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| 1 | 儿童功能性胃肠病罗马Ⅳ标准显示文摘罗马标准是目前关于功能性胃肠病( FGID)分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年,根据年龄不同,婴幼儿(0-36个月)和儿童(〉36个月) FGID的罗马Ⅲ诊断标准发布,但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。 | Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. James Roberts Neil L. Schechter Jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert J. Shulman Annamaria Staiano Miranda van Tilburg | 2017 | 中华儿科杂志2017，55，1： | 108 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 4 | Laparoscopic liver resection for hepatocellular adenoma显示文摘AIM:To investigate the role of laparoscopy in the surgical management of hepatocellular adenoma(HA). METHODS:We reviewed a prospectively collected database of consecutive patients undergoing laparoscopic liver resection for HA. RESULTS:Thirteen patients underwent fifteen pure laparoscopic liver resections for HA(male/female:3/10; median age 42 years,range 22-72 years).Two patients with liver adenomatosis required two different laparoscopic operations for ruptured adenomas.Indications for surgery were:symptoms in 12 cases,need to rule out malignancy in 2 cases and preoperative diagnosis of large HA in one case.Symptoms were related to bleeding in 10 cases,sepsis due to liver abscess following embolization of HA in one case and mass effect in one case(shoulder tip pain).Five cases with ruptured bleeding adenoma required emergency admis-sion and treatment with selective arterial embolization. Laparoscopic liver resection was then semi-electively performed.Eight patients(62%)required major hepatectomy[right hepatectomy(n=5),left hepatectomy (n=3)].No conversion to open surgery occurred.The median operative time for pure laparoscopic procedures was 270 min(range 135-360 min).The median size of the excised lesions was 85 mm(range 25-180 mm). One patient with adenomatosis developed postoperative bleeding requiring embolization.Mortality was nil. The median hospital stay was 4 d(range 1-18 d)with a median high dependency unit stay of 1 d(range 0-7 d). CONCLUSION:The laparoscopic approach represents a safe option for the management of HA in a semi-elective setting and when major hepatectomy is required. | Mohammed Abu Hilal Francesco Di Fabio Robert David Wiltshire Mohammed Hamdan David M Layfield Neil William Pearce | 2011 | World Journal of Gastrointestinal Surgery2011，3，7： | 4 |
| 5 | Mass spectrometry-based proteomics and peptidomics for systems biology and biomarker discovery显示文摘科学界在生物学为它的应用在集体基于 spectrometry 的 proteomics 和 peptidomics 的领域里显示出大兴趣。Proteomics 技术演变生产涉及的蛋白质或肽的大数据集合各种各样生物学并且为复杂生物学的问题产生可试验的假设的疾病前进过程。这评论包括生物学的材料选择,样品准备,分离技术,肽破碎, translational 以后修正, quantification,生物信息学,和 biomarker 在 proteomics 和 peptidomics 提供介绍给相关话题发现和确认。另外,为 proteomics 和 peptidomics 的当前的文学,留下的挑战,和新兴的技术被介绍。 | Robert CUNNINGHAM Di MA Lingjun LI | 2012 | Frontiers in Biology2012，7，4： | 3 |
| 6 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 7 | The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis <ce:link locator='fx1'/>显示文摘 | Arun J. Sanyal Robert J. Fontana Adrian M. Di Bisceglie James E. Everhart Michael C. Doherty Gregory T. Everson John A. Donovan Peter F. Malet Savant Mehta Muhammad Y. Sheikh Andrea E. Reid Marc G. Ghany David R. Gretch the HALT-C Trial Group | 2006 | Gastrointestinal Endoscopy2006，，6： | 2 |
| 8 | Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1显示文摘 | Teresa Di Desidero Anna Fioravanti Paola Orlandi Bastianina Canu Riccardo Giannini Nicla Borrelli Shan Man Ping Xu Gabriella Fontanini Fulvio Basolo Robert S. Kerbel Giulio Francia Romano Danesi Guido Bocci | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，9： | 2 |
| 9 | Inequality and happiness: are Europeans and Americans different?显示文摘 | Alberto Alesina Rafael Di Tella Robert MacCulloch | 2003 | Journal of Public Economics2003，，9： | 2 |
| 10 | Nanocapsules of oxalate oxidase for hyperoxaluria treatment显示文摘 | Ming Zhao Duo Xu Di Wu James W. Whittaker Robert Terkeltaub Yunfeng Lu | 2018 | Nano Research2018，11，5： | 2 |
| 11 | Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale: Patent Foramen Ovale in Cryptogenic Stroke Study显示文摘 | Shunichi Homma Ralph L. Sacco Marco R. Di Tullio Robert R. Sciacca J. P. Mohr | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 12 | Discovery of a wild,genetically pure Chinese giant salamander creates new conservation opportunities显示文摘Effective conservation of threatened biota relies on accurate assessments and scientific guidance.As an unfortunate example,Chinese giant salamanders(Andrias,CGS)remain critically endangered in nature.Misguided conservation efforts,e.g.,commercial propagation and releasing of millions of likely non-indigenous or interspecific hybrids,have further compromised conservation initiatives.Limited information on wild populations of CGS poses a significant conservation challenge.Following 18-month long field monitoring,we now report the discovery of a wild population of CGS in a closed nature reserve in Jiangxi Province,China.Genomic assessments reveal its genetic distinctiveness and do not detect genetic admixture with other species.Based on morphological and molecular evidences,we describe this CGS as a new species Andrias jiangxiensis sp.nov.This is the only known species of CGS today with a genetically pure,reproducing,in situ population.This discovery emphasizes the important role that closed nature reserves play in protecting species,and the necessity of integrating long-term field monitoring and genetic assessments.It sets a new pathway for discovering and conserving endangered species,especially for those biotas that are similarly being extirpated by anthropogenic translocations and overexploitation. | Jing Chai Chen-Qi Lu Mu-Rong Yi Nian-Hua Dai Xiao-Dong Weng Ming-Xiao Di Yong Peng Yong Tang Qing-Hua Shan Kai Wang Huan-Zhang Liu Hai-Peng Zhao Jie-Qiong Jin Ru-Jun Cao Ping Lu Lai-Chun Luo Robert W.Murphy Ya-Ping Zhang Jing Che | 2022 | Zoological Research2022，43，3： | 2 |
| 13 | Molecular biology of microbial ureases显示文摘 | Harryl TM Michael DI Robert PH | 1995 | Microbiol Rev1995，59，3： | 1 |
| 14 | RIBBON-l: randomized, double-blind, placebo-controlled, phase III trial of chemother- apy with or without bevacizumab for first-line treatment of hu- man epidermal growth factor receptor 2-negative, locally recur- rent or metastatic breast cancer显示文摘 | Robert NJ Di e ras V Glaspy J | 2011 | J Clin Oncol2011，29，10： | 1 |
| 15 | Portfolio based assess- ments in medical education: are they valid and reliable for sum- mative purposes 显示文摘 | Roberts C Newble DI O' Rourke AJ | 2002 | Med Educ2002，36，： | 1 |
| 16 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 17 | Local Delivery Versus Intracoronary Infusion of Abciximab in Patients With Acute Coronary Syndromes显示文摘 | Francesco Prati Davide Capodanno Tomasz Pawlowski Vito Ramazzotti Mario Albertucci Alessio La Manna Marilena Di Salvo Robert J. Gil Corrado Tamburino | 2010 | JACC: Cardiovascular Interventions2010，，9： | 1 |
| 18 | Endoplasmic reticulum aminopeptidases: biolo- and pathogenic potential 显示文摘 | Nigil H Robert DI | 2010 | Nature Reviews2010，6，： | 1 |
| 19 | Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer显示文摘 | Valentina Guarneri David Miles Nicholas Robert Véronique Diéras John Glaspy Ian Smith Christoph Thomssen Laura Biganzoli Tanya Taran PierFranco Conte | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 20 | Leukocyte Count Is Associated With Aortic Arch Plaque Thickness显示文摘 | Mitchell S.V. Elkind Robert Sciacca Bernadette Boden-Albala Shunichi Homma Marco R. Di Tullio | 2002 | Stroke: Journal of the American Heart Association2002，，11： | 1 |
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