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| 1 | Service-aware 6G:An intelligent and open network based on the convergence of communication,computing and caching显示文摘With the proliferation of the Internet of Things(IoT),various services are emerging with totally different features and requirements,which cannot be supported by the current fifth generation of mobile cellular networks(5G).The future sixth generation of mobile cellular networks(6G)is expected to have the capability to support new and unknown services with changing requirements.Hence,in addition to enhancing its capability by 10–100 times compared with 5G,6G should also be intelligent and open to adapt to the ever-changing services in the IoT,which requires a convergence of Communication,Computing and Caching(3C).Based on the analysis of the requirements of new services for 6G,this paper identifies key enabling technologies for an intelligent and open 6G network,all featured with 3C convergence.These technologies cover fundamental and emerging topics,including 3C-based spectrum management,radio channel construction,delay-aware transmission,wireless distributed computing,and network self-evolution.From the detailed analysis of these 3C-based technologies presented in this paper,we can see that although they are promising to enable an intelligent and open 6G,more efforts are needed to realize the expected 6G network. | Yiqing Zhou Ling Liu Lu Wang Ning Hui Xinyu Cui Jie Wu Yan Peng Yanli Qi Chengwen Xing | 2020 | Digital Communications and Networks2020，6，3： | 57 |
| 2 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 3 | Convergence proof of the DSMC method and the Gas-Kinetic Unified Algorithm for the Boltzmann equation显示文摘This paper investigates the convergence proof of the Direct Simulation Monte Carlo(DSMC) method and the Gas-Kinetic Unified Algorithm in simulating the Boltzmann equation.It can be shown that the particle velocity distribution function obtained by the DSMC method converges to a modified form of the Boltzmann equation,which is the equation of the gas-kinetic unified algorithm to directly solve the molecular velocity distribution function.Their convergence is derived through mathematical treatment.The collision frequency is presented using various molecular models and the local equilibrium distribution function is obtained by Enskog expansion using the converged equation of the DSMC method.These two expressions agree with those used in the unified algorithm.Numerical validation of the converging consistency between these two approaches is illustrated by simulating the pressure driven Poiseuille flow in the slip transition flow regime and the two-dimensional and three-dimensional flows around a circular cylinder and spherical-cone reentry body covering the whole flow regimes from low speed micro-channel flow to high speed non-equilibrium aerothermodynamics. | LI Zhi Hui FANG Ming JIANG XinYu WU JunLin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 10 |
| 4 | A brief introduction to the FUTang Updating medical REcords(FUTURE)database显示文摘Introduction Futang Research Center of Pediatric Development(FRCPD),the first nonprofit social service organization engaging in pediatric research in China,was founded in May 2013.Until August 2021,FRCPD has 40 tertiary children’s hospitals,accounting for about 65.6%of all national public children’s hospitals,which was reported to be 61 in China Health Statistical Yearbook(2020).The hospitals are distributed in 30 provinces,autonomous regions,and municipalities(except for Tibet autonomous region),and most of them are in the capital of the province,forming a broad frontline representing the best quality of health care for the diagnosis and treatment of children’s disease in China.Based on the idea of sharing,FRCPD realized the exchange of experts,medical resources,research findings,educational events,preventive strategies,and management experiences among members.In the long run,FRCPD aims to continuously promote the quality of healthcare and medical service capability for children in China. | Xinyu Wang Yueping Zeng Jian Tian Hui Xu Fei Song Yongli Guo Xin Xu Guoshuang Feng Xin Ni | 2021 | Pediatric Investigation2021，5，3： | 6 |
| 5 | A water-evaporation-induced self-charging hybrid power unit for application in the Internet of Things显示文摘A self-charging hybrid power unit has been developed by integrating a water-evaporation-induced nano- generator with a flexible nano-patterned supercapacitor. The nanogenerator can harvest environmental thermal energy and mechanical energy through the water evaporation process, and the supercapacitor can be charged simultaneously. The former offers stable electrical power as output, whereas the Ppy- based supercapacitor shows a capacitance of 12.497 m F/cm^2 with 96.42% retention after 4,000 cycles. After filling the power unit with water as the fuel, it can be fully charged in about 20 min. The power unit can be flexibly integrated with electronic devices such as sensor nodes and wireless transmitters employ- ing the Internet of Things. This new approach can offer new possibilities in continuous future operation of randomly distributed electronic devices incorporated in the Internet of Things. | Haoxuan He Tianming Zhao Hongye Guan Tianyan Zhong Hui Zeng Lili Xing Yan Zhang Xinyu Xue | 2019 | Science Bulletin2019，64，19： | 5 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | Postsynthetic functionalization of covalent organic frameworks显示文摘Covalent organic frameworks(COFs)have been at the forefront of porous-material research in recent years.With predictable structural compositions and controllable functionalities,the structures and properties of COFs could be controlled to achieve targeted materials.On the other hand,the predesigned structure of COFs allows fruitful postsynthetic modifications to introduce new properties and functions.In this review,the postsynthetic functionalizations of COFs are discussed and their impacts towards structural qualities and performances are comparatively elaborated on.The functionalization involves the formation of specific interactions(covalent or coordination/ionic bonds)and chemical reactions(oxidation/reduction reaction)with pendant groups,skeleton and reactive linkages of COFs.The chemical stability and performance of COFs including catalytic activity,storage,sorption and opto-electronic properties might be enhanced by specific postsynthetic functionalization.The generality of these strategies in terms of chemical reactions and the range of suitable COFs places them as a pivotal role for the development of COF-based smart materials. | Yusran Yusran Xinyu Guan Hui Li Qianrong Fang Shilun Qiu | 2020 | National Science Review2020，7，1： | 4 |
| 8 | Sn02 nanoparticles anchored on graphene oxide as advanced anode materials for high-performance lithium-ion batteries显示文摘Lithium-ion batteries (LIBs) with high energy density have attracted great attention for their wide applications in electric vehicles, and the exploration of the nextgeneration anode materials with high theoretical capacity is highly desired. In this work, Sn02 nanoparticles with the particle size of 200 nm uniformly anchored on the surface of graphene oxide (GO) was prepared by combination of the ultrasonic method and the following calcination process. The Sn02/GO composite with the weight ratio of Sn02 to GO at 4:1 exhibits excellent electrochemical performance, which originates from the synergistic effects between GO and Sn02 nanoparticles. A high discharge capacity of 492 mA·h·g^-1 can be obtained after 100 cycles at 0.2C, and after cycling at higher current densities of 1C and 2C, a discharge capacity of 641 mA·h·g^-1 can be restored when the current density goes back to 0.1C. The superior electrochemical performance and simple synthesis process make it a very promising candidate as anode materials for LIBs. | Ruiping LIU Ning ZHANG Xinyu WANG Chenhui YANG Hui CHENG Hanqing ZHAO | 2019 | Frontiers of Materials Science2019，13，2： | 4 |
| 9 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 10 | Research progress on aging of organic pollutants in geosorbents:a review显示文摘Geosorbents are the main host of anthropogenic organic pollutants and play a vital role in their fate and transport in the natural environment.Soil and sediment are the most common and abundant geosorbents in the natural environment;their interactions with organic pollutants,especially sorption and desorption processes,have been extensively studied from the perspectives of thermodynamics and kinetics.Recently,the aging of organic pollutants in geosorbents has drawn increased attention,leading to an improved understanding of interactions between organic pollutants and geosorbents and informing remediation criteria.Aging has been deemed important in accurately assessing ecologic and health risks of organic pollutants,and both positive and negative impacts have been reported in studies of natural and artificial sorbents.This paper summarizes recent research progress on organic pollutant aging in geosorbents,including related mechanism research,influence factors,bioavailability assessments,and biological and physicochemical remediation of aged organic pollutants.We also discuss issues in the current research and bring forward suggestions for future study. | Xianjin An Baohua xiao Xinyue Di Hui Dong Haiming Tang | 2017 | Acta Geochimica2017，36，1： | 3 |
| 11 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 12 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 13 | Multiscale model of micro curing residual stress evolution in carbon fiber-reinforced thermoset polymer composites显示文摘In this study,the micro curing residual stresses of carbon fiber-reinforced thermoset polymer(CFRP)composites are evaluated using a multiscale modeling method.A thermochemical coupling model is developed at the macroscale level to obtain the distributions of temperature and degree of cure.Meanwhile,a representative volume element model of the composites is established at the microscale level.By introducing the information from the macroscale perspective,the curing residual stresses are calculated using the microscale model.The evolution of curing residual stresses reveals the interaction mechanism of fiber,matrix,and interphase period during the curing process.Results show that the curing residual stresses mostly present a tensile state in the matrix and a compressive state in the fiber.Furthermore,the curing residual stresses at different locations in the composites are calculated and discussed.Simulation results provide an important guideline for the analysis and design of CFRP composite structures. | Xinyu HUI Yingjie XU Weihong ZHANG | 2020 | Frontiers of Mechanical Engineering2020，15，3： | 2 |
| 14 | Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1显示文摘TANK-binding kinase 1(TBK1)is an essential protein kinase for activation of interferon regulatory factor 3(IRF3)and induction of the type I interferons(IFN-I).Although the biochemical regulation of TBK1 activation has been studied,little is known about how enterovirus 71(EV71)employs the deubiquitinases(DUBs)to regulate TBK1 activation for viral immune evasion.Here,we found that EV71 infection upregulated the expression of ubiquitinspecific protease 24(USP24).Further studies revealed that USP24 physically interacted with TBK1,and can reduce K63-linked polyubiquitination of TBK1.Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination,promoted the phosphorylation and nuclear translocation of IRF3,and in turn improved IFN-I production during EV71 infection.As a consequence,USP24 knockdown dramatically inhibited EV71 infection.This study revealed USP24 as a novel regulator of TBK1 activation,which promotes the understanding of immune evasion mechanisms of EV71 and could provide a potential strategy for treatment of EV71 infection. | Lichao Zang Jin Gu Xinyu Yang Yukang Yuan Hui Guo Wei Zhou Jinhong Ma Yan Chen Yumin Wu Hui Zheng Weifeng Shi | 2023 | Virologica Sinica2023，38，1： | 2 |
| 15 | Orientation-selective responses in the mouse lateral geniculate nucleus 显示文摘 | Zhao Xinyu Chen Hui Liu Xiaorong | 2013 | The Journal of Neuroscience2013，33，12： | 1 |
| 16 | Giant Electrocaloric Response Over A Broad Temperature Range in Modified BaTiO<sub>3</sub> Ceramics显示文摘 | Xiao‐Shi Qian Hui‐Jian Ye Ying‐Tang Zhang Haiming Gu Xinyu Li C. A. Randall Q. M. Zhang | 2014 | Adv Funct Mater2014，，9： | 1 |
| 17 | Motion Model of Floating Weather Sensing Node for Typhoon Detection显示文摘To improve the accuracy of typhoon prediction,it is necessary to detect the internal structure of a typhoon.The motion model of a floating weather sensing node becomes the key to affect the channel frequency expansion performance and communication quality.This study proposes a floating weather sensing node motion modeling method based on the chaotic mapping.After the chaotic attractor is obtained by simulation,the position trajectory of the floating weather sensing node is obtained by space and coordinate conversion,and the three-dimensional velocity of each point on the position trajectory is obtained by multidimensional linear interpolation.On this basis,the established motion model is used to study the Doppler frequency shift,which is based on the software and physical platform.The software simulates the relative motion of the transceiver and calculates the Doppler frequency shift.The physical platform can add the Doppler frequency shift to the actual transmitted signal.The results show that this method can effectively reflect the influence of the floating weather sensing node motion on signal transmission.It is helpful to research the characteristics of the communication link and the design of a signal transceiver for typhoon detection to further improve the communication quality and to obtain more accurate interior structure characteristic data of a typhoon. | Hui Lu Xinyu Dong Xianbin Cao | 2022 | Complex System Modeling and Simulation2022，2，1： | 1 |
| 18 | Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide(GLP-1) secretion function of the mouse intestine显示文摘IF1(ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP production.IF1 activity remains unknown in the regulation of GLP-1 activity.In this study,IF1 was examined in the diet-induced obese mice using the gene knockout(If1-KO) mice.The mice gained more body weight on a high fat diet without a change in food intake.Insulin tolerance was impaired,but the oral glucose tolerance was improved through an increase in GLP-1 secretion.The KO mice exhibited an improved intestine structure,mitochondrial superstructure,enhanced mitophagy,reduced apoptosis and decreased adenine nucleotide translocase 2(ANT2) protein in the intestinal epithelial cells together with preserved gut microbiota.The data suggest that GLP-1 secretion was enhanced in the obese If1-KO mice to preserve glucose tolerance through a signaling pathway of ANT2/mitochondria/L-cells/GLP-1/insulin.IF1 is a potential mitochondrial target for induction of GLP-1 secretion in L-cells. | Ying Wang Jiaojiao Zhang Xinyu Cao Yaya Guan Shuang Shen Genshen Zhong Xiwen Xiong Yanhong Xu Xiaoying Zhang Hui Wang Jianping Ye | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 19 | Conversion of methanol to aromatics in fluidized bed reactor显示文摘 | Tong Wang Xiaoping Tang Xiaofan Huang Weizhong Qian Yu Cui Xinyu Hui Wei Yang Fei Wei | 2014 | Catalysis Today2014，，： | 1 |
| 20 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
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