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| 1 | Design and Simulation of Electro-hydrostatic Actuator with a Built-in Power Regulator显示文摘电动静液作动器(EHA)是一种功率电传(PBW)作动器,可将电能输入转换为局部液压能以实现飞行控制。通过取消中央液压源和液压管路,电动静液作动器的可靠性和效率获得提高,但是带宽和刚度受到限制。为解决上述问题,本文提出了一种基于能量调节的新型电动静液作动器。能量调节器由高压蓄能器和比例阀组成,可以根据不同的控制需求储存和管理液压能。提出了转移体积的概念用于评价调节器的工作能力。液压锁用于保持作动器的输出位置。仿真结果表明:经过优化的新结构有效扩展了系统频宽。 | Kang Rongjie Jiao Zongxia Wang Shaoping Chen Lisha | 2009 | Chinese Journal of Aeronautics2009，22，6： | 16 |
| 2 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 3 | Preparation of modified MFI (ZSM-5 and silicalite-1) zeolites for potassium extraction from seawater显示文摘 | Rongjie Ling Wu Chen Jin Hou | 2018 | Particuology2018，16，1： | 2 |
| 4 | Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction显示文摘 | Chongming Wu Yan Li Yan Chen Xinyuan Lao Linghui Sheng Rongji Dai Weiwei Meng Yulin Deng | 2010 | Phytomedicine2010，，4： | 1 |
| 5 | Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP显示文摘PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide(PACAP),which mediates neuroprotective and nerve regenerative activities of PACAP.In this study,we found that in both PAC1R-CHO cells with high expression of PAC1R-eGFP and retinal ganglion cells(RGC-5)with the natural expression of PAC1-R,oligo-peptide PACAP(28-38)and the positively charged arginine-rich penetrating peptide TAT,as positive allosteric modulators of PAC1-R,significantly trigger the nuclear translocation of PAC1-R.The chromatin immunoprecipitation(ChIP)-PCR results show that the nuclear translocated PAC1-R binds with the promoter regions of PAC1-R and its specific ligand PACAP.The up-regulated promoter activities of PAC1-R and PACAP induced by PACAP(28-38)or TAT are positively correlative with the increase of the expression levels of PAC1-R and PACAP.Moreover,the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT is significantly inhibited by the mutation of PAC1-R on Cys25 and the palmitoylation inhibitor 2-bromopalmitate.Meanwhile,the increase in both PAC1-R and PACAP levels and the neuroprotective activities of PACAP(28-38)and TAT in MPPinduced cell model of Parkinson’s disease are synchronously inhibited by 2-bromopalmitate,which are positively correlated with the nuclear translocation of PAC1-R induced by PACAP(28-38)or TAT.Bioinformatics analysis and motif enrichment analysis following ChIP-sequencing show that the transcription factors including SP1,Zic2,GATA1,REST and YY1 may be recruited by nuclear PAC1-R and involved in regulating the promoter activities of PAC1-R and PACAP.ChIP-sequencing and related bioinformatics analysis show that the downstream target genes regulated by the nuclear PAC1-R are mostly involved in the process of cellular stress and related to neuroprotection,neuronal genesis and development. | Guangchun Fan Zhengxin Tao Shang Chen Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 6 | Establishing and anal- ysis of the noise model in the ventilation room 显示文摘 | WANG Rongjie CHEN Hongwei | 2008 | Jour- nal of Huaqiao University : Natural Science2008，29，1： | 1 |
| 7 | Testing and Modeling of the Dynamic Response Characteristics of Pulsating Heat Pipes during the Start-up Process显示文摘Pulsating heat pipes(PHPs) are two-phase heat transfer heat pipes with high heat transfer capability and simple structure. Heating power is an important factor that affects the start-up response characteristics of PHPs. The operational characteristics during the start-up and stable operating stages were studied through experiments, and the corresponding dynamic response model under a specified heating power was established based on experimental data and flow pattern in the tube. The starting time, starting temperature, and dynamic response characteristic parameters at a certain heating power were calculated by the dynamic response model. The response characteristics of working fluid during the stable operation of PHPs were deduced based on the dynamic response curve of PHPs during the non-operational and stable operation stages. The response characteristics of PHPs for the step effect(given heating power) were quantitatively described by amplification factor K and time constant τ, thereby presenting the basis for the study on heat and mass transfer mechanisms of PHPs from non-operational to steady operation stage. Results showed that the minimum thermal resistance and the minimum time constant of the PHP are approximately 0.28 °C/W and 75, respectively, obtained at a heating power of 160 W. Moreover, these results indicated that the dynamic response of PHPs demonstrates a favourable performance and rapidly reaches another stable working state when their heat transfer performance is stable. However, the dynamic response time constant of pure fluids decreases when the quantity of the liquid working fluid in the PHP decreases with the increase in heating power. | XU Rongji CHEN Hao WU Qingping XU Shuhui WANG Ruixiang | 2019 | Journal of Thermal Science2019，28，1： | 1 |
| 8 | The hydrothermal synthesis of sodium manganese oxide and a lithium vanadium oxide显示文摘 | Chen Rongji Chirayil T Zavalij P | 1996 | Solid State Ionics1996，，1： | 1 |
| 9 | Rapid Purifi- eation of Lys-C from Lysobacter enzymogenes Cultures 显示文摘 | Philip A K Rongji Chen Aleantara J | 2009 | BioProeess International2009，28，： | 1 |
| 10 | Heat Leakage Numerical Investigation of a Compound Parabolic ConcentratorPulsating Heat Pipe Solar Collector显示文摘As a new type of equipment for solar medium temperature utilization, the compound parabolic concentrator-pulsating heat pipe solar collector(CPC-PHPSC) uses pulsating heat pipe(PHP) as an endotherm, which can realize efficient energy conversion. The design of proper concentration ratio of compound parabolic concentrator(CPC) ensures that the incident sunlight can be concentrated on the evaporator section surface of PHP without solar tracking system. The objective of the present work is to study the influence of solar radiation intensity, air speed, material thickness(glass and insulation board) and tilt angle on the thermal performance of the new collector, which is difficult to control in the experiment. The heat leakage process and characteristics of the CPC-PHPSC were numerically studied by establishing a 3D numerical model of the collector unit. The results show that the theoretical collector efficiency of CPC-PHPSC reaches 74.5%, which is consistent with the experimental results. During operation, the heat collection performance is the best when the tilt angle is 45° and the solar radiation intensity is 1000 W/m^(2), while the excessive air speed will increase the convective heat loss. Increasing the thickness of insulation board and glass has little effect on the collector efficiency. | XU Rongji CHEN Jingyan ZHANG Xiaohui WANG Ruixiang XU Shuhui | 2022 | Journal of Thermal Science2022，31，5： | 0 |
| 11 | Variation in Bombyx mori immune response against fungal pathogen Beauveria bassiana with variability in cell wallβ-1,3-glucan显示文摘Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of fungi.However,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain unclear.Three Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx mori.The molecular mechanisms underlying the immune response in B.mori were investigated using RNA sequencing,which revealed differences in the immune response to different B.bassiana strains at 12 h post-infection.Immunofluorescence assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence strains.BmβGRP4 silencing in B.mori with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of B.bassiana was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by BmβGRP4.Furthermore,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between B.bassiana strains.These results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of B.mori. | Yulong Wang Zhen Liu Xuebing Yin Shihong Liu Kai Wang Rongjie Wan Haoran Chen Xinyang Li Bo Huang | 2024 | Insect Science2024，31，1： | 0 |
| 12 | Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex显示文摘Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction. | Zongqin Xiang Shu He Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long Ma Ying Sun Yongpeng Qin Yi Chen Wen Li Xiangyu Wang Gong Chen Wenliang Lei | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 13 | A VIRTUAL MESH METHOD FOR THE OPTIMIZED DESIGN OF COMPLEX STRUCTURES显示文摘Concepts for a virtual 3D space and a hyper-sphere are proposed and the formulae for determining the computable nodes of the mesh are derived. Then a new optimization design method ('Virtual Mesh Method' or V.M.M) is developed. Three examples are given, showing that the method proposed is especially suitable for the optimized design of complex structures, and that the global approximate optimal solution can be searched with remarkably reduced computational work. | Du Taisheng Huang Rongjie Song Tianxia Chen Chuanyao (College of Civil Engineering and Mechanics,Huazhong University of Science and Technology,Wuhan 430074,China) | 2003 | Acta Mechanica Solida Sinica2003，16，3： | 0 |
| 14 | A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model显示文摘As a neuropeptide pituitary adenylate cyclase-activating polypeptide(PACAP)-preferring receptor,PAC1-R mediates effective neuroprotective activity.Based on the finding that the antibiotic doxycycline(DOX)with clinical neuroprotective activity functions as a positive allosteric modulator(PAM)of neuropeptide PACAP receptor 1(PAC1-R),we use virtual and laboratory screening to search for novel small molecule PAMs of PAC1-R.Virtual screening is carried out using a small-molecule library TargetMol.After two-level precision screening with Glide,the top five compounds with the best predicted affinities for PAC1-R are selected and named small positive allosteric modulator 1-5(SPAM1-5).Our results show that only 4-[4-(4-Oxo-3,4-2-yl)butanamido]methyl)benzoic acid(SPAM1)has stronger neuroprotective activity than DOX in the MPP+PD cell model and MPTP PD mouse model.SPAM1 has a higher affinity for PAC1-R than DOX,but has no antibiotic activity.Moreover,both SPAM1 and DOX block the decrease of PAC1-R level in mouse brain tissues induced by MPTP.The successful screening of SPAM1 offers a novel drug for the treatment of neurodegenerative disease targeting the PAC1-R. | Guangchun Fan Shang Chen Zhengxin Tao Huahua Zhang Rongjie Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 15 | Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells显示文摘The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secreting inflammatory cytokines, and is an important target in the treatment of nerve inflammation and neurodegenerative diseases. In the present study, we observed the effects of transfecting three amyloid precursor-like protein 2(APLP2) C-terminal fragments(CTFs; C57, C50 and C31) in the p EGFP-N1 vector on S100A9 expression in BV2 cells. Reverse transcription-PCR, western blot assay and immunocytochemistry revealed that S100A9 protein and m RNA expression was greater in BV2 cells after CTF transfection than after mock transfection with an empty vector. Furthermore, transfection of full-length APLP2-751 resulted in low levels of S100A9 protein expression. Our results show that APLP2-CTFs upregulate S100A9 protein and m RNA expression in BV2 cells, and identify a novel pathway involved in neuronal injury and apoptosis, and repair and protection in Alzheimer's disease. | Guangzhe Li Hui Chen Lin Cheng Rongjie Zhao Junchang Zhao Yanji Xu | 2014 | Neural Regeneration Research2014，9，21： | 0 |
| 16 | MET fusions and splicing variants convergently defne a subgroup of glioma sensitive to MET inhibitors显示文摘Purpose:Our previous study has shown that PTPRZ1-MET(ZM)fusion is a viable target for MET inhibitors in gliomas.However,the diversity and prevalence of somatic MET alterations in difuse gliomas are still elusive and need to be extensively characterized for identifying novel therapeutic targets.Methods:Totally,1,350 glioma patients and 31 patient-derived cells were collected from the Chinese Glioma Genome Atlas(CGGA)and published data.All kinds of MET fusions and/or splicing variants(MET F/SVs)were identifed by bioinformatical methods.Single-cell RNA sequencing(scRNA-seq)were used for validation.In vitro experiments of drug resistance were conducted for the possibility of MET-targeted treatment.Results:MET F/SVs but not genomic amplifcation,were highly enriched in the secondary glioblastomas(sGBM)and marked worse prognosis.Further molecular and scRNA-seq analysis revealed that MET F/SVs were induced in the course of glioma evolution and highly associated with MET overexpression.Subsequent in vitro and the clinical study showed that cells and patients harboring MET F/SVs have better response to MET inhibitors.Conclusion:Our fndings expanded the percentage of gliomas with abnormal MET alterations and suggested that a subgroup of gliomas harboring MET F/SVs may beneft from MET-targeted therapy. | Ke-Nan Zhang Zheng Zhao Jing Chen Zhaoshi Bao Rui-Chao Chai Zhiyan Sun Lingxiang Wu Zhiliang Wang Hanjie Liu Quanhua Mu Huimin Hu Fan Zeng Zheng Wang Guanzhang Li Yuanhao Chang Qiangwei Wang Fan Wu Ying Zhang Yuqing Liu Chunjie Jiang Ulf Dietrich Kahlert Do-Hyun Nam Wei Zhang Chunsheng Kang Jiguang Wang Rongjie Tao Qianghu Wang Tao Jiang | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 17 | Uncertainty Quantification of Store-Separation Simulation Due to Ejector Modeling using a Monte Carlo Approach with Kriging Model显示文摘Precise calculation of the trajectory of store separation is critical in assess-ing whether the store can be released safely.Store ejection is the initial stage of the releasing process and any uncertainty introduced at this stage will propagate through the whole trajectory.In this work,the impact of the uncertainties in ejector modeling on the simulation of a generic store separation is investigated by using a Monte-Carlo-based approach.To reduce the extremely large computation cost resulted from the direct use CFD in Monte Carlo simulation,the CFD solutions are represented by a time-dependent Kriging model,which is constructed at each time step by using the samples from the URANS simulations.The stochastic outputs,including the distri-bution of probability density function,expected value and 95%confidence interval of store separation trajectory,are obtained by the Monte Carlo simulations.The sensitiv-ity analysis is also carried out by using the Monte-Carlo-based method to determine the most significant variables in ejector modeling,which affect the output uncertainty.Our results show that ejector modeling is one of the main uncertainty sources of store separation simulation and the approximation in ejector modeling can cause a signifi-cant deviation,especially in the angular displacement. | Shuling Tian Rongjie Li Jiawei Fu Zihan Jiao Jiangtao Chen | 2022 | Advances in Applied Mathematics and Mechanics2022，14，3： | 0 |
| 18 | Unprecedent green macroalgae bloom:mechanism and implication to disaster prediction and prevention显示文摘Green macroalgae bloom(GMB),with the dominant species of Ulva prolifera,has regularly occurred since 2007 along the China coast.Although disaster prevention and control achieved favorable results in 2020,the satellite-observed GMB annual maximum coverage(AMC)rebounded sharply in 2021 to an unprecedented level.The reasons for this rebound and the significant interannual variability over past 15 years are still open questions.Here,by using long-term time-series(2007-2022)optical and Synthetic Aperture Radar satellite observations(1000+scenes),meteorological data and water quality statistics,the mechanism analysis was performed by exploring effects from natural factors and human activities.Two key determinants for AMC are successfully identified from numerous potential factors which are the macroalgae distribution in a key area(the Subei Shoal)during a critical period(from April to May 20)and the nutrient availability.Furthermore,by using these two parameters,a novel model for AMC prediction(R^(2)=0.87,p<0.01)is proposed and independently validated,which can reasonably explain the significant interannual variability(2014-2021)and agree well with the latest observation in 2022(percentage difference 12%).Finally,suggestions are proposed for future disaster prevention and alleviation.This work may aid future bloom prediction and management measure optimization. | Mengmeng Cao Xuyan Li Tingwei Cui Xinliang Pan Yan Li Yanlong Chen Ning Wang Yanfang Xiao Xingai Song Yuzhu Xu Runa A Bing Mu Song Qing Rongjie Liu Wenjing Zhao Yuhai Bao Jie Zhang Lan Wei | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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