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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 3 | Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure显示文摘根据银 nanoparticles (Ag NP ) 的当前的问题以抗菌剂性能,我们与取向附生地作为一个潜在的抗菌剂代理人在金 nanorods (Au@PtAg NR ) 上种的 AgPt 合金 nanodots 设计了新奇 trimetallic 核心 / 壳 nanostructure。两 Escherichia coli (E。coli ) 并且葡萄球菌 aureus (S。aureus ) 被学习。抗菌剂活动展出明显的作文依赖。在在合金壳增加 Ag 部分直到 80% 以后,抗菌剂活动逐渐地增加,表明一个灵活方法调节这项活动。在 80% Ag,抗菌剂活动比纯 Ag 壳的好。改进抗菌剂能力主要由于点形态学在壳表面上源于银的高暴露。当为基于 Ag 的 nanomaterials 保留高化学的稳定性时,我们因此证明形成合金是改进抗菌剂活动的一个有效方法。而且,由于悦耳的局部性的表面 plasmonic 反应在在红外线附近(NIR ) 光谱区域,对把 lightsuch 用作杀死的 photothermal 和 phototriggered 银离子 releaseis 的抗菌剂活动的另外的控制期望。作为示范,高度提高了抗菌剂活动被利用 nanostructures 的 NIR photothermal 效果显示出。我们的结果显示如此的定制的 nanostructures 将在对细菌的未来战斗发现一个角色,包括 multidrug 抵抗的增加的严厉的挑战。 | Xiaona Hu Yuyun Zhao Zhijian Hu Aditya Saran Shuai Hou Tao Wen Wenqi Liu Yinglu Ji Xingyu Jiang Xiaochun Wu | 2013 | Nano Research2013，6，11： | 9 |
| 4 | Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling显示文摘The B7-family inducible costimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization.This costimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase Lck.TMD-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and costimulatory signaling activity of ICOS.TMD-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in vivo.When transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target cells.Therefore,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology. | Zurong Wan Xingxing Shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong Wanli Liu Hai Qi | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 5 | Hydrogen sulfide prodrugs—a review显示文摘Hydrogen sul fi de(H_2S) is recognized as one of three gasotransmitters together with nitric oxide(NO) and carbon monoxide(CO). As a signaling molecule, H_2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H_2S prodrugs for various reasons. In this review, we summarize different H_2S prodrugs, their chemical properties, and some of their potential therapeutic applications. | Yueqin Zheng Xingyue Ji Kaili Ji Binghe Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 4 |
| 6 | Correlation analysis between characteristics under gastroscope and image information of tongue in patients with chronic gastritis显示文摘OBJECTIVE:To explore the correlation between diagnostic information of tongue and gastroscopy results of patients with chronic gastritis.METHODS:Frequent pattern growth(FP-Growth),SPSS Modeler was used to analyze the correlation rules between the image information of tongue parameters and the characteristics of the stomach and duodenum seen under gastroscopy.RESULTS:Ranking in order of confidence:cyanotic tongue,slippery fur,yellow fur and spotted tongue were sequently associated with both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.L,one value of tongue coating color,which counted among(30,60),tooth-marked tongue and b,one value of tongue coating color,which counted in the range of(5,20)were sequently associated with gastric antrum mucosal erythema/macula.A,one value of tongue body color,which counted in the range of(0,20),was related to both gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.a,one value of tongue coating color,which counted in the range of(15,35),was associated with gastric antrum mucosal erythema/macula.There are a total of 9 strong correlation rules.CONCLUSIONS:Cyanotic tongue,slippery fur,yellow fur,the CIE Lab value of tongue coating,a,the value of tongue body color,spotted tongue,and tooth-marked tongue are all related to the gastric antrum mucosal hyperemia or edema and gastric antrum mucosal erythema/macula.The conditions of gastric mucosa could be predicted by the examination of the above related image information of tongue. | SHANG Zimeng DU Zhengguang GUAN Bei JI Xingyu CHEN Longchang WANG Yongji MA Yun | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 2 |
| 7 | Influence of barium dissolution on microstructure and oxygen permeation performance of Ba 1.0 Co 0.7 Fe 0.2 Nb 0.1 O 3?δ membrane in aqueous medium显示文摘 | Zhen Geng Weizhong Ding Haihai Wang Chengzhang Wu Peijun Shen Xingyu Meng Yongqian Gai Futang Ji | 2012 | Journal of Membrane Science2012，，： | 1 |
| 8 | Summertime primary production in northwest South China Sea:Interaction of coastal eddy,upwelling and biological processes显示文摘 | Song Xingyu Lai Zhigang Ji Rubao | 2012 | Continental Shelf Research2012，48，： | 1 |
| 9 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 10 | Summer time primary production in northwest South China Sea:interaction of coastal eddy,upwelling and biological processes显示文摘 | Song Xingyu Lai Zhigang Ji Rubao | 2012 | Continental Shelf Research2012，48，： | 1 |
| 11 | Synthesis and antiviral activities of a novel class of thioflavone and flavonoid analogues显示文摘A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71(EV71)and the coxsackievirus B3(CVB3)and B6(CVB6)were evaluated.Compounds 7d and 9b showed potent antiviral activities against EV71 with ICso values of 8.27 and 5.48μM,respectively.Compound 7f,which has been synthesized for the first time in this work,showed the highest level of inhibitory activity against both CVB3 and CVB6 with an ICso value of 0.62 and 0.87μM.Compounds 4b,7a,9c and 9e also showed strong inhibitory activities against both the CVB3 and CV B6 at low concentrations(IC_(50)=1.42-7.15μM),whereas compounds 4d,7c,7e and 7g showed strong activity against CVB6(IC_(50)=2.91-3.77μM)together with low levels of activity against CVB3.Compound 7d exhibited stronger inhibitory activity against CVB3(IC_(50)=6.44μM)thaln CVB6(IC_(50)>8.29μM).The thioflavone derivatives 7a,7c,7d,7e,7f and 7g,represent a new class of lead compounds for the development of novel antiviral agents. | Dajun Zhang Xingyue Ji Rongmei Gao Huiqiang Wang Shuai Meng Zhaojin Zhong Yuhuan Lin Jiandong Jiang Zhuorong Li | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 0 |
| 12 | Electronic structure of LaIrIn5and f-electron character in its related Ce-115 compounds显示文摘LaIrIn5 is a reference compound of the heavy-fermion superconductor LaIrIn5.The lack of f electrons in LaIrIn5 indicates that there should not be any f electron participating in the construction of its Fermi surface.Thus the electronic structure comparison between LaIrIn5 and LaIrIn5 provides a good platform to study the properties of f electrons.Here angle-resolved photoemission spectroscopy(ARPES)measurements and density functional theory(DFT)calculations are performed to study the electronic structures of LaIrIn5 and LaIrIn5.We find the valence band structures of the two materials are similar to each other,except for the absence of f bands in LaIrIn5.By analyzing the Fermi crossings of the three conduction bands of the two materials quantitatively,we find the volumes of the electron pocketsαandβaround the M′point become larger from LaIrIn5 to LaIrIn5,while the hole pocketγaround theΓ′point becomes smaller.Together with the calculation results,we confirm that this is mainly originated from the f-electron contribution,while the lattice-constant difference between LaIrIn5 and LaIrIn5 only has a finite influence.We also give a summary of the f-electron character in its related Ce-115 heavy fermion compounds.Our results may be essential for the complete microscopic understanding of the 115 compounds and the related heavy-fermion systems. | Rui Zhou XueBing Luo ZhaoFeng Ding Lei Shu XingYu Ji ZiHao Zhu YaoBo Huang DaWei Shen ZhengTai Liu ZhongHao Liu Yun Zhang QiuYun Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，11： | 0 |
| 13 | TBHP-Mediated Oxidative Decarboxylative Cyclization in Water:Directand Sustainable Access to Anti-malarial Polycyclic Fused Quinazolinonesand Rutaecarpine显示文摘of main observation and conclusion Polycylic fused quinazolinones with anti-malarial activity were synthesized through tert-butyl hydro-peroxide(TBHP)-mediated oxidative decarboxylative cyclization between commercaly vailable isatins and cylic amines in one step.The reaction pro-ceeds smoothly in water without additional ransition-metal catalyt,acid and base.The newly synthesied products were evaluated to exhibit moderateto good anti-malaril activity against chloroquine drug-sensitive Plasmodium falciparum 3D7 strain.Additionally this method aso provides direct approach to Rutaecarpine in good yield. | Xingyu Chen Fei Xia Yifan Zhao Ji Ma Yue Ma Dong Zhang Lan Yang Peng Sun | 2020 | Chinese Journal of Chemistry2020，38，11： | 0 |
| 14 | Recent advances in high-β_(N) experiments and magnetohydrodynamic instabilities with hybrid scenarios in the HL-2A Tokamak显示文摘Over the past several years,high-β_(N) experiments have been carried out on HL-2A.The high-β_(N) is realized using double transport barriers(DTBs)with hybrid scenarios.A stationary high-β_(N) (>2)scenario was obtained by pure neutral-beam injection(NBI)heating.Transient high performance was also achieved,corresponding to β_(N)≥3,ne/ne_(G)∼0.6,H_(98)∼1.5,f_(bs)∼30%,q_(95)∼4.0,and��∼0.4.The high-β_(N) scenario was successfully modeled using integrated simulation codes,that is,the one modeling framework for integrated tasks(OMFIT).In high-����plasmas,magnetohydrodynamic(MHD)instabilities are abundant,including low-frequency global MHD oscilla-tion with n=1,high-frequency coherent mode(HCM)at the edge,and neoclassical tearing mode(NTM)and Alfvénic modes in the core.In some high-β_(N) discharges,it is observed that the NTMs with m/n=3/2 limit the growth of the plasma energy and decrease β_(N).The low-n global MHD oscillation is consistent with the coupling of destabilized internal(m/n=1/1)and external(m/n=3/1 or 4/1)modes,and plays a crucial role in triggering the onset of ELMs.Achieving high-β_(N) on HL-2A suggests that core-edge interplay is key to the plasma confinement enhancement mechanism.Experiments to enhance β_(N) will contribute to future plasma operation,such as international thermonuclear experimental reactor. | Wei Chen Liming Yu Min Xu Xiaoquan Ji Zhongbing Shi Xiaoxue He Zhengji Li Yonggao Li Tianbo Wang Min Jiang Shaobo Gong Jie Wen Peiwan Shi Zengchen Yang Kairui Fang Jia Li Lai Wei Wulv Zhong Aiping Sun Jianyong Cao Xingyu Bai Jiquan Li Xuantong Ding Jiaqi Dong Qingwei Yang Yi Liu Longwen Yan Zhengxiong Wang Xuanru Duan | 2022 | Fundamental Research2022，2，5： | 0 |
| 15 | New Dead⁃zone Compensation Approach for Proportional Flow Valve显示文摘To solve the dead⁃zone in the output flow curve of the proportional flow valve without displacement sensor,a dead⁃zone compensation approach is proposed in this paper.Instead of detection and feedback of the valve spool position,the proposed approach adopted the pressure drop across the valve metering orifice to accomplish the dead⁃zone compensation.The first step was to test and get the_(max)imum output flow,Q_(max),at a preset reference pressure drop,such asΔP_(0).The next step was to construct the target compensation flow curve,which is a line through(0,0)and(ΔP_(0),Q_(max)).Then a compensation law was designed to approach the target curve.However,the research results show that the above strategy caused over⁃compensation once the actual pressure drop deviated fromΔP_(0).Thus a correction coefficient,β,was presented to correct the initial compensation law as the pressure drop deviated fromΔP_(0).For example,the test results indicate that the corrected compensation approach could reduce the dead⁃zone from 53.9%to 3.5%at a pressure drop of 1 MPa;as the pressure drop was increased to 5 MPa,the dead⁃zone was reduced from 51.7%to 3.5%.Therefore,the following conclusions can be drawn:the proposed compensation approach is feasible,which can effectively reduce the dead⁃zone and improve the output flow static performance of the proportional flow valve without spool displacement feedback. | Qiang Wu Xingyu Ji He Wang Huimin Hao Jiahai Huang | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，1： | 0 |
| 16 | Growth Behavior of Rubrene Thin Films on Hexagonal Boron Nitride in the Early Stage显示文摘Two-dimensional materials,with an in-plane ordered and dangling-bonding-free surface,are ideal substrates for fabricating high-quality crystalline thin films.Here,we show a systematic study on the growth of a benchmark organic semiconductor,rubrene,on hexagonal boron nitride(h-BN)substrate via physical vapor deposition from the initial amorphous phase to the final crystalline phase;the role of temperature in such transition and the epitaxy relationship between rubrene and h-BN are revealed.With the increase of substrate temperature,the critical thickness of amorphous-crystalline-transition decreases and the morphology of crystalline phase also evolves from porous to terrace-like.When substrate temperature reaches>100℃,the critical thickness reduces to only 0.5 nm and a precise layer-by-layer growth from the very first layer is achieved,which is quite rare for rubrene growing on other substrates.The high ordering can be attributed to the fine epitaxy relationship between rubrene films and the h-BN surface lattice,and this film demonstrates good charge transport ability with a p-type field-effect mobility of>1 cm^(2)·V^(-1)·s^(-1). | Yujia Wei Di Xue Lianlian Ji Jie Lu Qi Wang Xingyu Jiang Yinghui Sun Zi Wang Lizhen Huang Lifeng Chi | 2022 | Chinese Journal of Chemistry2022，40，11： | 0 |
| 17 | Engineering oxygen vacancies and localized amorphous regions in CuO-ZnO separately boost catalytic reactivity and selectivity显示文摘Generating different types of defects in heterogeneous catalysts for synergetic promotion of the reactivity and selectivity in catalytic reactions is highly challenging due to the lack of effective theoretical guidance.Herein,we demonstrate a facile strategy to introduce two types of defects into the CuO-ZnO model catalyst,namely oxygen vacancies(OVs)induced by H2 partial reduction and localized amorphous regions(LARs)generated via the ball milling process.Using industrially important Rochow–Müller reaction as a representative,we found OVs predominantly improved the target product selectivity of dimethyldichlorosilane,while LARs significantly increased the conversion of reactant Si.The CuO-ZnO catalyst with optimized OVs and LARs contents achieved the best catalytic property.Theoretical calculation further revealed that LARs promote the generation of the Cu3Si active phase,and OVs impact the electronic structure of the Cu3Si active phase.This work provides a new understanding of the roles of different catalyst defects and a feasible way of engineering the catalyst structure for better catalytic performances. | Yongjun Ji Xiaoli Chen Shaomian Liu Liwen Xing Xingyu Jiang Bin Zhang Huifang Li Wenxing Chen Ziyi Zhong Ligen Wang Guangwen Xu Fabing Su | 2023 | Nano Research2023，16，2： | 0 |
| 18 | Electronic structure of La (0001) thin films on W (110) studied by photoemission spectroscopy and first principle calculations显示文摘Surface states that have a dz2 symmetry around the center of the surface Brillouin zone(BZ)have been regarded common in closely-packed surfaces of rare-earth metals.In this work,we report the electronic structure of dhcp La(0001)thin films by ultrahigh energy resolution angle-resolved photoemission spectroscopy(ARPES)and first principle calculations.Our first principle analysis is based on the many-body approach,therefore,density function theory(DFT)combined with dynamic mean-field theory(DMFT).The experimentally observed Fermi surface topology and band structure close to the Fermi energy qualitatively agree with first principle calculations when using a renormalization factor of between 2 and 3 for the DFT bands.Photon energy dependent ARPES measurements revealed clear kZ dependence for the hole-like band around the BZ center,previously regarded as a surface state.The obtained ARPES results and theoretical calculations suggest that the major bands of dhcp La(0001)near the Fermi level originate from the bulk La 5d orbits as opposed to originating from the surface states. | XingYu Ji QiuYun Chen XinChun Lai Li Huang ShiYong Tan | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，6： | 0 |
| 19 | DDB1-and CUL4-associated factor 8 plays a critical role in spermatogenesis显示文摘Cullin-RING E3 ubiquitin ligase(CRL)-4 is a member of the large CRL family in eukaryotes.It plays important roles in a wide range of cellular processes,organismal development,and physiological and pathological conditions.DDB1-and CUL4-associated factor 8(DCAF8)is a WD40 repeat-containing protein,which serves as a substrate receptor for CRL4.The physiological role of DCAF8 is unknown.In this study,we constructed Dcaf8 knockout mice.Homozygous mice were viable with no noticeable abnormalities.However,the fertility of Dcaf8-deficient male mice was markedly impaired,consistent with the high expression of DCAF8 in adult mouse testis.Sperm movement characteristics,including progressive motility,path velocity,progressive velocity,and track speed,were significantly lower in Dcaf8 knockout mice than in wild-type(WT)mice.However,the total motility was similar between WT and Dcaf8 knockout sperm.More than 40%of spermatids in Dcaf8 knockout mice showed pronounced morphological abnormalities with typical bent head malformation.The acrosome and nucleus of Dcaf8 knockout sperm looked similar to those of WT sperm.In vitro tests showed that the fertilization rate of Dcaf8 knockout mice was significantly reduced.The results demonstrated that DCAF8 plays a critical role in spermatogenesis,and DCAF8 is a key component of CRL4 function in the reproductive system. | Xiuli Zhang Zhizhou Xia Xingyu Lv Donghe Li Mingzhu Liu Ruihong Zhang Tong Ji Ping Liu Ruibao Ren | 2021 | Frontiers of Medicine2021，15，2： | 0 |
| 20 | Assessing the role of mineral particles in the atmospheric photooxidation of typical carbonyl compound显示文摘Mineral particles are ubiquitous in the atmosphere and exhibit an important effect on the photooxidation of volatile organic compounds(VOCs).However,the role of mineral particles in the photochemical oxidation mechanism of VOCs remains unclear.Hence,the photooxi-dation reactions of acrolein(ARL)with OH radical(OH)in the presence and absence of SiO_(2) were investigated by theoretical approach.The gas-phase reaction without SiO_(2) has two distinct pathways(H-abstraction and OH-addition pathways),and carbonyl-H-abstraction is the dominant pathway.In the presence of SiO_(2),the reaction mechanism is changed,i.e.,the dominant pathway from carbonyl-H-abstraction to OH-addition to carbonyl C-atom.The energy barrier of OH-addition to carbonyl C-atom deceases 21.33 kcal/mol when SiO_(2) is added.Carbonyl H-atom of ARL is occupied by SiO_(2) via hydrogen bond,and carbonyl C-atom is ac-tivated by SiO_(2).Hence,the main product changes from H-abstraction product to OH-adduct in the presence of SiO_(2).The OH-adduct exhibits a thermodynamic feasibility to yield HO_(2) radical and carboxylic acid via the subsequent reactions with O_(2),with implications for O 3 formation and surface acidity of mineral particles. | Yongpeng Ji Xingyu Chen Yuqi Xiao Yuemeng Ji Weina Zhang Jiaxin Wang Jiangyao Chen Guiying Li Taicheng An | 2021 | Journal of Environmental Sciences2021，33，7： | 0 |
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