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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Synthesis and Enhanced Photocatalytic Activity of Regularly Shaped Cu2O Nanowire Polyhedra显示文摘一系列唯一的 nanowire 上层建筑, Cu2O nanowire polyhedra,通过一条划算的热水的线路被综合了。nanowire polyhedra 的三种类型,也就是 octahedra,凹面 octahedra,和昆虫,被面对羧基的酸与 o-anisidine 或 o-phenetidine 减少含铜的醋酸盐在高词法的收益(90%) 形成。这些 Cu2O nanowire polyhedra 的体系结构被电子显微镜学检验,它在多面的轮廓以内揭示了订的、高度排列的 Cu2O nanowires。Cu2O nanowire polyhedra 的生长被取向和被羧基的酸的增加调整的 nanowire 分支的生长率控制。比作样品在最近的文学报导了的 Cu2O, Cu2O nanowire octahedra 展览显著地在可见的光下面面对 H2O2 为染料降级提高了 photocatalytic 活动,可能,由于高密度的费用搬运人,从有他们的专辑的分叉的 nanowires 的 photoexcited 组织。另外,在当为染料的直接 photodegradation 的 H2O2 不在时的 Cu2O 的 photocatalytic 活动的最近的文学的讨论似乎可疑。 | Jing Shi Jin LI Xiaojian Huang Yiwei Tan | 2011 | Nano Research2011，4，5： | 12 |
| 3 | Ultrahigh-Q silicon racetrack resonators显示文摘An ultrahigh-Q silicon racetrack resonator is proposed and demonstrated with uniform multimode silicon photonic waveguides.It consists of two multimode straight waveguides connected by two multimode waveguide bends(MWBs).In particular,the MWBs are based on modified Euler curves,and a bent directional coupler is used to achieve the selective mode coupling for the fundamental mode and not exciting the higher-order mode in the racetrack.In this way,the fundamental mode is excited and propagates in the multimode racetrack resonator with ultralow loss and low intermode coupling.Meanwhile,it helps achieve a compact 180°bend to make a compact resonator with a maximized free spectral range(FSR).In this paper,for the chosen 1.6μm wide silicon photonic waveguide,the effective radius Reffof the designed 180°bend is as small as 29μm.The corresponding FSR is about 0.9 nm when choosing 260μm long straight waveguides in the racetrack.The present high-Q resonator is realized with a simple standard single-etching process provided by a multiproject wafer foundry.The fabricated device,which has a measured intrinsic Q-factor as high as 2.3×10~6,is the smallest silicon resonator with a>106Q-factor. | LONG ZHANG LANLAN JIE MING ZHANG YI WANG YIWEI XIE YAOCHENG SHI DAOXIN DAI | 2020 | Photonics Research2020，8，5： | 7 |
| 4 | Wavelength-selective 2 × 2 optical switch based on a Ge2Sb2Te5-assisted microring显示文摘A novel wavelength-selective 2×2 optical switch based on a Ge2Sb2Te5(GST)-assisted microring-resonator(MRR)is proposed.The present GST-assisted MRR consists of two access optical waveguides and an MRR coupled with a bent GST-loaded silicon photonic waveguide.The 2×2 optical switch is switched ON or OFF by modifying the GST state to be crystalline or amorphous.In particular,the microring waveguide and the bent GST-loaded waveguide are designed to satisfy the phase-matching condition when the GST is crystalline.As a result,the MRR becomes highly lossy and the resonance peak is depressed significantly.On the other hand,when it is off,there is little coupling due to the significant phase mismatching.Consequently,one has a low-loss transmission at the drop port for the resonance wavelength.In this paper,the simulation using the three-dimensional finite-difference method shows that the extinction ratio of the designed photonic switch is^20 d B at the resonance wavelength,while the excess losses at the through port and drop port are 0.9 d B and 2 d B.In particular,the resonance wavelength changes little between the ON and OFF states,which makes it suitable for multichannel wavelength-division-multiplexing systems. | Changping Zhang Ming Zhang Yiwei Xie Yaocheng Shi Rajesh Kumar Roberto R.Panepucci Daoxin Dai | 2020 | Photonics Research2020，8，7： | 3 |
| 5 | Clinical study of transcatheter occlusion in treating ventricular septal defect combined with right coronary cusp bulge显示文摘Background: Perimembranous ventricular septal defect combined with right coronary cusp bulge generally should be treated with surgical thoracotomy, owing to the potential aortic regurgitation. However, the minimally invasive method of transcatheter closure has always attracted the attention of cardiologists and patients. The present study aimed to apply transcatheter occlusion in treating ventricular septal defect with right coronary cusp bulge and further evaluate the clinical effect through follow-up. Materials and methods: A total of 40 children diagnosed as having a ventricular septal defect with right coronary cusp bulge, examined using transthoracic echocardiography and cardiovascular angiography, were enrolled in this study. The ventricular septal defects were closed by placing occluders through transcatheter occlusion treatment. During the operation process, the children underwent angiography and transthoracic echocardiography examinations to check the position of the occlude and the extent of aortic regurgitation. The influence of occlusion on the conduction system was evaluated using a surface electrocardiogram. The children were followed up after their procedures. Results: All 40 patients were immediately and successfully occluded. Three patients with filament residual shunts were observed during the operations. No major surgical complications occurred during the perioperative period. During the follow-up period, the positions of all the occluders were good, the residual shunts in the three patients disappeared, and no new or aggravated aortic regurgitation occurred. Electrocardiogram did not reveal any atrioventricular blocks. Only one patient suffered from an incomplete right bundle branch block. Conclusions: Children diagnosed with ventricular septal defect combined with right coronary cusp bulge could be considered for transcatheter occlusion. With appropriate indications and methods, the effect may be favorable. | Wei Ji Zhifang Zhang Wenchuo Zhao Jie Shen Lijun Fu Lin Shi Yiwei Chen Fen Li | 2018 | Journal of Interventional Medicine2018，1，4： | 3 |
| 6 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 7 | Effect of zinc addition on catalytic properties of PtSnK/γ-Al 2 O 3 catalyst for isobutane dehydrogenation显示文摘 | Yiwei Zhang Yuming Zhou Junjun Shi Xiaoli Sheng Yongzheng Duan Shijian Zhou Zewu Zhang | 2012 | Fuel Processing Technology2012，，： | 1 |
| 8 | Effect of znic ad- dition on catalytic properties of Pt - Sn - K/y - AI203 catalyst for isobutane dehydrogenation 显示文摘 | Zhang Yiwei Zhou Yuming Shi Junjun | 2012 | Fuel Processing Technology2012，93，96： | 1 |
| 9 | The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice显示文摘Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus. | Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong Deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li Zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 10 | 显示文摘 | TAN YIWEI SHI CHUNSHAN | 2000 | J Solid State Chemistry2000，150，： | 1 |
| 11 | Comparative study of bimetallic Pt - Sn catalysts supported on different supports for propane dehydrogenation 显示文摘 | Zhang Yiwei Zhou Yuming Shi Junjun ct al | 2014 | Journal of Molecular Catalysis A : Chemical2014，160，381： | 1 |
| 12 | Effect of zinc addition on catalytic properties of PtSnK/γ-Al2 O3 catalyst for isobutane dehydrogenation显示文摘 | Zhang Yiwei Zhou Yuming Shi Junjun | | 0，，： | 1 |
| 13 | Propane dehydrogena- tion over PtSnNa/La - doped A1203 catalyst: Effect of La eon- tent显示文摘 | Zhang Yiwei Zhou Yuming Shi Junjun | 2013 | Fuel Processing Technology2013，，111： | 1 |
| 14 | Synthesis ofmagnesium-modified mesoporous A1203 with enhanced cat-alytic performance for propane dehydrogenation 显示文摘 | Shi Junjun Zhou Yuming Zhang Yiwei | 2014 | Journalof Materials Science2014，49，16： | 1 |
| 15 | Flexible silver-coated hollow fibers for remote Raman spectroscopic measurements显示文摘 | Liu Binghong Shi Yiwei | 2013 | Appl Opt2013，52，21： | 1 |
| 16 | Practice of improving the hot blast temperature for the 2500 m^3 BF显示文摘A high blast temperature is an effective measure that improves pulverized coal injection(PCI)and energy consumption,decreases the cost of blast furnaces(BF).Apart from using technology such as the increased vault temperature of the hot-blast stove,the increased temperature of the waste gas,the preheating of combustion air and gas, and fully closed mixed air valves,other measures,such as using an oxygen-enriched blast stove,burning high heating value converter gas,increasing the number of stove changes to reduce the time needed for stove blasts,were taken to increase the blast temperature of the 2500 m^3 BF in recent years.The blast temperature of the 2500 m^3 BF was continuously increased in these years.The monthly average temperature of the 2500 m^3 BF reached 1158℃,with the highest blast temperature reaching 1195℃in 2006.This technique of increased blast temperatures has reached an advanced level in China. | Li Yiwei Shi Jian' en Bao Lei Wang Yi | 2008 | Baosteel Technical Research2008，2，2： | 0 |
| 17 | Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor显示文摘P-glycoprotein(P-gp)highly expressed in cancer cells can lead to multidrug resistance(MDR)and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment.In this study,we established a label-free and detergent-free system combining surface plasmon resonance(SPR)biosensor with styrene maleic acid(SMA)polymer membrane proteins(MPs)stabilization technology to screen potential P-gp inhibitors.First,P-gp was extracted from MCF-7/ADR cells using SMA polymer to form SMA liposomes(SMALPs).Following that,SMALPs were immobilized on an SPR biosensor chip to establish a P-gp inhibitor screening system,and the affinity between P-gp and small molecule ligand was determined.The methodological investigation proved that the screening system had good specificity and stability.Nine P-gp ligands were screened out from 50 natural products,and their affinity constants with P-gp were also determined.The in vitro cell verification experiments demonstrated that tetrandrine,fangchinoline,praeruptorin B,neobaicalein,and icariin could significantly increase the sensitivity of MCF-7/ADR cells to Adriamycin(Adr).Moreover,tetrandrine,praeruptorin B,and neobaicalein could reverse MDR in MCF-7/ADR cells by inhibiting the function of P-gp.This is the first time that SMALPs-based stabilization strategy was applied to SPR analysis system.SMA polymer can retain P-gp in the environment of natural lipid bilayer and thus maintain the correct conformation and physiological functions of P-gp.The developed system can quickly and accurately screen small molecule ligands of complex MPs and obtain affinity between complex MPs and small molecule ligands without protein purification. | Yuhong Cao Jiahao Fang Yiwei Shi Hui Wang Xiaofei Chen Yue Liu Zhenyu Zhu Yan Cao Zhanying Hong Yifeng Chai | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 0 |
| 18 | Automated cone photoreceptor cell identication in confocal adaptive optics scanning laser ophthalmoscope images based on object detection显示文摘Cone photoreceptor cell identication is important for the early diagnosis of retinopathy.In this study,an object detection algorithm is used for cone cell identication in confocal adaptive optics scanning laser ophthalmoscope(AOSLO)images.An effectiveness evaluation of identication using the proposed method reveals precision,recall,and F_(1)-score of 95.8%,96.5%,and 96.1%,respectively,considering manual identication as the ground truth.Various object detection and identication results from images with different cone photoreceptor cell distributions further demonstrate the performance of the proposed method.Overall,the proposed method can accurately identify cone photoreceptor cells on confocal adaptive optics scanning laser ophthalmoscope images,being comparable to manual identication. | Yiwei Chen Yi He Jing Wang Wanyue Li Lina Xing Xin Zhang Guohua Shi | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 0 |
| 19 | Advances in Multiplexed Microfluidics for Infectious Disease Detection显示文摘Microfluidics enables miniaturization,functionality,high throughput and reproducibility of multipathogen detection.Multiplexed microfluidic devices are electrochemical sensor–based,optical sensor–based,immunosensor-based and paper-based multiplexed microfluidics.However,the simultaneous detection ofmultiple pathogens is limited because of the complexity and diversity of infectious disease sources and mutual interference among analytes.This review provides an overview of recent advances in developing multiplex diagnostic microfluidic devices for detecting infectious diseases and discusses practical issues and perspectives.This review also coversmicrofluidic nucleic acid amplification strategies to improve detection sensitivity.Finally,we discuss the limitations and challenges in the design of multiplexed microfluidics. | Yiwei Shi Jiayi Zhao Guangwen Cao | 2023 | Infectious Microbes & Diseases2023，5，2： | 0 |
| 20 | Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy显示文摘The effect of anti-programmed cell death 1(anti-PD-1)immunotherapy is limited in patients with hepatocellular carcinoma(HCC).Yes-associated protein 1(YAP1)expression increased in liver tumor cells in early HCC,and Akkermansia muciniphila abundance decreased in the colon.The response to anti-PD-1 treatment is associated with A.muciniphila abundance in many tumors.However,the interaction between A.muciniphila abundance and YAP1 expression remains unclear in HCC.Here,anti-PD-1 treatment decreased A.muciniphila abundance in the colon,but increased YAP1 expression in the tumor cells by mice with liver tumors in situ.Mechanistically,hepatocyte-specific Yap1 knockout(Yap1^(LKO))maintained bile acid homeostasis in the liver,resulting in an increased abundance of A.muciniphila in the colon.Yap1 knockout enhanced anti-PD-1 efficacy.Therefore,YAP1 inhibition is a potential target for increasing A.muciniphila abundance to promote anti-PD-1 efficacy in liver tumors.Dihydroartemisinin(DHA),acting as YAP1 inhibitor,increased A.muciniphila abundance to sensitize anti-PD-1 therapy.A.muciniphila by gavage increased the number and activation of CD8^(+)T cells in liver tumor niches during DHA treatment or combination with anti-PD-1.Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment. | Zhiqin Zhang Xinli Shi Jingmin Ji Yinglin Guo Qing Peng Liyuan Hao Yu Xue Yiwei Liu Caige Li Junlan Lu Kun Yu | 2023 | Frontiers of Medicine2023，17，4： | 0 |
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