|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Characterization and Evaluation of OsLCT1 and OsN ramp5 Mutants Generated Through CRISPR/Cas9-Mediated Mutagenesis for Breeding Low Cd Rice显示文摘To explore how rice(Oryza sativa L.) can be safely produced in Cd-polluted soil, OsLCT1 and OsNramp5 mutant lines were generated by CRISPR/Cas9-mediated mutagenesis. One of OsLCT1 mutant(lct1×1) and two of OsNramp5 mutants(nramp5×7 and nramp5×9) were evaluated for grain Cd accumulation and agronomic performances. In paddy field soil containing approximately 0.9 mg/kg Cd, lct1×1 grains contained approximately 40%(0.17 mg/kg) of the Cd concentration of the wild type parental line, less than the China National Food Safety Standard(0.20 mg/kg). Both OsNramp5 mutants showed low grain Cd accumulation(< 0.06 mg/kg) in the paddy(approximately 0.9 mg/kg Cd) or in pots in soil spiked with 2 mg/kg Cd. However, only nramp5×7 showed normal growth and yield, whereas the growth of nramp5×9 was severely impaired. The study showed that lct1×1 could be used to produce rice grains safe for human consumption in lightly contaminated paddy soils and nramp5×7 used in soils contaminated by much higher levels of Cd. | LIU Songmei JIANG Jie LIU Yang MENG Jun XU Shouling TAN Yuanyuan LI Youfa SHU Qingyao HUANG Jianzhong | 2019 | Rice science2019，26，2： | 15 |
| 3 | Specific cellular immune responses in mice immunized with DNA,adeno-associated virus and adenoviral vaccines of Epstein-Barr virus-LMP2 alone or in combination显示文摘Cellular immune responses,particularly those associated with CD3+CD8+ cytotoxic T lymphocytes (CTL),are critical factors in controlling viral infection.Nasopharyngeal carcinoma (NPC) is closely associated with persistent Epstein-Barr virus (EBV) infection.NPC vaccine studies have focused on enhancing specific antiviral CTL responses.In this study,three vaccines capable of expressing the EBV-latent membrane protein 2 (LMP2) (a DNA vector,an adeno-associated virus (AAV) vector,and a replication-defective adenovirus serotype 5 (Ad5) vector) were respectively used to immunize female Balb/c mice (4-6 weeks old) at weeks 0,2 and 4,either alone or in combination.Our results suggest that combined immunization with DNA,AAV,and adenovirus vector vaccines induced specific cellular immunity more effectively than any of these vectors alone or a combination of two of the three,constituting a sound vaccine strategy for the prevention and treatment of NPC. | WANG Zhan YANG SongMei ZHOU Ling DU HaiJun MO WuNing ZENG Yi | 2011 | Science China(Life Sciences)2011，54，3： | 10 |
| 4 | Preparation and characterization of the TiO_2-V_2O_5 photocatalyst with visible-light activity显示文摘Visible-light responsive TiO2-V2O5 catalyst was prepared using a binary sol-gel and in-situ intercalation method. The TiO2 sol and V2O5 sol were mixed to disperse the V2O5 species in the TiO2 phase at molecular level. The binary sol was then intercalated into interspaces of polyaniline (PANI) by means of in-situ polymerization of aniline. Conglomeration of the TiO2-V2O5 clusters during the calcination process was avoided because of the wrap of polyaniline. The surface mor- phology, the crystal phases, the structure, and the absorption spectra of (PANI)n/TiO2-V2O5 and the composite catalyst were studied using SEM, XRD, FT-IR, and UV-Vis. The photoactivity of the prepared catalyst under UV and visible light irra- diation were evaluated by decolorization of methylene blue (MB) solution. The results showed that the composite catalyst displayed a homogeneous anatase phase, and the vanadium pentoxide species was highly dispersed in the TiO2 phase. The composite catalyst responded to visible light because of the narrowed band gap. In this study, the catalyst with the sol vol- ume ratio of TiO2 : V2O5 = 10:1 presented the best photocatalytic activity. | LIU Jianhua YANG Rong LI Songmei | 2006 | Rare Metals2006，25，6： | 7 |
| 5 | Preparation and characterization of high photoactive TiO_2 catalyst using the UV irradiation-induced sol-gel method显示文摘High photoactive TiO2 catalyst was prepared using the sol-gel method through UV irradiation during the formation stage of nuclei. The surface morphology and microstructure of the prepared catalyst were characterized using scanning electron microscopy (SEM), X-ray diffraction patterns (XRD), and Fourier transform infrared spectroscopy (FT-IR). The photoactivity was evaluated by the degradation of methylene blue. The results show that the photocatalysis of the prepared catalyst is higher than that of conventional heat-treated particles. The higher photoactivity is a combined result of favorable microstructure, appropriate hydroxyl groups, and active sites of Ti3+ ions on the surface of TiO2. It is concluded that the ultraviolet irradiation-induced sol-gel method is an effective method to enhance the photocatalysis of TiO2. | Jianhua Liu Rong Yang Songmei Li | 2006 | Journal of University of Science and Technology Beijing2006，13，4： | 4 |
| 6 | N-terminal domains of ARC1 are essential for interaction with the N-terminal region of Exo70A1 in transducing self-incompatibility of Brassica oleracea显示文摘自我障碍(SI ) 是一个重要交配系统阻止使近交并且支持 outcrossing。ARC1 和 Exo70A1 在 Brassica SI 发信号作为 S 地点受体 kinase 和戏保守人士角色的下游的目标工作。基于顺序相同, Exo70A1 被划分成四子域:白氨酸拉链(列伊 128-Leu149), hypervariable 区域(重量的单位 172-Leu197), 相扑修正主题(Glu 260-Ile275), 和 pfamExo70 领域(他的 271-Phe627) 。ARC1 如下包含四个领域:白氨酸拉链(列伊 116-Leu137), 卷卷领域(Thr 210-Val236),U 盒子(毒蛇 282-Trp347) 主题,和手臂(翼 415-Thr611) 领域。生物信息学分析,酵母二混血儿的屏蔽和 ARC1 116-236 的白氨酸拉链和卷卷主题为和 Exo70A1 的相互作用被要求的下拉试金表演,当手臂主题的增加导致和 Exo70A1 的相互作用的损失时。同时,没有任何域的 Exo70A1 的N终端与 ARC1 显示出一个弱相互作用,并且 LacZ 表示的水平与白氨酸拉链的增加增加并且与 hypervariable 区域和相扑修正主题到达最大的值,显示那个 hypervariable 区域和 Exo70A1 172-275的相扑修正主题为有 ARC1 的绑定主要负责,而 pfamExo70 领域为 ARC1 有很少亲密关系。位于 Exo70A1 hypervariable 区域的 Lys 181 可以是调停的 ubiquitination 地点在 ARC1 和 Exo70A1 之间的相互作用。因此,两有 ARC1 116-236, 和 hypervariable 区域和 Exo70A1 172-275 的相扑修正主题的卷卷结构的白氨酸拉链是在 ARC1 和 Exo70A1 之间的核心相互作用领域。影响这些核心领域的任何因素将是调停的 ARC1 的管理者在自我不兼容的系统的 ubiquitin 降级。 | Songmei Shi Qiguo Gao Jing Zeng Xiaohuan Liu Quanming Pu Guixi Liu Hecui Zhang Xiaohong Yang Liquan Zhu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 3 |
| 7 | The subsistence patterns of the Shengedaliang site(-4,000 yr BP)revealed by stable carbon and nitrogen isotopes in northern Shaanxi,China显示文摘In order to explore subsistence patterns in northern Shaanxi Province around 4,000 yr BP,28 human and 24 animal bones from the Shengedaliang site were sampled for stable carbon and nitrogen isotope ratio analysis.The results show that most people primarily subsisted on C_4 resources,e.g.millet and millet-related animal products,despite the fact that there was some intake of C_3 plants by some individuals.Stable nitrogen isotope values indicate that there were differences in meat consumption between individuals at the site.Pigs were mainly foddered with millet and millet byproducts,as well as some cattle,according to their highδ^(13)C values.However,most cattle and the sheep/goats consumed wild C_3 plants at Shengedaliang.Our above findings indicates that subsistence patterns in northern Shaanxi around 4,000 yr BP were characterized by millet farming,while the grassland animal husbandry,e.g.cattle and sheep/goats raising,displayed very little contribution to local economy.The intensive millet farming in northern Shaanxi provided enough food for population growth,ensured the accumulation of wealth,and consequently accelerated social differentiation and complexity. | CHEN XiangLong GUO XiaoNing WANG WeiLin HU SongMei YANG MiaoMiao WU Yan HU YaoWu | 2017 | Science China Earth Sciences2017，60，2： | 2 |
| 8 | Fast Cryomediated Dynamic Equilibrium Hydrolysates towards Grain Boundary-Enriched Platinum Scaffolds for Efficient Methanol Oxidation显示文摘Although platinum nanocrystals have been considered as potential electrocatalysts for methanol oxidation reaction(MOR)in fuel cells,the large-scale practical implementation has been stagnated by their limited abundance,easy poisoning,and low durability.Here,grain boundary-enriched platinum(GB-Pt)scaffolds are produced in large scale via facilely reducing fast cryomediated dynamic equilibrium hydrolysates of platinum salts.Such plentiful platinum grain boundaries are originated from the fast fusion of short platinum nanowires during reduction of the individually and homogeneously dispersed platinum intermediates.These grain boundaries can provide abundant active sites to efficiently catalyze MOR and meanwhile enable to oxidize the adsorbed poisonous CO during the electrocatalytic process.As a consequence,the as-synthesized GB-Pt scaffolds exhibit an impressively high mass activity of 1027.1 mA mgPt^(−1) for MOR,much higher than that of commercial Pt/C(345.2 mA mgPt^(−1)),as well as good stability up to 5000 cycles.We are confident that this synthetic protocol can be further extended to synthesize various grain boundary-enriched metal scaffolds with broad applications in catalysis. | Chao Zhang Huajie Huang Jianan Gu Zhiguo Du Bin Li Songmei Li Shubin Yang | 2019 | Research2019，，1： | 2 |
| 9 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 10 | Ancient DNA traces a Chinese 5400-year-old cat specimen as leopard cat(Prionailurus bengalensis)显示文摘Now,widely distributed modern cats are the descendant of wildcat(Felis silvestris lybica),which are assumed to have originally taken advantage of resources in human settlements,before being tamed in the Near East via a commensal pathway(Driscoll et al.,2007;Larson and Fuller,2014). | Shilun Zhu Zehui Chen Songmei Hu Weilin Wang Peng Cao Feng Liu Qingyan Dai Xiaotian Feng Ruowei Yang Wanjing Ping Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，11： | 1 |
| 11 | Efficacy of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for the treatment of poor sleep quality:a multi-center,randomized controlled,superiority trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for treating poor sleep quality.METHODS:This multi-center,dynamic blockrandomized,parallel-group superiority clinical trial included 130 patients.The combined treatment group received Zhumian Tang formula granules combined with eszopiclone treatment,and the control group received eszopiclone treatment only.The group allocation ratio was 1∶1.The duration of treatment was 2 weeks.Participants were asked to complete questionnaires before treatment,after 1 week of the intervention,after 2 weeks of the intervention,and at the follow-up on week 3.The primary outcomes were the Pittsburgh Sleep Quality Index(PSQI)score and the total effective rate of treatment.The secondary outcome was the rate of adverse effects.RESULTS:Compared with the eszopiclone treatment group,the PSQI score of the combined treatment group was significantly lower after 2 weeks of the intervention(6.98 vs 8.26,P<0.05).However,there was no significant difference in the mean PSQI score after 1 week of the intervention(9.89 vs 9.15,P=0.124).After the follow-up on week 3,the PSQI score of the combined treatment group remained significantly lower than that of the eszopiclone treatment group(6.12 vs 8.31,P<0.001).The total effective rates of treatment of the combined group and the eszopiclone group were 36.92%vs 35.38%(Z=0.033,P=0.855)after 1 week of the intervention,83.08%vs 58.46%(Z=9.519,P<0.05)after 2 weeks of the intervention,and 83.08%vs 61.54%(Z=7.530,P<0.05)and after the follow-up on week 3,respectively.There was no significant difference in the overall rate of adverse reactions between the combined and eszopiclone treatment groups(21.53%vs 31.8%,P=0.318).CONCLUSION:The combination of Zhumian Tang formula granules with eszopiclone was found to be safe and more effective in improving sleep quality than eszopiclone alone.Traditional Chinese medicine can enhance the effectiveness of Western medicine in the treatment of insomnia. | WANG Yichen WU Shiyi WANG Zhengyan CHANG Wenling XIE Zhihao TANG Xing ZHAO Songmei ZHOU Jing CHEN Zehong WANG Chao() YANG Chunxia | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 12 | Revisiting aluminum current collector in lithium-ion batteries:Corrosion and countermeasures显示文摘With the large-scale service of lithium-ion batteries(LIBs),their failures have attracted significant attentions.While the decay of active materials is the primary cause for LIB failures,the degradation of auxiliary materials,such as current collector corrosion,should not be disregarded.Therefore,it is necessary to conduct a comprehensive review in this field.In this review,from the perspectives of electrochemistry and materials,we systematically summarize the corrosion behavior of aluminum cathode current collector and propose corresponding countermeasures.Firstly,the corrosion type is clarified based on the properties of passivation layers in different organic electrolyte components.Furthermore,a thoroughgoing analysis is presented to examine the impact of various factors on aluminum corrosion,including lithium salts,organic solvents,water impurities,and operating conditions.Subsequently,strategies for electrolyte and protection layer employed to suppress corrosion are discussed in detail.Lastly and most importantly,we provide insights and recommendations to prevent corrosion of current collectors,facilitate the development of advanced current collectors and the implementation of next-generation high-voltage stable LIBs. | Shanglin Yang Jinyan Zhong Songmei Li Bin Li | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 13 | Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway显示文摘Acute myeloid leukemia(AML)is one of the most common malignancies of the hematopoietic progenitor cell in adults.Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity.Herein,we aim to investigate the anti-leukemia mechanism of quercetin and to decipher the signaling pathway of quercetin in HL-60 leukemic cells.We observed that quercetin induces apoptosis and autophagic cell death,in which both pathways play an important role in suppressing the viability of leukemia cells.Phosphorylated AMPK(p-AMPK)protein expressions are lower in primary AML cells,HL-60 cells,KG-1 and THP-1 cells than in peripheral blood monocular cells.After quercetin treatment,the expression of p-AMPK is increased while the expression of pmTOR is decreased in a dose-dependent manner.Mechanistically,compound C,an AMPK phosphorylation inhibitor,upregulates the phosphorylation of mTOR and inhibits autophagy and apoptosis in quercetin-induced HL-60 cells,while silencing of CaMKKβinhibits the quercetin-induced phosphorylation of AMPK,resulting in increased mTOR phosphorylation.Furthermore,silencing of CaMKKβinhibits the autophagy in HL-60 cells.Taken together,our data delineate that quercetin plays its anti-leukemia role by inhibiting cell viability and inducing apoptosis and autophagy in leukemia cells.Quercetin inhibits the phosphorylation of mTOR by regulating the activity of AMPK,thus playing a role in the regulation of autophagy and apoptosis.CaMKKβis a potential upstream molecule for AMPK/mTOR signaling pathway,through which quercetin induces autophagy in HL-60 cells. | Jie Xiao Ben Zhang Songmei Yin Shuangfeng Xie Kezhi Huang Jieyu Wang Wenjuan Yang Hongyun Liu Guoyang Zhang Xiaoyan Liu Yiqing Li Danian Nie | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 14 | Ancient DNA reveals the maternal genetic history of East Asian domestic pigs显示文摘Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China and Eastern Anatolia along with the development of agricultural communities and civilizations.However,the genetic history of domestic pigs,especially in China,has not been fully explored.In this study,we generate 42 complete mitochondrial DNA sequences from~7500-to 2750-year-old individuals from the Yellow River basin.Our results show that the maternal genetic continuity of East Asian domestic pigs dates back to at least the Early to Middle Neolithic.In contrast,the Near Eastern ancestry in European domestic pigs saw a near-complete genomic replacement by the European wild boar.The majority of East Asian domestic pigs share close haplotypes,and the most recent common ancestor of most branches dates back to less than 20,000 years before present,inferred using new substitution rates of whole mitogenomes or combined protein-coding regions.Two major population expansion events of East Asian domestic pigs coincided with changes in climate,widespread adoption of introduced crops,and the development of agrarian societies.These findings add to our understanding of the maternal genetic composition and help to complete the picture of domestic pig evolutionary history in East Asia. | Ming Zhang Yichen Liu Zhipeng Li Peng Lü Jacob D.Gardner Maolin Ye Jihuai Wang Miaomiao Yang Jing Shao Weilin Wang Qingyan Dai Peng Cao Ruowei Yang Feng Liu Xiaotian Feng Lizhao Zhang Enwei Li Yunzheng Shi Zehui Chen Shilun Zhu Weiwei Zhai Tao Deng Ziyuan Duan E.Andrew Bennett Songmei Hu Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 15 | Middle Holocene hunting-gathering culture and environmental background of the steppe area of northern China显示文摘For a long time,the academic community has known very little about hunter-gatherers in the steppe area of northern China in the mid-Holocene.This article reports on the Ula Usu West site in Siziwangqi Banner,Inner Mongolia,including basic information about the site,animal bones,lithic artifacts and the environmental background.The age of the site is 4.8–4.4 cal.kyr BP,placing it in the Late Neolithic period.Considering integrated evidence from flotation,zooarchaeology,ZooMS analysis and lithic artifacts,the preliminary inference is that the population lived in a hunting-gathering economy.They used lithic tools represented by arrowheads to hunt mainly Antilopinae animals(e.g.,Procapra gutturosa).Pollen analysis suggests that the climate was relatively humid,providing advantageous living conditions for the population.The climate evidence is consistent with a warm event at approximately 4.7 kyr BP.A dry-cold event(4.5–4.0 kyr BP)and the gradual expansion of agriculture and breeding might have resulted in the final decline of the population.This article provides new materials for research on the“last”hunter-gatherers in the steppe area of northern China. | Jiacheng MA Xinying ZHOU Shixia YANG Huiyun RAO Jiaoyang LI Songmei HU Yimin YANG Xiaoqiang LI | 2022 | Science China Earth Sciences2022，65，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员