but with inconsistent results.This study investigated the relationship between HBW and childhood obesity,and further explored the interaction of HBW with behavioral and socio-economic determinants of obesity.Methods This cross-sectional study enrolled 1906 grade-two children of Guangzhou,China,from June to November,2016.Overweight/obesity corresponded to a body mass index higher than the sex–age-specific criteria.Abdominal obesity was assessed using the sex-specific waist–height ratio cutoffs.The association of HBW with obesity was evaluated in multivariable logistic regression model.The relative excess risk due to interaction(RERI)and the attributable proportion of interaction(AP)indices were used to measure additive interaction,while applying the interaction of OR index for multiplicative interaction assessment.Results Children with HBW had an increased risk of overweight/obesity[odds ratio(OR)=2.42,95%confidence interval(CI)=1.56–3.76]compared with those without HBW.Significant additive interaction of HBW with physical activity was found for overweight/obesity[relative excess risk due to interaction(RERI)=2.69,95%CI=0.62–4.75;attributable proportion of interaction(AP)=0.72,95%CI=0.42–1.02].The HBW children with insufficient activity had higher odds of overweight/obesity compared to the non-HBW children with sufficient activity(OR=3.75,95%CI=2.06–6.83).In addition,we identified a significant interaction of HBW with household income for abdominal obesity(RERI=1.20,95%CI=0.02–2.37;AP=0.76,95%CI=0.16–1.36).Conclusions HBW confers an increased risk for childhood overweight/obesity.Physical activity attenuates the effect of HBW on overweight/obesity,and HBW possibly synergistically interacts with high household income to promote abdominal obesity in childhood. | Jia-Ru Deng Wei-Qing Tan Shu-Yi Yang Li-Ping Ao Jian-Ping Liang Li-Xia Li Yan-Hui Gao Yi Yang Li Liu | 2020 | World Journal of Pediatrics2020，16，4： | 2 |
| 15 | A genome-wide association study of Alzheimer's disease using random forests and enrichment analysis显示文摘Alzheimer's disease(AD) is a serious neurodegenerative disorder and its cause remains largely elusive.In past years,genome-wide association(GWA) studies have provided an effective means for AD research.However,the univariate method that is commonly used in GWA studies cannot effectively detect the biological mechanisms associated with this disease.In this study,we propose a new strategy for the GWA analysis of AD that combines random forests with enrichment analysis.First,backward feature selection using random forests was performed on a GWA dataset of AD patients carrying the apolipoprotein gene(APOEε4) and 1058 susceptible single nucleotide polymorphisms(SNPs) were detected,including several known AD-associated SNPs.Next,the susceptible SNPs were investigated by enrichment analysis and significantly-associated gene functional annotations,such as 'alternative splicing','glycoprotein',and 'neuron development',were successfully discovered,indicating that these biological mechanisms play important roles in the development of AD in APOEε4 carriers.These findings may provide insights into the pathogenesis of AD and helpful guidance for further studies.Furthermore,this strategy can easily be modified and applied to GWA studies of other complex diseases. | ZOU Liang HUANG Qiong LI Ao WANG MingHui | 2012 | Science China(Life Sciences)2012，55，7： | 2 |
| 16 | Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma(LUAD)progression by targeting MAP3K9显示文摘Lung adenocarcinoma(LUAD)characterized by high metastasis and mortality is the leading subtype of non-small cell lung cancer.Evidence shows that some microRNAs(miRNAs)may act as oncogenes or tumor suppressor genes,leading to malignant tumor occurrence and progression.To better understand the molecular mechanism associated with miRNA methylation in LUAD progression and clinical outcomes,we investigated the correlation between miR-148a-3p methylation and the clinical features of LUAD.In the LUAD cell lines and tumor tissues from patients,miR-148a-3p was found to be significantly downregulated,while the methylation of miR-148a-3p promoter was notably increased.Importantly,miR-148a-3p hypermethylation was closely associated with lymph node metastasis.We demonstrated that mitogen-activated protein(MAP)kinase kinase kinase 9(MAP3K9)was the target of miR-148a-3p and that MAP3K9 levels were significantly increased in both LUAD cell lines and clinical tumor tissues.In A549 and NCI-H1299 cells,overexpression of miR-148a-3p or silencing MAP3K9 significantly inhibited cell growth,migration,invasion and cytoskeleton reorganization accompanied by suppressing the epithelial-mesenchymal transition.In a nude mouse xenograft assay we found that tumor growth was effectively inhibited by miR-148a-3p overexpression.Taken together,the promoter methylation-associated decrease in miR-148a-3p could lead to lung cancer metastasis by targeting MAP3K9.This study suggests that miR-148a-3p and MAP3K9 may act as novel therapeutic targets for the treatment of LUAD and have potential clinical applications. | Lu Liang Wen-yan Xu Ao Shen Hui-yu Cen Zhi-jun Chen Lin Tan Ling-min Zhang Yu Zhang Ji-jun Fu Ai-ping Qin Xue-ping Lei Song-pei Li Yu-yan Qin Jiong-hua Huang Xi-yong Yu | 2022 | Acta Pharmacologica Sinica2022，43，11： | 1 |
| 17 | All-Polymer Solar Cells and Photodetectors with Improved Stability Enabled by Terpolymers Containing Antioxidant Side Chains显示文摘It is of vital importance to improve the long-term and photostability of organic photovoltaics,including organic solar cells(OSCs)and organic photodetectors(OPDs),for their ultimate industrialization.Herein,two series of terpolymers featuring with an antioxidant butylated hydroxytoluene(BHT)-terminated side chain,PTzBI-EHp-BTBHTx and N2200-BTBHTx(x=0.05,0.1,0.2),are designed and synthesized.It was found that incorporating appropriate ratio of benzothiadiazole(BT)with BHT side chains on the conjugated backbone would induce negligible effect on the molecular weight,absorption spectra and energy levels of polymers,however,which would obviously enhance the photostability of these polymers.Consequently,all-polymer solar cells(all-PSCs)and photodetectors were fabricated,and the all-PSC based on PTzBI-EHp-BTBHT0.05:N2200 realized an optimal power conversion efficiency(PCE)approaching~10%,outperforming the device based on pristine PTzBI-EHp:N2200.Impressively,the all-PSCs based on BHT-featuring terpolymers displayed alleviated PCEs degradation under continuous irradiation for 300 h due to the improved morphological and photostability of active layers.The OPDs based on BHT-featuring terpolymers achieved a lower dark current at−0.1 bias,which could be stabilized even after irradiation over 400 h.This study provides a feasible approach to develop terpolymers with antioxidant efficacy for improving the lifetime of OSCs and OPDs. | Chunyang Zhang Ao Song Qiri Huang Yunhao Cao Zuiyi Zhong Youcai Liang Kai Zhang Chunchen Liu Fei Huang Yong Cao | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 18 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 19 | Strategies of binder design for high-performance lithium-ion batteries:a mini review显示文摘Developing high-performance lithium-ion batteries (LIBs) with high energy density, rate capability and long cycle life are essential for the ever-growing practical application. Among all battery components, the binder plays a key role in determining the preparation of electrodes and the improvement of battery performance, in spite of a low usage amount. The main function of binder is to bond the active material, conductive additive and current collector together and provide electron and ion channels to improve the kinetics of electrochemical reaction. With the ever-increasing requirement of high energy density by LIBs, technical challenges such as volume expansion and active material dissolution are attracting worldwide attentions, where binder is thought to provide a new solution.There are two main categories (organic solvent soluble binder and water-soluble binder) and abundant polar functional groups providing adhesion ability. It is of great significance to timely summarize the latest progress in battery binders and present the principles for designing novel binders with both robust binding interaction and outstanding electrode stabilization function. This review begins with an introduction of the binding mechanism and the related binding forces, including mechanical interlocking forces and interfacial forces. Then, we discussed four different strategies (the enhancement of binding force,the formation of three-dimensional (3D) network, the enhancement of conductivity and binders with special functions) for constructing ideal binder system in order to satisfy the specific demands of different batteries, such as LIBs and lithium–sulfur (Li–S) batteries. Finally, some prospective and promising directions of binder design are proposed based on the existing and emerging binders and guide the development of the next-generation LIBs. | Yan-Bo Wang Qi Yang Xun Guo Shuo Yang Ao Chen Guo-Jin Liang Chun-Yi Zhi | 2022 | Rare Metals2022，41，3： | 1 |
| 20 | Work function engineering to enhance open-circuit voltage in planar perovskite solar cells by g-C_(3)N_(4) nanosheets显示文摘Enhancement of open-circuit voltage(Voc)is an effective way to improve power conversion efficiency(PCE)of the perovskite solar cells(PSCs).Theoretically,work function engineering of TiO2 electron transport layer can reduce both the loss of Voc and current hysteresis in PSCs.In this work,two-dimensional g-C_(3)N_(4) nanosheets were adopted to modify the compact TiO2 layers in planar PSCs,which can finely tune the work function(WF)and further improve the energy level alignment at the interface to enhance the Voc and diminish the hysteresis.Meanwhile,the quality of perovskite films and charge transfer of the devices were improved by g-C_(3)N_(4) nanosheets.Therefore,the PCE of the planar PSCs was champed to 19.55%without obvious hysteresis compared with the initial 15.81%,mainly owing to the remarkable improvement of VOC from 1.01 to 1.11 V.In addition,the stability of the devices was obviously improved.The results demonstrate an effective strategy of W_(F) engineering to enhance Voc and diminish hysteresis phenomenon for improving the performance of PSCs. | Jian Yang Liang Chu Ruiyuan Hu Wei Liu Nanjing Liu Yuhui Ma Waqar Ahmad Xing’ao Li | 2021 | Nano Research2021，14，7： | 1 |
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