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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Effect of Silane KIt-550 to Polypropylene/Brucite Composite 显示文摘 | Ma Zhiling Wang Jinghui Zhang Xiaoyu | 2008 | Appl Polym Sci2008，107，2： | 1 |
| 3 | Compatibili- zation of Intumescent Flame Retardant/Polypropylene Composites Based on Alpha-methacrylic Acid Grafted Pol- ypropylene 显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | Journal of Applied Polymer Science2002，83，14： | 1 |
| 4 | Studies on Compatibilization of Intumescent Flame Retardant/PP Composites Based on Etched PP显示文摘 | Ma Zhiling Pang Xiuyan Zhang Jie | 2002 | Journal of Applied Polymer Science2002，84，： | 1 |
| 5 | CmNF-YB8 affects drought resistance in chrysanthemum by altering stomatal status and leaf cuticle thickness显示文摘Drought is a major abiotic stress that limits plant growth and development.Adaptive mechanisms have evolved to mitigate drought stress,including the capacity to adjust water loss rate and to modify the morphology and structure of the epidermis.Here,we show that the expression of CmNF-YB8,encoding a nuclear factor Y(NF-Y)B-type subunit,is lower under drought conditions in chrysanthemum(Chrysanthemum morifolium).Transgenicchrysanthemumlinesinwhich transcript levels of CmNF-YB8 were reduced by RNA interference(CmNF-YB8-RNAi)exhibited enhanced drought resistance relative to control lines,whereas lines overexpressing CmNF-YB8(CmNF-YB8-OX)were less tolerant to drought.Compared to wild type(WT),CmNF-YB8-RNAi plants showed reduced stomatal opening and a thicker epidermal cuticle that correlated with their water loss rate.We also identified genes involved in stomatal adjustment(CBLinteracting protein kinase 6,CmCIPK6)and cuticle biosynthesis(CmSHN3)that are more highly expressed in CmNF-YB8-RNAi lines than in WT,CmCIPK6 being a direct downstream target of CmNF-YB8.Virus-induced gene silencing of CmCIPK6 or CmSHN3 in the CmNFYB8-RNAi background abolished the effects of CmNF-YB8-RNAi on stomatal closure and cuticle deposition,respectively.CmNF-YB8 thus regulates CmCIPK6 and CmSHN3 expression to alter stomatal movement and cuticle thickness in the leaf epidermis,thereby affecting drought resistance. | Tianle Wang Qian Wei Zhiling Wang Wenwen Liu Xin Zhao Chao Ma Junping Gao Yanjie Xu Bo Hong | 2022 | Journal of Integrative Plant Biology2022，64，3： | 1 |
| 6 | Synthesis of AgInS_2 QDs in droplet microreactors:Online fluorescence regulating through temperature control显示文摘For the synthesis of AgInS_2 quantum dots(QDs), a suitable temperature is extremely important for control of the size, shape and fluorescence properties of QDs. Most of synthesis methods for AgInS_2 QDs are based on batch reactors, which bring uneven distribution of temperature, affecting their fluorescence properties and size uniformity. Here we designed a droplet microreactor with a temperature-controllable region, and successfully synthesized water-soluble AgInS_2 QDs. By accurately controlling temperature,we also studied how the reaction temperature affected the fluorescence properties of AgInS_2 QDs. The results showed that with the increasing of reaction temperature, the QDs size increased and the fluorescence peak constantly red-shifted along with enhanced fluorescence intensity. Based on the droplet microreactor, we could achieve more appropriate reaction condition to synthesize AgInS_2 QDs with higher fluorescence quantum yield(QY) and intensity. | Haotian Ma Liangjun Pan Ji Wang Li Zhang Zhiling Zhang | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 7 | Effect of silane KH-550 to polypropylene/brucite composite显示文摘 | Ma Zhiling Wang Jinhui Ma Chunyu | 2008 | Journal of Applied Polymer Science2008，107，2： | 1 |
| 8 | Compati- bilization of Intumescent Flame Retardant/Polypropylene Composites Based on o-Methacrylic Acid Grafted Polypropylene显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | Journal of Applied Polymer Science2002，83，14： | 1 |
| 9 | Effect of Silane KH-550 to Polypropylene/brucite Composite 显示文摘 | Ma Zhiling Wang Jinhui Ma Chunyu | 2008 | Journal of Applied Polymer Science2008，107，2： | 1 |
| 10 | Synthesis and characterization of water borne intumescent fire retard- ant varnish based on phosphate resin acid cold cured amino resin显示文摘 | MA Zhiling WANG Jiangjiang CHEN Shu | 2012 | Progress in Organic Coatings2012，，74： | 1 |
| 11 | Compatibilization of Intumesent flame retardant/polypropylene composites based on α-methacrylic acid grafted polypropylene 显示文摘 | Ma Zhiling Zhao Min Hu Hanfang | 2002 | J Appl Polym Sci2002，83，： | 1 |
| 12 | Using PA6 as a char- ring agent in intumescent polypropylene formulations based on carboxylated polypropylene compatibilizer and nano- montmorillonite synergistic agent 显示文摘 | Ma Zhiling Zhang Weiyan Liu Xinyu | 2006 | Journal of Applied Polymer Science2006，101，1： | 1 |
| 13 | Synergy of magnesium and calcium oxides in intumescent flame-retarded polypropylene显示文摘 | Ma Zhiling Fan Congran Lu Guangyu | 2012 | Journal of Applied Polymer Science2012，125，5： | 1 |
| 14 | Studies of polypropylene intumescent flame retardant composites based on etched polypropylene as a coupling agent显示文摘 | MA Zhiling GAO Jungang BAI Ligai | 2004 | Journal of Applied Polymer Science2004，92，： | 1 |
| 15 | Synthesis and properties of intumescent phosphorus-containing flame-retardant polyesters 显示文摘 | Ma Zhiling Zhao Wenge Liu Yangfang | 1997 | Journal of Applied Polymer Science1997，63，12： | 1 |
| 16 | Analyses on the Overall Codon Usage Pattern in Fish Rhabdovirus显示文摘The codon usage bias and the base compositions in the available 49 complete fish rhabdovirus genome sequences were investigated. The high correlation between GC12% and GC3% suggested that mutational pressure rather than natural selection was the main factor determining the codon usage and base component in fish rhabdovirus,most of the spots lying below the expected curve( ENC vs GC3%) also suggested that codon usage bias in these 49 genomes was influenced by mutational pressure in codon usage pattern. Through PCA analysis based on RSCU,all ORFs in the 49 fish rhabdoviurs genomes were clustered into two parts,and this result showed that hosts played a role in codon usage pattern of fish rhabdovirus genomes. Further,comparison between SVCV,INHV,VHSV and their hosts suggested the effect of natural host on the codon usage pattern took part in the evolution process of fish rhabdovirus. This study represents the most comprehensive analysis to date for fish rhabdovirus codon usage patterns. | Yanping MA Hao KE Jiangyao MA Zhiling LIANG Le HAO Zhenxing LIU | 2018 | Agricultural Biotechnology2018，7，1： | 0 |
| 17 | The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China显示文摘Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources. | Zhiling Liang Yunjiang Yu Bingbing Sun Qian Yao Xihua Lin Yongsheng Wang Jianping Zhang Yingzi Li Xuefeng Wang Zhengzheng Tang Shexia Ma | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 18 | Novel biomarkers identifying hypertrophic cardiomyopathy and its obstructive variant based on targeted amino acid metabolomics显示文摘Background:Hypertrophic cardiomyopathy(HCM)is an underdiagnosed genetic heart disease worldwide.The management and prognosis of obstructive HCM(HOCM)and non-obstructive HCM(HNCM)are quite different,but it also remains challenging to discriminate these two subtypes.HCM is characterized by dysmetabolism,and myocardial amino acid(AA)metabolism is robustly changed.The present study aimed to delineate plasma AA and derivatives profiles,and identify potential biomarkers for HCM.Methods:Plasma samples from 166 participants,including 57 cases of HOCM,52 cases of HNCM,and 57 normal controls(NCs),who first visited the International Cooperation Center for HCM,Xijing Hospital between December 2019 and September 2020,were collected and analyzed by high-performance liquid chromatography-mass spectrometry based on targeted AA metabolomics.Three separate classification algorithms,including random forest,support vector machine,and logistic regression,were applied for the identification of specific AA and derivatives compositions for HCM and the development of screening models to discriminate HCM from NC as well as HOCM from HNCM.Results:The univariate analysis showed that the serine,glycine,proline,citrulline,glutamine,cystine,creatinine,cysteine,choline,and aminoadipic acid levels in the HCM group were significantly different from those in the NC group.Four AAs and derivatives(Panel A;proline,glycine,cysteine,and choline)were screened out by multiple feature selection algorithms for discriminating HCM patients from NCs.The receiver operating characteristic(ROC)analysis in Panel A yielded an area under the ROC curve(AUC)of 0.83(0.75-0.91)in the training set and 0.79(0.65-0.94)in the validation set.Moreover,among 10 AAs and derivatives(arginine,phenylalanine,tyrosine,proline,alanine,asparagine,creatine,tryptophan,ornithine,and choline)with statistical significance between HOCM and HNCM,3 AAs(Panel B;arginine,proline,and ornithine)were selected to differentiate the two subgroups.The AUC values in the training and validation sets for Panel B were 0.83(0.74-0.93)and 0.82(0.66-0.98),respectively.Conclusions:The plasma AA and derivatives profiles were distinct between the HCM and NC groups.Based on the differential profiles,the two established screening models have potential value in assisting HCM screening and identifying whether it is obstructive. | Lanyan Guo Bo Wang Fuyang Zhang Chao Gao Guangyu Hu Mengyao Zhou Rutao Wang Hang Zhao Wenjun Yan Ling Zhang Zhiling Ma Weiping Yang Xiong Guo Chong Huang Zhe Cui Fangfang Sun Dandan Song Liwen Liu Ling Tao | 2022 | Chinese Medical Journal2022，135，16： | 0 |
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