|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX. | XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian | 2006 | Chinese Science Bulletin2006，51，14： | 12 |
| 2 | Toward Enhancing Wearability and Fashion of Wearable Supercapacitor with Modified Polyurethane Artificial Leather Electrolyte显示文摘Inspired by the sophisticated artificial leather garment industry and toward enhancing wearability of energy storage devices, we demonstrate a polyurethane artificial leather supercapacitor with large sheet electrodes embedded in theleather layer simultaneously working as a polyelectrolyte. This design totally reserves textiles underneath and thus addresses the well-known challenge of wearing comfortability. It provides a revolutionary configuration of wearable supercapacitors: the artificial leather on garment is also a supercapacitor.Unlike the polyvinyl alcohol-based acidic electrolytes, which are widely used, sodium chloride is used to modify the intrinsically fluorescent polyurethane leather for ionic transportation, which has no harm to human. The fluorescent leather supercapacitor is easily transferrable from any arbitrary substrates to form various patterns, enabling multifunctionalities of practical wearability, fashion, and energy storage. | Yan Huang Zijie Tang Zhuoxin Liu Jun Wei Hong Hu Chunyi Zhi | 2018 | Nano-Micro Letters2018，10，3： | 10 |
| 3 | Recent Progress of MXene-Based Nanomaterials in Flexible Energy Storage and Electronic Devices显示文摘The increasing demands for wearable electronics have stimulated the rapid development of flexible energy storage devices.MXenes are considered as promising flexible electrodes due to the ultrahigh volumetric specific capacitance,metallic conductivity,superior hydrophily,and rich surface chemistry. | Qi Yang Yukun Wang Xinliang Li Hongfei Li Zifeng Wang Zijie Tang Longtao Ma Funian Mo Chunyi Zhi | 2018 | Energy & Environmental Materials2018，1，4： | 8 |
| 4 | Studies of poly-L-lysine-starch nanoparticle preparation and its application as gene carrier显示文摘Anion starch nanoparticle (StNP) with a diameter of 50 nm was prepared in wa- ter-in-oil microemulsion, with soluble starch as raw materials and POCl3 as crosslinking agent. PLL-StNP was prepared by linking poly-L-lysine (PLL) on the surface of StNP. At the same time, the size of PLL-StNP and its stability in aqueous solution were checked by AFM. The analysis of plasmid DNA binding, DNase I enzymatic degradation, toxicity and transfection were done. We discovered that PLL-StNP may be used as non-virus nanoparticle gene carrier. And we devel- oped the method of preparing PLL-StNP gene carrier and used it in cell transfection. As non-virus gene carrier, PLL-StNP has some advantages, such as large load of DNA, high transfection effi- ciency, low cell toxicity and biodegradability. | XIAO Suyao LIU Xuanming TONG Chunyi LIU Jun TANG Dongying ZHAO Lijian | 2005 | Science China Chemistry2005，48，2： | 7 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons显示文摘Deep brain stimulation of the subthalamic nucleus(STN)is an effective therapy for motor deficits in Parkinson’s disease(PD),but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation.It is unclear how STN neurons represent and modulate feeding behavior in different internal states.In the present study,we found that feeding caused a robust activation of STN neurons in mice(GCaMP6 signal increased by 48.4%±7.2%,n=9,P=0.0003),and the extent varied with the size,valence,and palatability of food,but not with the repetition of feeding.Interestingly,energy deprivation increased the spontaneous firing rate(8.5±1.5 Hz,n=17,versus 4.7±0.7 Hz,n=18,P=0.03)and the depolarization-induced spikes in STN neurons,as well as enhanced the STN responses to feeding.Optogenetic experiments revealed that stimulation and inhibition of STN neurons respectively reduced(by 11%±6%,n=6,P=0.02)and enhanced(by 36%±15%,n=7,P=0.03)food intake only in the dark phase.In conclusion,our results support the hypothesis that STN neurons are activated by feeding behavior,depending on energy homeostatic status and the palatability of food,and modulation of these neurons is sufficient to regulate food intake. | Haichuan Wu Xiang Yan Dongliang Tang Weixin Gi Yiwen Luan Haijiang Cai Chunyi Zhou Cheng Xiao | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 7 | Integration designs toward new-generation wearable energy supply-sensor systems for real-time health monitoring:A minireview显示文摘Wearable sensing systems,as a spearhead of artificial intelligence,are playing increasingly important roles in many fields especially health monitoring.In order to achieve a better wearable experience,rationally integrating the two key components of sensing systems,that is,power supplies and sensors,has become a desperate requirement.However,limited by device designs and fabrication technologies,the current integrated sensing systems still face many great challenges,such as safety,miniaturization,mechanical stability,energyefficiency,sustainability,and comfortability.In this review,the key challenges and opportunities in the current development of integrated wearable sensing systems are summarized.By summarizing the typical configurations of diverse wearable power supplies,and recent advances concerning the integrated sensing systems driven by such power supplies,the representative integrated designs,and micro/nanofabrication technologies are highlighted.Lastly,some new directions and potential solutions aiming at the device-level integration designs are outlooked. | Yongchao Tang Xuejin Li Haiming Lv Wenlong Wang Chunyi Zhi Hongfei Li | 2020 | InfoMat2020，2，6： | 2 |
| 8 | Large-scale fabrication of boron nitride nanosheets and their utilization in polymer composites with improved thermal and mechanical properties显示文摘 | Zhi Chunyi Bando Y Tang Chengchun | 2009 | Adv Mater2009，21，28： | 1 |
| 9 | Effects of fiber surface chemistry and size on the structure and properties of poly ( vinyl alcohol ) composite films rein- forced with eleetrospun fibers 显示文摘 | TANG Chunyi WU Meiyu WU Yiqiong | 2011 | Composites Part A: Applied Science and Manufacturing2011，42，9： | 1 |
| 10 | Cellulose nanofiber rein- forced poly(vinyl alcohol) composite film with high visi-ble light transmittance 显示文摘 | TANG Chunyi LIU Haiqing | 2008 | Composites Part A : Applied Science and Manufacturing2008，39，10： | 1 |
| 11 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 12 | Syntheses of novel photosensitive polysiloxanes and their effects on properties of UV-cured epoxy methacrylate coatings显示文摘 | Tang Chunyi Liu Weiqu | 2010 | Journal of Coatings Technology and Research2010，7，5： | 1 |
| 13 | Relation between Cardiac Injury and Elevated Levels of Inflammatory Biomarkers in Patients with Severe COVID-19显示文摘Background:Since early December 2019,coronavirus disease 2019(COVID-19)has emerged as a global pandemic and public health crisis.This study aims to explore the relationship between cardiac injury and infl ammatory biomarkers in patients with severe COVID-19.Methods:We collected data on 91 patients with a confi rmed diagnosis of severe COVID-19 from February 8 to March 31,2020.Demographic characteristics,clinical data,and in-hospital outcomes were compared.The relationship between cardiac injury and infl ammatory biomarkers was analyzed.Logistic regression was used to explore the independent risk factors for cardiac injury.Results:The mean age of all patients was 61 years±14 years.About half of the patients were male.Hypertension and coronary heart disease were more common in the cardiac injury group.The levels of infl ammatory biomarkers in patients who experienced cardiac injury were generally higher than the levels of those without cardiac injury,including interleukin-6,interleukin-2 receptor(IL-2R),procalcitonin,and high-sensitivity C-reactive protein.There were positive correlations between the levels of high-sensitivity troponin I and N-terminal prohormone of brain natriuretic peptide and the levels of infl ammatory biomarkers.Logistic regression shows that IL-2R(odds ratio 1.001,95%confi dence interval 1.000–1.002,P=0.045)and comorbidities(odds ratio 4.909,95%confi dence interval 1.231–19.579,P=0.024)are independent risk factors for cardiac injury in patients with severe COVID-19.Conclusion:High levels of infl ammatory biomarkers are associated with higher risk of cardiac injury in patients with severe COVID-19.IL-2R and comorbidities are predictors of cardiac injury. | Jing Li Lijie Sun Fang Wang Bing Liu Hui Li Guodong Tang Zhigang Chang Aihua Liu Chunyi Fu You Lv Jing Gao Jing Li | 2021 | Cardiovascular Innovations and Applications2021，，1： | 0 |
| 14 | Antibacterial Activity of Polymeric Quaternary Ammonium Compounds Tuned by Incorporating Hydrophilic co-Monomer显示文摘 | ZUO Huajiang WEN Wanhua WU Dingcai FU Ruowen TANG Chunyi | 2015 | Chemical Research in Chinese Universities2015，31，1： | 0 |
| 15 | Self-healable electroluminescent devices显示文摘Electroluminescent(EL)devices have been extensively integrated into multi-functionalized electronic systems in the role of the vitally constituent light-emitting part.However,the lifetime and reliability of EL devices are often severely restricted by concomitant damage,especially when the strain exceeds the mechanical withstanding limit.We report a self-healable EL device by adopting a modified self-healable polyacrylic acid hydrogel as the electrode and a selfhealable polyurethane as a phosphor host to realize the first omni-layer-healable light-emitting device.The physicochemical properties of each functionalized layer can be efficiently restored after experiencing substantial catastrophic damage.As a result,the luminescent performance of the self-healable EL devices is well recovered with a high healing efficiency(83.2%for 10 healing cycles at unfixed spots,and 57.7%for 20 healing cycles at a fixed spot).In addition,inter-device healing has also been developed to realize a conceptual“LEGO”-like assembly process at the device level for light-emitting devices.The design and realization of the self-healable EL devices may revive their performance and expand their lifetime even after undergoing a deadly cut.Our self-healable EL devices may serve as model systems for electroluminescent applications of the recently developed ionically conductive healable hydrogels and dielectric polymers. | Guojin Liang Zhuoxin Liu Funian Mo Zijie Tang Hongfei Li Zifeng Wang Venkateshwarlu Sarangi Abhijit Pramanick Jun Fan Chunyi Zhi | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 16 | Electrolyte/Structure‑Dependent Cocktail Mediation Enabling High‑Rate/Low‑Plateau Metal Sulfide Anodes for Sodium Storage显示文摘As promising anodes for sodium-ion batteries,metal sulfides ubiquitously suffer from low-rate and high-plateau issues,greatly hindering their application in full-cells.Herein,exemplifying carbon nanotubes(CNTs)-stringed metal sulfides superstructure(CSC)assembled by nano-dispersed SnS_(2) and CoS_(2) phases,cocktail mediation effect similar to that of high-entropy materials is initially studied in ether-based electrolyte to solve the challenges.The high nano-dispersity of metal sulfides in CSC anode underlies the cocktail-like mediation effect,enabling the circumvention of intrinsic drawbacks of different metal sulfides.By utilizing ether-based electrolyte,the reversibility of metal sulfides is greatly improved,sustaining a long-life effectivity of cocktail-like mediation.As such,CSC effectively overcomes low-rate flaw of SnS_(2) and highplateau demerit of CoS_(2),simultaneously realizes a high rate and a low plateau.In half-cells,CSC delivers an ultrahigh-rate capability of 327.6 mAh g^(−1) anode at 20 A g^(−1),far outperforming those of monometallic sulfides(SnS_(2),CoS_(2))and their mixtures.Compared with CoS_(2) phase and SnS_(2)/CoS_(2) mixture,CSC shows remarkably lowered average charge voltage up to ca.0.62 V.As-assembled CSC//Na1.5VPO4.8F0.7 full-cell shows a good rate capability(0.05~1.0 A g^(−1),120.3 mAh g^(−1) electrode at 0.05 A g^(−1))and a high average discharge voltage up to 2.57 V,comparable to full-cells with alloy-type anodes.Kinetics analysis verifies that the cocktail-like mediation effect largely boosts the charge transfer and ionic diffusion in CSC,compared with single phase and mixed phases.Further mechanism study reveals that alternative and complementary electrochemical processes between nano-dispersed SnS_(2) and CoS_(2) phases are responsible for the lowered charge voltage of CSC.This electrolyte/structure-dependent cocktail-like mediation effect effectively enhances the practicability of metal sulfide anodes,which will boost the development of high-rate/-voltage sodium-ion full batteries. | Yongchao Tang Yue Wei Anthony F.Hollenkamp Mustafa Musameh Aaron Seeber Tao Jin Xin Pan Han Zhang Yanan Hou Zongbin Zhao Xiaojuan Hao Jieshan Qiu Chunyi Zhi | 2021 | Nano-Micro Letters2021，13，11： | 0 |
| 17 | Highly uniform Co-Cu bimetallic sulfides for rechargeable alkaline aqueous zinc batteries显示文摘Rechargeable alkaline aqueous zinc batteries(RAZBs)have attracted increasing attention.However,most RAZBs are hindered by the limited availability of cathode materials.The practical electrochemical performance of most cathode materials is lower than the theoretical value due to their poor electrical conductivity and low utilization capacity.In this work,we develop a facile hydrothermal procedure to prepare highly uniform bimetallic sulfides as novel cathode materials for RAZBs.Copper-cobalt binary metallic oxides materials possess higher conductivity and larger capacity compared with their mono-metal oxides compounds due to bimetallic synergistic effects and multiple oxidation states.Furthermore,bimetallic sulfide compounds have smaller bond energy and longer bond length than their oxides,leading to less structural damage,faster kinetics of electrochemical reactions,and better stability.The as-prepared Co-Cu bimetallic sulfides show enhanced electrochemical performance due to various valences of Co and Cu as well as the existence of S.As a result,aqueous Zn/CuCo_(2)S_(4) battery shows a high specific capacity of 117.4 mAh/g at 4 A/g and a good cycle life of over 8000 cycles.Based on PANa hydrogel electrolytes,a flexible Zn/CuCo_(2)S_(4) battery demonstrates excellent cycling stability.This battery can also meet the requirements of electronic devices with different shapes and performs well in extreme environments,such as freezing,drilling,and hammering.This work opens new avenues to obtain high-rate and long-life cathode materials for RAZBs by utilizing the synergistic effects of bimetallic sulfides and provides a new platform for flexible energy storage devices. | Xiaofang Bai Yuwei Zhao Mangwei Cui Tianshuo Guo Zijie Tang Chuan Li Heng Gao Shuo Yang Lingzhi Zhao Chunyi Zhi Hongfei Li | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 18 | Animal biodistribution, safety and validation study of dopamine transporter PET imaging agent ^(18)F-FECNT显示文摘This work was to investigate the pharmacologic characteristics of 18F-FECNT (2β-carbomethoxy-3β- (4-chlorophenyl)-8-(2-[18F]fluoroethyl)nortropane) as a dopamine transporter (DAT) PET imaging agent. Its partition coefficients were determined in n-octanol and phosphate buffer (PB) (pH 7.0 and pH 7.4). 6-Hydroxydopamine (6-OHDA) left-sided lesioned Parkinsonian rats were established and validated by rotational behavior tests. Biodistribution in vivo in mice, autoradiography in normal and hemi-Parkinsonian rat brains, and toxicity test were performed. The results showed that partition coefficients were 34.14 (pH 7.0) and 56.41 (pH 7.4), respectively. Biodistribution exhibited rapid uptake and favorable retention in the mice brains. The major radioactivity was metabolized by the hepatic system. The autoradiography showed that 18F-FECNT was highly concentrated in striatum, and that the left and the right striatal uptake were symmetrical in normal SD rat brains. In left-sided lesioned PD rat brains, the striatal uptake of 18F-FECNT bilaterally decreased in comparison with normal rats. No significant uptake was visible in the 6-OHDA lesioned-sided striatal areas. The results demonstrated that 18F-FECNT binds to DAT was specific. Toxicity trial displayed that the acceptable dose per kilogram to mice was 625 times greater than that to human. These indicate that 18F-FECNT is a potentially safe and useful DAT PET imaging agent in the brain. | WANG Songpei CHEN Zhengping LI Xiaomin TANG Jie LIU Chunyi ZOU Meifen PAN Donghui LU Chunxiong XU Yuping XU Xijie ZHOU Xingqin JIN Jian | 2009 | Nuclear Science and Techniques2009，20，1： | 0 |
| 19 | Semi-automated synthesis,validation and microPET imaging of ^(18)F-FP-DTBZ as a vesicular monoamine transporter ligand显示文摘This work was to develop a semi-automated synthesis of 18F-9-fluoropropyl-9-desmethyl-DTBZ (18F-FP-DTBZ) and validate its potential as a vesicular monoamine transporter 2 (VMAT2) ligand.18F-FP-DTBZ was synthesized by a semi-automated procedure in a 21-35% yield without decay correction and with a radiochemical purity of >98%.Bioistribution in rats exhibited a favorable brain uptakes of the ligand (0.31±0.04 ID% at 60min post injection,n=8).The highest radioactivity located in VMAT2 enriched striatal tissue.The target-to-nontarget ratio (striatum/cerebellum,ST/CB) was 4.81±0.84.Blocking studies implied that striatum uptake could be blocked by DTBZ (a VMAT2 inhibitor) but could not by CFT (a dopamine transporter inhibitor).MicroPET imaging with 18F-FP-DTBZ in normal rats gave high quality images in which high radioactivity were observed in the striatal tissue.Time-and-activity curves revealed good retention in the target (striatum) and rapid clearance in the background (cerebellum),which resulted in a maximum ST/CB ratio of 5.08±0.81 (n=3) in 80-120min.By contrast,the 6-hydroxydopamine unilateral lesioned rats gave asymmetrical striata images with higher 18F-FP-DTBZ concentration on the unlesioned side (unlesioned-ST/CB=5.21±0.38,n=3) than the lesioned (lesioned-ST/CB=2.34±0.51).The results validated that 18F-FP-DTBZ is a favorable PET ligand binding to VMAT2. | CHEN Zhengping LIU Chunyi LI xiaomin TANG Jie TAN Cheng HUANG Hongbo YU Huixin LUO Shineng | 2012 | Nuclear Science and Techniques2012，23，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员