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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 4 | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury显示文摘The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 si RNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma. | Qi-shan Ran Yun-hu Yu Xiao-hong Fu Yuan-chao Wen | 2015 | Neural Regeneration Research2015，10，8： | 11 |
| 5 | Comparison of the performance of the CRUSADE, ACUITY-HORIZONS, and ACTION bleeding scores in ACS patients undergoing PCI: insights from a cohort of 4939 patients in China显示文摘BackgroundThe 十字军,行动和尖酸地平线分数通常被使用预言与急性冠的症候群(交流) 在病人为事件放血的在里面医院专业,但是这些的同类的性质为人口限制建模 ? 简单推测到另外的本地人口。我们试图在中国 patients.MethodsWe 比较三个风险模型的表演评估了三的表演为预言主要流血事件在心肌的梗塞( TIMI )由 thrombolysis 定义的在里面医院预言分数严肃(专业和未成年者)事件,在有 non-ST-elevation 交流(NSTE交流)或圣举起的中国交流病人的一个队心肌的梗塞( STEMI )。三个风险模型的刻度和辨别被 Hosmer-Lemeshow 测试和 C 统计数值分别地评估。我们由严肃的流血率是的 Delong 非参量的 test.ResultsTIMI 比较了风险分数的预兆的精确性 1.1% 外套(1.9% 和 0.86% 为 STEMI 和 NSTE 交流,分别地) 。十字军,行动和 ACUTIY 地平线分数为主要流血显示出一个足够的差别对待的能力:在全面病人, C 统计数值分别地是 0.80, 0.77,和 0.70;在 NSTE 交流病人, C 统计数值分别地是 0.73, 0.72,和 0.64;在 STEMI 病人, C 统计数值分别地是 0.91, 0.92,和 0.75。为尖酸地平线模型的 C 统计数值是比为 TIMI 的预言的 CRUSADE 和行动分数的那些显著地低的在全面病人的严肃的流血(与十字军相比, z = 3.83, P = 0.02;与行动相比, z = 3.51, P = 0.03 ) ;在 NSTE 交流病人(与十字军相比, z = 2.37, P = 0.01;与行动相比, z = 2.11, P = 0.04 ) ,并且在 STEMI 病人(与十字军相比, z = 2.6.77, P = 0.02;与行动相比, z = 7.91, P = 0.002 ) 。当 CRUSADE 和行动模型与对方相比时,没有差别被观察,不管全面病人( z = 0.68 , P = 0.31 )并且两个都交流打字(NSTE交流, z = 0.52 , P = 0.60 ),并且 STEMI 病人( z = 0.36 , P = 0.74 )。然而,三个风险分数都在我们的学习在每风险层化过高估计绝对主要流血风险。例如,在高风险层化的十字军 20 的预言的率是 11.9% 对 5.3%.ConclusionsThe 十字军和行动分数的实际的率为在里面医院专业与尖酸地平线相比流血让更大的刻度和辨别与经历一种总线标准的交流在中国病人得分。然而,他们都为中国人口过高估计流血风险率。这些风险分数的刻度将为在中国人口的归纳是有用的。 | Ran LIU Shu-Zheng LYU Guan-Qi ZHAO Wen ZHENG Xiao WANG Xue-Dong ZHAO Sheng-Hui ZHOU Lei ZHEN Shao-Ping NIE | 2017 | Journal of Geriatric Cardiology2017，14，2： | 9 |
| 6 | Risks faced by donors of right lobe for living donor liver transplantation显示文摘BACKGROUND:Because of the shortage of deceased donors with livers fit for transplantation,living donor liver transplantation(LDLT)is becoming an attractive alternative.Attention should be paid to the donors,especially to those of the right lobe.In this study,we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.METHODS:The perioperative data from 105 consecutive living donors of the right lobe performed in West China Hospital from January 2002 to December 2007 were retrospectively studied.Preoperative evaluation included CT,MRCP,and intraoperative cholangiography,showing liver volume,hepatic vasculature and the biliary system.The standard liver volume(SLV)and the ratio of left lobe volume to SLV were calculated.The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein without inflow vascular occlusion,using an ultrasonic dissector.After operation the donors were monitored in the Intensive Care Unit for about three days.Each donor was followed up for at least 6 months.RESULTS:There was no donor mortality.Major complications occurred in 14 donors(13.3%),of whom 3 received conservative treatment,8 required invasive paracentesis,and 3 required further surgery.All donors were recovered well and resumed their previous occupations.CONCLUSIONS:Donors of the right lobe face low risks.The preoperative evaluation,especially evaluation of the volume of the remnant liver,should be exact.During the operation,the patency of the remnant hepatic vasculature and bile duct must be preserved,and the extent of injury to the remnant liver should be limited as much as possible.The detection and treatment of postoperative complications should be diligently performed. | Ran, Shun Wen, Tian-Fu Yan, Lu-Nan Li, Bo Zeng, Yong Chen, Zhe-Yu Zhang, Yu Liao, Zhi-Xue Liang, Guan-Lin Li, Guo Zhang, Xian-Hua | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 7 | Extended optimal guidance law with impact angle and acceleration constriants显示文摘The extended optimal guidance law with terminal constraints of miss distance and impact angle is derived by the Schwartz inequality. To reduce terminal acceleration and eliminate gravity disturbance absolutely, the object function, which designs the weight of control command to be the power function of time-to-go's reciprocal, is given. And the gravity is considered when building the state equation. Based on the parsing express of the guidance command change with varying time and adjoint system analysis method, the command characteristics and the non-dimensional miss distance of the guidance law are analyzed,a design principle of guidance order coefficients is discussed. Finally, based on the requirement of engineering, the method to calculate the guidance condition and maximal required acceleration of the guidance law is given. The simulation demonstrates that not only the guidance law can satisfy the terminal position and impact angle constraints, but also the terminal acceleration can be converged toward zero, which will support a good situation for the terminal angle of attacking control. | Ran Li Qunli Xia Qiuqiu Wen | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 7 |
| 8 | Adaptive weighting impact angle optimal guidance law considering seeker's FOV angle constraints显示文摘In this paper, a new adaptive optimal guidance law with impact angle and seeker's field-of-view(FOV) angle constraints is proposed. To this end, the generalized optimal guidance law is derived first. A changeable impact angle weighting(IAW) coefficient is introduced and used to modify the guidance law to make it adaptive for all guidance constraints. After integrating the closed-form solution of the guidance command with linearized engagement kinematics, the analytic predictive models of impact angle and FOV angle are built, and the available range of IAW corresponding to constraints is certain. Next, a calculation scheme is presented to acquire the real-time value of IAW during the entire guidance process. When applying the proposed guidance law, the IAW will keep small to avoid a trajectory climbing up to limit FOV angle at an initial time but will increase with the closing target to improve impact position and angle accuracy, thereby ensuring that the guidance law can juggle orders of guidance accuracy and constraints control. | LI Ran WEN Qiuqiu TAN Wangchun ZHANG Yijie | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 6 |
| 9 | A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia显示文摘 | Fang Wang Ran Li Ying Shang Can Wang Guo-Qing Wang DeXun Zhou Dong-Hong Yang Wen Xi Ke-QiangWang Jing Bao Yu Kang Zhan-Cheng Gao | 2016 | Chinese Medical Journal2016，，2： | 5 |
| 10 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 11 | Bioinspired hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers显示文摘Bio-sourced nanocellulosic materials are promising candidates for spinning high-performance sustainable macrofibers for advanced applications.Various strategies have been pursued to gain nanocellulose-based macrofibers with improved strength.However,nearly all of them have been achieved at the expense of their elongation and toughness.Inspired by the widely existed hierarchical helical and nanocomposite structural features in biosynthesized fibers exhibiting exceptional combinations of strength and toughness,we report a design strategy to make nanocellulose-based macrofibers with similar characteristics.By combining a facile wet-spinning process with a subsequent multiple wet-twisting procedure,we successfully obtain biomimetic hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers,realizing impressive improvement in their tensile strength,elongation and toughness simultaneously.The achievement certifies the validity of the bioinspired hierarchical helical and nanocomposite structural design proposed here.This bioinspired design strategy provides a potential platform for further optimizing or creating many more strong and tough nanocomposite fiber materials for diverse applications. | Huai-Ling Gao Ran Zhao Chen Cui Yin-Bo Zhu Si-Ming Chen Zhao Pan Yu-Feng Meng Shao-Meng Wen Chuang Liu Heng-An Wu Shu-Hong Yu | 2020 | National Science Review2020，7，1： | 4 |
| 12 | Comparison of three remotely sensed drought indices for assessing the impact of drought on winter wheat yield显示文摘Agricultural drought threatens food security.Numerous remote-sensing drought indices have been developed,but their different principles,assumptions and physical quantities make it necessary to compare their suitability for drought monitoring over large areas.Here,we analyzed the performance of three typical remote sensing-based drought indices for monitoring agricultural drought in two major agricultural production regions in Shaanxi and Henan provinces,northern China(predominantly rain-fed and irrigated agriculture,respectively):vegetation health index(VHI),temperature vegetation dryness index(TVDI)and drought severity index(DSI).We compared the agreement between these indices and the standardized precipitation index(SPI),soil moisture,winter wheat yield and National Meteorological Drought Monitoring(NMDM)maps.On average,DSI outperformed the other indices,with stronger correlations with SPI and soil moisture.DSI also corresponded better with soil moisture and NMDM maps.The jointing and grain-filling stages of winter wheat are more sensitive to water stress,indicating that winter wheat required more water during these stages.Moreover,the correlations between the drought indices and SPI,soil moisture,and winter wheat yield were generally stronger in Shaanxi province than in Henan province,suggesting that remote-sensing drought indices provide more accurate predictions of the impacts of drought in predominantly rain-fed agricultural areas. | Jianxi Huang Wen Zhuo Ying Li Ran Huang Fernando Sedano Wei Su Jinwei Dong Liyan Tian Yanbo Huang Dehai Zhu Xiaodong Zhang | 2020 | International Journal of Digital Earth2020，13，4： | 4 |
| 13 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 14 | Tenofovir vs.entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy显示文摘Background:Hepatectomy for hepatocellular carcinoma(HCC)beyond the Milan criteria is shown to be beneficial.However,a high rate of post-operative HCC recurrence hinders the long-term survival of the patients.This study aimed to investigate and compare the impacts of tenofovir(TDF)and entecavir(ETV)on the recurrence of hepatitis B viral(HBV)-related HCC beyond the Milan criteria.Methods:Data pertaining to 1532 patients who underwent hepatectomy and received antiviral therapy between January 2014 and January 2019 were collected from five centers.Recurrence-free survival(RFS)analysis was performed using the Kaplan-Meier method.Cox proportional hazards regression analysis was performed to determine prognostic factors for HCC recurrence.Results:The analysis incorporates 595 HBV-related HCC patients.The overall 5-year RFS was 21.3%.Among them,533 and 62 patients received ETV and TDF treatment,respectively.The 1-,3-,and 5-year RFS rates were 46.3%,27.4%,and 19.6%,respectively,in the ETV group compared with 65.1%,41.8%,and 37.2%,respectively,in the TDF group(P<0.001).Multivariate analysis showed that TDF treatment(hazard ratio[HR]:0.604,P=0.005),cirrhosis(HR:1.557,P=0.004),tumor size(HR:1.037,P=0.008),microvascular invasion(MVI)(HR:1.403,P=0.002),portal vein tumor thrombus(PVTT)(HR:1.358,P=0.012),capsular invasion(HR:1.228,P=0.040),and creatinine levels(CREA)(HR:0.993,P=0.031)were statistically significant prognostic factors associated with RFS.Conclusions:Patients with HCC beyond the Milan criteria exhibited a high rate of HCC recurrence after hepatectomy.Compared to the ETV therapy,TDF administration significantly lowered the risk of HCC recurrence. | Junyi Shen Weili Qi Junlong Dai Shusheng Leng Kangyi Jiang Yu Zhang Shun Ran Chuan Li Tianfu Wen | 2022 | Chinese Medical Journal2022，，3： | 3 |
| 15 | Research on optimization and design methods for air distribution system based on target values显示文摘To achieve sufficient air conditioning of large buildings,reasonable air distribution in indoor spaces is an effective method for creating stratified air conditioning.Therefore,optimizing the air distribution in large buildings is extremely significant.In this paper,we expound on a new method for air distribution design and optimization based on target value evaluation and summarize the relevant design processes based on an orthogonal test and by decoupling the effects of the size of the tuyere,airflow temperature,air-supply angle and velocity on air distribution.Then,we present a design case.To optimize the distribution of a lateral air supply in winter,the deflection angle,velocity and temperature of the air supply can be determined in turn.For the large and tall building types addressed in this paper,the optimal air-supply angle is 2°,the optimal air-supply velocity is 8 m/s,and the optimal air-supply temperature is 19℃. | Ran Gao Hengchun Zhang Angui Li Shihao Wen Wuyi Du Baoshun Deng | 2021 | Building Simulation2021，14，3： | 3 |
| 16 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 17 | SJES14110700244576显示文摘 | Ran Chen Fei Ma Pei-Wu Li Wen Zhang Xiao-Xia Ding Qi Zhang Min Li Yan-Ru Wang Bao-Cheng Xu | 2014 | Food Chemistry2014，，： | 2 |
| 18 | Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis显示文摘To the Editor:Hepatic alveolar echinococcosis(AE)is a lethal infectious disease caused by the larval stage Echinococcus multilocularis(E.multilocularis)and exhibits low prevalence in endemic areas with high morbidity and mortality.AE lesions invading the hepato-caval confluence,including main hepatic veins and retro-hepatic inferior vena cava(IVC),may result in Budd-Chiari Syndrome(BCS),which was a severe complication of AE presented with abdominal pain,ascites,and hepatomegaly.In this study,we reported a case of chronic BCS caused by hepatic AE and summarized the therapeutic method of left trisectionectomy and supra-hepatic IVC replacement with prosthetic grafts. | Bo Ran Tie-Min Jiang Aimaiti Yasen Abudusalamu Aini Qiang Guo Rui-Qing Zhang Ying-Mei Shao Hao Wen Aji Tuerganaili | 2019 | Chinese Medical Journal2019，，23： | 2 |
| 19 | Multi-component immunochromatographic assay for simultaneous detection of aflatoxin B 1 , ochratoxin A and zearalenone in agro-food显示文摘 | Xin Li Peiwu Li Qi Zhang Ran Li Wen Zhang Zhaowei Zhang Xiaoxia Ding Xiaoqian Tang | 2013 | Biosensors and Bioelectronics2013，，： | 2 |
| 20 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
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