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| 1 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 4 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 5 | CD24: from A to Z显示文摘作为到 CD24 的重要性的一篇遗嘱,包括适应免疫,发炎,自体免疫的疾病和癌症,有多样的兴趣的研究人员遇到了 CD24。CD24 是在许多癌症的 overexpressed 并且出现 oncogenic。在适应有免疫力的反应, CD24 是在 costimulation 富有的淋巴的机关的一个冗余的 costimulatory 分子,但是在测试的选择目标机关是必要的,例如大脑和皮肤。更最近的研究建议它可以在由树枝状的房间区别危险和联系病原体的分子的模式有一个角色。CD24 的生物学吸引人却糟糕听说。这里,我们总结与 CD24 联系为可以表明在多样的过程之中的内在的连接由 CD24 调停了的进一步的研究刺激新想法的主要调查结果。 | Xianfeng Fang Pan Zheng Jie Tang Yang Liu | 2010 | Cellular & Molecular Immunology2010，7，2： | 8 |
| 6 | Efficient parallel implementation of the lattice Boltzmann method on large clusters of graphic processing units显示文摘Many-core processors, such as graphic processing units (GPUs), are promising platforms for intrinsic parallel algorithms such as the lattice Boltzmann method (LBM). Although tremendous speedup has been obtained on a single GPU compared with mainstream CPUs, the performance of the LBM for multiple GPUs has not been studied extensively and systematically. In this article, we carry out LBM simulation on a GPU cluster with many nodes, each having multiple Fermi GPUs. Asynchronous execution with CUDA stream functions, OpenMP and non-blocking MPI communication are incorporated to improve efficiency. The algorithm is tested for two-dimensional Couette flow and the results are in good agreement with the analytical solution. For both the oneand two-dimensional decomposition of space, the algorithm performs well as most of the communication time is hidden. Direct numerical simulation of a two-dimensional gas-solid suspension containing more than one million solid particles and one billion gas lattice cells demonstrates the potential of this algorithm in large-scale engineering applications. The algorithm can be directly extended to the three-dimensional decomposition of space and other modeling methods including explicit grid-based methods. | XIONG QinGang LI Bo XU Ji FANG XiaoJian WANG XiaoWei WANG LiMin HE XianFeng GE Wei | 2012 | Chinese Science Bulletin2012，57，7： | 6 |
| 7 | Human activities and elevational constraints restrict ranging patterns of snub-nosed monkeys in a mountainous refuge显示文摘Both natural conditions and anthropogenic factors affect the survivability,distribution,and population density of wildlife.To understand the extent and how these factors drive species distributions,a detailed description of animal movement patterns in natural habitats is needed.In this study,we used satellite telemetry to monitor elevational ranges favored by endangered golden snub-nosed monkeys(Rhinopithecus roxellana),in the Qinling Mountains,central China.We investigated the abundance and distribution of food resources through sampling vegetation quadrats at different elevations and sampled anthropogenic activities using field surveys.Our results indicated that although there was no significant variation in food resources between low-(<1500 m)and middle-elevations(1500–2200 m),monkeys were found most often in areas above 1500 m,where there was less anthropogenic development(e.g.houses and roads);however,monkeys rarely ranged above 2200 m and had limited food availability at this altitude.There was limited human disturbance at this elevation.We suggest that both human activity and ecological constraints(i.e.food resources)have considerable effects on elevational use of R.roxellana in the Qinling Mountains.This study highlights the critical roles these factors can play in shaping the vertical distribution of high-altitude primates.This research provides useful insights for habitat-based conservation plans in which human disturbance management and habitat restoration should be prioritized. | Pengzhen HUANG Kun BIAN Zhipang HUANG Qi Li Derek WDUNN Gu FANG Jiahui LIU Mengyao WANG Xianfeng YANG Ruliang PAN Cunlao GAO Kaichuang SI Baoguo LI Xiaoguang QI | 2021 | Integrative Zoology2021，16，2： | 3 |
| 8 | Management System Study on Large Hydropower Station Reservoirs Groups in Upper Yangtze River显示文摘 | HUANG Xianfeng DAI Huichao FANG Guohua | 2011 | Procedia Environmental Sciences2011，，10： | 1 |
| 9 | Embedding ultrasmall Ag nanoclusters in Luria-Bertani extract via light irradiation for enhanced antibacterial activity显示文摘Ultrasmall silver nanoclusters(Ag NCs)with rich surface chemistry and good biocompatibility are promising in antibacterial application,however,further development of Ag NCs for practical settings has been constrained by their relatively weak antibacterial activity.Using the nutritionally-rich medium for bacteria(e.g.,Luria-Bertani(LB)medium)to coat active Ag NCs could further improve their antibacterial activity.Here,we provide a delicate design of a highly efficient Ag NCs@ELB antibacterial agent(ELB denotes the extract of LB medium)by anchoring Ag NCs inside the ELB species via light irradiation.The as-designed Ag NCs with bacterium-favored nutrients on the surface can be easily swallowed by the bacteria,boosting the production of the intracellular reactive oxygen species(ROS,about 2-fold of that in the pristine Ag NCs).Subsequently,a higher concentration of ROS generated in Ag NCs@ELB leads to enhanced antibacterial activity,and enables to reduce the colony forming units(CFU)of both gram-positive and gram-negative bacteria with 3–4 orders of magnitude less than that treated with the pristine Ag NCs.In addition,the Ag NCs@ELB also shows good biocompatibility.This study suggests that surface engineering of active species(e.g.,Ag NCs)with nutritionally-rich medium of the bacteria is an efficient way to improve their antibacterial activity. | Ziping Wang Yushuang Fang Xianfeng Zhou Zhibo Li Haiguang Zhu Fanglin Du Xun Yuan Qiaofeng Yao Jianping Xie | 2020 | Nano Research2020，13，1： | 1 |
| 10 | Calculation of one-valued control limits by control chart of angles显示文摘 | LI Yuansheng FANG Ying ZHU Xianfeng | 2001 | J Chinese University of Mining and Technology2001，11，2： | 1 |
| 11 | CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys显示文摘Viral pneumonia is a major cause of mortality caused by both systemic and respiratory infections.The danger-associated molecular patterns(DAMPs)released during cell death in viral infection may cause a self-propagating inflammatory response with lasting lung damage.The CD24–Siglec 10/G interaction is an emerging immune checkpoint that regulates inflammation caused by DAMPs.1,2,3 While we have demonstrated that fortifying this immune checkpoint can reduce inflammation in the colon,4 joints5 and central nervous system,6 it is unclear whether CD24Fc can protect against pneumonia.To address this issue,we evaluated the lung pathology of simian immunodeficiency virus(SIV)-infected rhesus monkeys that received either normal saline(NS)or CD24Fc. | Ren-Rong Tian Ming-Xu Zhang Mingyue Liu Xianfeng Fang Dongling Li Liguo Zhang Pan Zheng Yong-Tang Zheng Yang Liu | 2020 | Cellular & Molecular Immunology2020，17，8： | 1 |
| 12 | Non-rigid registration of mural images and laser scanning data based on the optimization of the edges of interest显示文摘The orientation and correction of mural images by registering them with laser scanning data is critical for the digital protection of ancient murals.This paper proposes a method for the non-rigid registration of mural images and laser scanning data based on the optimization of the edge of interest by using laser echo intensity information as an intermediary.First,the intensity image was generated from the laser echo intensity information,and registered with the mural image using a rigid transformation model.Second,the edges of interest in the mural image and the gradient field of the intensity images were processed as registration primitives.Third,every edge of interest was registered with the optimization base used in the rigid registration of the mural image and intensity image.Finally,the registration was completed after a non-rigid transformation model between these two images was constructed using the control points on the optimized edges.Our experimental results show that the proposed method can obtain high registration accuracy for different data sets. | ZHANG Fan HUANG XianFeng FANG Wei LI DeRen | 2013 | Science China(Information Sciences)2013，56，6： | 1 |
| 13 | Simultaneous enhancement of strength and ductility in friction stir processed 2205 duplex stainless steel with a bimodal structure:experiments and crystal plasticity modeling显示文摘Achieving excellent strength-ductility synergy is a long-lasting research theme for structural materials.However,attempts to enhance strength usually induce a loss of ductility,i.e.,the strength-ductility trade-off.In the present study,the strength-ductility trade-off in duplex stainless steel(DSS)was overcome by developing a bimodal structure using friction stir processing(FSP).The ultimate tensile strength and elongation were improved by 140%and 109%,respectively,compared with those of the asreceived materials.Plastic deformation and concurrent dynamic recrystallization(DRX)during FSP were responsible for the formation of bimodal structure.Incompatible deformation resulted in the accumulation of dislocations at the phase boundaries,which triggered interpenetrating nucleation between the austenite and ferrite phases during DRX,leading to a bimodal structure.The in situ mechanical responses of the bimodal structure during tensile deformation were investigated by crystal plasticity finite element modeling(CPFEM).The stress field distribution obtained from CPFEM revealed that the simultaneous enhancement of strength and ductility in a bimodal structure could be attributed to the formation of a unique dispersion-strengthened system with the austenite and ferrite phases.It is indicated that the present design of alternating fine austenite and coarse ferrite layers is a promising strategy for optimizing the mechanical properties of DSSs. | Yanying Hu Zexin Fang Yongbing Peng Weiqi Yang Xianfeng Ma Jinglong Li Yunqiang Zhao Biao Wang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 0 |
| 14 | Punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice显示文摘The aim of this study was to investigate whether punicalagin(PU)could prevent obesity-related cardiac dysfunction by promoting DNA demethy lation,and to explore its possible mechanism.C57BL/6J mice were fed with standard diet,high-fat diet(HFD),HFD supplemented with resveratrol,low-dose PU(LPU)and high-dose PU(HPU)for 8 weeks.Compared with HFD group,body weight was significantly lower in PU treatment groups,number of cardionwocytes and the protein level of myosin heavy chain 7B were significantly higher in PU treatment groups.Levels of 5-hydroxymethylcytosine and 5-formylcytosine were significantly lower in HFD group than in other groups.Compared with the HFD group,the protein level of ten-eleven translocation enzyme(TET)2 was significantly higher in PU treatment groups,p-AMP-activated protein kinase(AMPK)was significantly higher in LPU group.Levels of total antioxidant capacity and the protein levels of complexesⅡ/Ⅲ/Ⅴ,oxoglutarate dehydrogenase,succinate dehydrogenase B and fumarate hdrolase were significantly lower in HFD group than PU treatment group.The ratio of(succinic acid+fumaric acid)/a-ketoglutarate was significantly higher in HFD group than other groups.In conclusion,PU up-regulated TETs enzyme activities and TET2 protein stability through alleviating mitochondrial dysfunction and activating AMPK,so as to promote DNA demethylation,thus preventing obesity-related cardiac dysfunction. | Shengjie Pei Run Liu Qingqing Ma Peng Jiang Xin He Zhongshi Qi Jiacheng Fang Xu Yang Zirui Yao Xiaoqian Liu Xianfeng Jing Lei Chen Duo Li | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 15 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
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