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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 3 | Occurrence, sources and fate of pharmaceuticals and personal care products in the groundwater: A review显示文摘The presence of pharmaceuticals and personal care products(PPCPs)in the aquatic environment may pose potential threat to the ecosystem and human health,hence PPCPs have aroused much concern over the world.The contamination of PPCPs in the groundwater,the main source of drinking water supply in many countries and regions,has been extensively studied in the last decade.This paper reviews the occurrence of frequently detected PPCPs,including antibiotics,anti-inflammatories,lipid-regulators,carbamazepine,caffeine,and N,N-diethyl-m-toluamide in groundwater,with special concern to the progress made over the past three years.Possible emission sources for PPCPs in groundwater,such as wastewater and contaminated surface water,landfills,septic systems,livestock breeding and sewer leakage,are summarized.Besides,adsorption,migration and degradation,the dominant mechanisms in the subsurface transport and fate of PPCPs,are discussed,and the insights into the future study of PPCPs in the groundwater are provided. | Qian Sui Xuqi Cao Shuguang Lu Wentao Zhao Zhaofu Qiu Gang Yu | 2015 | Emerging Contaminants2015，1，1： | 20 |
| 4 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 5 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 6 | Removal of pharmaceutical and personal care products by sequential ultraviolet and ozonation process in a full-scale wastewater treatment plant显示文摘在市政的废水处理植物(WWTP ) 的适当先进处理过程的应用程序就新兴的沾染物的消除而言成为了一个重要问题,例如药品、个人的照顾产品(PPCP ) 。在现在的学习,属于不同的治疗学的班由的 13 PPCP 的移动顺序紫外(紫外) 并且在在北京的照原尺寸的 WWTP 的 ozonation 过程在十个月的功课上被调查。大多数目标 PPCP 有效地被移开,并且单个 PPCP 的中部的移动效率,从 13% ~ 89%,依赖于他们有分子的臭氧的反应率常数。在一样的 PPCP 的移动效率的显著变化在不同采样运动被观察。不过,顺序紫外并且仍然在照原尺寸的 WWTP 成为重要贡献到大多数 PPCP 的全部的消除的 ozonation 过程,由由生物学的处理补偿 PPCP 的差或变动的移动性能处理。 | Qian SU Jun HUANG Shuguang LU Shubo DENG Bin WANG Wentao ZHAO Zhaofu QIU Gang YU | 2014 | Frontiers of Environmental Science & Engineering2014，8，1： | 6 |
| 7 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 8 | Simplified analysis of frame structures with viscoelastic dampers considering the effect of soil-structure interaction显示文摘In this study, simplified numerical models are developed to analyze the soil-structure interaction(SSI) effect on frame structures equipped with viscoelastic dampers(VEDs) based on pile group foundation.First, a single degree-offreedom(SDOF) oscillator is successfully utilized to replace the SDOF energy dissipated structure considering the SSI effect.The equivalent period and damping ratio of the system are obtained through analogical analysis using the frequency transfer function with adoption of the modal strain energy(MSE) technique.A parametric analysis is carried out to study the SSI effect on the performance of VEDs.Then the equilibrium equations of the multi degree-of-freedom(MDOF) structure with VEDs considering SSI effect are established in the frequency domain.Based on the assumption that the superstructure of the coupled system possesses the classical normal mode, the MDOF superstructure is decoupled to a set of individual SDOF systems resting on a rigid foundation with adoption of the MSE technique through formula derivation.Numerical results demonstrate that the proposed methods have the advantage of reducing computational cost, however, retaining the satisfactory accuracy.The numerical method proposed herein can provide a fast evaluation of the efficiency of VEDs considering the SSI effect. | Zhao Xuefei Wang Shuguang Du Dongsheng Liu Weiqing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 6 |
| 9 | Preparation of alumina supported on carbon nano-tubes and its application in fluoride adsorption from an aqueous solution显示文摘A novel material, alumina supported on carbon nanotubes (Al2O3/CNT), was prepared from carbon nano-tubes and A1(NO3)3. X-ray diffraction (XRD) spectra demonstrate that alumina is amorphous, and scanning electron microscope (SEM) images show that CNT and alumina are homogeneously mixed. Furthermore, the fluoride adsorption behavior on the surface of Al2O3/CNT has been investigated and compared with other adsorbents. The results indicate that Al2O3/CNT has a high adsorption capacity, with a saturation adsorption capacity of 39.4 mg/g. It is also found that the adsorption capacity of Al2O3/CNT is 3.0-4.5 times that of γ-Al2O3 while almost equal to that of IRA-410 polymeric resin at 25°C . The adsorption isotherms of fluoride on Al2O3/CNT fit the Freundlich equation well, and optimal pH ranging from 5.0 to 9.0. | WANG Shuguang LI Yanhui ZHAO Dan XU Cailu LUAN Zhaokun LIANG Ji WU Dehai | 2002 | Chinese Science Bulletin2002，47，9： | 5 |
| 10 | Graphitizing N-doped mesoporous carbon nanospheres via facile single atom iron growth for highly efficient oxygen reduction reaction显示文摘Single atom catalyst is of great importance for the oxygen reduction reaction(ORR).However,facile preparation of single atom catalyst without using well-designed precursors or labor-intensive acid leaching remains an urgent challenge.Herein,a simple pyrolysis of Fe3+-loaded mesoporous phenolic resin(mPF)-melamine precursor is used to prepare the single atom iron-anchored N-doped mesoporous graphitic carbon nanospheres(Fe/N-MGN).Investigation of the synthesis reveals the appropriate Fe-assisted catalysis effect and mPF template effect,which not only spurs the highly graphitic porous framework of Fe/N-MGN with plentiful pyridinic N/graphitic N,but also assures the dispersed single atom Fe anchoring without elaborated procedures.As a result,the as-synthesized Fe/N-MGN demonstrates high catalytic activity,good durability and excellent methanol tolerance for ORR.This work promises a facile method to regulate the graphitic carbon growth and single atom Fe loading for the highly efficient electrocatalysis. | Yunshi Xu Liping Zhu Xuexue Cui Mingyu Zhao Yaling Li Leilei Chen Weicun Jiang Ting Jiang Shuguang Yang Yi Wang | 2020 | Nano Research2020，13，3： | 5 |
| 11 | Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China显示文摘 | Wentao Zhao Ying Guo Shuguang Lu Pingping Yan Qian Sui | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 4 |
| 12 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 13 | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber(Cucumaria frondosa) gonad hydrolysates in type Ⅱ diabetic rats显示文摘The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates(SCGH)in a rat model of type II diabetes induced by streptozotocin(STZ)combined with high-fat diet(HFD).Results showed that SCGH significantly reduced water intake,fasting blood glucose level and glycated hemoglobin level.Moreover,the oral glucose tolerance,insulin resistance and plasma lipid level in diabetic rats were also alleviated.Furthermore,histological analysis showed that SCGH effectively protected the tissue structure of liver.In addition,mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway,and promoted lipid metabolism via activating the AMPK signaling pathway.In summary,these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders. | Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 14 | Review on corrosion and corrosion scale formation upon unlined cast iron pipes in drinking water distribution systems显示文摘The qualified finished water from water treatment plants(WTPs) may become discolored and deteriorated during transportation in drinking water distribution systems(DWDSs), which affected tap water quality seriously. This water stability problem often occurs due to pipe corrosion and the destabilization of corrosion scales. This paper provides a comprehensive review of pipe corrosion in DWDSs, including corrosion process, corrosion scale formation, influencing factors and monitoring technologies utilized in DWDSs. In terms of corrosion process, corrosion occurrence, development mechanisms, currently applied assays, and indices used to determine the corrosion possibility are summarized, as well as the chemical and bacterial influences. In terms of scale formation, explanations for the nature of corrosion and scale formation mechanisms are discussed and its typical multilayered structure is illustrated. Furthermore, the influences of water quality and microbial activity on scale transformation are comprehensively discussed. Corrosion-related bacteria at the genus level and their associated corrosion mechanism are also summarized. This review helps deepen the current understanding of pipe corrosion and scale formation in DWDSs, providing guidance for water supply utilities to ensure effective measures to maintain water quality stability and guarantee drinking water safety. | Haiya Zhang Dibo Liu Lvtong Zhao Jun Wang Shuguang Xie Shuming Liu Pengfei Lin Xiaojian Zhang Chao Chen | 2022 | Journal of Environmental Sciences2022，34，7： | 2 |
| 15 | Biodegradation of bezafibrate by the activated sludge under aerobic condition:Effect of initial concentration,temperature and pH显示文摘Lab-scale experiments were conducted to investigate the effect of initial concentration,temperature and pH on the removal of bezafibrate(BF)by activated sludge under aerobic condition.The results showed that adsorption of BF onto activated sludge was negligible,and biodegradation was the main removal mechanism of BF.The removal of BF in the aqueous phase by the activated sludge can be described by a pseudo-first-order reaction.The reaction rate constants had a negative relationship with the initial concentration of BF,and dramatically reduced from 0.050 to 0.007 h^-1,when the temperature dropped from 20℃to 10℃.Variation of pH between 5.0 and 9.0 did not have significant influence on the removal of BF,indicating a high adaptation of microorganism in the activated sludge responsible for BF degradation to a wide pH range.The findings of this study are helpful to improve the removal of pharmaceuticals during the wastewater treatment plants by selecting the appropriate process variables,and eventually eliminate their release to the environment. | Qian Sui Pingping Yan Xuqi Cao Shuguang Lu Wentao Zhao Maozhe Chen | 2016 | Emerging Contaminants2016，2，4： | 2 |
| 16 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 17 | Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects显示文摘 | Dongxin Zhao Song Chen Shuguang Duo Chengang Xiang Jun Jia Mina Guo Wei Lai Shichun LU Hongkui Deng | 2013 | Cell Research2013，23，1： | 2 |
| 18 | Task scheduling optimization in cloud computing based on heuristic algorithm 显示文摘 | Guo Lizheng Zhao Shuguang Shen Shigen | 2012 | Journal of Networks2012，7，3： | 1 |
| 19 | LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells显示文摘 | Lijin Zhao Rigao Yang Long Cheng Maijian Wang Yan Jiang Shuguang Wang | 2011 | Journal of Surgical Research2011，，2： | 1 |
| 20 | Key Technology for Liquid Spawn Production and Green and High-yield Cultivation of Pleurotus eryngii显示文摘[Objectives]Pleurotus eryngii is currently the second largest edible fungus variety cultivated in China,and it mainly adopts the bag cultivation mode.This study aims to effectively solve the problems of high cost of solid spawn,long spawn production cycle,low application level of green and high-yield cultivation technology and equipment,and unstable output and quality in the factory production process and to further promote industrial upgrading.[Methods]Since June,2018,a series of research and technical optimizations had been carried out by a technical research team consisting of personnels from Vegetable Office of Guannan County,Institute of Edible Fungi of Shanghai Academy of Agricultural Sciences and Jiangsu Xiangru Biotechnology Co.,Ltd.,around the production of liquid spawn,introduction of excellent varieties of P.eryngii,medium pretreatment,autoclaving,clean room inoculation,digital cultivation,harvesting,packaging,etc.[Results]The key technology of industrial production,liquid spawn production and green and high-yield cultivation of P.eryngii are summarized.[Conclusions]The economic benefit of liquid spawn of P.eryngii is extremely considerable compared with liquid spawns such as branch spawn. | Yali ZHANG Shuguang ZHAO Yu LI Zhengpeng LI Cuie ZHANG Xiaotao SUN | 2020 | Asian Agricultural Research2020，12，7： | 1 |
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