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| 1 | A review on thermal conductivity of magnesium and its alloys显示文摘This review summarizes recent researching works the thermal conductivity of Mg–Zn,Mg–Al,Mg–Mn and Mg–RE alloys.Solute atoms,heat treatment,deformation and temperature,which have significant influence on the thermal conductivity of magnesium alloys,are highlighted.For an individual solute atom,its effects on thermal conductivity are highly dependent on its chemical valence,radius and extra-nuclear electrons.The thermal conductivity of Mg alloys is decreased by solution treatment,but improved by aging and/or annealing treatments.As for the deformed Mg alloys,the thermal conductivity along transverse or normal direction is superior to that of along extrusion or rolling direction.We expect this review is helpful for those who are working on developing Mg alloys with superior thermal conductivity.©2020 Published by Elsevier B.V.on behalf of Chongqing University. | Shubo Li Xinyu Yang Jiangtao Hou Wenbo Du | 2020 | Journal of Magnesium and Alloys2020，8，1： | 18 |
| 2 | MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors显示文摘胃肠的 stromal 肿瘤(大意) 是胃肠的道的最普通的间充质的肿瘤之一。尽管 imatinib 改进结果,药抵抗为扩大耐心的幸存仍然是主要问题。药目标的基因变化是为 imatinib 抵抗的已知的机制。然而,它不能 imatinib 抵抗的现象解释所有,并且众多的另外的机制被建议了在各种各样的模型系统说明 imatinib 抵抗。在这研究,我们使用了屏蔽差别的基于反应的数组途径表示了的 SYBR 绿的量的聚合酶链在主要大意病人和 imatinib 抵抗的病人之间的 miRNAs。选择候选人 miRNAs 在 12 个大意病人的一个队被验证。我们发现 miR-320a 的那低表情与 imatinib 抵抗的短时间被相关,并且为 imatinib 抵抗建议了 miR-320a 的潜在的机制。 | Xiaodong Gao Kuntang Shen Cuizhong Wang Jiaqian Ling Hongshan Wang Yong Fang Yuan Shi Yingyong Hou Jin Qin Yihong Sun Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 9 |
| 3 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 4 | Incorporation of NLR into NIH stratificationsystem increases predictive accuracy for surgically resected gastrointestinal stromal tumors显示文摘以前的研究报导了那外科手术前的 neutrophil-to-lymphocyte (NLR ) , platelet-to-lymphocyte 比率为癌症的各种各样的类型是预示的。这研究的目的是与胃肠的 stromal 肿瘤(大意) 在病人调查外科手术前的外部血计数的预兆的实用程序。我们注册了为主要、局部性的大意经历了外科的 510 个连续、以前未经治疗的病人。在没有复发的幸存和结果变量之间的关系被 univariate 和 multivariate 分析估计,当 NLR 的 clinicopathologic 关联用 Chi 平方测试是坚定的时。外科手术前的 NLR 2 在为主要、局部性的大意经历手术的病人与差的预后被联系。它在是分类的病人仅仅是一个独立预言者 ? 健康高风险然而并非在全部人口的国家研究所。外科手术前的 NLR 是帮助为集中的辅助治疗和经常的监视识别病人的可行、可再现的外部 biomarker。 | Anwei Xue Xiaodong Gao Yong Fang Ping Shu Jiaqian Ling Kuntang Shen Yihong Sun Jing Qin Xinyu Qin Yingyong Hou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 4 |
| 5 | Distinct contribution of PD-L1 suppression by spatial expression of PD-L1 on tumor and non-tumor cells显示文摘Programmed cell death receptor 1(PD-1)and its ligand,PD-L1,are important immune checkpoint proteins.Although antibodies that block PD-1/PD-L1 have shown promising clinical efficacy in a subset of cancer patients,the detailed cellular and molecular mechanisms behind anti-PD-1 and anti-PD-L1 immunotherapy are not well defined.Specifically,the way in which PD-L1 contributes to immune suppression on tumor and non-tumor cells remains controversial.By selectively blocking PD-L1 on either tumor or non-tumor cells,we demonstrated that PD-L1 from both sources suppressed the anti-tumor T-cell response.Blocking PD-L1 on either tumor cells or non-tumor cells inhibited tumor growth and enhanced immune cell infiltration,as well as the tumor-specific T-cell response.Further,simultaneously blocking tumor-and non-tumor-derived PD-L1 maximized anti-tumor T-cell responses and demonstrated synergy.In addition,the relative contribution of PD-L1 on tumor and non-tumor cells to immune suppression depended on the PD-L1 expression level.Lastly,we found that the F4/80 receptor was involved in the anti-tumor effect of PD-L1 blockade.Taken together,our data indicate that PD-L1 on both tumor and non-tumor cells is critical for T-cell inhibition,which provides new directions for the optimization of PD-L1-blocking antibodies and the development of clinical biomarker strategies. | Xiaoqing Zhang Chen Cheng Jiyan Hou Xinyue Qi Xin Wang Ping Han Xuanming Yang | 2019 | Cellular & Molecular Immunology2019，16，4： | 3 |
| 6 | Application of orthogonal design to the extraction and HPLC analysis of sedimentary pigments from lakes of the Tibetan Plateau显示文摘沉积颜料是在湖、海洋的生态系统的浮游植物生物资源,社区结构,主要生产率和人的影响的有用代理指示物。颜料由于他们的复杂化学结构是相对易变的,它做质问的沉积颜料的抽取和分析。另外,选择适当方法在缺乏以前的调查的区域学习沉积颜料是重要的。在这研究,我们采用了 L 9(34) 开发抽取和 HPLC (高效液体层析) 的方法的直角的设计在西藏的高原上的二个湖的沉积颜料的分析:meromictic lake-Dagze 公司和 dimictic lake-Jiang 公司直角的设计为抽取和 HPLC 分析包括各种各样的参数的 9 联合。结果证明溶剂的类型和体积是为颜料抽取的最重要的因素,并且活动阶段和列选择为 HPLC 分析是最重要的。为学习地点,我们发现提取沉积颜料的最好的方法如下:acetone:methanol:water 的混合物的使用(80:15:5, v:v:v ) 作为抽取溶剂;10 mL/g 的 solvent/ 样品比率;为 30 s 的 sonication 和为 6 h 的站的抽取。为 HPLC 分析的最好的方法如下:加有活动阶段 A 的 C8 列的 Zorbax 日蚀, methanol:acetonitrile:0.25 M 水的 pyridine (50:25:25, v:v:v ) 并且活动阶段 B,甲醇:acetonitrile:丙酮(20:60:20, v:v:v ) ;活动阶段 A 的 pH 与醋酸适应了 6;并且 HPLC 列温度在 40 | LIANG Jie LI Dong WANG MingDa ZHANG XinYu HOU JuZhi | 2016 | Science China Earth Sciences2016，59，6： | 3 |
| 7 | Preparation and characterization of β-cyclodextrin grafted N-maleoyl chitosan nanoparticles for drug delivery显示文摘β-cyclodextrin (CD) grafted N-maleoyl chitosan (CD-g-NMCS) with two different degrees of substitution (DS) of N-maleoyl (DS = 21.2% and 30.5%) were synthesized from maleic anhydride and chitosan bearing pendant cyclodextrin (CD-g-CS). CD-g-NMCS based nanoparticles were prepared via an ionic gelation method together with chitosan and CD-g-CS nanoparticles.The size and zeta potential of prepared CD-g-NMCS nanoparticles were 179.2~274.0 nm and 36.2~42.4 m V, respectively. In vitro stability test indicated that CD-g-NMCS nanoparticles were more stable in phosphate-buffered saline compared with chitosan nanoparticles. Moreover, a poorly water-soluble drug, ketoprofen (KTP), was selected as a model drug to study the obtained nanoparticle’s potentials as drug delivery carriers. The drug loading efficiency of CD-g-NMCS20 nanoparticles were 14.8% for KTP. MTT assay showed that KTP loaded CD-g-NMCS nanoparticles were safe drug carriers. Notably, in vitro drug release studies showed that KTP was released in a sustained-release manner for the nanoparticles. The pharmacokinetic of drug loaded CD-g-NMCS20 nanoparticles were evaluated in rats after intravenous administration. The results of studies revealed that, compared with free KTP, KTP loaded CD-g-NMCS20 nanoparticles exhibited a significant increase in AUC0→24h and mean residence time by 6.6-fold and 2.9-fold, respectively. Therefore, CD-g-NMCS nanoparticles could be used as a novel promising nanoparticle-based drug delivery system for sustained release of poorly water-soluble drugs. The carboxylic acid groups of the CD-g-NMCS molecule provide convenient sites for further structural modifications including introduction of tissue-or disease-specific targeting groups. | Xinyu Hou Wenjuan Zhang Muye He Yiben Lu Kaiyan Lou Feng Gao | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 3 |
| 8 | Highly stretchable and reliable graphene oxide- reinforced liquid gating membranes for tunable gas/liquid transport显示文摘The ability of membrane technologies to dynamically tune the transport behavior for gases and liquids is critical for their applications.Although various methods have been developed to improve membrane success,tradeoffs still exist among their properties,such as permeability,selectivity,fouling resistance,and stability,which can greatly affect the performance of membranes.Existing elastomeric membrane designs can provide antifracture properties and flexibility;however,these designs still face certain challenges,such as low tensile strength and reliability.Additionally,researchers have not yet thoroughly developed membranes that can avoid fouling issues while realizing precise dynamic control over the transport substances.In this study,we show a versatile strategy for preparing graphene oxide-reinforced elastomeric liquid gating membranes that can finely modulate and dynamically tune the sorting of a wide range of gases and liquids under constant applied pressures.Moreover,the produced membranes exhibit antifouling properties and are adaptable to different length scales,pressures,and environments.The filling of graphene oxide in the thermoplastic polyurethane matrix enhances the composites through hydrogen bonds.Experiments and theoretical calculations are carried out to demonstrate the stability of our system.Our membrane exhibits good stretchability,recovery,and durability due to the elastic nature of the solid matrix and dynamic nature of the gating liquid.Dynamic control over the transport of gases and liquids is achieved through our optimized interfacial design and controllable pore deformation,which is induced by mechanical stimuli.Our strategy will create new opportunities for many applications,such as gas-involved chemical reactions,multiphase separation,microfluidics,multiphase microreactors,and particulate material synthesis. | Wei Lv Zhizhi Sheng Yinglin Zhu Jing Liu Yi Lei Rongrong Zhang Xinyu Chen Xu Hou | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 9 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 10 | Light-responsive and corrosion-resistant gas valve with non-thermal effective liquid-gating positional flow control显示文摘Safe and precise control of gas flow is one of the key factors to many physical and chemical processes,such as degassing,natural gas transportation,and gas sensor.In practical application,it is essential for the gas-involved physicochemical process to keep everything under control and safe,which significantly relies on the controllability,safety,and stability of their valves.Here we show a light-responsive and corrosion-resistant gas valve with non-thermal effective liquid-gating positional flow control under a constant pressure by incorporating dynamic gating liquid with light responsiveness of solid porous substrate.Our experimental and theoretical analysis reveal that the photoisomerization of azobenzene-based molecular photoswitches on the porous substrate enabled the gas valve to possess a light-responsive and reversible variation of substantial critical pressure of non-thermal effective gas flow switch.Moreover,the chemically inert gating liquid prevented the solid substrate from corrosion and,by combining with the high spatiotemporal resolution of light,the gas valve realizes a precisely positional open and close under a steady-state pressure.The application demonstrations in our results show the potentials of the new gas valve for bringing opportunities to many applications,such as gas-involved reaction control in microfluidics,soft actuators,and beyond. | Baiyi Chen Rongrong Zhang Yaqi Hou Jian Zhang Shiyan Chen Yuhang Han Xinyu Chen Xu Hou | 2021 | Light(Science & Applications)2021，10，7： | 3 |
| 11 | Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1显示文摘Human cytosolic sulfotransferase 2 A1(SULT2A1) is an important phase II metabolic enzyme. The detection of SULT2A1 is helpful for the functional characterization of SULT2A1 and diagnosis of its related diseases. However, due to the overlapping substrate specificity among members of the sulfotransferase family, it is difficult to develop a probe substrate for selective detection of SULT2A1. In the present study, through characterization of the sulfation of series of bufadienolides, arenobufagin(AB) was proved as a potential probe substrate for SULT2A1 with high sensitivity and specificity. Subsequently, the sulfation of AB was characterized by experimental and molecular docking studies. The sulfate-conjugated metabolite was identified as AB-3-sulfate.The sulfation of AB displayed a high selectivity for SULT2A1 which was confirmed by in vitro reaction phenotyping assays. The sulfation of AB by human liver cytosols and recombinant SULT2A1 both obeyed Michaelis-Menten kinetics, with similar kinetic parameters. Molecular docking was performed to understand the interaction between AB and SULT2A1, in which the lack of interaction with Met-137 and Tyr-238 of SULT2A1 made it possible to eliminate substrate inhibition of AB sulfation. Finally, the probe was successfully used to determine the activity of SULT2A1 and its isoenzymes in tissue preparations of human and laboratory animals. | Xiangge Tian Chao Wang Peipei Dong Yue An Xinyu Zhao Weiru Jiang Gang Wang Jie Hou Lei Feng Yan Wang Guangbo Ge Xiaokui Huo Jing Ning Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 12 | Hyperterpenoids A and B:Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii显示文摘Hyperterpenoid A(1)and B(2),two pairs of enantiomers,with an unprecedented 6/6/4/6/6 polycyclic skeleton,along with one known compoud hypermonone A(3)were isolated from Hypericum beanii.The racemate(±)-1 and(±)-2 were successfully separated into the two optically pure enantiomers(ee>99%)using a preparative HPLC system.Their absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction method.The related plausible biogenetic pathways were pre sented.Compound 1-3 showed significant neuroprotective activity and potential antiinflammatory activity.The result that(+)-2 and(-)-2 presented different anti-inflammatory properties,may lead us to new discovery of structure activity relationship between racemates,enantiomers,and diastereomers,as well as further research regarding the binding of drugs to target proteins. | Bo Zhen Xinyue Suo Jun Dang Huilan Yue Yanduo Tao Jia-Jia Wang Li Li Ming-Bao Lin Qi Hou Wei-Ping Wang Xiao-Liang Wang Jian-Dong Jiang Teng-Fei Ji | 2021 | Chinese Chemical Letters2021，32，7： | 2 |
| 13 | Kernel position effects of grain morphological characteristics by X-ray micro-computed tomography (μCT)显示文摘Grain size and shape are important factors for yield and quality.The difference in grain phenotypic characteristics in the same maize hybrid is related to its position in the ear.This study aimed to clarify the distribution characteristics of grain morphological characteristics in the ear and to provide guidance for research of grain phenotype and kernel position effects.Three maize hybrids were used in the experiment,namely,Denghai 618(DH618),KX3564,and Xianyu 335(XY335),and the kernel number per row were 40,40,and 36,respectively.The X-rayμCT was applied to obtain five kernel morphological indicators,including grain length,width,thickness,volume,surface area.Grain sphericity,length-width ratio,specific surface area,and volume coefficient were further calculated.The results showed that there were three types of maize ear morphological indicators trends:grain length,width,volume,and surface area were parabolic;thickness and sphericity were inverted parabolic;length-to-width ratio and specific surface area were irregular.The volume coefficient of grain at different parts of the ear,namely the relation coefficient between grain volume and grain length,width,and thickness,was determined.The average value of the middle grains morphological indicators of the ear was taken to select kernels representing stable characteristics of the variety.Within the range of 5%deviation from the morphological mean value of the middle grains of the ear,the grains in the middle part accounted for 26.39%of the total ear,about 10 grains extending from the 14th grain at the base of the ear to the top.Within the range of 10%deviation,the middle accounted for 47.22%,about 18 grains extending from the 12th grain at the base of the ear to the top.This study found that grain morphological indicators were greatly different at different positions of the maize ear,and showed different change rules as extend from the base to the top of the ear.Therefore,there were different grain volume coefficients at different positions of maize ear.And the representative sampling range on maize ear was determined based on the comprehensive analysis of different morphological indexes variation of grain. | Xuebo Yin Junfeng Hou Bo Ming Ying Zhang Xinyu Guo Shang Gao Keru Wang Peng Hou Shaokun Li Ruizhi Xie | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 14 | Nickel single atom overcoordinated active sites to accelerate the electrochemical reaction kinetics for Li-S cathode显示文摘Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their applications.Herein,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S batteries.Due to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously improved.The batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))condition.Meanwhile,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and LiPSs.Thus,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC host.This study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode. | Juan Zhu Xinyue Wang Tian Ke Mingji Jia Biyu Jin Yuanyuan Li Qiwei Yang Lanhui Ren Yongyuan Ren Dangguo Cheng Jianguo Lu Xiang Gao Qinggang He Yang Hou Xiaoli Zhan Qinghua Zhang | 2023 | Journal of Energy Chemistry2023，，3： | 2 |
| 15 | hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells显示文摘 | Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma Jingze Lu Tao Xu Junjie Hou Eli Song | 2018 | Protein & Cell2018，9，10： | 2 |
| 16 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 17 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 18 | Continuous water-water hydrogen bonding network across the rim of carbon nanotubes facilitating water transport for desalination显示文摘The development of membranes featuring carbon nanotubes(CNTs)have provided possibilities of next-generation solar desalination technologies.For solar desalination,the microstructures and interactions between the filter membrane and seawater play a crucial role in desalination performance.Understanding the mechanisms of water evaporation and ion rejection in confined pores or channels is necessary to optimize the desalting process.Here,using non-equilibrium molecular dynamics simulations,we found that continuous water-water hydrogen bonding network across the rims of CNTs is the key factor in facilitating water transport through CNTs.With the continuous hydrogen bonding network,the water flux is two times of that without the continuous hydrogen bonding network.In CNT arrays,each CNT transports water molecules and rejects salt ions independently.Based on these observations,using CNT arrays consisted with densely packed thin CNTs is the most advisable strategy for evaporation desalination,possessing high transport flux as well as maintaining high salt rejection. | Yaqi Hou Miao Wang Xinyu Chen Xu Hou | 2021 | Nano Research2021，14，7： | 1 |
| 19 | Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin显示文摘This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin(a-CD). The effect of a-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol(mPEG) grafted chitosan(CS) was studied. The results showed that the mPEG grafted chitosan(mPEG-[9_TD$IF]g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of a-CD to mPEG, as characterized by atomic force microscopy(AFM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of a-CD. The correlation between zeta potential and particle size of a-CD/mPEG-[9_TD$IF]g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-[9_TD$IF]g-CS was proposed. | Lei Huang Jiaojiao Chen Muye He Xinyu Hou Yiben Lu Kaiyan Lou Feng Gao | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 20 | A new inorganic–organic hybrid compound constructed from polyoxoanions and rare earth coordination complexes显示文摘 | Juan Li Xihe Yu Hongfang Wang Kun Xu Xinyu Wu Lei Hou Jing Li | 2006 | Transition Metal Chemistry2006，，6： | 1 |
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