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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 3 | Effects of Adipose-derived Mesenchymal Stem Cell Exosomes on Corneal Stromal Fibroblast Viability and Extracellular Matrix Synthesis显示文摘 | Ting Shen Qing-Qing Zheng Jiang Shen Qiu-Shi Li Xing-Hui Song Hong-Bo Luo Chao-Yang Hong Ke Yao | 2018 | Chinese Medical Journal2018，，6： | 23 |
| 4 | Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease显示文摘 | Lei Wang Ke Hao Ting Yang Chen Wang | 2017 | Chinese Medical Journal2017，，17： | 20 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)-associated protein 9(CRISPR-Cas9) system provides a novel genome editing technology that can precisely target a genomic site to disrupt or repair a specific gene. Some CRISPR-Cas9 systems from different bacteria or artificial variants have been discovered or constructed by biologists, and Cas9 nucleases and single guide RNAs(sgRNA) are the major components of the CRISPR-Cas9 system. These Cas9 systems have been extensively applied for identifying therapeutic targets, identifying gene functions, generating animal models, and developing gene therapies.Moreover, CRISPR-Cas9 systems have been used to partially or completely alleviate disease symptoms by mutating or correcting related genes. However, the efficient transfer of CRISPR-Cas9 system into cells and target organs remains a challenge that affects the robust and precise genome editing activity. The current review focuses on delivery systems for Cas9 mRNA, Cas9 protein, or vectors encoding the Cas9 gene and corresponding sgRNA. Non-viral delivery of Cas9 appears to help Cas9 maintain its on-target effect and reduce off-target effects, and viral vectors for sgRNA and donor template can improve the efficacy of genome editing and homology-directed repair. Safe, efficient, and producible delivery systems will promote the application of CRISPR-Cas9 technology in human gene therapy. | Zhi-Yao He Ke Men Zhou Qin Yang Yang Ting Xu Yu-Quan Wei | 2017 | Science China(Life Sciences)2017，60，5： | 10 |
| 7 | Salmeterol/fluticasone treatment reduces circulating C-reactive protein level in patients with stable chronic obstructive pulmonary disease显示文摘背景证据建议那全身的发炎可以在长期的妨碍的肺的疾病的前进和病态起一个重要作用。是否与收缩筋能稀释的长行动的 2-adrenoceptor 在联合吸入 corticosteroid,仍然保持争论全身的发炎。我们在稳定的长期的妨碍的肺的疾病 patients.Methods 在传播 C 反应的蛋白质水平上评估了 salmeterol/fluticasone propionate 的效果开标签的临床的审判与稳定的 moderate-to-severe 被进行到成员 122 门诊病人从在 2007 年 6 月和 2008 年 3 月之间的二所教学医院里的呼吸的药的部门的长期的妨碍的肺的疾病。病人们被使随机化进二个组(1:1 ) 也收到 50 ug salmeterol 和 500 ug fluticasone 的联合两次日报(n=61 ) ,或 206 ug albuterol 和 36 ug ipratropium 的联合在 6 个月的 q.i.d (n=61 ) 。传播 C 反应的蛋白质集中在随机化前并且在后续期间被测量。治疗的功效被呼吸量测定法,以及健康地位和呼吸困难分数也在基线并且在二个组的 6 月的 treatment.Results 基线特征以后估计是类似的。与 ipratropium/albuterol 相比, salmeterol/fluticasone 的联合显著地减少了 C 反应的蛋白质的传播水平(-1.73 对 0.08 mg/L,分别地 P < 0.05 ) 在 6 月的治疗以后。在一秒(FEV1 ) 和健康地位的强迫的吐气的体积也与 ipratropium/albuterol 相比在 salmeterol/fluticasone 组显著地改善了。有传播C反应的蛋白质水平的减少的 Salmeterol/fluticasone 治疗题目与那些相比在 FEV1 和圣乔治的呼吸问询表全部的分数有重要改进( 185 对 83 ml 和 -5.71 对 -1.79 单位,分别地两 P < 0.01 ) .Conclusion Salmeterol/fluticasone 治疗在临床上稳定的 moderate-to-severe 减少了传播C反应的蛋白质集中在6月的治疗以后的长期的妨碍的肺的疾病病人。 | TANG Yong-jiang WANG Ke YUAN Tao QIU Ting XIAO Jun YI Qun FENG Yu-lin | 2010 | Chinese Medical Journal2010，，13： | 9 |
| 8 | Radiomic features from computed tomography to differentiate invasive pulmonary adenocarcinomas from non-invasive pulmonary adenocarcinomas appearing as part-solid groundglass nodules显示文摘Objective:We aim to investigate radiomic imaging features extracted in computed tomography(CT)images to differentiate invasive pulmonary adenocarcinomas(IPAs)from non-IPAs appearing as part-solid ground-glass nodules(GGNs),and to incorporate significant radiomic features with other clinically-assessed features to develop a diagnostic nomogram model for IPAs.Methods:This retrospective study was performed,with Institutional Review Board approval,on 88 patients with a total of 100 part-solid nodules(56 IPAs and 44 non-IPAs)that were surgically confirmed between February 2014and November 2016 in the First Affiliated Hospital of China Medical University.Quantitative radiomic features were computed automatically on 3D nodule volume segmented from arterial-phase contrast-enhanced CT images.A set of regular risk factors and visually-assessed qualitative CT imaging features were compared with the radiomic features using logistic regression analysis.Three diagnostic models,i.e.,a basis model using the clinical factors and qualitative CT features,a radiomics model using significant radiomic features,and a nomogram model combining all significant features,were built and compared in terms of receiver operating characteristic(ROC)curves.Decision curve analysis was performed for the nomogram model to explore its potential clinical benefit.Results:In addition to three visually-assessed qualitative imaging features,another three quantitative features selected from hundreds of radiomic features were found to be significantly(all P<0.05)associated with IPAs.The diagnostic nomogram model showed a significantly higher performance[area under the ROC curve(AUC)=0.903]in differentiating IPAs from non-IPAs than either the basis model(AUC=0.853,P=0.0009)or the radiomics model(AUC=0.769,P<0.0001).Decision curve analysis indicates a potential benefit of using such a nomogram model in clinical diagnosis.Conclusions:Quantitative radiomic features provide additional information over clinically-assessed qualitative features for differentiating IPAs from non-IPAs appearing as GGNs,and a diagnostic nomogram model including all these significant features may be clinically useful in preoperative strategy planning. | Ting Luo Ke Xu Zheng Zhang Lina Zhang Shandong Wu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 8 |
| 9 | Decreased miR-320 expression is associated with breast cancer progression, cell migration, and invasiveness via targeting Aquaporin 1显示文摘我们的以前的研究证明了 Aquaporin 1 (AQP1 ) 是在乳癌的 overexpressed。然而,机制留下逃犯。MicroRNA 320 (miR-320 ) downregulation 在癌症的各种各样的类型被报导了,并且它可以调整 AQP1 表示。在这研究, miR-320 和 AQP1 表情被量的反向的 transcription-PCR 调查,在 situ 杂交,和 immunohistochemistry。这些分子的 clinicopathological 含意也被分析。我们发现那 miR-320 表情在人的乳癌病人是在血浆和肿瘤织物的 downregulated。幸存分析证明 miR-320 的那减少的表情和 AQP1 的 overexpression 与更坏的预后被联系。酶试金证明 miR-320 否定地调整 AQP1 表示。另外,房间增长,移植,和侵略试金被执行在乳癌房间上调查 miR-320 的效果。我们的结果证明 miR-320 overexpression 由 downregulating AQP1 在乳癌房间禁止房间增长,移植,和侵略。这些观察建议 miR-320 downregulation 可以在乳癌提高 AQP1 表示,赞成肿瘤前进。我们的调查结果显示 miR-320 和 AQP1 可以在乳癌的治疗用作预示的 biomarkers 和治疗学的目标。 | Liang Luo Rui Yang Shaojie Zhao Yu Chen Shanchao Hong Ke Wang Tiejun Wang Jing Cheng Ting Zhang Daozhen Chen | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 6 |
| 10 | Extremely low warfarin dose in patients with genotypes of CYP2C9*3/*3 and VKORCl-1639A/A显示文摘有两 CYP2C9 *3 / *3 和 VKORC1-1639 A/A 的遗传型的背景病人被期望要求 warfarin 的最低剂量,并且在如此的极其稀罕的案例中为 warfarin 的 dosing 有 bleeding.The 经验的极大地增加的风险是很少,人口统计的 reported.Methods 和从有在中国的 warfarin 的稳定的低剂量的二个案例的临床的数据被重新定序学习在他们的整个血 DNA.The 潜在的临床的价值的相应基因片断 pharmacogenetic | GAO Lei HE Lei LUO Jin XU Bin YANG Jie ZHANG Yu-xiao YANG Ting LI Ke TIAN Jin-wen WANG Hong-juan ZHAO Yu-sheng LU Cai-yi ZHANG Wen-zi YIN Tong | 2011 | Chinese Medical Journal2011，，17： | 6 |
| 11 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 12 | Characteristic Analysis of OC and EC in PM_(2.5) of Typical Haze Weather in Wuhan City显示文摘Long-time large-area haze weather appeared in Wuhan on June 11,2012. It was monitored that PM2. 5hourly concentration obviously rose,and peak value reached 658 μg /m3. OC and PM2. 5presented high correlation,and correlation coefficient was 0. 96. OC daily average concentration occupied 10%-20% in PM2. 5,and difference was big between haze and normal weather. EC occupied 5%,and difference was very small between haze and normal weather. By analyzing change trend of OC/EC,it was found that OC/EC presented increasing trend in late May and was even higher than that during 11-15 June. It was clear that biomass combustion taking straw as the representation has started in late May.But two strong precipitation on May 29 and June 6 inhibited haze weather,and specific meteorological condition caused haze on June 11. Proportion of SOC to OC reached 14%-70%,illustrating that daily difference of secondary photochemical reaction was very big in Wuhan. OC/EC values were respectively 2. 7,3. 5 and 4. 2 in May,June and haze period. SOC daily means were respectively( 5. 33 ±4. 77) and( 32. 5 ±23. 4) μg /m3in May and haze period. Major pollution source of haze weather was biomass combustion,and haze occurrence had very big relationship with special meteorological condition. | Zhong Zhangxiong Hu Ke Huang Zhen Yin Ting Shen Longjiao | 2014 | Meteorological and Environmental Research2014，5，4： | 6 |
| 13 | Association between body mass index and pulmonary function of patients with chronic obstructive pulmonary disease显示文摘 | QIU Ting TANG Yong-jiang XU Zhi-bo XU Dan XIAO Jun ZHANG Ming-ke FENG Yu-lin WANG Ke | 2009 | Chinese Medical Journal2009，，9： | 6 |
| 14 | Hyperechoic demarcation line between a tumor and the muscularis propria layer as a marker for deciding the endoscopic treatment of gastric submucosal tumor显示文摘Minimally invasive endoscopic resection has been rapidly adopted as a new technique for treating patientswith gastric submucosal tumors (SMTs) originating in the muscularis propria (MP) layer. This study was conducted toevaluate the information obtained from endoscopic ultrasonography (EUS) to determine the appropriate endoscopicdissection method for treating SMTs originating in the MP layer. Between February 2014 and May 2016, a total of 50patients with gastric SMTs originating in the MP layer were enrolled in this study. The clinical features of the patientsand their endoscopic, EUS, and histopathologic findings, as well as their postoperative follow-up data, were analyzedin this retrospective study. The mean age of the patients was (55.0±10.2) years, and the male/female ratio was 17:33.Endoscopic submucosal dissection (ESD) was performed on 43 patients and an endoscopic full-thickness resection(EFR) was performed on seven patients. The most frequent location for an SMT was in the upper body region of thestomach (n=16), and the most common pathological diagnosis was a gastrointestinal stromal tumor (GIST) (n=32).The overall rates for complete resection were 95.3% (41/43) and 100.0% (7/7) when the SMTs were treated by ESDand EFR, respectively. The presence of a complete tumor capsule was significantly associated with a complete re-section (P=0.001). Of the cases treated by ESD, nine patients developed perforation, one of whom required laparo-scopic surgery. The remaining patients were closed with clips or purse-string sutures. The presence of an MP2-typetumor (P=0.018) and a wide connection with the MP layer (P=0.044) were significantly associated with perforation. Apreoperative evaluation of the integrity and the location of a tumor capsule and the length of the tumor connection withthe MP layer by EUS can improve the complete resection rate and reduce the occurrence of intraoperative complica-tions. Tumors with a complete capsule originating from the superficial MP layer or with a narrow connection with theMP layer are appropriate candidates for treatment by ESD. | Yu ZHANG Zhen WANG Ting JIN Kai-qiang LI Ke HAO WeiZHANG Bao-ying FEI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，8： | 5 |
| 15 | The Mechanism and Influence of AKAP12 in Different Cancers显示文摘The development of cancer is a complex process that requires the participation of many factors, including mutations in genes, regulation of signaling pathways, disruption of homeostasis, and failure of self-monitoring mechanisms. Sufficient evidence has shown that the A kinase anchoring protein (AKAP) family plays an important role in signal transduction in cancer. AKAP12 and AKAP12-regulated signaling pathways are critically involved in the development and progression of a variety of tumors. | WU Xuan WU Tong LI Ke LI Yuan HU Ting Ting WANG Wei Feng QIANG Su Jing XUE Shao Bo LIU Wei Wei | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 16 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 17 | Optimal waiting period for fresh embryo transfer after hysteroscopic adhesiolysis: a retrospective cohort study显示文摘Background:Very few studies have been conducted regarding the optimal time interval between hysteroscopic adhesiolysis and the embryo transfer(ET).Investigation of this optimal time may be helpful for assisted reproductive technology.Therefore,we investigated effects of the interval between hysteroscopic adhesiolysis and ET upon in vitro fertilization(IVF)cycle outcomes.Methods:Patients were recruited between January 2014 and September 2017 at the Reproductive Hospital Affiliated to Shandong University.Patients who were diagnosed with intra-uterine adhesion(IUA)and underwent hysteroscopic adhesiolysis before fresh IVF-ET or intra-cytoplasmic sperm injection cycles were classified into three groups according to the interval between hysteroscopic adhesiolysis and ET:less than 90 days(Group 1),90 to 180 days(Group 2),and greater than 180 days(Group 3).Baseline characteristics,controlled ovarian stimulation(COS)response,and pregnancy outcomes after ET were compared.Analysis of variance or non-parametric tests were used to test numerical data.The Pearson’s Chi-squared test was used to test categorical data.Results:A total of 312 patients were recruited as follows:112 in Group 1,137 in Group 2,and 63 in Group 3.There were no differences in baseline and COS characteristics among the three groups.The live-birth rate in Group 2(40.1%)was significantly higher than that in Group 1(17.9%;χ^2=14.545,P<0.001).There were no significant differences in the rates of biochemical,ongoing,and clinical pregnancy,and biochemical and clinical pregnancy abortion,as well as stillbirth among the groups.In the mild IUA patients,the live-birth rate was significantly higher in Group 2(42.6%)compared with Group 1(22%;χ^2=8.413,P=0.004).In the moderate IUA patients,Group 2(35.7%)had a higher frequency of live births than Group 1(6.7%;χ^2=8.187,P=0.004).Conclusions:The optimal waiting period for fresh ET after hysteroscopic adhesiolysis was 90 to 180 days in the current study. | Ke Deng Xiao-Hua Song Xue-Mei Han Wei-Ya Kong Wei Liu Ting Han Lei Yan | 2019 | Chinese Medical Journal2019，，19： | 5 |
| 18 | Progress and challenges in blocked impurity band infrared detectors for space-based astronomy显示文摘Astronomical detection at infrared wavelengths is crucial in astrophysics due to the critical information in this wavelength range.Blocked impurity band(BIB) infrared detectors are desirable for space-based astronomical observation due to their broad response range, low dark currents, high quantum efficiencies, and excellent radiation resistance. In this review, typical BIB device structures and device physics development are first introduced. Subsequently, we discuss progress in Si-based BIB detectors with different doping types and emphasize their applications in space-based infrared detection. Additionally, we discuss recent efforts on pixel performance optimization, response extension, and higher operating temperature devices. Finally,we conclude by proposing the challenges and perspectives of BIB detectors with improved detection performances. | Yunlong Xiao He Zhu Ke Deng Peng Wang Qing Li Ting He Tao Zhang Jinshui Miao Ning Li Wei Lu Ning Dai Weida Hu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 4 |
| 19 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 20 | Soil properties and herbaceous characteristics in an age sequence of Haloxylon ammodendron plantations in an oasis-desert ecotone of northwestern China显示文摘Haloxylon ammodendron,a typical desert shrub with C4 pathway of photosynthesis,possessing a strong ability to adapt to an extreme drought environment,has a rapid growth rate in sandy lands and is widely used in sand-fixing shelter-forest systems in oasis-desert ecotones.To assess the effects of H.ammodendron plantation on the soil,we measured soil properties and herbaceous characteristics along a nearly 40-year chronosequence after H.ammodendron was planted in shifting sand dunes in an oasis-desert ecotone.Results showed that silt and clay fractions increased significantly in the topsoil.The accumulation rates of soil organic carbon(SOC),total nitrogen(TN) and total phosphorus(TP) were faster in the early stages(0–9 years) and slower in the late stages(9–39 years).The soil p H and electrical conductivity(EC) were higher than those in the non-vegetation dunes.Moreover,the soil properties in the topsoil(0–5 cm) showed larger variation scope than those in the deeper soil layers(5–20 cm).The significant relationships of the soil silt+clay content with the chemical properties mainly appeared in the topsoil.The wind erosion susceptibility of the soil,evaluated by erodible fraction(EF),decreased significantly with increasing H.ammodendron plantation age.Additionally,the annual pioneer herb,Agriophyllum squarrosum,was gradually substituted by the annual salt-tolerant herb,Bassia dasyphylla,with increasing plantation age.These results showed beneficial effects of H.ammodendron plantation on improving soil conditions.However,the dynamics of the herbaceous species also reminded us that the longterm effects of H.ammodendron plantation,especially on changes in vegetation composition,still need further evaluation. | ZHANG Ke SU Yongzhong WANG Ting LIU Tingna | 2016 | Journal of Arid Land2016，8，6： | 4 |
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