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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 3 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 4 | Characterzation of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatographt/time-of-flight mass spectrometry显示文摘 | Zhu Shukui Lu Xin Li Keliang | 2007 | Analytica Chimica Acta2007，597，： | 1 |
| 5 | Characterization of flavor compounds in Chinese liquor Moutai by compre hensive two-dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | Shukui Zhu Xin Lu Keliang Ji | 2007 | Analytica Chimica Acta2007，597，： | 1 |
| 6 | Characterization of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | Shukui Zhu Xin Lu Keliang Ji Kunliang Guo Yanli Li Caiying Wu Guowang Xu | 2007 | Analytica Chimica Acta2007，，2： | 1 |
| 7 | Characterization of flavor compounds in Chinese liquor Moutai by compre hensive two-dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | Zhu Shukui Lu Xin Ji Keliang | 2007 | Analytica Chimica Acta2007，，597： | 1 |
| 8 | Charactcrzation of flavor compounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatographt/time-of-flight mass spectrometry显示文摘 | ZHU Shukui LU Xin LI Keliang | 2007 | Analytica Chimica Acta2007，597，2： | 1 |
| 9 | Characterzation of flavor compounds in Chinese liquor Moutai by comprehensive two - dimensional gas chromatographt/time - of - flight mass spectrometry 显示文摘 | Shukui Zhu Xin Lu Keliang Li | 2007 | Analytica Chimica Acta2007，597，： | 1 |
| 10 | Characterization of flavor compounds in Chinese liquor Mautai by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | ZHU Shukui LU Xin JI Keliang | 2007 | Analytica Chimica Acta2007，597，： | 1 |
| 11 | Characterzation of flavorcompounds in Chinese liquor Moutai by comprehensive two-dimensional gas chromatographt/time-of-flight mass spectrometry显示文摘 | ZHU Shukui LU Xin LI Keliang | 2007 | Analytica Chimica Acta2007，597，2： | 1 |
| 12 | Characterization of flavor compounds in Chinese liquor Moutai by comprehensive two- dimensional gas chromatography/time-of-flight mass spectrometry显示文摘 | ZHU Shukui LU Xin JI Keliang | 2007 | Analytica Chimica Acta2007，597，2： | 1 |
| 13 | Characterization of flavor compounds in Chinese liquor Moutai by comprehensive twodimensional gas chromatography / time - of - flightmass spectrometry显示文摘 | Zhu Shukui Lu Xin Ji Keliang | 2007 | Analytica Chimica Acta2007，597，： | 1 |
| 14 | Determination of retention indices in constant inlet pressure mode and conversion among different column temperature conditions in comprehensive two-dimensional gas chromatography 显示文摘 | ZHU Shukui LU Xin QIU Yaqiong | 2007 | Journal of Chromatography A2007，1150，12： | 1 |
| 15 | Characterization of flavor com- pounds in Chinese liquor Moutai by comprehensive two-dimen- sional gas chromatography/time-of-flight mass spectrometry 显示文摘 | Zhu shukui L x Ji keliang | 2007 | Analytica Chimica Acta2007，597，2： | 1 |
| 16 | Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib显示文摘Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was unsatisfying.Our objective was to examine the association between radiological characteristics and efficacy/prognosis.Methods:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)images.Qualitative and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were evaluated.The progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard model.Efficacy was analyzed by logistic-regression models.Results:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative parameters.In the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined margins.Conclusions:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib. | Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang Haoyun Shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 17 | Comparison of Time Interval Statistic and Pulse Shape Discrimination in Fast Neutron Detection Method with Liquid Scintillation Detector Loaded Gd显示文摘Neutron usually appears with gamma,which is requiring the detector has the capability of n gamma discrimination.Pulse shape discrimination(PSD)is a common approach of n,gamma judgment,but required a complex process to select a suitable discrimination factor,and poor performance in the low energy range.A method based on the time interval of adjacent Signals was disrupted and adopted to compare to pulse shape discrimination in the fast neutron detection method.A good agreement between the adopted method and PSD method was achieved,including the total count ratio and neutron count ratio.The comparison proves the correctness of the theoretical derivation and validates the method in practice.The advantages and limitations of the method based on time Interval of adjacent signals were analyzed.The method provides an effective way to confirm the calibration of the neutron detection of a liquid scintillation detector.Also,as a simple way only requiring the time information about events,the described method has large application potential in some case of fast neutron flux or intensity measurement. | Mohammed Adel Al-jumaili Qiang Du Jingjun Zhu Xinde Lin Wenbin Lin Changjian Tang Mustafa Raad Kadhim Haoyang Xing Shukui Liu | 2017 | 应用物理前沿(中英文版)2017，5，1： | 0 |
| 18 | Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search显示文摘The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper. | Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
| 19 | One-step synthesis of triazine-based covalent organic frameworks at room temperature for efficient photodegradation of bisphenol A under visible light irradiation显示文摘Herein,a novel visible-light-responsive photocatalyst with high efficiency was firstly synthesized at room temperature.The mild synthetic method resulted in a uniform spherical triazine-based covalent organic framework(TrCOF2)with ultra-high specific surface area as well as chemical stability.Due to the synergistic effect between the self-assembled uniform spherical structure and the abundant triazine-based structure,photoelectron–hole pairs were efficiently separated and migrated on the catalysts.On this basis,TrCOF2 was successfully applied to efficiently degrade bisphenol A(BPA).More than 98%of BPA was deraded after 60 min of visible light treatment,where the active specie of•O_(2)^(−)played a vital role during the degradation of BPA.The holes of TrCOF2 could produce O_(2)by direct reaction with water or hydroxide ions.Simultaneously,photoelectrons can be captured by O_(2)to generate•O_(2)^(−).Moreover,density functional theory(DFT)calculations proved the outstanding ability of the exciting electronic conductivity.Remarkably,a reasonable photocatalytic mechanism for TrCOF2 catalysts was proposed.This research can provide a facile strategy for the synthesis of TrCOFs catalysts at room temperature,which unfolds broad application prospects in the environmental field. | Pin Chen Siyuan Di Weixin Xie Zihan Li Shukui Zhu | 2023 | Frontiers of Materials Science2023，17，4： | 0 |
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