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| 1 | A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles显示文摘Dear Editor,Since the outbreak of a novel coronavirus disease(COVID-19)in late 2019,it has spread rapidly and developed into a global pandemic.As of August 12,2020,more than 215 countries and territories around the world have reported more than 20.5 million confirmed COVID-19 cases with over 745,693 deaths(http://gffzz58cf6dffd44b443cs099cpn56q9c669qk.ffgz.tsg.suse.edu.cn/coronavirus/#countries).Such harsh conditions urged scientists across the world to gear up to develop vaccines and antiviral drugs against COVID-19,which also lead to massive requirement for experimental animals. | Ya-Nan Zhang Xiao-Dan Li Zhe-Rui Zhang Hong-Qing Zhang Na Li Jing Liu Jia-Qi Li Hua-Jun Zhang Ze-Jun Wang Shuo Shen Zheng-Li Shi Hong-Ping Wei Zhi-Ming Yuan Han-Qing Ye Bo Zhang | 2020 | Cell Research2020，30，11： | 7 |
| 2 | Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes显示文摘AIM: To investigate the candidate microRNA(miRNA), miR-221 as a novel biomarker for diabetic retinopathy(DR) in patients associated with type 2 diabetes(T2D).METHODS: The subjects involved were divided into four groups: healthy control(HC), no diabetic retinopathy(NDR), non-proliferative diabetic retinopathy(NPDR) and proliferative diabetic retinopathy(PDR) group. Serum miR-221 was validated by real-time quantitative reversetranscription polymerase chain reaction(qRT-PCR). Also, serum angiotensin II(Ang II) and vascular endothelial growth factor(VEGF) were examined by enzyme-linked immunosorbent assay. In addition, receiver operating characteristic(ROC) curve was performed to explore the diagnostic accuracy of miR-221, Ang Ⅱ and VEGF for DR in patients with T2D. Spearman's rank correlation coefficient was executed to estimate the correlations of serum miR-221 with metabolic parameters and serum markers in patients with T2D.RESULTS: Primarily, serum miR-221, Ang Ⅱ and VEGF were increased significantly in T2D patients compared to HC participant respectively, and progressive up-regulated in NDR, NPDR and PDR groups(P<0.001). Additionally, miR-221 in serum was remarkably positively correlatedwith metabolic parameters such as glycated hemoglobin(r=0.310, P=0.002) and homeostasis model assessment for insulin resistance(r=0.413, P<0.001), as well as serum markers for instance Ang Ⅱ(r=0.667, P<0.001) and VEGF(r=0.499, P<0.001). Furthermore, serum miR-221(AUC, 0.894; 95%CI, 0.833-0.955; P<0.001), Ang Ⅱ(AUC, 0.888; 95%CI, 0.828-0.949; P<0.001) and VEGF(AUC, 0.785; 95%CI, 0.695-0.875; P<0.001) had evidently diagnostic efficiency in DR, and miR-221 is the most effective among them.CONCLUSION: Serum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D. However, a prospective clinical trial is warranted. | He-Nan Liu Xun Li Na Wu Meng-Meng Tong Shuo Chen Shan-Shan Zhu Wei Qian Xiao-Long Chen | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 6 |
| 3 | Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes显示文摘Whether supplementation of curcuminoids decreases serum adipocyte-fatty acid binding protein(A-FABP) level and whether this decrease benefits glucose control is unclear.One-hundred participants(n=50 administered curcuminoids,n=50 administered placebo) from our previous report on the effect of curcuminoids on type 2 diabetes in a 3-month intervention were assessed for levels of serum A-FABP,oxidative stress,and inflammatory biomarkers.Curcuminoids supplementation led to significant decreases in serum A-FABP,C-reactive protein(CRP),tumor necrosis factor-α,and interleukin-6 levels.Curcuminoids supplementation also significantly increased serum superoxide dismutase(SOD) activity.The change in serum A-FABP levels showed positive correlations with changes in levels of glucose,free fatty acids(FFAs),and CRP in subjects supplemented with curcuminoids.Further stepwise regression analysis showed that A-FABP was an independent predictor for levels of FFAs,SOD,and CRP.These results suggest that curcuminoids may exert anti-diabetic effects,at least in part,by reductions in serum A-FABP level.A-FABP reduction is associated with improved metabolic parameters in human type 2 diabetes. | NA Li Xin YAN Bo Lin JIANG Shuo CUI Hong Li LI Ying SUN Chang Hao | 2014 | Biomedical and Environmental Sciences2014，27，11： | 6 |
| 4 | Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway显示文摘OBJECTIVE: To investigate the effect of Danggui Buxue Tang(DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying mechanism.METHODS: Forty male Sprague-Dawley rats were randomly divided into sham group, model group,prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin. Body weight and lung index were monitored. Histopathologic examination and collagen deposition were determined using Hematoxylin and eosin(HE) and Masson's trichrome staining. Immunohistochemistry staining was applied to observe the expression of alpha-smooth muscle actin(α-SMA). m RNA expression of α-SMA,collagen Ⅰ and collagen Ⅲ were measured by realtime fluorescence quantitative PCR(RT-q PCR). Inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6) and IL-1β in serum were detected by Enzyme-linked immunosorbent assay. Alkali hydrolysis method was conducted to investigate the content of hydroxyproline(HYP). Transforming growth factor-β1(TGF-β1),Smad3 and plasminogen activator inhibitor-1(PAI-1) protein level were examined by Western blot assay.RESULTS: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction(%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ,TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of prednisone.CONCLUSION: Our findings suggest that DBT is able to ameliorate the pulmonary fibrosis, the possible mechanism may involve inhibition of pulmonary inflammation and collagen deposition, possibly via suppressing TGF-β1/Smad3/PAI-1 signaling pathway. | Wang Jiepeng Fang Chaoyi Wang Shaoxian Fang Fang Chu Xinqiao Liu Na Lu Chenxi Wang Shuo Li Wei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 5 |
| 5 | A novel 4/6-type alpha-conotoxin VilA selectively inhibits nAchR α3β2 subtype显示文摘 | Liang Li Na Liu Rong Ding Shuo Wang Zhuguo Liu Haiying Li Xing Zheng Oiuyun Dai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 4 |
| 6 | Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression显示文摘Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment. | Junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li Yang Huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen | 2022 | Bioactive Materials2022，7，4： | 4 |
| 7 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 8 | Treatment of pulmonary fibrosis in one convalescent patient with corona virus disease 2019 by oral traditional Chinese medicine decoction:A case report显示文摘After one-month of oral treatment with traditional Chinese medicine decoction,without using other drugs,the lung inflammatory exudate,pulmonary fibrosis and quality of life of a 61-year-old female patient with corona virus disease 2019(COVID-19)were significantly improved.No recurrence or deterioration of the patient’s condition was found within seven weeks of treatment and follow-up,and no adverse events occurred,indicating that oral Chinese medicine decoction was able to improve the pulmonary inflammation and fibrosis in a patient recovering from COVID-19,but further research is still needed. | Na Zhi Qian Mo Shuo Yang Yuan-xing Qin Hao Chen Zeng-guang Wu Cai-hong Lan Jun Zhang Yin-long Li | 2021 | Journal of Integrative Medicine2021，19，2： | 4 |
| 9 | Efficacy and Safety of Medium-to-long-term Use of Tolterodine Extended Release with or without Tamsulosin in Patients with Benign Prostate Hyperplasia and Larger Prostate Size: A Double-blind, Placebo-controlled, Randomized Clinical Trial显示文摘 | Jian-Liang Cai Zhe Zhou Yan Yang Yi-Fu Yan Shuo Jing Yan-Qun Na | 2016 | Chinese Medical Journal2016，，24： | 3 |
| 10 | Chemical oxidation of arsenic in the environment and its application in remediation: A mini review显示文摘Arsenic(As)contamination in soil and water poses a serious threat to the ecosystem health and human beings,and is of widespread concern.The main As species found in soil and water are arsenite As(Ⅲ)and arsenate As(V).Because As(Ⅲ)is more toxic and often more mobile than As(Ⅴ),many remediation strategies aim to oxidize As(Ⅲ)to As(Ⅴ).In the environment,the reduction of As(Ⅴ)under anaerobic conditions is mainly mediated by microorganisms,but the oxidation of As(Ⅲ)under aerobic conditions can be mediated primarily by chemical processes.This article first reviews the existing knowledge on chemical oxidation of As(Ⅲ)in the environment,with an emphasis on the roles of iron(Fe)and manganese(Mn)oxides.The application of Fe and Mn oxides for the remediation of As-contaminated soil and water is then summarized.The oxidation of As(Ⅲ)by oxygen is very slow in the absence of catalysts.Many Mn oxides,on the other hand,can efficiently oxidize As(Ⅲ).Although the oxidation of As(Ⅲ)by Fe(Ⅲ)is also slow,this process can be accelerated by light or Fe(Ⅱ).Iron and Mn oxides are widely used for the remediation of As-contaminated soil and water,with Fe oxides generally acting as absorbents while Mn oxides as oxidants.To better understand and regulate As transformation and transport in the environment,further study is needed on the mechanisms and influencing factors of As(Ⅲ)oxidation by Fe and Mn oxides,and the development of innovative methods and materials based on Fe and Mn oxides are desired. | Chaolei YUAN Qi LI Zhaoyang SUN Wenjun ZHANG Jiangrong CHEN Zheng CHEN Shuo NA Hongwen SUN | 2023 | Pedosphere2023，33，1： | 2 |
| 11 | Study on the surface-modification of nano-hydroxyapatite with lignin and the corresponding nanocomposite with poly (lactide-co-glycolide)显示文摘To obtain nano-hydroxyapatite/poly(lactideco-glycolide)(n-HA/PLGA)nanocomposite with superior mechanical properties,here,lignin was chosen to surfacemodify for n-HA through co-precipitation method.The different reaction conditions of reaction time,phosphorus source,and the lignin addition amount were studied by fourier transformation infrared spectra,X-ray diffraction,the intuitionistic dispersion experiment,transmission electron microscope and thermal gravimetric analysis.The reaction mechanism and the best appropriate reaction condition were obtained.More importantly,the results of electromechanical universal tester,scanning electron microscope,differential scanning calorimetric analyzer,polarized optical microscopy and dynamic mechanical analysis confirmed that the obtained n-HA could greatly increase the mechanical strength of PLGA,owing to the excellent dispersion and promotion crystallization effect.Moreover,in vitro cell culture experimental results indicated that the n-HA surface-modified by lignin was favorable to improve the cell biocompatibility of PLGA.The study suggested that the introduction of lignin was a novel method to acquire a highly dispersed n-HA,which would provide a new idea to achieve the n-HA/PLGA nanocomposite as bone materials in future,and it would pave the way towards a new application of lignin in biomedical field. | Haojie Ding Liuyun Jiang Chunyan Tang Shuo Tang Bingli Ma Na Zhang Yue Wen Yan Zhang Liping Sheng Shengpei Su Xiang Hu | 2021 | Frontiers of Chemical Science and Engineering2021，15，3： | 1 |
| 12 | Synthesis of molecular imprinted polymer modified TiO2 nanotube array electrode and their photoelectrocatalytic activity 显示文摘 | Lu Na Chen Shuo Wang Hong tao | 2008 | Journal of Solid State Chemistry2008，181，10： | 1 |
| 13 | Clinical Progress and Risk Factors for Death in Severe Fever with Thrombocytopenia Syndrome Patients显示文摘 | Zhong-Tao Gai Ying Zhang Mi-Fang Liang Cong Jin Shuo Zhang Cheng-Bao Zhu Chuan Li Xiao-Ying Li Quan-Fu Zhang Peng-Fei Bian Li-Hua Zhang Bin Wang Na Zhou Jin-Xia Liu Xiu-Guang Song Anqiang Xu Zhen-Qiang Bi Shi-Jun Chen De-Xin Li | 2012 | Journal of Infectious Diseases2012，，7： | 1 |
| 14 | Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters显示文摘Dear Editor,The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to disrupt global public health since its first report in December 2019,resulting in more than 380 billion confirmed cases including nearly 5.7 billion deaths worldwide(http://gffzz902b66c35c194404s099cpn56q9c669qk.ffgz.tsg.suse.edu.cn). | Ya-Nan Zhang Zhe-Rui Zhang Hong-Qing Zhang Na Li Qiu-Yan Zhang Xiao-Dan Li Cheng-Lin Deng Fei Deng Shuo Shen Bing Zhu Bo Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 15 | CENP-A的Ser68位动态磷酸化调控它在着丝粒区域的细胞周期依赖性装配显示文摘细胞出版社《发育细胞》创刊于2001年,本刊致力于搭建细胞生物学与发育生物学两大学科之间的桥梁。受过专业博士训l练的科学编辑与作者、审稿人、编委会成员共同合作,及时发布横跨两个领域令人振奋的研究成果,强调两个领域之间共同面临的问题以及相互之间的关系。该杂志2015年公布的影响因子为9.708。 | Zhouliang Yu Xiang Zhou Wenjing Wang Wenqiang Deng Junnan Fang Hao Hu Zichen Wang Shangze Li Lei Cui Jing Shen Linhui Zhai Shengyi Peng Jiemin Wong Shuo Dong Zengqiang Yuan Guangshuo Ou Xiaodong Zhang Ping Xu Jizhong Lou Na Yang Ping Chen Rui-Ming Xu 李国红 | 2016 | 科学新闻2016，0，1： | 1 |
| 16 | Effect of Acid Treatment on the Saccharification of Wheat Bran Cellulose显示文摘[Objective] The aim was to improve the saccharification of wheat bran cellulose. [Method] Taking the wheat bran as raw materials, and using orthogonal method, the effects of acid concentration, temperature, times and substrate concentration on the saccharification were investigated. [Result] The influence of temperature on the acid treatment of the saccharification of wheat bran cellulose was significant. Influences of acid concentration on the hydrolysis were distinct. Influences of time and substrate concentration were insignificant. The optimal pretreatment conditions were 1.5% of sulfuric acid concentration and 0.067 g/ml of substrate concentration at 100 ℃ in three hours. Under this condition, the sugar concentration was 38.137 mg/ml, and the hydrolysis rate reached 51.485%. [Conclusion] The study improved the saccharification of wheat bran cellulose, which provided theoretical basis for the application of wheat bran industrial process. | GUO Na JIANG Shao-tong LI Xing-jiang LI Shuo | 2012 | Chinese Food Science2012，1，3： | 0 |
| 17 | Carrier-Envelope Phase-Dependent Phase Matching of Terahertz Emission in Laser Plasma显示文摘We investigate off-axis phase-matched terahertz(THz)radiation in laser plasma pumped by few-cycle laser pulses.We find that the THz amplitude and angular distributions in the far field are sensitively dependent on the pump pulse’s focal carrier-envelope phase(CEP).Ring-like profiles of THz radiation are obtained at CEP values of 0.5πand 1.5π,due to the inversely symmetric local THz waveforms emitted before and after laser focus.Off-axis phase-matched THz radiation offers a tool to accurately measure the CEP of few-cycle pulses at the center of a medium. | Wang Shuo Li Fangshu Lu Haocheng Zheng Wenyang Zhao Xulin Jiang Yang Li Na Bai Ya Liu Peng | 2023 | 激光与光电子学进展2023，60，7： | 0 |
| 18 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 19 | Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation显示文摘Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great challenges.Herein,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic structure.It exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and selectivity.Specifically,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) pathway.This study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts. | Qianying Lin Jiwu Zhao Pu Zhang Shuo Wang Ying Wang Zizhong Zhang Na Wen Zhengxin Ding Rusheng Yuan Xuxu Wang Jinlin Long | 2024 | Carbon Energy2024，6，1： | 0 |
| 20 | Lower synaptic density associated with gaming disorder:an^(18)F-SynVesT-1 PET imaging study显示文摘Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD.Aims This study aimed to determine whether subjects with IGD have lower synaptic density than control subjects and the relationship between synaptic density and IGD severity.Methods Eighteen unmedicated subjects diagnosed with current IGD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria and 16 demographically matched healthy controls(HCs)participated in the study and underwent 18F-labelled difluoro-analogue of UCB-J(18F-SynVesT-1)positron emission tomography scans to assess the density of synaptic vesicle glycoprotein 2A(SV2A).The Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Hamilton Rating Scale for Depression(HAMD),Hamilton Anxiety Rating Scale(HAMA),Barratt Impulsiveness Scale Version 11(BIS-11),Stroop Colour-Word Test(SCWT),stop-signal paradigms and N-back tasks were administered to all subjects.Results Patients with IGD had significantly higher scores on the IGDS9-SF,HAMD,HAMA and BIS-11 than HCs.HCs performed better on the two-back and SCWT tests as well as in terms of stop-signal reaction times(SSRTs)in the stop-signal paradigms than patients with IGD.Lower uptake was found in the bilateral putamen,right pregenual anterior cingulate cortex and Rolandic operculum of patients with IGD compared with HCs.Furthermore,in the IGD group,IGDS9-SF scores and daily gaming hours were negatively correlated with the standardised uptake value ratios of 18F-SynVesT-1 in the bilateral putamen.Longer SSRTs were significantly associated with lower SV2A density in the right pregenual anterior cingulate cortex and right Rolandic operculum.Conclusions The in vivo results in this study suggest that lower synaptic density contributes to the severity and impairments in inhibitory control of IGD.These findings may provide further incentive to evaluate interventions that restore synaptic transmission and plasticity to treat IGD. | Jiale Hou Qian Xiao Ming Zhou Ling Xiao Ming Yuan Na Zhong Jiang Long Tao Luo Shuo Hu Huixi Dong | 2023 | General Psychiatry2023，36，5： | 0 |
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