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| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 3 | Risk Factors for Lymph Node Metastasis from Gastric Cancers with Submucosal Invasion显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Shigeo Aoki Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato | 2010 | Annals of Surgical Oncology2010，，6： | 2 |
| 4 | Endoscopic submucosal dissection for cancers of the remnant stomach after distal gastrectomy显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Takao Tsuzuki Satoru Yagi Jun Kato Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Masahiro Nakagawa Motowo Mizuno Tomoki Inaba Tatsuya Toyokawa Kohsaku Sakaguchi | 2008 | Gastrointestinal Endoscopy2008，，2： | 2 |
| 5 | Methylation of BNIP3 and DAPK indicates lower response to chemotherapyand poor prognosis in gastric cancer显示文摘 | Hirofumi Sugita Satoru Iida Mikito Inokuchi Keiji Kato Megumi Ishiguro Toshiaki Ishikawa Yoko Takagi Megumu Enjoji Hiroyuki Yamada Hiroyuki Uetake Kazuyuki Kojima Kenichi Sugihara | 2011 | Oncology Reports2011，，2： | 2 |
| 6 | Use of the “supercharge” technique in esophageal and pharyngeal reconstruction to augment microvascular blood flow显示文摘 | Mitsuru Sekido Yuhei Yamamoto Hidehiko Minakawa Satoru Sasaki Hiroshi Furukawa Tsuneki Sugihara Kunihiko Nohira Kazuyoshi Yajima Yoshihisa Shintomi Syunichi Okushiba Hiroyuki Kato Masao Hosokawa | 2003 | Surgery2003，，3： | 1 |
| 7 | Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation显示文摘 | Takeshi Hori Kenji Nagata Satoru Hasuike Masaaki Onaga Mizue Motoda Akihiro Moriuchi Hisayoshi Iwakiri Hirofumi Uto Jyunya Kato Akio Ido Katsuhiro Hayashi Hirohito Tsubouchi | 2003 | Journal of Gastroenterology2003，，10： | 1 |
| 8 | C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma显示文摘 | Futoshi Kawamata Shigenori Homma Hirofumi Kamachi Takahiro Einama Yasutaka Kato Masumi Tsuda Shinya Tanaka Masahiro Maeda Kazunori Kajino Okio Hino Norihiko Takahashi Toshiya Kamiyama Hiroshi Nishihara Akinobu Taketomi Satoru Todo | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 9 | Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells显示文摘 | Yoshiki Koriyama Yuya Nakayama Seiichi Matsugo Kayo Sugitani Kazuhiro Ogai Tsuneo Takadera Satoru Kato | 2013 | Neuroscience Research . 2013 (1-2)2013，，1： | 1 |
| 10 | Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Masafumi Inoue Seiji Kawano Daisuke Tanioka Takao Tsuzuki Satoru Yagi Jun Kato Masayuki Uemura Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Kazuhide Yamamoto | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 11 | Polymer waveguide module for visible wavelength divi- sion multiplexing plastic optical fiber communication显示文摘 | Masatoshi Yonemura Akari Kawasaki Satoru Kato | 2005 | Optics Letters2005，30，17： | 1 |
| 12 | Geochemistry and mineralogy of REY-rich mud in the eastern Indian Ocean显示文摘 | Kazutaka Yasukawa Hanjie Liu Koichiro Fujinaga Shiki Machida Satoru Haraguchi Teruaki Ishii Kentaro Nakamura Yasuhiro Kato | 2014 | Journal of Asian Earth Sciences2014，，： | 1 |
| 13 | Differentiating sclerosing cholangitis caused by autoimmune pancreatitis and primary sclerosing cholangitis according to endoscopic duodenal papillary features显示文摘 | Kensuke Kubota Shingo Kato Tomoyuki Akiyama Masato Yoneda Koji Fujita Masami Ogawa Masahiko Inamori Noritoshi Kobayashi Satoru Saito Yukio Kakuta Hisashi Ohshiro Atsushi Nakajima | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 14 | A case of breast cancer metastatic to the tail of the pancreas显示文摘 | Noriyuki Tohnosu Kazuo Narushima Keita Sunouchi Takeshi Saito Takanori Shimizu Hajime Tanaka Takashi Maruyama Yoshiji Watanabe Taku Kato Shinichiro Shimizu Toshitaka Uehara Satoru Ishii | 2006 | Breast Cancer2006，，2： | 1 |
| 15 | Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama Atsushi Nakajim | 2007 | Journal of Gastroenterology2007，，5： | 1 |
| 16 | Product modularization for parts reuse in inverse manufacturing 显示文摘 | Fumihiko Kimura Satoru Kato Tomoyuki Hata | 2001 | Annals of CIRP2001，50，1： | 1 |
| 17 | High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Hiroshi Iida Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama At | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 18 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging During Laparoscopic Surgery in Gastric Cancer显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato Mitsuo Kusano | 2010 | Annals of Surgical Oncology2010，，7： | 1 |
| 19 | Preoperative Embolization Significantly Decreases Intraoperative Blood Loss During Palliative Surgery for Spinal Metastasis显示文摘 | Kato Satoshi Murakami Hideki Minami Tetsuya Demura Satoru Yoshioka Katsuhito Matsui Osamu Tsuchiya Hiroyuki | 2012 | EN2012，，： | 1 |
| 20 | Product modularization for parts reuse in inverse manufacturing显示文摘 | Fumihiko Kimura Satoru Kato Tomoyuki Hata | 2001 | Annals of CIRP2001，50，1： | 1 |
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