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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Synergistic effect of fluorination on both donor and acceptor materials for high performance non-fullerene polymer solar cells with 13.5% efficiency显示文摘A high performance polymer solar cells(PSCs) based on polymer donor PM6 containing fluorinated thienyl benzodithiophene unit and n-type organic semiconductor acceptor IT-4 F containing fluorinated end-groups were developed. In addition to complementary absorption spectra(300–830 nm) with IT-4 F, the PM6 also has a deep HOMO(the highest occupied molecular) level(-5.50 e V), which will lower the open-circuit voltage(V_(oc)) sacrifice and reduce the E_(loss) of the IT-4 F-based PSCs. Moreover, the strong crystallinity of PM6 is beneficial to form favorable blend morphology and hence to suppress recombination. As a result, in comparison with the PSCs based on a non-fluorinated D/A pair of PBDB-T:ITIC with a medium PCE of 11.2%, the PM6:IT-4 Fbased PSCs yielded an impressive PCE of 13.5% due to the synergistic effect of fluorination on both donor and acceptor, which is among the highest values recorded in the literatures for PSCs to date. Furthermore, a PCE of 12.2% was remained with the active layer thickness of up to 285 nm and a high PCE of 11.4% was also obtained with a large device area of 1 cm^2. In addition, the devices also showed good storage, thermal and illumination stabilities with respect to the efficiency. These results indicate that fluorination is an effective strategy to improve the photovoltaic performance of materials, as well as the both fluorinated donor and acceptor pair-PM6:IT-4 F is an ideal candidate for the large scale roll-to-roll production of efficient PSCs in the future. | Qunping Fan Wenyan Su Yan Wang Bing Guo Yufeng Jiang Xia Guo Feng Liu Thomas P.Russell Maojie Zhang Yongfang Li | 2018 | Science China Chemistry2018，61，5： | 18 |
| 3 | Reinforcing Paper Strength by Dual Treatment of a Cationic Water-soluble Polymer and Cellulose Nanofibril显示文摘Cellulose nanofibril(CNF)was used as the anionic component of two dual strengthening systems wherein polyamidopolyamine epichlorohydrin resin(PAE)or cationic starch(CS)was used as the cationic component.Their strengthening effects were investigated for lowbasis-weight(30 g/m2)paper composed of a mixture of fully bleached softwood and hardwood pulp in a 4:1 mass ratio.Using the PAE/CNF or CS/CNF dual system,it was generally easier to achieve higher wet and dry tensile strengths of paper compared to the paper using the single PAE or CS system.For example,the paper using the PAE(0.4%)/CNF(0.3%)dual system exhibited 89%higher wet tensile strength than the paper using the single PAE(0.4%)system,and the paper using CS(1.3%)/CNF(0.3%)dual treatment showed 21%higher dry strength than that using the single CS(1.3%)system.However,the PAE/CNF system only showed small improvement in the dry strength of paper(11%higher than that of paper using the single PAE system),so did the CS/NFC system on wet strength improvement(only 17%higher than that of paper using the single CS system). | Aijiao Wang Lijun Wang Jianmei Jiang Xianping Yao Wenyan Zhao | 2019 | Paper And Biomaterials2019，4，4： | 7 |
| 4 | Precipitation Responses to Radiative Effects of Ice Clouds:A Cloud-Resolving Modeling Study of a Pre-Summer Torrential Precipitation Event显示文摘The precipitation responses to the radiative effects of ice clouds are investigated through analysis of five-day and horizontally averaged data from 2D cumulus ensemble model experiments of a pre-summer torrential precipitation event.The exclusion of the radiative effects of ice clouds lowered the precipitation rate through a substantial reduction in the decrease of hydrometeors when the radiative effects of water clouds were switched on,whereas it increased the precipitation rate through hydrometeor change from an increase to a decrease when the radiative effects of ice clouds were turned off.The weakened hydrometeor decrease was associated with the enhanced longwave radiative cooling mainly through the decreases in the melting of non-precipitating ice to non-precipitating water.The hydrometeor change from an increase to a decrease corresponded to the strengthened longwave radiative cooling in the upper troposphere through the weakened collection of non-precipitating water by precipitation water. | Xinyong SHEN Wenyan HUANG Chunyan GUO Xiaocen JIANG | 2016 | Advances in Atmospheric Sciences2016，33，10： | 3 |
| 5 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 6 | A redox-active conjugated microporous polymer cathode for highperformance lithium/potassium-organic batteries显示文摘Organic redox-active materials have emerged as a class of electrode materials for rechargeable batteries due to their high redox activity,low cost,structure diversity and flexibility.However,the high solubility of organic small molecules in organic electrolytes commonly leads to the fast capacity decay with cycling.Herein,we report a redox-active conjugated microporous polymer of poly(pyrene-co-anthraquinone)(Py Aq)cathode material consisting of pyrene and anthraquinone units.Benefiting from the highly cross-linked polymer structure with insoluble nature in organic electrolytes,the high surface area and the plentiful redox-active carbonyl groups,the Py Aq cathode demonstrates outstanding electrochemical performances for both lithium-ion batteries(LIBs)and potassium-ion batteries(KIBs).Specifically,the Py Aq cathode for LIBs delivers a high reversible capacity of 169 m Ah g^-1 at the current density of 20 m A g^-1,a high rate capability(142 m Ah g^-1 at 1000 m A g^-1)and an excellent cycling stability for 4000 cycles.Additionally,the Py Aq cathode for KIBs also exhibits a high reversible capacity of143 m Ah g^-1 with a long cycling life over 800 cycles.The excellent electrochemical performance demonstrates that the newly developed Py Aq could be an attractive cathode material for the advanced energy storage technologies. | Lian-Wei Luo Chong Zhang Peixun Xiong Yongbo Zhao Wenyan Ma Yu Chen Jing Hui Zeng Yunhua Xu Jia-Xing Jiang | 2021 | Science China Chemistry2021，64，1： | 3 |
| 7 | Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study显示文摘Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder. | Wenyan Jiang Zhongmin Yint Yixin Pang Feng Wu Lingtao Kong Ke Xu | 2012 | Neural Regeneration Research2012，7，15： | 3 |
| 8 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 9 | Specnuezhenide suppresses diabetes-induced bone loss by inhibiting RANKL-induced osteoclastogenesis显示文摘Diabetes osteoporosis is a chronic complication of diabetes mellitus(DM)and is associated with osteoclast formation and enhanced bone resorption.Specnuezhenide(SPN)is an active compound with anti-inflammatory and immunomodulatory properties.However,the roles of SPN in diabetic osteoporosis remain unknown.In this study,primary bone marrow macrophages(BMMs)were pretreated with SPN and were stimulated with receptor activator of nuclear factor kappa B ligand(RANKL;50 ng/mL)to induce osteoclastogenesis.The number of osteoclasts was detected by tartrate-resistant acid phosphatase(TRAP)staining.The protein levels of cellular oncogene fos/nuclear factor of activated T cells c1(c-Fos/NFATc1),nuclear factor kappa-B(NF-κB),and mitogen-activated protein kinases(MAPKs)were evaluated by western blot analysis.NF-κB luciferase assays were used to examine the role of SPN in NF-κB activation.The DM model group received a high-glucose,high-fat diet and was then intraperitoneally injected with streptozotocin(STZ).Micro-CT scanning,serum biochemical analysis,histological analysis were used to assess bone loss.We found that SPN suppressed RANKL-induced osteoclast formation and that SPN inhibited the expression of osteoclast-related genes and c-Fos/NFATc1.SPN inhibited RANKL-induced activation of NF-κB and MAPKs.In vivo experiments revealed that SPN suppressed diabetes-induced bone loss and the number of osteoclasts.Furthermore,SPN decreased the levels of bone turnover markers and increased the levels of runt-related transcription factor 2(RUNX2),osteoprotegerin(OPG),calcium(Ca)and phosphorus(P).SPN also regulated diabetes-related markers.This study suggests that SPN suppresses diabetes-induced bone loss by inhibiting RANKL-induced osteoclastogenesis,and provides an experimental basis for the treatment of diabetic osteoporosis. | Xiaoshuang Ye Juanjuan Jiang Juan Yang Wenyan Yan Luyue Jiang Yan Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 2 |
| 10 | Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system显示文摘 | David Bikard Wenyan Jiang Poulami Samai Ann Hochschild Feng Zhang Luciano A. Marraffini | 2013 | Nucleic Acids Research2013，，15： | 2 |
| 11 | LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process显示文摘 | Yi Qin Wenwei Zhu Wenyan Xu Bo Zhang Si Shi Shunrong Ji Jiang Liu Jiang Long Chen Liu Liang Liu Jin Xu Xianjun Yu | 2014 | Cancer Letters2014，，： | 1 |
| 12 | Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer显示文摘 | Si Shi Shunrong Ji Yi Qin Jin Xu Bo Zhang Wenyan Xu Jiang Liu Jiang Long Chen Liu Liang Liu Quanxing Ni Xianjun Yu | 2015 | Cancer Letters2015，，2： | 1 |
| 13 | Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5+ cells during mouse inner ear development显示文摘Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells(HCs)and supporting cells during mouse inner ear development;however,the relationship between the two signaling pathways in the mouse cochlea remains largely unknown.Here,we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5+progenitors during different cochlear development stages.We found that the downregulation of Notch1 in Lgr5+cells from embryonic day(E)14.5 to E18.5 can drive the quiescent Lgr5+cells to re-enter the cell cycle and differentiate into extra HCs,whereas the upregulation of Notch1 expression did not affect the proliferation or differentiation of otic progenitor cells.No effect was observed on the upregulation or downregulation of Notch1 in Lgr5+cells from E10.5 to E14.5.We concluded that the roles of Notch1 in Wnt-responsive Lgr5+cells are unidirectional and stage dependent and Notch1 serves as a negative regulator for Lgr5+progenitor activation during cochlear differentiation.Our findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear development. | Hui Jiang Shan Zeng Wenli Ni Yan Chen Wenyan Li | 2019 | Frontiers of Medicine2019，13，6： | 1 |
| 14 | Transient responses of some antennas under the impact of an intention- ally incident high-power electromagnetic pulse 显示文摘 | JIANG Zheng YIN Wenyan LIU Qifeng | 2010 | Progress in Electromagnetics Research2010，105，： | 1 |
| 15 | Alterations in amplitude of low frequency fluctuation in treatment‐na?ve major depressive disorder measured with resting‐state fMRI显示文摘 | Jie Liu Ling Ren Fay Y. Womer Jue Wang Guoguang Fan Wenyan Jiang Hilary P. Blumberg Yanqing Tang Ke Xu Fei Wang | 2014 | Hum. Brain Mapp2014，，10： | 1 |
| 16 | Identification of quantitative trait loci for seed storability in rice ( Oryza sativa L.)显示文摘 | LINFANG LI QIUYUN LIN SHIJIA LIU XI LIU WENYAN WANG NGO THI HANG FENG LIU ZHIGANG ZHAO LING JIANG JIANMIN WAN | 2012 | Plant Breeding2012，，6： | 1 |
| 17 | Influences of screen ruling on printing quality in CTP workflow 显示文摘 | Jiang Wenyan | 2011 | Advanced Materials Re-search2011，，174： | 1 |
| 18 | Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system显示文摘 | David Bikard Wenyan Jiang Poulami Samai Ann Hochschild Feng Zhang Luciano A. Marraffini | 2013 | Nucleic Acids Research2013，，： | 1 |
| 19 | The national multi-center artificial intelligent myopia prevention and control project显示文摘In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results. | Xun Wang Yahan Yang Yuxuan Wu Wenbin Wei Li Dong Yang Li Xingping Tan Hankun Cao Hong Zhang Xiaodan Ma Qin Jiang Yunfan Zhou Weihua Yang Chaoyu Li Yu Gu Lin Ding Yanli Qin Qi Chen Lili Li Mingyue Lian Jin Ma Dongmei Cui Yuanzhou Huang Wenyan Liu Xiao Yang Shuiming Yu Jingjing Chen Dongni Wang Zhenzhe Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence,Medical Artificial Intelligence Branch of Guangdong Medical Association | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 20 | The semiquantitative determination and morphology of ettringite in pastes containing expansive agent cured in elevated temperature显示文摘 | Peiyu Yan Xiao Qin Wenyan Yang Jiang Peng | 2001 | Cement and Concrete Research2001，，9： | 1 |
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