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| 1 | Laparoscopic common bile duct exploration with primary closure is safe for management of choledocholithiasis in elderly patients显示文摘Background:Laparoscopic common bile duct exploration(LCBDE)is one of the minimally invasive options for choledocholithiasis.Primary closure of the common bile duct(CBD)upon completion of laparoscopic choledochotomy is safe in selected patients.The present study aimed to evaluate the feasibility and safety of primary closure of CBD after LCBDE in patients aged 70 years or older.Methods:A total of 116 patients(51 males and 65 females)who suffered from choledocholithiasis and underwent primary closure of the CBD(without T-tube drainage)after LCBDE from January 2003 to December 2017 were recruited.They were classified into two groups according to age:group A(≥70 years,n=56),and group B(<70 years,n=60).The preoperative characteristics,intraoperative details,and postoperative outcomes of the two groups were evaluated.Results:The mean operative time was 172.02 min for group A and 169.92 min for group B(P=0.853).The mean hospital stay was 7.40 days for group A and 5.38 days for group B(P<0.001).Bile leakage occurred in two patients in group A and one in group B(3.57%vs 1.67%,P=0.952).There were no significant differences in the rates of postoperative complications and mortality between the two groups.At median follow-up time of 60 months,stone recurrence was detected in one patient in group A and two in group B(1.79%vs 3.33%,P=1.000).Stenosis of CBD was not observed in group A and slight stenosis in one patient in group B(0 vs 1.67%,P=1.000).Conclusion:Primary closure of the CBD upon completion of laparoscopic choledochotomy is safe and feasible in elderly patients≥70 years old. | Xiang Wu Ze-Jian Huang Jin-Yi Zhong Yi-Hong Ran Ming-Lei Ma Hong-Wei Zhang | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 30 |
| 2 | A meta-analysis of the yield of capsule endoscopy compared to double-balloon enteroscopy in patients with small bowel diseases显示文摘AIM:To compare the diagnostic yield of capsule endoscopy (CE) with that of double-balloon enteroscopy (DBE). METHODS:Pubmed,Embase,Elsevier ScienceDirect,the China Academic Journals Full-text Database,and Cochrane Controlled Trials Register were searched for the trials comparing the yield of CE with that of DBE. Outcome measure was odds ratio (OR) of the yield. Fixed or random model method was used for data analysis. RESULTS:Eight studies (n = 277) which prospectively compared the yield of CE and DBE were collected. The results of meta-analysis indicated that there was no difference between the yield of CE and DBE 170/277 vs 156/277,OR 1.21 (95% CI:0.64-2.29). Based on sub analysis,the yield of CE was significantly higher than that of double-balloon enteroscopy without combination of oral and anal insertion approaches 137/219 vs 110/219,OR 1.67 (95% CI:1.14-2.44),P < 0.01),but not superior to the yield of DBE with combination of the two insertion approaches 26/48 vs 37/48,OR 0.33 (95% CI:0.05-2.21),P > 0.05). A focused meta-analysis of the fully published articles concerning obscure GI bleeding was also performed and showed similar results wherein the yield of CE was significantly higher than that of DBE without combination of oral and anal insertion approaches 118/191 vs 96/191,fixed model:OR 1.61 (95% CI:1.07-2.43),P < 0.05) and the yield of CE was significantly lower than that of DBE by oral and anal combinatory approaches 11/24 vs 21/24,fixed model:OR 0.12 (95% CI:0.03-0.52),P < 0.01). CONCLUSION:With combination of oral and anal approaches,the yield of DBE might be at least as high asthat of CE. Decisions made regarding the initial approach should depend on patient's physical status,technology availability,patient's preferences,and potential for therapeutic endoscopy. | Xiang Chen Zhi-Hua Ran Jin-Lu Tong | 2007 | World Journal of Gastroenterology2007，13，32： | 26 |
| 3 | Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence显示文摘The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century.Mammalian sirtuin 1(SIRT1) has been shown to decrease high-glucose-induced endothelial cell senescence in vitro and prevent hyperglycemia-induced vascular dysfunction.However,a role for SIRT1 in prevention of hyperglycemia-induced vascular cell senescence in vivo remains unclear.We used endothelium-specific SIRT1 transgenic(SIRT1-Tg) mice and wild-type(WT) mice to construct a 40-week streptozotocin(STZ)-induced diabetic mouse model.In this mode,42.9% of wild-type(WT) mice and 38.5% of SIRT1-Tg mice were successfully established as diabetic.Forty weeks of hyperglycemia induced significant vascular cell senescence in aortas of mice,as indicated by upregulation of expression of senescence-associated markers including p53,p21 and plasminogen activator inhibitor-1(PAI-1).However,SIRT1-Tg diabetic mice displayed dramatically decreased expression of p53,p21 and PAI-1 compared with diabetic WT mice.Moreover,manganese superoxide dismutase expression(MnSOD) was significantly downregulated in the aortas of diabetic WT mice,but was preserved in diabetic SIRT1-Tg mice.Furthermore,expression of the oxidative stress adaptor p66Shc was significantly decreased in aortas of SIRT1-Tg diabetic mice compared with WT diabetic mice.Overall,these findings suggest that SIRT1-mediated inhibition of hyperglycemia-induced vascular cell senescence is mediated at least partly through the reduction of oxidative stress. | CHEN HouZao WAN YanZhen ZHOU Shuang LU YunBiao ZHANG ZhuQin ZHANG Ran CHEN Feng HAO DeLong ZHAO Xiang GUO ZhiChen LIU DePei LIANG ChihChuan | 2012 | Science China(Life Sciences)2012，55，6： | 14 |
| 4 | Effects of gas supersaturation on lethality and avoidance responses in juvenile rock carp(Procypris rabaudi Tchang)显示文摘Laboratory experiments were conducted to determine the effects of total dissolved gas(TDG) supersaturation on acute lethality and avoidance responses in juvenile rock carp(Procypris rabaudi Tchang).The juvenile rock carp were exposed to water with different levels of supersaturation(105%,115%,120%,125%,130%,135%,140%,and 145%) and depth of 0.20 m at 25 °C for 60 h.Median lethal time(LT50) was used to assess the lethal responses corresponding to different levels of gas supersaturation.The results show that half of the juvenile rock carp died at the 120%,125%,130%,135%,140%,and 145% levels of supersaturation,and the LT50 corresponding to different levels of supersaturation was 18.7,15.4,8.2,6.6,3.5,and 1.7 h.When the level of supersaturated water is below 115%,the mortality is negligible.Avoidance responses were observed 5 min after the fish were put into equilibrated water(99%,0.08 m deep) and water with different supersaturated levels(105%,115%,125%,135%,and 145%,0.08 m deep) at 25 °C.The fish exhibited strong avoidance responses in supersaturated water when the gas supersaturation was above 135%.However,they exhibited an obvious preference to supersaturated water when the gas supersaturation was below 115%.Thus,the juvenile rock carp can likely survive in water with a supersaturated level of 115%. | Xiang HUANG Ke-feng LI Jun DU Ran LI | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，10： | 13 |
| 5 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 6 | Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2显示文摘MicroRNAs (miRNAs ) 是与癌症的致病有关的小非编码的 RNA 并且仔细的一个班。增加的证据显示 miR-30a 在癌症的发展期间起一个深刻作用。然而,在 non-small-cell 肺癌症(NSCLC ) 的 miR-30a 的功能仍然是模糊的。这里,我们发现 miR-30a 被 qRT-PCR 从 14 个病人在肺腺癌 A549 房间并且在织物样品减少,并且也发现在 A549 房间的 miR-30a 的 overexpression 由愈合创伤的试金禁止了移植和侵略然而并非房间增长和房间周期前进, matrigel 侵略试金,基于山的房间增长试金,和流动 基于cytometry 的房间周期分析分别地。我们进一步在肺腺癌房间行探索了 miR-30a-mediated 基因规定的潜在的机制。EYA2 是 miR-30a 的一个预言的目标,并且 EYA2 表示被 miR-30a 在乳癌房间禁止,这被发现了。我们证明 EYA2 是由在 A549 房间使用双酶的记者试金的 miR-30a 的一个直接目标并且证明 EYA2 蛋白质层次相反地在 A549 和 BEAS-2B 房间与 miR-30a 表示被相关。另外,我们也与表示向量和 miR-30a 模仿的 EYA2 由 cotransfection 在 A549 房间证实了 EYA2 overexpression 的营救效果。一起拿,我们的结果证明在肺腺癌 A549 房间的 miR-30a 的 overexpression 能禁止房间移植和侵略,它部分被归因于 EYA2 的减少表示。我们的调查结果建议 miR-30a 以后可以为肺腺癌的治疗被用作一个新潜在的目标。 | Yuncang Yuan Shangyong Zheng Qian Li Xudong Xiang Tangxin Gao Pengzhan Ran Lijuan Sun Qionglin Huang Fei Xie Jing Du Chunjie Xiao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 12 |
| 7 | 离岸大型风电场的双馈感应发电机与高压直流输电系统的协调控制显示文摘该文介绍了在远离海岸边的岛屿上大型风力发电场中的双馈感应发电机(DFIG)通过高压直流(HVDC)输电系统向大陆主电网送电时,发电机同HVDC系统的协调控制策略。 | Dawei Xiang Li Ran Jim R Bumby 杨秀(选编) | 2006 | 华东电力2006，34，12： | 10 |
| 8 | miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN显示文摘Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through exosomes.Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting.Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. | LIU Meng Xin LIAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 9 | The maximum coseismic vertical surface displacement and surface deformation pattern accompanying the Ms 8.0 Wenchuan earthquake显示文摘The amount of coseismic deformation and its distribution of the Wenchuan earthquake provide important scientific bases for revealing the mechanisms of earthquake preparation and characterizing the rupture propagation of the Wenchuan earthquake. The previous studies have indicated that the earthquake ruptured the middle-to-north segment of the Longmenshan central fault and the middle segment of the Longmenshan range-front fault, which are characterized by two surface rupture zones of 240 km and 90 km in length, respectively. Based on the pre-earthquake information and photos of landforms and buildings obtained through ge-ologic and geomorphic survey of the area around Shaba Village of Beichuan County, Sichuan Province and the extensive interview with local villagers, we measured the displacements of the major terrain features and the dislocated buildings by total station instruments and differential GPS and obtained the maximum vertical displacement of 9±0.5 m and right-lateral displacement of 2±0.5 m around the Zou’s house in Shaba Village. Though the near-surface deformation exhibits a normal faulting around Shaba Village, the dynamic environment has not changed on the whole. The NW wall of the fault uplifted but without gravity gliding as normally occurring on the hanging wall of a normal fault, which proves that the 9±0.5 m displacement should be the maximum coseismic vertical displacement of the May 12, 2008 Ms 8.0 Wenchuan earthquake. | Ran YongKang Shi Xiang Wang Hu Chen LiChun Chen Jie Liu RuiChun Gong Huiling | 2010 | Chinese Science Bulletin2010，55，9： | 9 |
| 10 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 11 | Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis(Bunge)Regel Saponins against the Snail Oncomelania Hupensis显示文摘Objective To observe the toxicity of Pulsatilla chinensis(Bunge) Regel saponins(PRS) against Oncomelania hupensis(O.hupensis).Methods O.hupensis snails were exposed to 40% and 80% of 24 h LC50 of PRS for 24 h,and then choline esterase(CHE),alanine aminotransferase(ALT),alkaline phosphatase(ALP),lactate dehydrogenase(LDH) activities in cephalopodium and liver of snails were determined.Niclosamide(NIC) was used as the reference molluscicide.Zebra fish lethality test was evaluated to non-target aquatic species of PRS.Results The molluscicidal activity of PRS(LC50 at 24 h:0.48 mg/L) was similar to that of NIC(LC50 at 24 h:0.16 mg/L).Significant alterations about CHE,ALP,and ALT activities both in the cephalopodium and the liver of snails were observed when O.hupensis was exposed to 40% and 80% LC50 of PRS or NIC for 24 h.PRS and NIC could not affect LDH activity in the cephalopodium and the liver.Lower toxicity to fish of PRS was observed up to the highest concentration tested than NIC.Conclusion PRS,as compared with the reference molluscicide NIC,is thought to be used for the control of harmful vector snails safely. | CHEN Yan Qin XU Qiong Ming LIU Yan Li LI Xiao Ran YANG Shi Lin ZHUGE Hong Xiang | 2012 | Biomedical and Environmental Sciences2012，25，2： | 8 |
| 12 | The role of non-coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential显示文摘Oral squamous cell carcinoma(OSCC),the eighth most prevalent cancer in the world,arises from the interaction of multiple factors including tobacco,alcohol consumption,and betel quid.Chemotherapeutic agents such as cisplatin,5-fluorouracil,and paclitaxel have now become the first-line options for OSCC patients.Nevertheless,most OSCC patients eventually acquire drug resistance,leading to poor prognosis.With the discovery and identification of non-coding RNAs(ncRNAs),the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized.The mechanisms of drug resistance of OSCC are intricate and involve drug efflux,epithelial-mesenchymal transition,DNA damage repair,and autophagy.At present,strategies to explore the reversal of drug resistance of OSCC need to be urgently developed.Nano-delivery and self-cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting,controlled release,and consistent pharmacokinetic profiles.In particular,the combined application of new technologies(including CRISPR systems)opened up new horizons for the treatment of drug resistance of OSCC.Hence,this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC,elucidated multiple ncRNA-meditated mechanisms of drug resistance of OSCC,and discussed the potential value of drug delivery platforms using nanoparticles and self-cells as carriers in drug resistance of OSCC. | Xiang Meng Qiu-Yue Lou Wen-Ying Yang Yue-Rong Wang Ran Chen Lu Wang Tao Xu Lei Zhang | 2021 | Cancer Communications2021，41，10： | 8 |
| 13 | Nonlinear regression model for peak-failure strength of rockfill materials in general stress space显示文摘A nonlinear regression model for peak-failure strength prediction of rockfill materials is proposed. It is based on the relationship between the peak-failure stress ratio and the normalized confining pressure as well as the relationship between the normalized peak-failure stress ratio and the exponent function of the intermediate principal stress ratio. This model can well predict the variations of the peak-failure stress ratio with the initial confining pressure and the intermediate principal stress ratio for different rockfill materials under different general stress paths. Comparisons of the measured and predicted results show that the peak-failure strength under the constant-p' and constant-b path is larger than that under the constant-σ'_3 and constant-b path. The predictive capacity of the proposed model for the peakfailure stress ratio is better than that for the peak-failure friction angle. | Yang Xiao Minqiang Meng Hui Chen Xiang He Jinyu Ran Weicheng Shi | 2018 | Geoscience Frontiers2018，9，6： | 6 |
| 14 | Advances in lung cancer screening and early detection显示文摘Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. | Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang | 2022 | Cancer Biology & Medicine2022，19，5： | 6 |
| 15 | Effects of nociceptin/orphanin FQ on rats with cathartic colon显示文摘AIM: To demonstrate the change and effect of nociceptin/orphanin FQ in the colon of rats with cathartic colon. METHODS: The cathartic colon model was established by feeding rats rhubarb for 3 mo, the changes of colonic electromyography were investigated by both suspension muscle strips test and serosal recordings of colonic myoelectrical activity. Immunohistochemical staining (S-P methods) and image analysis were used to determine the changes of nociceptin/orphanin FQ in the proximal colon and distal colon of rats with cathartic colon. RESULTS: Suspension muscle strips test in vitro showed OFQ (10-9-10-6 mol/L) concentration dependently caused an immediate tonic contraction in the isolated colon. But the increase of tension in cathartic colon was less than control groups (P < 0.01). Intravenous administration of OFQ (1 μg/kg) caused phasic contractions in the proximal colon, while the amplitude of phasic contractions caused by OFQ in cathartic colon was much lower than that in the control groups (2.58 ± 0.41 vs 4.16 ± 0.53, t = -2.6, P = 0.012). OFQ was highly expressed in the myenteric plexus of the rat colon but not in the muscle cells. The immunoreactivity of OFQ in the proximal colon in cathartic colon rats decreased significantly compared with the control group (P = 0.001). CONCLUSION: Colonic smooth muscle of cathartic colon showed low sensitivity to the stimulation of OFQ, suggesting that it might be caused by the abnormal distribution of OFQ or the abnormalities of receptors, leading to the disorganization of dynamic and incoordinated contractions. | Hai-Yan Li Xiang Yan Quan-Lai Xue Yong-Ning Zhou Yan Gao Rui Wang Yong-Ming Liu Jun-Tao Ran | 2007 | World Journal of Gastroenterology2007，13，1： | 5 |
| 16 | A Text Zero-Watermarking Algorithm Based on Chinese Phonetic Alphabets显示文摘The text watermarking is a feasible method to protect the copyright from being copied and tampered. In this paper, a text zero-watermarking algorithm is proposed based on the connection between the Chinese characters and the Chinese phonetic alphabets. According to the predefined interval threshold, the proposed algorithm extracts the characteristics of the text content by valuing on the basis of the custom of Chinese phonetic alphabets. After being chaotic transformed, the algorithm combines the text characteristics with the embedded watermarking information in the Chinese text. The experimental results show that the watermarking's capability of preventing tampering is up to 0.1%, which demonstrates the strong robustness and resistance to aggressive behavior of the algorithm. | ZHU Ping XIANG Guangli SONG Wenna LI Ankang ZHANG Yuexin TAO Ran | 2016 | Wuhan University Journal of Natural Sciences2016，21，4： | 5 |
| 17 | Tree of life for the genera of Chinese vascular plants显示文摘我们重建了使用的中国脉管的植物(Tracheophyta ) 的一棵种系发生的树叶绿体基因 atpB, matK, ndhF,和 rbcL 和 mitochondrial matR 定序。我们生产了包括 6098 种类并且包括 13 个 695 DNA 序列, 1803 最新被产生的一个矩阵。我们的分类采样跨越了代表中国脉管的植物的 323 个家庭的 3114 个类,盖住从中国知道的超过 93% 所有类。全面大发展史支持大多数关系在之中并且在最近的分子的种系发生的研究为 lycophytes,蕨纲植物(monilophytes ) ,裸子植物,和被子植物认出的家庭以内。为被子植物,在被子植物发展史组 IV 的大多数家庭作为 monophyletic 被养活,除了 paraphyletic Dipterocarpaceae 和 Santalaceae。一些大类的几个大家庭并且 monophyly 的 infrafamilial 关系被我们的稠密的分类采样很好支持。我们的结果证明 Eberhardtia 的二种是到 Sapotaceae 的所有另外的 taxa 形成的 clade 的姐妹,除了 Sarcosperma。我们经由 SoTree (http://gffzz52bf878016c04d01hkbo0nu599uqq66b6.ffgz.tsg.suse.edu.cn/flora/index.shtml ) 做了我们为子树的创造公开地可得到的中国脉管的植物的发展史,为生态学家的一个自动化发展史集会工具。 | Zhi-Duan Chen Tuo Yang Li Lin Li-Min Lu Hong-Lei Li Miao Sun Bing Liu Min Chen Yan-Ting Niu Jian-Fei Ye Zhi-Yong Cao Hong-Mei Liu Xiao-Ming Wang Wei Wang Jing-Bo Zhang Zhen Meng Wei Cao Jian-Hui Li Sheng-Dan Wu Hui-Ling Zhao Zhong-Jian Liu Zhi-Yuan Du Qing-Feng Wang Jing Guo Xin-Xin Tan Jun-Xia Su Lin-Jing Zhang Lei-Lei Yang Yi-Ying Liao Ming-He Li Guo-Qiang Zhang Shih-Wen Chung Jian Zhang Kun-Li Xiang Rui-qi Li Douglas E. Soltis Pamela S. Soltis Shi-Liang Zhou Jin-Hua Ran Xiao-quan Wang Xiao-Hua Jin You-Sheng Chen Tian-Gang Gao Jian-Hua Li Shou-Zhou Zhang An-Ming Lu China Phylogeny Consortium | 2016 | Journal of Systematics and Evolution2016，54，4： | 5 |
| 18 | Seismotectonic environment of occurring the February 3, 1996 Lijiang M=7.0 earthquake, Yunnan Province显示文摘Lijiang-Daju fault, the seismogenic fault of the 1996 Lijiang M=7.0 earthquake, can be divided into Lijiang-Yuhu segment in the south and Yuhu-Daju segment in the north. The two segments show clear difference in geological tectonics, but have the similar dynamic features. Both normal dip-slip and sinistral strike-slip coexist on the fault plane. This kind of movement started at the beginning of the Quaternary (2.4~2.5 Ma B.P.). As to the tectonic types, the detachment fault with low angle was developed in the Early Pleistocene and the normal fault with high angle only after the Mid-Pleistocene (0.8 Ma B.P.). Based on the horizontal displacements of gullies and the vertical variance of planation surfaces cross the Lijiang-Daju fault at east piedmont of Yulong-Haba range, the average horizontal and vertical slip rates are calculated. They are 0.84 mm/a and 0.70 mm/a since the Quaternary and 1.56 mm/a and 1.69 mm/a since the Mid-Pleistocene. The movements of the nearly N-S-trending Lijiang-Daju fault are controlled not only by the regional stress field, but also by the variant movement between the Yulong-Haba range and Lijiang basin. The two kinds of dynamic processes form the characteristics of seismotectonic environment of occurring the 1996 Lijiang earthquake. | HAN Zhu-jun(韩竹军) GUO Shun-min(虢顺民) XIANG Hong-fa(向宏发) ZHANG Jia-sheng(张家声) RAN Yong-kang(冉勇康) | 2004 | Acta Seismologica Sinica(English Edition)2004，17，4： | 4 |
| 19 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 20 | Targeting integrin pathways:mechanisms and advances in therapy显示文摘Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix(ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide range of states in health and diseases.Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms,including protein-protein interactions,conformational changes,and trafficking.Due to their exposure on the cell surface and sensitivity to the molecular blockade,integrins have been investigated as pharmacological targets for nearly 40 years,but given the complexity of integrins and sometimes opposite characteristics,targeting integrin therapeutics has been a challenge.To date,only seven drugs targeting integrins have been successfully marketed,including abciximab,eptifibatide,tirofiban,natalizumab,vedolizumab,lifitegrast,and carotegrast.Currently,there are approximately 90 kinds of integrin-based therapeutic drugs or imaging agents in clinical studies,including small molecules,antibodies,synthetic mimic peptides,antibody-drug conjugates(ADCs),chimeric antigen receptor(CAR)T-cell therapy,imaging agents,etc.A serious lesson from past integrin drug discovery and research efforts is that successes rely on both a deep understanding of integrin-regulatory mechanisms and unmet clinical needs.Herein,we provide a systematic and complete review of all integrin family members and integrin-mediated downstream signal transduction to highlight ongoing efforts to develop new therapies/diagnoses from bench to clinic.In addition,we further discuss the trend of drug development,how to improve the success rate of clinical trials targeting integrin therapies,and the key points for clinical research,basic research,and translational research. | Xiaocong Pang Xu He Zhiwei Qiu Hanxu Zhang Ran Xie Zhiyan Liu Yanlun Gu Nan Zhao Qian Xiang Yimin Cui | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
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