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| 1 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 2 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 3 | Tectono–sedimentary Evolution of the Late Triassic Xujiahe Formation in the Sichuan Basin显示文摘The early stage of Sichuan Basin formation was controlled by the convergence of three major Chinese continental blocks during the Indosinian orogeny that include South China,North China,and Qiangtang blocks.Although the Late Triassic Xujiahe Formation is assumed to represent the commencement of continental deposition in the Sichuan Basin,little research is available on the details of this particular stratum.Sequence stratigraphic analysis reveals that the Xujiahe Formation comprises four third-order depositional sequences.Moreover,two tectono–sedimentary evolution stages,deposition and denudation,have been identified.Typical wedge-shaped geometry revealed in a cross section of the southern Sichuan Basin normal to the Longmen Shan fold–thrust belt is displayed for the entire Xujiahe Formation.The depositional extent did not cover the Luzhou paleohigh during the LST1 to LST2(LST,TST and HST mean lowstand,transgressive and highstand systems tracts,1,2,3 and 4 represent depositional sequence 1,2,3 and 4),deltaic and fluvial systems fed sediments from the Longmen Shan belt,Luzhou paleohigh,Hannan dome,and Daba Shan paleohigh into a foreland basin with a centrally located lake.The forebulge of the western Sichuan foreland basin was located southeast of the Luzhou paleohigh after LST2.According to the principle of nonmarine sequence stratigraphy and the lithology of the Xujiahe Formation,four thrusting events in the Longmen Shan fold–thrust belt were distinguished,corresponding to the basal boundaries of sequences 1,2,3,and 4.The northern Sichuan Basin was tilted after the deposition of sequence 3,inducing intensive erosion of sequences 3 and 4,and formation of wedge-shaped deposition geometry in sequence 4 from south to north.The tilting probably resulted from small-scale subduction and exhumation of the western South China block during the South and North China block collision. | LUO Liang JIA Dong QI Jiafu WEI Guoqi DENG Fei | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 4 |
| 4 | BRAF inhibitor:a novel therapy for ameloblastoma in mandible显示文摘Ameloblastoma is a benign but locally aggressive odontogenie neoplasm that accounts for 10% of all tumors arising in the mandible and maxilla (1).Eighty percent of ameloblastomas arise in the mandible,and they are usually found in young adults.It frequently recurs if not adequately resected.Therefore,the standard therapy for this tumor is complete bone resection with an adequate margin of safety: marginal or segmental osteotomy.However,aesthetic deformities,functional impairments and psychological impairments after radical surgery for large ameloblastoma, have been serious issues (1). | Masanobu Abe Liang Zong Takahiro Abe Hideyuki Takeshima Jiafu Ji Toshikazu Ushijima Kazuto Hoshi | 2018 | Chinese Journal of Cancer Research2018，30，6： | 3 |
| 5 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 6 | Detrital Zircon U-Pb Geochronology and Provenance of the Hebukesaier Formation in the Shaerbuerti Mountains,Northern West Junggar:Implication for Devonian Subduction of the Junggar–Balkhash Ocean显示文摘Limited Devonian magmatic record in northern West Junggar leads to contrasting models on its tectonic evolution.In this study,we conducted LA-ICP-MS U-Pb dating on detrital zircons of two sandstones from the Hebukesaier Formation in the Shaerbuerti Mountains.Detrital zircons with oscillatory zoning are characterized by high Th/U(>0.3)and low La/Yb(<0.15),indicating their magmatic origin.The youngest zircon ages of two samples are 402±2 Ma and 406±2 Ma,respectively,suggesting that the Hebukesaier Formation was deposited at the Early Devonian.Detrital zircon age patterns show single peaks(at ca.424 Ma,n=157),which indicates that these clastics were likely proximal accumulation after short distance transportation.Provenance of the Hebukesaier Formation was the Xiemisitai and Shaerbuerti Mountains.Detrital zircon ages range from 481 Ma to 395 Ma,which indicates that there was relatively continuous Early Paleozoic magmatism in the Xiemisitai and Shaerbuerti Mountains since the Early Ordovician.Age spectrums of sampled detrital zircons are distinct from those of Lower Devonian strata either in southern West Junggar or in East Junggar,which implies for individual tectonic evolution of northern West Junggar.We favor that Lower Devonian Hebukesaier Formation was developed in a fore–arc setting due to the northward subduction of the Junggar–Balkhash Ocean. | LIANG Hao CHEN Jiafu MA Xu YANG Hongzhang XIN Mingyang | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 7 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 8 | Surface Micro-crack Initiated Brittle Fracture in Fiber Reinforced Plastic Rod of Composite Insulator显示文摘 | Liang Xidong Wang Jiafu Dai Jianjun | 2010 | IEEE Transactions on Dielectrics and Electrical Insulation2010，17，2： | 1 |
| 9 | TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance显示文摘Immune checkpoint blockade(ICB)offers a new opportunity for treatment for gastric cancer(G.C.).Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy.Herein,using the CRISPR-Cas9-based genome-wide screening,we identified TRIM28 as one of the most significant regulators of PD-L1,a checkpoint protein,in G.C.cells. | Xiaoxiao Ma Shuqin Jia Gangjian Wang Min Liang Ting Guo Hong Du Sisi Li Xiaomei Li Longtao Huangfu Jianping Guo Xiaofang Xing Jiafu Ji | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 10 | Investigation on permeation properties of liquids into HTV silicone rubber materials显示文摘 | Gao Yanfeng Wang Jiafu Liang Xidong | 2014 | IEEE Transactions on Dielectrics And Electrical Insulation2014，21，6： | 1 |
| 11 | Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver显示文摘 | Guoxun Chen Guosheng Liang Jiafu Ou | 2004 | PNAS2004，31，11： | 1 |
| 12 | Healthy Urbanization:From Quantitative Growth to Qualitative Promotion–Adjustment on Emphasis of Urbanization Strategy显示文摘China is currently experiencing the dramatic process of rapid urbanization,and the issue of how to realize a healthy urbanization is such a hot topic that it attracts attention at various levels from the Central Government to the local governments,as well as in many fields from academic community to political circles.Around this issue,this article provides several related point of views from seven experts and scholars,in order to inspire the thoughts on the future of China’s urbanization. | Zhi YIN Qizhi MAO Jiafu LIU Liang LI Bing ZOU Xinzhe WANG Xiaogang SHAN Fang QIAN | 2013 | China City Planning Review2013，22，3： | 1 |
| 13 | Investigation on permeation properties of liquids into HTV silicone rubber materials显示文摘 | Gao Yanfeng Wang Jiafu Liang Xidong | 2014 | IEEE Transactions on Dielectrics and Electrical Insulation2014，21，6： | 1 |
| 14 | A capacitance study of anomalous diffusion of water into -1TV silicone rubber materials显示文摘 | Gao Yanfeng Liang Xidong Wang Jiafu | 2016 | IEEE Transactions on Dielectrics and Electrical Insulation2016，23，1： | 1 |
| 15 | Shape memory alloy-based 3D morphologically reconfigurable chiral metamaterial for tailoring circular dichroism by voltage control显示文摘Three-dimensional chiral materials with intrinsic chirality play a crucial role in achieving a strong chiral response and flexible light manipulation.Reconfigurable chirality through the 3D morphological transformation of chiral materials is significant for greater freedom in tailoring light but remains a challenge.Inspired by the unique 3D morphological memory capability of shape memory alloys(SMAs),we demonstrate and discuss a chiral resonator in the microwave regime that can realize reconfigurable chirality through 3D morphological transformation.The introduction of heating film realizes voltage control of SMA’s morphology for utilizing the temperature sensitivity of SMA better,enabling arbitrary control of circular dichroism(CD)flip and CD intensity.The qualitative and quantitative analysis of the surface current distribution of chiral enantiomers reveals that the chirality of metaatoms originates from the surge of electric dipole pxand electric quadrupole Q.It is worth mentioning that the proposed strategy to achieve reconfigurable chirality using 3D morphological transformations can be directly extended to other higher frequencies,such as visible,infrared,and terahertz bands.Significantly,our paradigm to study the relationship between complex 3D morphology and chirality holds potential for application in biosensing,spin detection,and spin-selective devices. | LIXIN JIANG QI YUAN HAO YANG YONGFENG LI LIN ZHENG ZHIBIAO ZHU SHUANG LIANG YONGQIANG PANG HE WANG JIAFU WANG SHAOBO QU | 2023 | Photonics Research2023，11，3： | 0 |
| 16 | Cenozoic Crustally-derived Carbonate-rich Magmatic Rocks in West Junggar,North Xinjiang,Western China:Geochronology,Geochemistry and Tectonic Implications显示文摘The carbonate-rich magmatic rocks of West Junggar are distributed in the Baijiantan and Darbut ophiolitic mélanges in the forms of extrusive rocks overlying the mélanges and dykes,either along the margins of the mélange or cross-cutting components of mélanges.Chilled margin and flow structures are present.A SHRIMP zircon U-Pb age of 39.7±1.3 Ma indicates that these carbonate-rich rocks in West Junggar were formed during the Eocene.They have low concentrations in REEs,Th,U,Nb,Ta and are characterized by extremely lowεN d(t),high(87 Sr/86 Sr)i ratios,relatively highδ18 OV-SMOW values and highδ13 CV-PDB values,which is similar with most sedimentary carbonates.Furthermore,no contemporaneous mantle-derived silicate rocks have yet been found in West Junggar.The carbonate-rich rocks in West Junggar are thus distinct from mantle-derived carbonatites and are interpreted to result from melting of the Carboniferous sedimentary carbonates at crustal levels,these rocks therefore being referred to as’crustal carbonatites’.The Eocene crustal carbonatites in West Junggar and other Cenozoic magmatic rocks in North Xinjiang are generally situated along regional strike-slip faults or fault intersections.Therefore,we propose that the reactivation of the Darbut and Baijiantan crustal-scale strike-slip fault zones(ophiolitic mélanges),due to the far-field effects of the Indian-Eurasian collision,enables decompression melting of the underlying continental lithospheric mantle.These resulting melts ascended to the lower crust through the strike-slip faults,causing partial melting of the Carboniferous carbonaceous sediments.The crustal carbonatites in West Junggar provide a new piece of evidence for Cenozoic magmatism in North Xinjiang and are also significant for the investigation of tectono-magmatic relations in North Xinjiang and the Central Asian Orogenic Belt. | CHEN Shi LIANG Xinxin ZHANG Yuanyuan GUO Zhaojie QI Jiafu | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 0 |
| 17 | Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2显示文摘Protein kinase CK2 consists of two catalytic subunits (CK2α) and two regulatory subunits (CK2β). Here, we report the crystal structures of rat CK2α mutant (rCK2α-△C, 1—335) and CK2β (rCK2β). The overall topology of rCK2α-△C and rCK2β are very similar to the human enzyme, although large structural differences could be observed in the N-terminal domain of rCK2α-△C. Our reported structure of rCK2α-△C is in the close conformation state while the counterpart hCK2α is in the open conformation state, indi- cating the conformation of CK2α molecule has high plasticity. The structure of rCK2β represents the conformation of free CK2β. Upon CK2α binding, the C-terminal region undergoes a drastic conformational change. The major region of interaction within the interface of CK2α/CK2β may serve as a bridge to transmit the conformational change and thus regulate the activity of CK2α. | ZHOU WeiHong QIN XiaoHong YAN XiaoJie XIE XingQiao LI Liang FANG ShaSha LONG JiaFu ADELMAN John TANG Wei-Jen SHEN YueQuan | 2009 | Chinese Science Bulletin2009，54，2： | 0 |
| 18 | Bovine Placental Bioactive Proteins Preparation and Efficacy Evaluation显示文摘Taking the qualified bovine placenta as the research object,a series of pure physical separation and extraction processes such as tissue fragmentation,ultrasound,freeze-thawed,centrifugation and filtration were used to prepare the bovine placental bioactive proteins.The results of protein concentration showed that bovine placental bioactive proteins prepared in this study could reach(11.33±2.09)mg/mL under optimal experimental condition.The determination of specific components showed that there were abundant exosome like vesicles in the product with particle size ranging from 30 to 150 nm,pie structure under transmission electron microscope and expressing CD9,CD63 and TSG101 by western blot detection.The results of cell efficacy evaluation showed that bovine placental bioactive proteins could significantly promote the proliferation of human skin fibroblasts and had anti-inflammatory effect via down-regulating IL-6 and TNF-αexpressionin RAW264.7 cells. | Li Xuejia Jiang Jiaohua Tang Huijuan Liang Jiafu Zhang Zhaoqing Qi Kangyi Yue Kun Ma yanyan Chen donghuang Chen Haijia Pang keliang | 2023 | China Detergent & Cosmetics2023，8，2： | 0 |
| 19 | Data mining-based model and risk prediction of colorectal cancer by using secondary health data:A systematic review显示文摘Objective:Prevention and early detection of colorectal cancer(CRC)can increase the chances of successful treatment and reduce burden.Various data mining technologies have been utilized to strengthen the early detection of CRC in primary care.Evidence synthesis on the model’s effectiveness is scant.This systematic review synthesizes studies that examine the effect of data mining on improving risk prediction of CRC.Methods:The PRISMA framework guided the conduct of this study.We obtained papers via Pub Med,Cochrane Library,EMBASE and Google Scholar.Quality appraisal was performed using Downs and Black’s quality checklist.To evaluate the performance of included models,the values of specificity and sensitivity were comparted,the values of area under the curve(AUC)were plotted,and the median of overall AUC of included studies was computed.Results:A total of 316 studies were reviewed for full text.Seven articles were included.Included studies implement techniques including artificial neural networks,Bayesian networks and decision trees.Six articles reported the overall model accuracy.Overall,the median AUC is 0.8243[interquartile range(IQR):0.8050-0.8886].In the two articles that reported comparison results with traditional models,the data mining method performed better than the traditional models,with the best AUC improvement of 10.7%.Conclusions:The adoption of data mining technologies for CRC detection is at an early stage.Limited numbers of included articles and heterogeneity of those studies implied that more rigorous research is expected to further investigate the techniques’effects. | Hailun Liang Lei Yang Lei Tao Leiyu Shi Wuyang Yang Jiawei Bai Da Zheng Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，2： | 0 |
| 20 | Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes显示文摘Sekeres et al.(1)conducted a multicenter randomized,controlled trial to compare whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates to azacitidine in the treatment of myelodysplastic syndromes(MDS).In that trial,224 patients with higher-risk MDS and 53 with chronic myelomonocytic leukemia(CMML)were | Guiping Wang Shanshan Guo Huashi Xiao Liang Zong Tetsuya Asakawa Masanobu Abe Wenqing Hu Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，6： | 0 |
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