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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 2 | Numerical investigation on effects of side curtain opening behavior on indoor climate of naturally ventilated dairy buildings显示文摘The side-curtain is popular in cattle buildings to regulate indoor climates and ventilation rates by adjusting the opening ratio.It normally had three different adjusting strategies relate to the position of rollers,i.e.central roller(S1),top roller(S2)and bottom roller(S3),which result in different opening behaviors to generate the same opening ratio but different opening positions in the side wall for a full-curtain house.Numerical simulations were conducted using computational fluid dynamics(CFD)to investigate the effects of the eight potential opening behaviors of side curtains on the indoor climates and airflow rates in winter for a typical naturally ventilated dairy house in China when the opening ratio were 8.5%and 17%.Airflow patterns,wind chilled temperature(WCT)and age of air were analyzed in the animal occupied zone(AOZ)by taking reference planes.Openings at the very bottom of side walls had more efficient ventilation due to the younger air age,more effective air disturbing,more uniformly distributed indicators in AOZ.However,it will result in a lower WCT in AOZ although a lower ventilation rate was observed in this case.Openings on the very top of side wall would generate a better thermal comfort in AOZ but with very poor air quality and nonuniformly distributed airflows in the dairy house.S1 was not recommended to the practical application due to the poor indoor climate and the higher cost of the mechanical structure.Based on the comprehensive evaluations of the analytic hierarchy process,the most satisfaction opening positions were at the bottom of the side curtains and the optimized adjusting strategy is S2. | Qifeng Li Chuanxia Yao Luyu Ding Ligen Yu Weihong Ma Ronghua Gao Wengang Zheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 3 | A novel approach to the Preparation of nanoblends of poly (2,6-dimethyl-1,4-phenylene oxlde)/polyamide 6显示文摘 | Ji Yali Li Wengang Ma Jinghong | 2005 | Macromol Rapid Commun2005，26，： | 1 |
| 4 | Review of transparent soil model testing technique for underground construction:Ground visualization and result digitalization显示文摘In geotechnical engineering,the transparent soil(also called transparent media)technique is an effective tool for conducting experimental tests and investigating the displacement characteristics and stress distribution of soils.It plays a vital role in the observation of internal soil deformations.This study aims to briefly review the current state of some of the common materials used to formulate transparent soil models and the application of the transparent soil technique to underground construction over the last 20 years.To this end,the basic concepts of transparent soils are introduced.Then,several representative applications of transparent soil in underground construction(i.e.,soil deformations induced by the penetration of pile foundations,tunnel excavation-induced movements,and structural responses caused by braced excavations)are presented.Because some research gaps may exist,certain potential research topics are proposed.This review can serve as a guideline for researchers performing experiments using transparent soils. | Wengang Zhang Xin Gu Wenhan Zhong Zhitao Ma Xuanming Ding | 2022 | Underground Space2022，7，4： | 1 |
| 5 | Effect of KCI on Growth of Carbon Fibers During Carbonization of Phenolic Resin显示文摘Effects of the KCl additions( 1%,3%,5% and7% of the phenolic resin mass) on phase composition and microstructure of the resin carbon and the growth mechanism of carbon fibers were investigated by using commercial liquid phenolic resin as carbon source and micron-scaled KCl as catalyzer,mixing,hexamethylenetetramine solidification treating,carbon-embedded firing at 1 000 ℃ for 3h in order to accelerate the graphitization of phenolic resin during carbonization. The results show that the graphitization degree of resin carbon is improved by catalysis of KCl,numerous carbon fibers with30-200 nm in diameter and 10-20 μm in length and sheet-like carbon in situ grow in resin carbon. The optimal addition of KCl is 5% when lots of carbon fibers can be found in resin carbon,and d002 diffraction peak of graphite appears obviously in the XRD pattern. The growth mechanism of carbon fiber is that the molten KCl at high temperatures absorbs carbonaceous gas from the decomposition of phenolic resin,accelerating the diffusion of solid C atoms in liquid KCl; after the dissolution of C saturates,carbon atoms separate continuously in local parts to form carbon fibers or flakes; meanwhile,the concentration gradient formed by local carbon atoms in the melt offers growth drive for the separation of carbon fibers or flakes on KCl surface. | WU Xiaoxian LI Hongxia LIU Guoqi YANG Wengang MA Tianfei | 2016 | China's Refractories2016，25，2： | 1 |
| 6 | Me- chanical Performance Evaluation of A New Type of Cable --Stayed Beam- Arch Combination Bridge Based on Field Tests显示文摘 | Ma Wengang Huang Qiao Chen Xiaoqiang | 2012 | Journal of Southeast University2012，28，1： | 1 |
| 7 | Resistive switching characteristic of electrolyte-oxide-semiconductor structures显示文摘The resistive switching characteristic of SiO_2 thin film in electrolyte-oxide-semiconductor(EOS) structures under certain bias voltage is reported.To analyze the mechanism of the resistive switching characteristic,a batch of EOS structures were fabricated under various conditions and their electrical properties were measured with a set of three-electrode systems.A theoretical model based on the formation and rupture of conductive filaments in the oxide layer is proposed to reveal the mechanism of the resistive switching characteristic,followed by an experimental investigation of Auger electron spectroscopy(AES) and secondary ion mass spectroscopy(SIMS) to verify the proposed theoretical model.It is found that different threshold voltage,reverse leakage current and slope value features of the switching I-V characteristic can be observed in different EOS structures with different electrolyte solutions as well as different SiO_2 layers made by different fabrication processes or in different thicknesses.With a simple fabrication process and significant resistive switching characteristic,the EOS structures show great potential for chemical/biochemical applications. | Xiaoyu Chen Hao Wang Gongchen Sun Xiaoyu Ma Jianguang Gao Wengang Wu | 2017 | Journal of Semiconductors2017，38，8： | 0 |
| 8 | Damage Mechanism and Countermeasures of Carbon Bonded Refractories for Continuous Casting显示文摘The long nozzle,stopper,and submerged entry nozzle play an important role in continuous casting. They are of the similar composition and are mainly damaged by liquid steel thermal shock which leads to immediate cracks or fracture in their combined area because of the thermal mechanical properties mismatch,or damaged by corrosion on their interface. The failure mechanisms are the thermal shock damage and continuous reaction corrosion. High efficiency and long life of the long nozzle,stopper,and submerged entry nozzle can be realized by optimizing the thermal mechanical properties,the key erosion step,and the combination match. | QIAN Fan LI Hongxia LIU Guoqi YANG Wengang YU Jianbin MA Weikui | 2016 | China's Refractories2016，25，3： | 0 |
| 9 | Control Effect of UAV Low Volume Spray Technology on Thrips and Tomato Spotted Wilt Virus in Tobacco Field显示文摘[Objectives]The paper was to explore the influence of unmanned aerial vehicle(UAV)low volume spray technology on the control effect of viruliferous thrips and tomato spotted wilt virus(TSWV)under different pesticide concentrations,and to explore the effective control nodes and methods of thrips and TSWV.[Methods]According to the occurrence characteristics of thrips and TSWV,the field control effects of 4 pesticides on thrips and TSWV were tested by UAV with the thrips number and disease index as indicators,following the principle of regional and periodic control trials.[Results]In the groups of UAV and artificial prevention and control,4 agents were used alternatively,including 1%emamectin benzoate ME,1.7%abamectin imidacloprid ME,5%emamectin benzoate WDG,and 30%pyriproxyfen dinotefuran SL.There was no significant difference in the control effect of thrips and TSWV among treatment 1(recommended dosage of UAV agent),treatment 2(reduction of recommended dosage of UAV agent by 25%)and treatment 4(recommended dosage of artificial control agent),and the control effects on thrips were more than 83.16%in the 3 treatments.The disease index of TSWV in the 3 treatments decreased from 8.64±1.37 in the blank control group to less than 3,which reached the prevention and control threshold.But treatment 3(reduction of recommended dosage of UAV agent by 50%)did not reach the prevention and control threshold.The disease index of TSWV in the blank control area increased with the increase of the number of live nymphs of thrips,and there was a significant positive correlation,with good fitness.[Conclusions]UAV has a significant impact on the control effect of thrips and TSWV under different pesticide concentrations.In the actual flight control application,it is recommended that the amount of the pesticides is about 3/4 and not less than 1/2 of that of the artificial application.The control area should be extended to 100 m of the ridge of the tobacco field,and UAV is used periodically to control thrips and TSWV for 5 times from pre-transplanting stage to pre-squaring stage of flue-cured tobacco.The control effect is significantly different from the traditional artificial application. | Zefan LIU Dean XIE Jiabao HAN Yanfen XIE Li MA Siyuan GAO Ruiqi PENG Yuting ZHAO Xiangze FU Wengang CHENG Yonghong FENG Yan ZHANG Huaping ZHANG Ying HUANG Leijie DAI Lanfeng WANG | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 10 | Design of Composite Ladle Shroud for Improving Thermal Shock Resistance显示文摘A ladle shroud is one of the functional refractories for continuous casting,which undergoes severe thermal shock by molten steel when used without pre-heating.The composite ladle shroud with an insulating liner presents excellent thermal shock resistance.Finite element simulation is an effective method to explore the maximum thermal stress for predicting the thermal shock resistance of ladle shrouds.In this paper,the influence of the lining materials and the structure of ladle shrouds on the thermal stress distribution is systematically researched.The working mechanism of the lining material on the body material is also presented.Lining materials with low thermal expansion,elastic modulus and thermal conductivity are helpful to improve the thermal shock resistance and an optimum lining thickness is suggested.The lining material can both serve as thermal resistance for the body material to buffer the thermal stress,and apply a strain load to the body material by the thermal strain to increase the stress. | LIU Guoqi LI Hongxia YANG Wengang QIAN Fan YU Jianbin MA Weikui | 2021 | China's Refractories2021，30，1： | 0 |
| 11 | Optimization and Simulation of Inclined Channel Area Lining for CDQ Ovens显示文摘The mechanical force borne by the lintel and“brackets”in the inclined channel area of CDQ and the thermal stress generated by the top-down temperature gradient were simulated by ANSYS software.The following conclusions are drawn.(1)The mechanical force has very mild effect on the damage of the“brackets”.(2)The temperature gradient caused by the uneven temperature distribution of CDQ oven is the key factor affecting the“bracket”damage.The different expansion of refractory materials in various parts results in the thermal stress concentration which tears the“brackets”.(3)The structure adjustment of the“brackets”has very little effect on the thermal stress distribution.(4)The multi-phase nitride bonded silicon carbide for CDQ can effectively alleviate the stress concentration at the“brackets”,realizing the long-life and stable operation. | CAO Huiyan FENG Yanbin ZHANG Haiyan MA Zhaoyang LI Jie WANG Xinhui WU Jiguang YANG Wengang | 2022 | China's Refractories2022，31，2： | 0 |
| 12 | Reflection-type surface lattice resonances in all-metal metasurfaces for refractive index sensing显示文摘Surface lattice resonance(SLR)is a pretty effective mechanism to realize ultranarrow linewidths in the spectrum.Herein,we propose and demonstrate reflection-type SLRs in all-metal metasurfaces experimentally,compared with the traditional transmission-type SLR,which can avoid the refractive index(RI)mismatch problem and are more suitable for high-efficiency RI sensing due to direct contact and strong light–matter interaction.The measured SLR linewidth is 13.5 nm influenced by the meta-atom size,which needs a compromise design to keep a balance between the narrow linewidth and noise immunity.Notably,the SLR sensitivity is determined by the lattice period along the polarization direction with regularity,which establishes an intuitive link between structures and optical responses and provides a theoretical guide for metasurface designs.Additionally,incident angle multiplexing will make the resonance wavelength red shift or blue shift in the case of orthogonal polarization.The rectangular array metasurface can realize dual SLRs with different sensing performances.Flexibly,the SLR can also be formed by the different meta-atoms and arrays.This research supports SLR multifarious applications involving not only RI sensing but also nonlinear optics,nano-lasers,etc. | LIYE LI YIFAN OUYANG LIJUN MA HONGSHUN SUN YUSA CHEN MEIZHANG WU ZHIMEI QI WENGANG WU | 2023 | Photonics Research2023，11，12： | 0 |
| 13 | Influence of Glass Dust on Properties of Alumina-carbon Refractories显示文摘In order to improve the properties of alumina-carbon refractories,specimens were prepared using white fused corundum,zirconia-mullite and flake graphite as the raw materials,phenolic resin as the binder,adding different mass fractions(1.5%,2.0%,and 2.5%,respectively)of glass dust,cold isostatic pressing by 120 MPa,drying and firing at 900℃for 3 h.Effects of the glass dust addition on the apparent porosity,bulk density,cold modulus of rupture,hot modulus of rupture and thermal shock resistance were studied.The results show that the cold modulus of rupture of the specimens is improved significantly as the results of glass dust accelerating sintering.However,the hot modulus of rupture decreases.As the glass phase buffers the strain produced by thermal shock,the thermal shock resistance of alumina-carbon specimens is improved,especially for low carbon alumina-carbon materials. | MA Weikui LIU Guoqi YU Jianbin QIAN Fan YANG Wengang | 2019 | China's Refractories2019，28，4： | 0 |
| 14 | Structure Design of SEN for High Efficiency Thin Slab Continuous Casting显示文摘Four-hole submerged entry nozzles(SEN) with different structures were researched using the water simulation test by particle image velocimetry(PIV) and DJ800 hydraulic measurement system to get suitable SEN for high efficiency continuous casting. The influences of the exit area ratio(2∶1∶2,3∶2∶3,1∶1∶1 and 1∶2∶1),upper guide island angle θ(20°,40°,60° and 80°),and lower guide island angle α(60°,80°,100° and120°) on the vortex position in the mold and fluctuations were researched. The results show that the exit area ratio and the upper and low guide island angles have obvious influence on the flow field; the flow field in the mold is suitable at 1∶2 ∶1 of the exit area ratio,80° of upper guide island angle,and 100° of lower guide island angle. | YANG Wengang LI Hongxia LIU Guoqi MA Tianfei QIAN Fan YU Jianbin | 2018 | China's Refractories2018，27，1： | 0 |
| 15 | Modified corn-core powder for enhancing sludge dewaterability:Synthesis,characterization and sludge dewatering performance显示文摘The high water content of sludge has always posed significant challenges for its treatment.Synthetic flocculants,which are widely used in sewage treatment plants,can cause secondary pollution during their production and use.Thus,natural polymer flocculants made of natural materials have received increased research attention recently.Corncore,an agricultural waste,was modified through alkalization with sodium hydroxide(NaOH)and etherification with cetyltrimethylammonium bromide(CTMAB)in this study.The L16(45)orthogonal array was used to study the modification conditions.The moisture content(MC)of treated sludge was reduced by approximately 37%with the addition of modified corncore powder(MCCP),which was synthesized under optimal conditions.In addition,changes in the functional groups of the material before and after modification were determined by FTIR.Thermogravimetric analysis indicated that MCCP was steady at room temperature,moreover,BET analysis showed that MCCP had greater surface area.The microstructures of material before and after modification were examined by scanning electron microscopy,revealing that MCCP had a flakeshaped structure and had an increased area of contact area with sludge particles.MCCP is a dehydrating agent that can enhance sludge dewaterability through charge neutralization and reagglomeration and provide superior economic benefits. | Zhiying Guo Liping Ma I Quxiu Dai Xinbo Yang Ran Ao Jie Yang Jing Yang Wengang Li | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 0 |
| 16 | Structure and Material Design of High Performance Functional Refractories for High-speed Continuous Casting显示文摘Functional refractories,including submerged entry nozzle ( SEN) ,ladle shroud and monolithic stopper, are the key refractories for continuous casting. Driven by the demand of high-speed continuous casting,traditional functional refractories fail to meet the needs of long span life,and high performance functional refractories for continuous casting are increasingly required. Through structure and material design,the performance of functional refractories is significantly improved. In this paper,some research advances on functional refractories for continuous casting were mentioned. Through numerical modeling and hot simulation,the service life of non-preheating ladle shroud was increased from 8 h to more than 12 h. Through the water modeling,the flow patterns in the mold were significantly improved and through hot simulation and material design,the service life and reliability of SEN were also significantly improved. | LI Hongxia,LIU Guoqi,YANG Wengang,YU Jianbin,MA Tianfei,QIAN Fan State Key Laboratory of Advanced Refractories,Sinosteel Luoyang Institute of Refractories Research Co. ,Ltd. ,Luoyang 471039,China | 2012 | China's Refractories2012，21，1： | 0 |
| 17 | Application of Artificial Neural Network in Engineering显示文摘This paper mainly studies the dynamic direction of engineering valuation based on the artificial neural network methods,and seeks for a set of rapid,convenient and practical valuation models,for building construction projects. | ZHANG Fan WANG Lei ZHOU Zhou ZHAO Jiaxin ZHANG Sensen HU Shixiang MA Wengang | 2020 | International Journal of Plant Engineering and Management2020，25，3： | 0 |
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