|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent显示文摘铁在 Parkinson 的疾病(PD ) 起一个关键作用。substantia nigra (SN ) 的增加的铁内容在 PD 病人,和二价的金属 transporter 被发现了(DMT1 ) 1 被显示了在两个导致 MPTP 的 PD 模型和 PD 病人的 SN 起来调整。然而,位于 DMT1 起来规定下面的机制大部分是未知的。在现在的学习,我们观察到那在 6-hydroxydopamine ( 6-OHDA )的 SN 导致了 PD 老鼠,有铁的 DMT1 应答的元素(怒火, DMT1+IRE ),然而并非没有怒火( DMT1?IRE )的 DMT1 ,是起来调整的,建议那增加的 DMT1+IRE 表情可能在 PD 老鼠说明 nigral 铁累积。这可能性进一步被估计在一在里面 vitro 学习使用 6-OHDA-treated 和 DMT1+IRE-over-expressing MES23.5 房间。在 6-OHDA-treated MES23.5 房间,增加了铁规章的蛋白质(IRP ) 1 并且 IRP2 表示被观察,当 IRP 的 silencing 戏剧性地减少了时 6-OHDA-induced DMT1+IRE 起来规定。有 N-acetyl-L-cysteine 的预告的处理充分由 6-OHDA-induced 的抑制压制了 IRP 起来规定氧化应力。增加的 DMT1+IRE 表示由 MES23.5 房间导致了增加的铁流入。我们的数据提供 DMT1+IRE 起来规定能说明细胞内部的氧化应力和那增加了的 6-OHDA-induced 开始的 IRE/IRP-dependent 6-OHDA-induced 铁累积的直接证据细胞内部的铁的层次导致加重的氧化应力。这研究的结果提供在 PD 的处理支持抗氧化剂的使用的新奇证据,旨在禁止由 DMT1 表示的规定的铁累积。 | Hong Jiang Ning Song Huamin Xu Shuzhen Zhang Jun Wang Junxia Xie | 2010 | Cell Research2010，20，3： | 25 |
| 3 | Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission显示文摘 | Xiaohong Shi Xuefei Wang Xixi Xu Yongliang Feng Shuzhen Li Shuying Feng Bo Wang Suping Wang | 2017 | Frontiers of Medicine2017，11，4： | 11 |
| 4 | 新型固定式宫内节育器与TCu220C的临床效果比较性研究显示文摘本文系研究新型固定式宫内节育器(Fix—CuU300IUD)的临床避孕效果、副反应和可接受性,选用目前公认较为理想的TCu220C作对照,采用多中心随机比较性研究。自1993年2月至5月共接收合格对象2104例(各1052例),1年随访率为99.95%。使用12个月结果表明:FIX-Cu300IUD累积妊娠率为0.09%,对照组为1.43%(P<0.01);脱落率分别为0.95%和2.28%(P<0.05);因症取出率依次为1.04%和2.09%(P>0.05);续用率分别为97.33%和93.82%(P<0.05)。98%以上受试者对所使用的Fix-Cu300IUD的避孕效果满意,证实此种IUD符合WHO的可接受性IUD标准。 | Wang Shuzhen,et al. Wu Han New Type Fix - Cu IUD ResearchGroup, 430030. | 1995 | 中国实用妇科与产科杂志1995，11，4： | 11 |
| 5 | Effect of different sources and levels of iron in the diet of sows on iron status in neonatal pigs显示文摘This study was conducted to determine the effects of maternal dietary supplementation of ferrous glycine chelate(Fe-Gly) and ferrous sulfate monohydrate(FeSO_4·H_2O) on the relative organ weight, tissue iron contents, red blood cells(RBC), hemoglobin concentration(HGB) and hematocrit(HCT) in blood, as well as ferritin(Fn), serum iron(SI), and total iron binding capacity(TIBC) in serum of newborn piglets.Forty-five sows(Landrace × Large white, mean parity 3 to 4, no significant differences in BW) were randomly allotted to 9 treatments(n=5 sows/treatment): control(basal diet with no Fe supplementation), the basal diet supplemented with 50, 80, 110 or 140 mg Fe/kg as Fe-Gly, and the basal diet supplemented with 50, 80, 110 or 140 mg Fe/kg as FeSO_4·H_2O.The neonatal piglets(n=45) were used to determine the relative organ weight, tissue iron contents and blood biochemical indices.Compared with the control, the relative weight of spleen and kidney were significantly increased(P < 0.05) in the Fe-Gly groups.The iron contents in liver,spleen, kidney and femur were also found increased(P < 0.05) in the Fe-Gly groups.The RBC(d 1 and 21),HGB(d 1 and 21) and HCT(d 1 and 21) in blood and Fn(d 1) and SI(d 1 and 21) significantly increased(P < 0.05), but the TIBC(d 1 and 21) in serum decreased(P < 0.05) in the Fe-Gly groups.Moreover, the kidney relative weight, iron content in liver, spleen, kidney and femur, RBC(d 1) and HGB(d 21) in blood, and SI(d 1)in the Fe-Gly groups increased(P < 0.05) compared with the FeSO_4·H_2O treatment.Linear and quadratic responses of the kidney relative weight, the iron content in liver, spleen, kidney and femur, RBC(d 1 and 21),HGB(d 1 and 21) and HCT(d 1 and 21) in whole blood, SI(d 1) and TIBC(d 1 and 21) in the Fe-Gly groups were observed(P < 0.05).Linear responses of Fn(d 1 and 21) and SI(d 21) in the Fe-Gly groups, and spleen relative weight, HCT(d 1), Fn(d 1) and TIBC(d 1 and 21) in the FeSO_4·H_2O groups were observed(P < 0.05).These finding suggest that Fe-Gly supplemented at the level of 110 mg/kg in the diet of sows in this experiment is superior to other forms of supplementation, based on HGB concentration, the relative organ weight, tissue iron contents and blood biochemical indices of piglets. | Yan Li Weiren Yang Donghua Dong Shuzhen Jiang Zaibin Yang Yuxi Wang | 2018 | Animal Nutrition2018，，2： | 11 |
| 6 | Incidence of Extended-Spectrum β-Lactamases and Characterization of Integrons in Extended-Spectrum β-Lactamase-producing Klebsiella pneumoniae Isolated in Shantou, China显示文摘这研究涉及生产 Klebsiella pneumoniae 的抗菌素抵抗 ofextended 光谱 beta-lactamase (ESBL ) 的水平,在 Shantou,中国,和它的机制孤立。74 非重复临床 K 孤立。生产在 2 年的一个时期上孤立的 ESBLswere 的 pneumoniae。抗菌素危险性,由 Epsilometer 测试执行了,证明大多数 isolates 是多抵抗的。聚合酶链反应证明在 beta-lactamases 的几种类型之中, SHV 是最流行的, TEM 是第二个大多数流行,并且 CTX-M 是最不流行的。69 孤立为 integrase 基因 IntI1 是积极的,但是没有 IntI2 或 IntI3 基因被发现。班 1 integrons 的可变区域被定序放大并且进一步识别了。13 个不同基因盒子和 11 不同盒子联合被检测。Dfr 和 aadA 盒子是占优势的,盒子 combinationsdfrA12, orfF 和 aadA2 最经常被发现。编码 ESBL 的基因盒子都不是 found.Integrons 是流行的并且起了一个重要作用在多在生产 ESBL K.pneumoniae 的药抵抗。 | Fen YAO Yuanshu QIAN Shuzhen CHEN Peifen WANG Yuanchun HUANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 9 |
| 7 | Thermodynamic Modeling of Fluid-Bearing Natural Gas Inclusions for Geothermometer and Geobarometer of Overpressured Environments in Qiongdongnan Basin, South China Sea显示文摘It is a very difficult problem to directly determine fluid pressure during hydrocarbon migration and accumulation in sedimentary basins. pVt modeling of coupling hydrocarbon fluid inclusion of its coeval aqueous fluid inclusion provides a powerful tool for establishing the relationship of formation pressure evolution with time. Homogenization temperature of fluid inclusion can routinely be measured under microthermometric microscopy. Crushing technique has been employed to obtain the composition of fluid inclusions, and the commercial software VTFLINC easily and rapidly completes the construction of p t phase diagram. The minimum trapping pressure of hydrocarbon fluid inclusion would be then determined in the p t space. In this paper, three samples of YC21 1 1 and YC21 1 4 wells at YC21 1 structural closure, Qiongdongnan basin, South China Sea, were selected for the pVt modeling practice, and the formation pressure coefficient (equals to fluid pressure/hydrostatic pressure) changing trend with time has primarily been established. The modeling results also indicate that the reservoirs of Lingshui and Yacheng formations in YC21 1 structure are within a very high potential system and would have undergone a discharging of thermal fluids through top seal rupture, which depicts that there is a very high risk for natural gas exploration in this area. | Chen Honghan Yao Shuzhen Wang Jiahao Li Chunquan Institute of Resources, China University of Geosciences, Wuhan 430074 | 2002 | Journal of China University of Geosciences2002，13，3： | 7 |
| 8 | A Study of Tensile Strength Tests of Arborous Species Root System in Forest Engineering Technique of Shallow Landslide显示文摘One experiment was conducted, through tensile tests of Albazzia and Eucalypt roots culled from the fields. The other experiment was conducted, by testing anti-drawing strength of these root systems in the Albazzia and Eucalypt lands. These two experiments had an aim to give insights into the maximum tensile strength and anti-drawing strength of the root systems. Results indicated that the maximum tensile strength of root system is in an exponential relation with the diameter of root system while the maximum tensile strength is positively correlative with the diameter of root system. Anti-drawing force of root system together with root diameter, length, and soil bulk density are folded into a regression equation in an attempt to figure out the static friction coefficient between root system and its ambient soil. | YANG Yonghong LIU Shuzhen WANG Chenghua TANG Chuan | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 6 |
| 9 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 10 | Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response显示文摘The toxicity of chlortetracycline (CTC) on maize (Zea mays L.) growth and reactive oxygen species (ROS) generation was studied.The root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment (p < 0.05).Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/L.The spin trapping technique followed by electron paramagnetic resonance (EPR) analysis was used to quantify the ROS production.The ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical (·OH).The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed (p < 0.05).The dynamic changes of malondialdehyde (MDA) contents and the antioxidative enzyme activities in maize roots were also determined.As compared to the control group,CTC was found to significantly increase MDA content.Treatment of maize roots with the ·OH scavenger sodium benzoate (SB) reduced the MDA content and enhanced the antioxidative enzyme activities.The results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity. | Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu | 2012 | Journal of Environmental Sciences2012，24，6： | 6 |
| 11 | Influences of pH value in deposition-precipitation synthesis process on Pt-doped TiO_2 catalysts for photocatalytic oxidation of NO显示文摘This work has been undertaken to study the influences of pH value on the characteristics and activity of photocatalyst by depositionprecipitation method during its preparation process.A series of Pt-modified TiO 2 were prepared by deposition-precipitation method at different pH values as well as wet impregnation method,and characterized by XRD,XPS,TEM,UV-Vis and photoluminescence(PL).It was found that the catalysts had the highest photocatalytic activity for NO conversion when pH value was kept at around 7.And the sample prepared by deposition-precipitation method showed higher activity than that by impregnation method.This was mainly due to their high value in highly-dispersed platinum oxides(PtOx) content on the surface of the catalysts.The results from UV-Vis absorption showed that highest absorbance was obtained for Pt/TiO 2 prepared at pH values of around 7.And PL spectra results indicated that the recombination rate of photogenerated electrons and holes of the samples prepared by deposition-precipitation method was lower than that prepared by impregnation method.And in the zeta potential study,the pH values for the isoelectric point of the preparing slurry of 0.05 wt.%Pt/TiO 2 and 0.5 wt.%Pt/TiO 2 were determined to be 6.5-8.5,which further confirmed the enrichment of PtOx dopants for the catalysts repapered when pH value was around 7. | Shuzhen Song Zhongyi Sheng Yue Liu Haiqiang Wang Zhongbiao Wu | 2012 | Journal of Environmental Sciences2012，24，8： | 5 |
| 12 | Simultaneous determination of brominated phenols in soils显示文摘Brominated phenols(BPs),a widely used group of emerging flame retardants,are important environmental contaminants and exhibit endocrine disrupting potential.Method for simultaneous determination of tetrabromobisphenol A(TBBPA),tribromophenol(TBP),dibromophenols(DBPs)and monobromophenols(MBPs)in soils using gas chromatography-mass spectrometry analysis(GC/MS)was successfully developed.Cleanup methods for soil extracts including several solid-phase extraction cartridges and diferent elution solvents were compared and optimized.Florisil cartridge with dichloromethane as the elution reagent was selected for sample cleanup owing to its high and reproducible recoveries of the target analytes in soils.Derivatization conditions were tested and the optimal conditions were obtained with 20μL silylation reagent at room temperature.The chromatographic separation was optimized with diferent columns and DB-XLB column was selected for its excellent separation of the analytes.The limits of detection for the target compounds were from 0.04 to 0.19 ng/g.Mean recoveries of the compounds from spiked soils exceeded 84%with a good reproducibility,excepting that the recovery of 2-bromophenol was relatively poor(lower than 55%)due to its instability.The developed method was applied to the determination of the BPs in the soils collected from e-waste sites.The contents of BPs in the soils were at ng/g levels with TBBPA and TBP the most frequently detected.To our knowledge,this is the first report for the simultaneous determination of TBBPA,TBP,DBPs and MBPs in soils. | Wei Han Sen Wang Honglin Huang Lei Luo Shuzhen Zhang | 2013 | Journal of Environmental Sciences2013，25，11： | 5 |
| 13 | Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging显示文摘二维(2D ) nanosheets 在 biomedicines 的领域里与大潜力作为 nanomaterial 的一个重要的类出现了,特别地在癌症 theranostics。然而,由于综合的有效方法的缺乏有控制尺寸的一致 2D nanomaterials, 2D nanomaterials 的尺寸依赖者简历行为的系统的评估很少被报导。就我们的知识而言,我们是第一报导对他们的简历行为的 2D nanomaterials 的尺寸的影响的系统的评估。有从 5 ~ 80 nm 的直径的 2D Pd nanosheets 被综合并且在房间和动物模型测试了估计他们基因表示介绍的尺寸依赖者 bioapplication, biodistribution,消除,毒性,和 genomic。我们的结果证明尺寸显著地影响 Pd nanosheets 的生物行为,包括他们的 photothermal 和 photoacoustic 效果, pharmacokinetics,和毒性。比作大尺寸的 Pd nanosheets,更展出的小尺寸的 Pd nanosheets 在 ultralow 之上预付 photoacoustic 成像和 photothermal 效果激光照耀。而且,在 vivo,结果显示 5-nm Pd nanosheets 与更长的血半衰期逃离网状内皮组织的系统并且能被肾的排泄清除,当时有更大的尺寸的 Pd nanosheets 主要在肝和怒气积累。30-nm Pd nanosheets 展出了最高的肿瘤累积。尽管 Pd nanosheets 没在细胞的水平引起任何可估计的毒性,我们在怒气在肝和发炎观察了细微类脂化合物累积。Genomic 基因表达式分析证明 80-nm Pd nanosheets 与更细胞的部件交往了并且在肝影响了更生物的进程,作为与 5-nm Pd nanosheets 相比。我们相信这个工作将作为 nanomedicines 提供珍贵信息和卓见进 2D Pd nanosheets 的临床的申请。 | Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng | 2017 | Nano Research2017，10，4： | 5 |
| 14 | 152 W high-power blue diode laser operated at 447 nm显示文摘We demonstrate a high-power blue diode laser operated at 447 nm combining laser diodes using an optical fiber bundle. As many as 127 diode lasers at 447 nm were coupled into 400 μm/0.22 NA fibers using an aspherical lens group with different focus lengths. The bare fibers were mechanically bundled through high temperature ultraviolet adhesive after the coatings of the 127 fibers were stripped. The diameter of the fiber bundle was 6 mm. The total output power of such a bundle was 152 W with electro-optical conversion efficiency of 27.56%and the RMS power instability was less than ±1% within 3 h. | Peng Wu Ling Zhang Haijuan Yu Xiandan Yuan Zhiyan Zhang Pengfei Zhao Shuzhen Zou Chaojian He Yaoyao Qi Yingying Yang Gang Li Xubao Wang Xuechun Lin | 2017 | Journal of Semiconductors2017，38，7： | 4 |
| 15 | Development of highly glyphosate-tolerant tobacco by coexpression of glyphosate acetyltransferase gat and EPSPS G2-aroA genes显示文摘The widely used herbicide glyphosate targets 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS).Glyphosate acetyltransferase(GAT)effectively detoxifies glyphosate by N-acetylation.With the aim of identifying a new strategy for development of glyphosate-tolerant crops,the plant expression vector pG2-GAT harboring gat and G2-aroA(encoding EPSPS)has been transformed into tobacco(Nicotiana tabacum)to develop novel plants with higher tolerance to glyphosate.Results from Southern and Western blotting analyses indicated that the target genes were integrated into tobacco chromosomes and expressed effectively at the protein level.Glyphosate tolerance was compared among transgenic tobacco plants containing gat,G2-aroA,or both genes.Plants containing both gat and G2-aroA genes were the most glyphosate-tolerant.This study has shown that a combination of different strategies may result in higher tolerance in transgenic crops,providing a new approach for development of glyphosate-tolerant crops. | Baoqing Dun Xujing Wang Wei Lu Ming Chen Wei Zhang Shuzhen Ping Zhixing Wang Baoming Zhang Min Lin | 2014 | The Crop Journal2014，2，Z1： | 4 |
| 16 | In vitro and in silico analysis of dual-function peptides derived from casein hydrolysate显示文摘There is no study on food-derived peptide with both anticoagulant and angiotensin I-converting enzyme inhibitory (ACEI) activities yet. In this work, the anticoagulant and ACEI activities of the casein hydrolysates released by pepsin digestion were evaluated for the first time to the best of our knowledge. Results indicated that the casein hydrolysate exhibited potent anticoagulant activity by prolonging the thrombin time (TT) and the activated partial thromboplastin time (APTT). Compared with control samples, at 10 mg/mL, the TT and APTT of casein hydrolysate were 186.0 % ± 6.6 % and 163.5 % ± 7.4 %, respectively. The casein hydrolysate also showed a strong ACEI activity with an IC50 value of 1.775 mg/mL. The components of the bioactive casein hydrolysate were analyzed by nanoscale liquid chromatography quadrupole time-of-flight tandem mass spectrometry (NanoLC-Q-TOF-MS/MS). Total of 115 peptides were identified, among which 34, 9, 55 and 17 peptides were derived from α_(s1-), α_(s2-), β-, and κ-casein, respectively. The results of PeptideRanker and PepSite 2 analysis showed that 6 peptides (FRQFYQL, NENLLRF, NPWDQVKR, PVVVPPFLQ, PVRGPFPIIV, and ARHPHPHLSF) have both ACEI and anticoagulant activities by binding to the active sites of ACE and thrombin. This study indicated that casein is a potential functional food supplement that can be used for medical purposes. | Maolin Tu Xinyu Qiao Cong Wang Hanxiong Liu Shuzhen Cheng Zhe Xu Ming Du | 2021 | Food Science and Human Wellness2021，10，1： | 4 |
| 17 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 18 | Neuroprotective effect of Longshengzhi capsule following permanent middle cerebral artery occlusion in rats显示文摘Objective:Longshengzhi capsule(LSZC)is an optimized preparation based on the traditional Chinese Medicine formula Buyanghuanwu Decoction(BYHWD),and is approved by the China Food and Drug Administration for treating stroke-induced disability and vascular diseases.Herein,we examined the pharmacodynamics,anti-apoptotic and anti-oxidant actions,and potential mechanisms of action of LSZC following stroke in rats.Methods:Permanent middle cerebral artery occlusion(MCAO)was used as an ischemic stroke model.LSZC was administered intragastrically.We examined the survival rate,bodyweight,and neurological deficits in stroke rats.Brain infarct size was determined by 2,3,5-triphenyltetrazolium chloride staining.Brain pathology was examined using hematoxylin and eosin staining,Nissl staining,and TdT-mediated dUTP Nick-End Labeling staining.Malondialdehyde,catalase,superoxide dismutase,and glutathione levels were examined by commercial kits.Expression of Nrf2,heme oxygenase-1,Bax,Bcl-2,cleaved caspase-3,and caspase-3 proteins in brain tissue was measured by Western blot.Results:LSZC markedly improved the survival rate and bodyweight,and reduced infarct volume and neurological deficit scores,in MCAO stroke rats.LSZC also significantly attenuated oxidative stress,as indicated by decreased expression of malondialdehyde,and upregulation of Nrf2,heme oxygenase-1,catalase,superoxide dismutase,and glutathione.Moreover,LSZC significantly decreased apoptosis,including a decrease in Bax and cleaved caspase-3 expression,and an increase in Bcl-2,as well as a reduction in numbers of apoptotic neurons.Conclusion:LSZC treatment is neuroprotective against ischemic stroke,potentially via reducing oxidative stress and apoptosis.The Nrf2 and apoptotic signaling pathways may play important roles in the antioxidant and anti-apoptotic actions of LSZC. | Xiaoli Sun Shuzhen Guo Yong Wang Bangze Fu Junjie Liu Yili Zhang Ruocong Yang Chun Li Jian Gao Li Gao Wei Wang | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 4 |
| 19 | The Crustal Structure and Seismic Activity in North China显示文摘A layered crustal block model of North China has been constructed based on large amount of data from seismic sounding carried out in recent two decades. Some deep fault zones, such as the Zhangjiakou.Penglai and Tancheng-Lujiang fault zones, divide the upper crust of North China into three upper crustal terranes and nine bolcks. There are distinct differences in velocity and depth distributions, which reflects Cenozoic block faulting in North China in the process of formation of the deep structure. The upper crust shows the features of transition in isostatic adjustment. The existence of a low-velocity layer in the middle crust is characteristic of the crustal structure in North China. There seems to be an increase of rheology of the rocks in the lower crust and a persistence of stable regional stress field. The patterns of the Moho on two sides of the Yanshan-Taihang Mountains are different. The relief of the Moho around Beijing, Shijiazhuang and Guangrao where the deep faults join together shows a quadrantal distribution in some degree. The dynamic sources for seismic activity are the NE-SW horizontal compression and the diapirism of the upper mantle. The middle and upper crust, especially the layered block structure has the most significant effects on seismicity, and the occurrence of earthquakes is more closely related to them than to the Moho. | Feng Rui Institute of Geophysics, State Seismological Bureau, Beijing Huang Guifang, Zheng Shuzhen, Wang Jun, Yan Huifen Geophysical Prospecting Party, State Seismological Bureau, Zhengzhou, Henan and Zhang Ruoshui Seismological Technique College, State Seismological Bureau, Yanjiao,Hebei | 1989 | Acta Geologica Sinica(English Edition)1989，63，4： | 4 |
| 20 | Phyto-availability and speciation change of heavy metals in soils amended with lignin as micro-fertilizer显示文摘Lignin is a primary byproduct from the black liquor treatment in paper making industries, its application as micro-fertilizer in agricultural land might provide a promising alternative to sewage discharge. However, application of such a micro-fertilizer might affect the soil properties and result in soil pollution. In this study, the effects of lignin application on phytoavailability and speciation change of heavy metals in soils were investigated. Greenhouse experiments showed that lignin application improved the growth of winter wheat (Triticum aestivum L.) in all three soils investigated. The increase of the biomass for wheat shoot was 59.7%, 39.8% and 12.3% for Beijing soil, Jiangxi soil and Dongbei soil, respectively. In contrast, lignin amendment decreased the concentrations of heavy metals in wheat shoots from 2.2% to 61.0%. Sequential extraction procedure of a three-step BCR was used to investigate the fraction distribution. The extractable fractions were specified as fraction B1: water soluble, exchangeable and carbonate bound or weakly specifically adsorbed; B2: Fe-Mn oxide bound; B3: organic matter and sulfide bound. The results showed that lignin application led to the redistribution of heavy metals in each fraction. Generally, heavy metals decreased in B1 and B2 fractions and increased in B3 fraction. Upon the results short-term application of lignin in agricultural land not only improves the growth of wheat but also reduces the phyto-abailability of heavy metal in wheat. | WANG Songxue, ZHANG Shuzhen, SHAN Xiaoquan & MU Huanzhen Stale Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Science Academy of State Administration of Grain, Beijing 100037, China | 2005 | Science China(Life Sciences)2005，48，z1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员