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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 3 | Anti-fibrotic Effects of Salvia miltiorrhiza and Ligustrazine Injection on LX-2 Cells Involved with Increased N-myc Downstream-Regulated Gene 2 Expression显示文摘Objective: To investigate the effects of Salvia miltiorrhiza and Ligustrazine Injection(SML) on proliferation and apoptosis of human hepatic stellate cell LX-2 and the expression of N-myc downstreamregulated gene 2(NDRG2, a tumor suppressor gene). Methods: HSCs from the LX-2 cell line were cultured in vitro. The proliferative state of different initial LX-2 cell numbers was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) colorimetric assay. LX-2 cells were plated in 96-well plates at an approximate density of 2.50×10~4 cells/mL and cultured for 24 h followed by the application of different concentrations of SML(1, 2, 4 and 8 μL/mL). Cell proliferation was measured using the MTT assay at 24 and 48 h. Apoptosis was detected by flow cytometry at 24 h. LX-2 cells were treated with different concentrations of SML and extracted with protein lysis buffer. The levels of NDRG2 and β-catenin were measured by Western blot. Results: With the exception of the 1 and 2 μL/mL concentrations, 4 and 8 μL/mL SML inhibited cell proliferation in a concentration-dependent manner at 24 and 48 h(P<0.05). With the exception of the 1 and 2 μL/mL concentrations, the NDRG2 expression level was greatly increased in a concentration-dependent manner. However, the level of β-catenin was unaffected. Conclusion: SML inhibit LX-2 cell proliferation in a concentration-dependent manner, and the mechanism may be associated with NDRG2 over-expression. | zheng jin ma li-tian ren qin-you hu yue bai yang bian huan zhang yi zhou yong-chun yang ming-hui | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 13 |
| 4 | The positive function of selenium supplementation on reducing nitrate accumulation in hydroponic lettuce(Lactuca sativa L.)显示文摘High nitrate(NO_3^- ) in vegetables, especially in leaf vegetables poses threaten to human health. Selenium(Se) is an important element for maintaining human health, and exogenous Se application during vegetable and crop production is an effective way to prevent Se deficiency in human bodies. Exogenous Se shows positive function on plant growth and nutrition uptake under abiotic and/or biotic stresses. However, the influence of exogenous Se on NO_3^- accumulation in hydroponic vegetables is still not clear. In the present study, hydroponic lettuce plants were subjected to six different concentrations(0, 0.1, 0.5, 5, 10 and 50 μmol L–1) of Se as Na2 Se O3. The effects of Se on NO_3^- content, plant growth, and photosynthetic capacity of lettuce(Lactuca sativa L.) were investigated. The results showed that exogenous Se positively decreased NO_3^- content and this effect was concentration-dependent. The lowest NO_3^- content was obtained under 0.5 μmol L–1 Se treatment. The application of Se enhanced photosynthetic capacity by increasing the photosynthesis rate(Pn), stomatal conductance(Cs) and the transpiration efficiency(Tr) of lettuce. The transportation and assimilation of NO_3^- and activities of nitrogen metabolism enzymes in lettuce were also analysed. The NO_3^- efflux in the lettuce roots was markedly increased, but the efflux of NO_3^- from the root to the shoot was decreased after treated with exogenous Se. Moreover, Se application stimulated NO_3^- assimilation by enhancing nitrate reductase(NR), nitrite reductase(Ni R), glutamine synthetase(GS) and glutamate synthase enzyme(GOGAT) activities. These results provide direct evidence that exogenous Se shows positive function on decreasing NO_3^- accumulation via regulating the transport and enhancing activities of nitrogen metabolism enzyme in lettuce. We suggested that 0.5 μmol L–1 Se can be used to reduce NO_3^- content and increase hydroponic lettuce yield. | LEI Bo BIAN Zhong-hua YANG Qi-chang WANG Jun CHENG Rui-feng LI Kun LIU Wen-ke ZHANG Yi FANG Hui TONG Yun-xin | 2018 | Journal of Integrative Agriculture2018，17，4： | 9 |
| 5 | Highly effective direct synthesis of DMC from CH_3OH and CO_2 using novel Cu-Ni/C bimetallic composite catalysts显示文摘Novel Cu-Ni/C has been prepared and utilized as an efficient catalyst system in direct synthesis of DMC from CH_3OH and CO_2. | Jun Bian Min Xiao Shuan Jin Wang Yi Xin Lu Yue Zhong Meng | 2009 | Chinese Chemical Letters2009，20，3： | 8 |
| 6 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 7 | Performance of Fasting Plasma Glucose and Postprandial Urine Glucose in Screening for Diabetes in Chinese High-risk Population显示文摘 | Bing-Quan Yang Yang Lu Jia-Jia He Tong-Zhi Wu Zuo-Ling Xie Cheng-Hao Lei Yi Zhou Jing Han Mei-Qi Bian Hong You De-Xian Mei Zi-Lin Sun | 2015 | Chinese Medical Journal2015，，24： | 6 |
| 8 | Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery显示文摘AIM To clarify the prognostic significance of preoperative albumin-to-alkaline phosphatase ratio(AAPR) in cholangiocarcinoma(CCA) subjects receiving surgery.METHODS In this retrospective study, we included 303 CCA patients receiving surgery without preoperative therapy between 2002 and 2014. Clinicopathological characteristics(including AAPR) were analyzed to determine predictors of postoperative overall survival and recurrence-free survival(RFS). In addition,univariate and multivariate Cox proportional hazards models were conducted,followed by application of time-dependent receiver operating curves to identify the optimal cut-off.RESULTS Univariate and multivariate analyses revealed both decreased overall survival[hazard ratio(HR): 2.88, 95%CI: 1.19-5.78] and recurrence-free survival(HR: 2.31,95%CI: 1.40–3.29) in patients with AAPR < 0.41 compared to those with AAPR ≥0.41. The optimal cut-off of AAPR was 0.41. Of the 303 subjects, 253(83.5%) had an AAPR over 0.41. The overall 1-, 3- and 5-year survival rates were 70.2%, 38.0% and 16.5%, respectively in the low(< 0.41) AAPR group, which were significantly lower than those in the high(≥ 0.41) AAPR group(81.7%, 53.9%, and 33.4%,respectively)(P < 0.0001). Large tumor size, multiple tumors, and advanced clinical stage were also identified as significant predictors of poor prognosis.CONCLUSION Our outcomes showed that AAPR was a potential valuable prognostic indicator in CCA patients undergoing surgery, which should be further confirmed by prospective studies. Moreover, it is necessary to investigate the mechanisms concerning the correlation of low AAPR with poor post-operative survival in CCA patients. | Jian-Ping Xiong Jun-Yu Long Wei-Yu Xu Jin Bian Han-Chun Huang Yi Bai Yi-Yao Xu Hai-Tao Zhao Xin Lu | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 5 |
| 9 | Multimetallic AuPd@Pd@Pt core-interlayer-shell icosahedral electrocatalysts for highly efficient oxygen reduction reaction显示文摘Incorporating Pt with core metals into Pt-based core-shell catalysts is regarded as a promising strategy to substantially enhance the catalytic properties towards oxygen reduction reaction(ORR) in fuel cells due to the synergetic effect between distinct metals. In this wok, ultrathin Pt skins with two atomic layers were epitaxially coated on as-prepared icosahedral Au_50Pd_50, Au_60Pd_40 and Au_66Pd_34 nanocrystal seeds,which are constructed with alloyed cores and Pd shells with different thickness. Through electron microscopic characterizations, Pd interlayers with tunable thickness of 3, 6, and 12 atomic layers can be found in the Au_66Pd_34@Pt, Au_60 Pd_40@Pt and Au_50Pd_50@Pt icosahedra, respectively. These icosahedral Au Pd@Pd@Pt nanocrystals show substantially enhanced activities and durabilities in electrocatalytic measurements towards ORR compared to Au_75Pd_25@Pt icosahedra without Pd interlayer and commercial Pt/C catalysts. Specifically, Au_60Pd_40@Pt icosahedra with 6 atomically thick Pd interlayer display the best electrocatalytic performances, whose mass activities before and after durability tests of 50,000 cycles are11.6 and 30.2 times, respectively, as high as that of the commercial Pt/C. | Qingfeng Xu Wenlong Chen Yucong Yan Zhemin Wu Yi Jiang Junjie Li Ting Bian Hui Zhang Jianbo Wu Deren Yang | 2018 | Science Bulletin2018，63，8： | 5 |
| 10 | Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening显示文摘 | Hui Wang Lei Wang Zheng Wu Rong Sun Haifeng Jin Jifeng Ma Lili Liu Rui Ling Jun Yi Ling Wang Jiefang Bian Jianghao Chen Nanlin Li Shifang Yuan Jun Yun | 2014 | Medical Oncology2014，，12： | 4 |
| 11 | Complete or partial split in associating liver partition and portal vein ligation for staged hepatectomy: A systematic review and meta-analysis显示文摘BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been adopted by liver surgeons in recent years.However,high morbidity and mortality rates have limited the promotion of this technique.Some recent studies have suggested that ALPPS with a partial split can effectively induce the growth of future liver remnant(FLR)similar to a complete split with better postoperative safety profiles.However,some others have suggested that ALPPS can induce more rapid and adequate FLR growth,but with the same postoperative morbidity and mortality rates as in partial split of the liver parenchyma in ALPPS(p-ALPPS).AIM To perform a systematic review and meta-analysis on ALPPS and p-ALPPS.METHODS A systematic literature search of PubMed,Embase,the Cochrane Library,and ClinicalTrials.gov was performed for articles published until June 2019.Studies comparing the outcomes of p-ALPPS and ALPPS for a small FLR in consecutive patients were included.Our main endpoints were the morbidity,mortality,and FLR hypertrophy rates.We performed a subgroup analysis to evaluate patients with and without liver cirrhosis.We assessed pooled data using a random-effects model.RESULTS Four studies met the inclusion criteria.Four studies reported data on morbidity and mortality,and two studies reported the FLR hypertrophy rate and one study involved patients with cirrhosis.In the non-cirrhotic group,p-ALPPS-treated patients had significantly lower morbidity and mortality rates than ALPPStreated patients[odds ratio(OR)=0.2;95%confidence interval(CI):0.07–0.57;P=0.003 and OR=0.16;95%CI:0.03-0.9;P=0.04].No significant difference in the FLR hypertrophy rate was observed between the two groups(P>0.05).The total effects indicated no difference in the FLR hypertrophy rate or perioperative morbidity and mortality rates between the ALPPS and p-ALPPS groups.In contrast,ALPPS seemed to have a better outcome in the cirrhotic group.CONCLUSION The findings of our study suggest that p-ALPPS is safer than ALPPS in patients without cirrhosis and exhibits the same rate of FLR hypertrophy. | Han-Chun Huang Jin Bian Yi Bai Xin Lu Yi-Yao Xu Xin-Ting Sang Hai-Tao Zhao | 2019 | World Journal of Gastroenterology2019，25，39： | 4 |
| 12 | Divergence, evolution and adaptation in ray-finned fish genomes显示文摘With the rapid development of next-generation sequencing technologies and bioinformatics, over 50 ray-finned fish genomes by far have been sequenced with high quality. The genomic work provides abundant genetic resources for deep understanding of divergence, evolution and adaptation in the fish genomes. They are also instructive for identification of candidate genes for functional verification, molecular breeding, and development of novel marine drugs. As an example of other omics data, the Fish-T1 K project generated a big database of fish transcriptomes to integrate with these published fish genomes for potential applications. In this review, we highlight the above-mentioned recent investigations and core topics on the ray-finned fish genome research, with a main goal to obtain a deeper understanding of fish biology for theoretical and practical applications. | Chao Bian Yu Huang Jia Li Xinxin You Yunhai Yi Wei Ge Qiong Shi | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 13 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 14 | Evaluation of treatment response for breast cancer:are we entering the era of 'biological complete remission'?显示文摘Breast cancer is one of the most common malignancies in women.The post-operative recurrence and metastasis are the leading causes of breast cancer-related mortality.In this study,we tried to explore the role of circulating tumor cell(CTC) detection combination PET/CT technology evaluating the prognosis and treatment response of patients with breast cancer;meanwhile,we attempted to assess the concept of 'biological complete remission'(bCR) in this regard.A 56-year-old patient with breast cancer(T2N1M1,stage IV left breast cancer,with metastasis to axillary lymph nodes and lungs) received 6 cycles of salvage treatment with albumin-bound paclitaxel plus capecitabine and trastuzumab.Then,she underwent CTC detection and PET/CT for efficacy evaluation.CTC detection combination PET/CT is useful for the evaluation of the biological efficacy of therapies for breast cancer.The bCR of the patient appeared earlier than the conventional clinical imaging complete remission and promised the histological(pathological) complete remission.The integrated application of the concepts including bCR,imageological CR,and histological CR can achieve the early and accurate assessment of biological therapeutic reponse and prognosis of breast cancer. | Li Bian Tao Wang Yi Liu Hui-Qiang Zhang Jin-Jie Song Shao-Hua Zhang Shi-Kai Wu San-Tai Song Ze-Fei Jiang | 2012 | Chinese Journal of Cancer Research2012，24，4： | 3 |
| 15 | A P300 based online brain-computer interface system for virtual hand control显示文摘Brain-computer interface (BCI) is a communication system that can help lock-in patients to interact with the outside environment by translating brain signals into machine commands.The present work provides a design for a virtual reality (VR) based BCI system that allows human participants to control a virtual hand to make gestures by P300 signals,with a positive peak of potential about 300 ms posterior to the onset of target stimulus.In this virtual environment,the participants can obtain a more immersed experience with the BCI system,such as controlling a virtual hand or walking around in the virtual world.Methods of modeling the virtual hand and analyzing the P300 signals are also described in detail.Template matching and support vector machine were used as the P300 classifier and the experiment results showed that both algorithms perform well in the system.After a short time of practice,most participants could learn to control the virtual hand during the online experiment with greater than 70% accuracy. | Wei-dong CHEN | 2010 | Journal of Zhejiang University-Science C(Computers and Electronics)2010，11，8： | 3 |
| 16 | Green Synthesis of Magnetic Adsorbent Using Groundwater Treatment Sludge for Tetracycline Adsorption显示文摘Groundwater treatment sludge is an industrial waste that is massively produced from groundwater treatment plants.Conventional methods for treatment of this sludge,such as discharge into deep wells or the sea,or disposal at landfills,are not environmentally sustainable.Here,we demonstrate an alternative strategy to recycle the sludge by preparing a magnetic maghemite adsorbent via a one-step hydrothermal method with NaOH solution as the only solvent.With this method,the weakly magnetized sludge,which contained 33.2%iron(Fe)and other impurities(e.g.,silicon(Si),aluminum(Al),and manganese(Mn)),was converted to magnetic adsorbent(MA)with the dissolution of Si/Al oxides(e.g.,quartz and albite)into the liquid fraction.At a NaOH concentration of 2 mol L^-1,approximately 18.1%of the ferrihydrite in the Fe oxides of the sludge was converted into 11.2%maghemite and 6.9%hematite after the hydrothermal treatment.MA2(i.e.,MA produced by a 2 mol L^-1 NaOH concentration)exhibited a good magnetic response of 8.2 emu g^-1(1 emu=10^-3 A m^2),and a desirable surface site concentration of 0.75 mmol g^-1.The synthesized MA2 was used to adsorb the cationic pollutant tetracycline(TC).The adsorption kinetics of TC onto MA2 fitted well with a pseudo-second-order model,and the adsorption isotherms complied well with the Langmuir model.The maximum adsorption capacity of MA2 for TC was 362.3 mg g^-1,and the main mechanism for TC adsorption was cationic exchange.This study is the first to demonstrate the preparation of an MA from recycled sludge without a reductant and/or exogenous Fe source.The prepared adsorbent can be used as a low-cost adsorbent with high capacity for TC sorption in the treatment of TC-containing wastewater. | Zhan Qu Yaqiong Wu Suiyi Zhu Yang Yu Mingxin Huo Leilei Zhang Jiakuan Yang Dejun Bian Yi Wang | 2019 | Engineering2019，5，5： | 2 |
| 17 | The application of label-free imaging technologies in transdermal research for deeper mechanism revealing显示文摘The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects. | Danping Zhang Qiong Bian Yi Zhou Qiaoling Huang Jianqing Gao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 2 |
| 18 | A hybrid brain-computer interface control strategy in a virtual environment显示文摘This paper presents a hybrid brain-computer interface (BCI) control strategy,the goal of which is to expand control functions of a conventional motor imagery or a P300 potential based BCI in a virtual environment.The hybrid control strategy utilizes P300 potential to control virtual devices and motor imagery related sensorimotor rhythms to navigate in the virtual world.The two electroencephalography (EEG) patterns serve as source signals for different control functions in their corresponding system states,and state switch is achieved in a sequential manner.In the current system,imagination of left/right hand movement was translated into turning left/right in the virtual apartment continuously,while P300 potentials were mapped to discrete virtual device control commands using a five-oddball paradigm.The combination of motor imagery and P300 patterns in one BCI system for virtual environment control was tested and the results were compared with those of a single motor imagery or P300-based BCI.Subjects obtained similar performances in the hybrid and single control tasks,which indicates the hybrid control strategy works well in the virtual environment. | Yu SU | 2011 | Journal of Zhejiang University-Science C(Computers and Electronics)2011，12，5： | 2 |
| 19 | Quantitative changes of nitrergic neurons during postnatal development of chicken myenteric plexus显示文摘Objective: Information regarding the development of the enteric nervous system(ENS) is important for understanding the functional abnormalities of the gut.Because fertilized chicken eggs provide easy access to embryos,chicken models have been widely used to study embryonic development of myenteric plexus;however,no study has been focused on the postnatal period.The aim of this study was to perform a qualitative and quantitative analysis of the nitrergic neurons in the myenteric plexus of developing chickens in the postnatal period.Methods: Whole-mount preparations of the myenteric plexus were made in 7-d,15-d,and 40-d old(adult) chickens of either sex(n=15).The myenteric plexus was studied after nicotinamide adenine dinucleotide phosphate diaphorase(NADPH-d) histochemistry using light microscopy,digital photography,and Image-Pro Plus 6.0 software.The numbers of positively stained neurons and ganglia were counted in the duodenum,jejunum,ileum,caecum,and colon in the different age groups.Data were expressed as mean±standard deviation(SD),and statistical analysis was performed using a one-way analysis of variance(ANOVA) test.Results: The positively stained neurons showed various morphologies and staining intensities,and formed bead-shaped and U-shaped arrangements in the myenteric plexus.The densities of neurons and ganglia increased with age.However,the number of positive neurons per ganglion increased.The number of NADPH-d-positive neurons was highest in the colon,followed by the ileum,the jejunum,the duodenum,and the caeca in all age groups.Conclusions: Developmental changes in the myenteric plexus of chickens continue in the postnatal period,indicating that the maturation process of the gastrointestinal function is gradual.In addition,no significant difference is happening among different intestinal segments during postnatal development,suggesting that the function of different intestinal segments had been determined after birth. | Ping YANG Jameel Ahmed GANDAHI Qian ZHANG Lin-li ZHANG Xun-guang BIAN Li WU Yi LIU Qiu-sheng CHEN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，10： | 2 |
| 20 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
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