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| 1 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 2 | Diversity and conservation of Chinese wild begonias显示文摘Begonia, one of the most diverse plant taxa and the fifth or sixth largest angiosperm genus, consists of over1800 accepted species. The number of species recognized within this genus has greatly increased over the past 20 years, rising from 80 to 200 species in China alone. Based on recent field surveys, the number of begonia species in China is predicted to be between 250 and 300. Given the large number of begonia species that still remain to be described, further taxonomical work is urgently required. This is especially true for Chinese Begonia, in which there is a huge diversity of habitat, habit, plant size, leaf type, flower and fruit morphology, and most species are narrowly distributed in isolated habitats that are subject to negative disturbances from climate change, as well as agricultural and industrial activities. Although the conservation status for the majority of species has been evaluated using the standards of the International Union for Conservation of Nature, the results don't represent the truth in many species, and also about11.5% of which are data-absent. In addition, illegal collection and over-harvesting of wild begonias for ornamental or medicinal use has increased due to the rapid development of internet commerce. Far more often than predicted, these species should be categorized as rare and endangered and require immediate protection. Ex situ conservation of Chinese begonias started in 1995 and over 60% of the total species have been so far introduced into cultivation by several major botanical gardens in China. However, only few research institutions, limited funds and human resources have been involved in Begonia conservation;moreover, no project has conducted reintroduction. Therefore, more conservation-based work remains to be done. Improved conservation of Chinese begonias in the future depends on further field survey, an improved understanding of population diversity, and integrative approaches, including in situ and ex situ conservation, seed banking, and plant reintroduction. Species-targeted conservation zones should be established for endangered species excluded from the existing nature reserves. Additionally, laws pertaining to plant protection should be extended to prevent the illegal collection and transaction of wild plants, particularly for those species with unique habitats and small populations. | Daike Tian Yan Xiao Yi Tong Naifeng Fu Qingqing Liu Chun Li | 2018 | Plant Diversity2018，40，3： | 4 |
| 3 | Atomic-scale mechanism of the θ’’→θ’ phase transformation in Al-Cu alloys显示文摘The phase transformation of θ’’→θ’ in an Al-5.7 Cu alloy was investigated by aberration-corrected scanning transmission electron microscopy, and the tranformation mode of θ’’→θ’ during aging treatment was clarified. In the presence of the θ’ phases, θ’ was found to be formed by in-situ transformation fromθ’’ with the same plate shape, size and broad faces. The transformation starts from multiple sites within the θ’ precipitate and the whole θ’ phase finally forms as the preferential θ’ sections grow and connect with each other. Antiphase domain boundaries are also found in some θ’ precipitates when the disregistry exists between different θ’ sections. | Zhenju Shen Qingqing Ding Chunhui Liu Jiangwei Wang He Tian Jixue Li Ze Zhang | 2017 | Journal of Materials Science & Technology2017，33，10： | 3 |
| 4 | Establishment of a highly efficient hematopoietic differentiation model from human embryonic stem cells for functional screening显示文摘Human embryonic stem cells(hESCs)have been successfully differentiated into hematopoietic progenitor cells with colony formation capacity and further into various kinds of blood cells including erythrocytes,megakaryocytes,neutrophils,nature killer cells and T lymphocytes[1 7].Nevertheless,the differentiation efficiency is extremely low. | PANG SuLei WU QingQing TIAN Sha SU Pei BAI Yang GAO Jie YANG YiQing LIU Xin ZHU ZhengMao XU YuanFu ZHOU JiaXi | 2013 | Science China(Life Sciences)2013，56，12： | 3 |
| 5 | Thermal-reductive transformations of carbon dioxide catalyzed by small molecules using earth-abundant elements显示文摘In the present review, we summarize the progress for thermal reductive transformations of CO2 catalyzed by small homogeneous catalysts using earth-abundant elements. Three main types of transformations categorized by the use of different reductants(hydrogen, hydrosilanes, and boranes), in which no C–C bond formation is involved, are surveyed. | Muhua Liu Tian Qin Qingqing Zhang Chi Fang Yao Fu Bo-Lin Lin | 2015 | Science China Chemistry2015，58，10： | 3 |
| 6 | NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients显示文摘 | Ru-Hui Tian Shi Yang Zi-Jue Zhu Jun-Long Wang Yun Liu Chencheng Yao Meng Ma Ying Guo Qingqing Yuan Yanan Hai Yi-Ran Huang Zuping He Zheng Li | 2015 | Asian Journal of Andrology2015，17，6： | 2 |
| 7 | A Comparative Study of Electrochemical Capacitance of Graphene Oxide Affected by Oligomers of p-phenylenediamine and Hydrazine Hydrate in Solvothermal Condition显示文摘A systematic investigation of the graphene oxide composite reduced by either p-phenylenediamine oligomers or hydrazine hydrate was performed with field emission scanning electron microscopy,high resolution transmission electron microscopy,X-ray diffraction,fourier transform infrared,and X-ray photoelectron spectroscopy analyses.The electrical capacitance of the composite was evaluated by a cyclic voltammetry technique,while the properties of these prototype supercapacitors were measured by a chronopotentiometry technique.It was found that,under the solvothermal condition,the graphene oxide reduced by p-phenylenediamine oligomers was observed to have higher electrical capacitance than that reduced by hydrazine.The improved electrical capacitance can be attributed to that p-phenylenediamine oligomers are the more effective spacers for graphene layers;and they could also provide some pseudo-capacitance to the graphene oxide composite based on their conjugate structure.The results imply that graphene oxide modified by diamine oligomers has a good potential in energy storage devices. | ZHANG Qingqing ZHANG Qingwu LU Hao WANG Wei FANG Tian LIU Hongying LIU Jiaji WANG Shuangshuang | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，2： | 2 |
| 8 | Amorphization activated FeB_(2) porous nanosheets enable efficient electrocatalytic N_(2) fixation显示文摘Designing active,robust and cost-effective catalysts for the nitrogen reduction reaction(NRR) is of paramount significance for sustainable electrochemical NH3 synthesis.Transition-metal diborides(TMB_2)have been recently theoretically predicted to be a new class of potential NRR catalysts,but direct experimental evidence is still lacking.Herein,we present the first experimental demonstration that amorphous FeB_2 porous nanosheets(a-FeB_2 PNSs) could be a highly efficient NRR catalyst,which exhibited an NH3 yield of 39.8 μg h^(-1) mg^(-1)(-0.3 V) and a Faradaic efficiency of 16.7%(-0.2 V),significantly outperforming their crystalline counterpart and most of existing NRR catalysts.First-principle calculations unveiled that the amorphization could induce the upraised d-band center of a-FeB_2 to boost d-2π~* coupling between the active Fe site and ~*N_2 H intermediate,resulting in enhanced ~*N_2 H stabilization and reduced reaction barrier.Out study may facilitate the development and understanding of earth-abundant TMB_2-based catalysts for electrocatalytic N_2 fixation. | Ke Chu Weicong Gu Qingqing Li Yaping Liu Ye Tian Wuming Liu | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 9 | Microstructure and properties of glycerol plasticized soy protein plastics containing castor oil显示文摘 | Huafeng Tian Wenqian Wu Gaiping Guo Bagen Gaolun Qingqing Jia Aimin Xiang | 2011 | Journal of Food Engineering2011，，3： | 2 |
| 10 | Quercetin-derivatives painting the yellow petals of American lotus(Nelumbo lutea)and enzymatic basis for their accumulation显示文摘American lotus(Nelumbo lutea)is one of the two species in Nelumbo and has only yellow flower.Identification of total flavonoids showed wild American lotus contained almost only flavonols with quercetin 3-O-glucuronide to be the dominant pigment.The variation tendency of the total flavonol content was coincident with yellow color variation of petals during flower development.To understand the mechanism of accumulation and constituent of pigments in petals,three pivotal genes,NlFLS1,NlFLS2 and NlFLS3,which were predicted to encode flavonol synthases were isolated and characterized by analyses of basic bioinformatics,temporal and spatial expression patterns and enzymatic activity.Their temporal expression levels showed the same variation tendency,which was also consistent with the development-dependent variation of total flavonol content.Spatial expression patterns indicated the three genes should function in petals.All the three proteins were demonstrated to be bifunctional dioxygenase,possessing both flavonol synthase activity and flavanone 3-hydroxylase activity.Besides,other flavonol biosynthesis related genes were also investigated on their expression levels to give more clues on the mechanism.Substrate preferences of the three FLSs,substrate competitions between the FLSs and other flavonol biosynthesis related enzymes,and the greatly differential expression levels between F3’H(flavonoid 3-hydroxylase)and F3’5’H(flavonoid 3,5-hydroxylase)contributed to the flavonol constituent in the petals of America lotus,namely abundant quercetin-derivatives while very few kaempferol-derivatives and myricetin-derivatives. | Qingqing Liu Dasheng Zhang Fengluan Liu Zhuoxing Liu Xiaohan Wang Yong Yang Shanshan Li Hanchun Li Daike Tian Liangsheng Wang | 2023 | Horticultural Plant Journal2023，9，1： | 1 |
| 11 | Detection of trends in precipitation extremes in Zhejiang, east China显示文摘 | Ye Tian Yue-Ping Xu M. J. Booij Shengji Lin Qingqing Zhang Zhanghua Lou | 2012 | Theoretical and Applied Climatology2012，，1： | 1 |
| 12 | Design of Permanent Ma- gnet Brushless DC Motor Control System Based on DSP- IC30Fg012显示文摘 | WU Qingqing TIAN Wenchao | 2012 | Procedia Engineering2012，29，3： | 1 |
| 13 | Upregulation of Rpn10 promotes tumor progression via activation of the NF-κB pathway in clear cell renal cell carcinoma显示文摘The ubiquitin-proteasome system(UPS)plays a central role in regulating protein homeostasis in tumor progression.The proteasome subunit Rpn10 is associated with the progression of several tumor types.However,little is known regarding the role of Rpn10 in clear cell renal cell carcinoma(ccRCC).In this study,we found that overexpression of Rpn10 increased ccRCC cell proliferation,migration,and invasion.Silencing Rpn10 expression resulted in decreased cell proliferation,migration,and invasion in ccRCC cells.Knockdown of Rpn10 inhibits tumor growth and cell proliferation in vivo.Furthermore,we demonstrated that Rpn10 increased cell proliferation,migration,and invasion via regulation of the nuclear factor kappa B(NF-κB)pathway.Rpn10 directly promoted inhibitor of nuclear factor-kappa B alpha(IκBcx)degradation through the UPS.Moreover,we observed that upregulation of Rpn10 or downregulation of kBa in ccRCC was associated with poor prognosis.We found that the combination of these two parameters was a more powerful predictor of poor prognosis than either parameter alone.Collectively,these findings provide evidence that Rpn10 promotes the progression of ccRCC by regulation of the NF-κB pathways and is a prognostic indicator for patients with ccRCC. | Tingting Huang Wei Tian Qingqing Zhou Jiajun Li Zhiyuan Jiang Jinsi Chen Chao Ge Hua Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 1 |
| 14 | Influence of bubbles on the segregated stability of fine coal in a vibrated dense medium gas-solid fluidized bed显示文摘In this paper,the variation of bubble size and number in the separation process of vibrated fluidized bed as well as the influence of bubble movement on the axial distribution of fine coal in different positions of the bed were studied.The result revealed that the size and number of bubbles is correlated with the fine coal separation effect in the separation process.When the bed is in a uniform and stable fluidized state,the size of bubbles in the separation process was in the range of 1-2.5 cm and the number of bubbles was reduced by nearly 50%,which is helpful to promote the stratification and segregation of fine coal.Thereby,after separation,the ash content of refined coal products of anthracite and 1/3 coking coal was reduced to 12.1% and 23.7% respectively,and the content of refined coal was up to 42.5% and 68.5% respectively,which show that the vibrated fluidized bed has a good separation performance,and can separate efficiently the coal of size−6+1 mm. | Enhui Zhou Yadong Zhang Yuemin Zhao Qingqing Tian Zengqiang Chen Guannan lv Xuliang Yang Liang Dong Chenlong Duan | 2021 | Particuology2021，19，5： | 1 |
| 15 | Boron Nitride Quantum Dots/Ti_(3)C_(2)T_(x)-MXene Heterostructure For Efficient Electrocatalytic Nitrogen Fixation显示文摘Electrocatalytic N_(2) fixation through N_(2) reduction reaction(NRR)has been regarded as a promising route for sustainable NH_(3) synthesis,while exploring high-performing NRR catalysts is pivotal yet challenging.Herein,BN quantum dots/Ti_(3)C_(2)T_(x)-MXene(BNQDs/Ti_(3)C_(2)T_(x))heterostructure is demonstrated as an efficient and durable NRR catalyst,exhibiting a high NH_(3) yield of 52.8±3.3μg h^(-1) mg^(-1) with an FE of 19.1±1.6%at0.4 V(vs.RHE),which stand at the high level among all reported BN-and MXene-based NRR catalysts.Theoretical computations reveal that the electronic interactions between BNQDs and Ti_(3)C_(2)T_(x) enrich the electron density of B atoms at the heterointerface and endow them with enhanced electron-donating capability for N_(2) activation and protonation.Meanwhile,the decorated BNQDs can block the active sites of Ti_(3)C_(2)T_(x) for hydrogen evolution,rendering a high N_(2)-to-NH_(3) selectivity. | Ke Chu Xingchuan Li Ye Tian Qingqing Li Yali Guo | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 16 | Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer显示文摘Small-cell lung cancer(SCLC)is the most aggressive and lethal subtype of lung cancer,for which,better understandings of its biology are urgently needed.Single-cell sequencing technologies provide an opportunity to profile individual cells within the tumor microenvironment(TME)and investigate their roles in tumorigenic processes.Here,we performed high-precision single-cell transcriptomic analysis of~5000 individual cells from primary tumors(PTs)and matched normal adjacent tissues(NATs)from 11 SCLC patients,including one patient with both PT and relapsed tumor(RT).The comparison revealed an immunosuppressive landscape of human SCLC.Malignant cells in SCLC tumors exhibited diverse states mainly related to the cell cycle,immune,and hypoxic properties.Our data also revealed the intratumor heterogeneity(ITH)of key transcription factors(TFs)in SCLC and related gene expression patterns and functions.The non-neuroendocrine(non-NE)tumors were correlated with increased inflammatory gene signatures and immune cell infiltrates in SCLC,which contributed to better responses to immune checkpoint inhibitors.These findings indicate a significant heterogeneity of human SCLC,and intensive crosstalk between cancer cells and the TME at single-cell resolution,and thus,set the stage for a better understanding of the biology of SCLC as well as for developing new therapeutics for SCLC. | Yanhua Tian Qingqing Li Zhenlin Yang Shu Zhang Jiachen Xu Zhijie Wang Hua Bai Jianchun Duan Bo Zheng Wen Li Yueli Cui Xin Wang Rui Wan Kailun Fei Jia Zhong Shugeng Gao Jie He Carl MGay Jianjun Zhang Jie Wang Fuchou Tang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 1 |
| 17 | Genomic variation,origin tracing,and vaccine development of SARS-CoV-2:A systematic review显示文摘COVID-19 has spread globally to over 200 countries with more than 40 million confirmed cases and one million deaths as of November 1,2020.The SARS-CoV-2 virus,leading to COVID-19,shows extremely high rates of infectivity and replication,and can result in pneumonia,acute respiratory distress,or even mortality.SARS-CoV-2 has been found to continue to rapidly evolve,with several genomic variants emerging in different regions throughout the world.In addition,despite intensive study of the spike protein,its origin,and molecular mechanisms in mediating host invasion are still only partially resolved.Finally,the repertoire of drugs for COVID-19 treatment is still limited,with several candidates still under clinical trial and no effective therapeutic yet reported.Although vaccines based on either DNA/mRNA or protein have been deployed,their efficacy against emerging variants requires ongoing study,with multivalent vaccines supplanting the first-generation vaccines due to their low efficacy against new strains.Here,we provide a systematic review of studies on the epidemiology,immunological pathogenesis,molecular mechanisms,and structural biology,as well as approaches for drug or vaccine development for SARSCoV-2. | Tianbao Li Tao Huang Cheng Guo Ailan Wang Xiaoli Shi Xiaofei Mo Qingqing Lu Jing Sun Tingting Hui Geng Tian Leyi Wang Jialiang Yang | 2021 | The Innovation2021，2，2： | 1 |
| 18 | Simultaneous determination of five anthraquinones in medicinal plants and pharmaceutical preparations by HPLC with fluorescence detection 显示文摘 | Dongxiu He Bo Chen Qingqing Tian | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，4： | 1 |
| 19 | Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis:therapeutic potential for endogenous pulp regeneration显示文摘Pulp loss is accompanied by the functional impairment of defense,sensory,and nutrition supply.The approach based on endogenous stem cells is a potential strategy for pulp regeneration.However,endogenous stem cell sources,exogenous regenerative signals,and neovascularization are major difficulties for pulp regeneration based on endogenous stem cells.Therefore,the purpose of our research is to seek an effective cytokines delivery strategy and bioactive materials to reestablish an ideal regenerative microenvironment for pulp regeneration.In in vitro study,we investigated the effects of Wnt3a,transforming growth factor-beta 1,and bone morphogenetic protein 7(BMP7)on human dental pulp stem cells(h-DPSCs)and human umbilical vein endothelial cells.2D and 3D culture systems based on collagen gel,matrigel,and gelatin methacryloyl were fabricated to evaluate the morphology and viability of h-DPSCs.In in vivo study,an ectopic nude mouse model and an in situ beagle dog model were established to investigate the possibility of pulp regeneration by implanting collagen gel loading BMP7.We concluded that BMP7promoted the migration and odontogenic differentiation of h-DPSCs and vessel formation.Collagen gel maintained the cell adhesion,cell spreading,and cell viability of h-DPSCs in 2D or 3D culture.The transplantation of collagen gel loading BMP7 induced vascularized pulp-like tissue regeneration in vivo.The injectable approach based on collagen gel loading BMP7 might exert promising therapeutic application in endogenous pulp regeneration. | Cheng Liang Qingqing Liang Xun Xu Xiaojing Liu Xin Gao Maojiao Li Jian Yang Xiaotao Xing Haisen Huang Qi Tang Li Liao Weidong Tian | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 20 | Effect of alkylamine on activity and stability of immobilized angiotensin converting enzyme 显示文摘 | Tian Qingqing Zhou Naiyuan Zeng Weixiu | 2012 | Catal Commun2012，24，： | 1 |
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