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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Assimilating Doppler radar observations with an ensemble Kalman filter for convection-permitting prediction of convective development in a heavy rainfall event during the pre-summer rainy season of South China显示文摘This study examines the effectiveness of an ensemble Kalman filter based on the weather research and forecasting model to assimilate Doppler-radar radial-velocity observations for convection-permitting prediction of convection evolution in a high-impact heavy-rainfall event over coastal areas of South China during the pre-summer rainy season. An ensemble of 40 deterministic forecast experiments(40 DADF) with data assimilation(DA) is conducted, in which the DA starts at the same time but lasts for different time spans(up to 2 h) and with different time intervals of 6, 12, 24, and 30 min. The reference experiment is conducted without DA(NODA).To show more clearly the impact of radar DA on mesoscale convective system(MCS)forecasts, two sets of 60-member ensemble experiments(NODA EF and exp37 EF) are performed using the same 60-member perturbed-ensemble initial fields but with the radar DA being conducted every 6 min in the exp37 EF experiments from 0200 to0400 BST. It is found that the DA experiments generally improve the convection prediction. The 40 DADF experiments can forecast a heavy-rain-producing MCS over land and an MCS over the ocean with high probability, despite slight displacement errors. The exp37 EF improves the probability forecast of inland and offshore MCSs more than does NODA EF. Compared with the experiments using the longer DA time intervals, assimilating the radial-velocity observations at 6-min intervals tends to produce better forecasts. The experiment with the longest DA time span and shortest time interval shows the best performance.However, a shorter DA time interval(e.g., 12 min) or a longer DA time span does not always help. The experiment with the shortest DA time interval and maximum DA window shows the best performance, as it corrects errors in the simulated convection evolution over both the inland and offshore areas. An improved representation of the initial state leads to dynamic and thermodynamic conditions that are more conducive to earlier initiation of the inland MCS and longer maintenance of the offshore MCS. | BAO XingHua LUO YaLi SUN JiaXiang MENG ZhiYong YUE Jian | 2017 | Science China Earth Sciences2017，60，10： | 11 |
| 3 | Effects of mepiquat chloride on yield and main properties of cottonseed under different plant densities显示文摘Background:Cottonseed oil and protein content as well as germination traits are major indicators of seed quality.However,the responses of these indicators to plant density and mepiquat chloride(MC)are still uncertain.To investigate plant density and MC effects on cotto nseed yield and main quality parameters,we con ducted a twoyear field experiment including four plant densities(1.35,2.55,3.75 and 4.95 plants·m^-2)and two closes of MC(0 and 135g·hm^-2)in Dafeng,Jiangsu Province,in 2013 and 2014.Results:The application of MC reduced plant height,fruit branch length and fruiting branch number under different plant densities,resulting in a lower and more compact plant canopy.Cottonseed yield showed a nonlinear increase as plant density increasing and achieved the highest value at 3.75 plants·m^-2,regardless of MC application.No significant interactio ns were found between plant density and MC for cotton seed yield and quality parameters.The 100-seed weight,cottonseed oil content and vigor index significantly decreased as plant density increased,while these parameters significantly increased with MC applying under different plant densities.Seed vigor index was positively correlated with 100-seed weight and seed oil con tent across different plant densities and MC treatments.Conclusions:Thus,application of MC could realize a win-win situation between cottonseed yield and main quality parameters under various densities;and plant density of 3.75 plants·m^-2 combined with 135 g·hm^-2 of MC applying is optimal for high cottonseed yield and quality in this cotton production area. | ZHAO Wenqing YAN Qiang YANG Hongkun YANG Xiaoni WANG Leran CHEN Binglin MENG Yali ZHOU Zhiguo | 2019 | Journal of Cotton Research2019，2，2： | 3 |
| 4 | Effects of parental empathy and emotion regulation on social competence and emotional/behavioral problems of school‐age children显示文摘Importance Parents take the lead in parent–child interactions and their emotion regulation ability and empathy during parenting may be associated with children’s emotional/behavioral problems.However,the specific mechanisms underlying these associations remain unclear.Objective The present study aimed to explore the effect of parental empathy and emotional regulation on social competence and emotional/behavioral problems in school‐age children.Methods A questionnaire‐based survey was conducted with 274 parents of 8–11‐year‐old children using Achenbach’s Child Behavior Checklist,the Emotion Regulation Questionnaire,and the Questionnaire of Cognitive and Affective Empathy.Results Children with emotional/behavioral problems(n=37)had relatively lower social competence than children in a matched control group(n=37).Compared with the parents of children in the control group,parents of children with emotional/behavioral problems had significantly lower cognitive empathy scores,mainly manifested by low perspective‐taking and online simulation abilities.Mediation analysis showed that parental cognitive empathy had an indirect effect on children’s emotional/behavioral problems through children’s social competence.Interpretation Parental empathy may have a subtle influence on the social competence of school‐aged children,which further affects the severity of children’s emotional/behavioral problems. | Kun Meng Yizhe Yuan Yali Wang Jianning Liang Lijun Wang Jianfei Shen Yanyu Wang | 2020 | Pediatric Investigation2020，4，2： | 2 |
| 5 | Rapid and accurate detection of carbapenem-resistance gene by isothermal amplification in Acinetobacter baumannii显示文摘Background:Acinetobacter baumannii(A.baumannii)is one of the pivotal pathogens responsible for nosocomial infections,especially in patients with low immune response,and infection with carbapenem-resistant A.baumannii has been increasing in recent years.Rapid and accurate detection of carbapenem-resistance genes in A.baumannii could be of immense help to clinical staff.Methods:In this study,a 15-μL reaction system for recombinase polymerase amplification(RPA)was developed and tested.We collected 30 clinical isolates of A.baumannii from the Burn Institute of Southwest Hospital of Third Military Medical University(Army Medical University)for 6 months and tested antibiotic susceptibility using the VITEK 2 system.A.baumannii was detected based on the blaOXA-51 gene by PCR,qPCR and 15μL-RPA,respectively.Sensitivity and specificity were evaluated.In addition,PCR and 15μL-RPA data for detecting the carbapenem-resistance gene blaOXA-23 were comparatively assessed.Results:The detection limit of the blaOXA-51 gene by 15μL RPA was 2.86 CFU/ml,with sensitivity comparable to PCR and qPCR.No positive amplification signals were detected in non-Acinetobacter isolates,indicating high specificity.However,only 18 minutes were needed for the 15μL RPA assay.Furthermore,an antibiotic susceptibility test showed that up to 90%of A.baumannii strains were resistant to meropenem and imipenem;15μL RPA data for detecting blaOXA-23 showed that only 10%(n=3)of A.baumannii isolates did not show positive amplification signals,and the other 90%of(n=27)isolates were positive,corroborating PCR results.Conclusion:We demonstrated that the new 15μL RPA assay for detecting blaOXA-23 in A.baumannii is faster and simpler than qPCR and PCR.It is a promising alternative molecular diagnostic tool for rapid and effective detection of A.baumannii and drug-resistance genes in the field and point-ofcare testing. | Shuang Liu Guangtao Huang Yali Gong Xiaojun Jin Yudan Meng Yizhi Peng Junning Zhao Xiaolu Li Qin Li | 2020 | Burns & Trauma2020，8，1： | 2 |
| 6 | Genetic Analysis of Human Adenovirus Type 7 Strains Circulating in Different Parts of China显示文摘To investigate the molecular epidemiology and genetic variation of human adenovirus type 7(HAdV-7)in children with acute respiratory infections(ARI)in China.HAdV-7-positive respiratory samples collected from children with ARI in Beijing,Shijiazhuang,Wenzhou and Guangzhou from 2014–2018 were selected for gene amplification and sequence analysis.Fifty-seven HAdV-7 clinical strains with hexon,penton base and fiber gene sequences were obtained.Meanwhile17 strains were selected randomly from different cities for whole genome sequencing.Phylogenetic and variation analyses were performed based on the obtained sequences,HAdV-7 prototype strain Gomen(AY594255),vaccine strains(AY495969 and AY594256)and representative sequences of strains.The phylogenetic trees constructed based on whole genome sequences,major capsid protein genes(hexon,penton base and fiber)and the early genes(E1,E2,E3 and E4)were not completely consistent.The HAdV-7 strains obtained in this study always clustered with most of the circulating strains worldwide from the 1980 s to the present.Compared with the HAdV-7 prototype strain Gomen(AY594255),some amino acid mutations in loop1 and loop2 of hexon and the RGD loop region of the penton base gene were observed.Recombination analysis showed that partial regions of 55 k Da protein and 100 kDa hexon-assembly associated protein genes among all HAdV-7 strains in this study were from HAdV-16 and HAdV-3,respectively.Our study demonstrated the molecular evolution characteristics of HAdV-7 strains circulating in China and provided basic reference data for the prevention,control and vaccine development of HAdV-7. | Yali Duan Changchong Li Li Deng Shuhua An Yun Zhu Wei Wang Meng Zhang Lili Xu Baoping Xu Xiangpeng Chen Zhengde Xie | 2021 | Virologica Sinica2021，36，3： | 2 |
| 7 | Antioxidant enzyme activity and chilling injury during low-temperature storage of Kiwifruit cv. Hongyang exposed to gradual postharvest cooling显示文摘 | Qingzhen Yang Jingping Rao Shunchao Yi Kun Meng Jianfeng Wu Yali Hou | 2012 | Horticulture, Environment, and Biotechnology2012，，6： | 1 |
| 8 | Significant coal combustion contribution to water-soluble brown carbon during winter in Xingtai, China: Optical properties and sources显示文摘To understand the characteristics of atmospheric brown carbon(BrC),daily PM2.5 samples in Xingtai,a small city in North China Plain(NCP),during the four seasons of 2018-2019,were collected and analyzed for optical properties and chemical compositions.The light absorption at 365 nm(abs λ=365 nm)displayed a strong seasonal variation with the highest value in winter(29.0±14.3 M/m),which was 3.2∼5.4-fold of that in other seasons.A strong correlation of abs λ=365 nm with benzo(b)fluoranthene(BbF)was only observed in winter,indicating that coal combustion was the major source for BrC in the season due to the enhanced domestic heating.The mass absorbing efficiency of BrC also exhibited a similar seasonal pattern,and was found to correlate linearly with the aerosol pH,suggesting a positive effect of aerosol acidity on the optical properties and formation of BrC in the city.Positive matrix factorization(PMF)analysis further showed that on a yearly basis the major source for BrC was biomass burning,which accounted for 34% of the total BrC,followed by secondary formation(26.7%),coal combustion(21.3%)and fugitive dust(18%).However,the contribution from coal combustionwas remarkably enhanced in winter,accounting for∼40%of the total.Our work revealed that more efforts of“shifting coal to clean energy”are necessary in rural areas and small cities in NCP in order to further mitigate PM2.5 pollution in China. | Dapeng Li Can Wu Si Zhang Yali Lei Shaojun Lv Wei Du Shijie Liu Fan Zhang Xiaodi Liu Lang Liu Jingjing Meng Yuesi Wang Jian Gao Gehui Wang | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 9 | The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury显示文摘 | Nacheng Lin Xin’an Li Tianran Song Jingmei Wang Kui Meng Jun Yang Xianglin Hou Jianwu Dai Yali Hu | 2011 | Biomaterials2011，，： | 1 |
| 10 | Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma显示文摘 | Wu Yali Chen Wei Meng Fenghua | 2012 | Journal of Controlled Release2012，164，3： | 1 |
| 11 | Antioxidant enzyme activity and chilling injury during low-temperature storage of Kiwifruit cv. Hongyang exposed to gradual postharvest cooling显示文摘 | Qingzhen Yang Jingping Rao Shunchao Yi Kun Meng Jianfeng Wu Yali Hou | 2012 | Horticulture Environment and Biotechnology2012，，6： | 1 |
| 12 | Genomic basis of evolutionary adaptation in a warm-blooded fish显示文摘Few fishes have evolved elevated body temperatures compared with ambient temperatures,and only in opah(Lampris spp)is the entire body affected.To understand the molecular basis of endothermy,we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish,birds,and mammals,including slc8b1,which encodes the mitochondrial Na+/Ca2+exchanger and is essential for heart function andmetabolic heat production.Among endothermic fishes,44 convergent genes with suggestive metabolic functions were identified,such as glrx3,encoding a crucial protein for hemoglobin maturation.Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection.Analyses of opah’s unique inner-heat-producing pectoral muscle layer(PMI),an evolutionary key innovation,revealed that many proteins were co-opted from dorsal swimming muscles for thermogenesis and oxidative phosphorylation.Thus,the opah genome provides valuable resources and opportunities to uncover the genetic basis of thermal adaptations in fish. | Xin Wang Meng Qu Yali Liu Ralf F.Schneider Yue Song Zelin Chen Hao Zhang Yanhong Zhang Haiyan Yu Suyu Zhang Dongxu Li Geng Qin Shaobo Ma Jia Zhong Jianping Yin Shuaishuai Liu Guangyi Fan Axel Meyer Dazhi Wang Qiang Lin | 2022 | The Innovation2022，3，1： | 1 |
| 13 | Large-Scale Forward Genetic Screening Analysis of Development of Hematopoiesis in Zebrafish显示文摘Zebrafish 是为造血作用的调查的一个有力的模型。以便与造血的缺点孤立新奇异种, zebrafish 屏蔽的大规模 mutagenesis 被执行。由获得特定的造血的标记, 52 异种基于特定的 phenotypic 特点被鉴别然后分类类型进四。每异种代表了调整造血作用的相关方面的基因的一个通常认为的变化,包括早巨噬细胞开发,早 granulopoiesis,胚胎的 myelopoiesis,和权威的红血球生成 / 淋巴细胞增殖。我们的方法应该为在 zebrafish 的基因屏蔽的另外的类型是适用的。另外,我们识别了的异种的进一步的学习可以帮助揭开造血作用的分子的基础。 | Kun Wang Zhibin Huang Lingfeng Zhao Wei Liu Xiaohui Chen Ping Meng Qing Lin Yali Chi Mengchang Xu Ning Ma Yiyue Zhang Wenqing Zhang | 2012 | Journal of Genetics and Genomics2012，39，9： | 1 |
| 14 | Selective oxidation of methanol to dimethoxymethane on V2 05 - MoO3/y - A12 03 cat- alysts显示文摘 | Meng Yali Wang Tuo Chen Shuang | 2014 | Applied Catalysis B: Environmental2014，，160161： | 1 |
| 15 | 腹腔镜用于子宫内膜癌分期手术39例分析(英文)显示文摘Objective:The purpose of our study was to investigate the feasibility and short-term therapeutic effects of laparoscopic staging operation in women with endometrial carcinoma.Methods:We analyzed 86 patients with endometrial carcinoma in PLA general hospital between 2006 and 2009 retrospectively.Thirty-nine patients were performed laparoscopic modified radical hysterectomy plus systemic retroperitoneal lymphadenectomy.Forty-seven patients received traditional abdominal radical hysterectomy plus systemic retroperitoneal lymphadenectomy.We compared the operation time,blood loss,number of lymph nodes retrieved,time for restoration of gastrointestinal function,postoperative complications and morbidity,the incidence of wound infection,the length of hospital stay,and hospital charges.Results:There was no significant deviation between the two groups in age,clinical stage,and pathology.We found that there was no significant deviation between the two groups in the number of lymph nodes retrieved,postoperative complications,the rate of wound infection or hospital charge(P > 0.05).The laparoscopic group had an advantage in blood loss,time for restoration of gastrointestinal function,time for postoperative hospital stay(P < 0.05).Conclusion:Laparoscopic surgery,as a primary surgical intervention,seems to be a safe and feasible option especially in patients with early endometrial cancer. | Li'an Li Xiaofeng Wang Yan Zhang Wensheng Fan Yali Li Lei Song Yuanqing Yao Zheng Guan Yuanguang Meng | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 0 |
| 16 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139显示文摘The G protein-coupled receptor GPR139 is involved in neuromodulation,and one of its agonists is in clinical trials for the treatment of cognitive impairment and negative symptoms of schizophrenia.While GPR139 is a understudied‘orphan’receptor,it can be activated by the amino acids L-Trp,L-Phe1 orα-Melanocyte-stimulating hormone(α-MSH)which is an endogenous agonist of melanocortin receptors. | Yali Zhou Henrik Daver Boris Trapkov Lijie Wu Meng Wu Kasper Harpsøe Patrick R.Gentry Kaiwen Liu Marina Larionova Junlin Liu Na Chen Hans Bräuner-Osborne David E.Gloriam Tian Hua Zhi-Jie Liu | 2022 | Cell Research2022，32，2： | 0 |
| 17 | Projected Regional 1.50℃and 2.00℃Warming Threshold-crossing Time Worldwide Using the CMIP6 Models显示文摘The Paris Agreement aims to limit global warming to well below 2.00℃and pursue efforts to limit the temperature increase to 1.50℃.However,the response of climate change to unbalanced global warming is affected by spatial and temporal sensitivities.To better understand the regional warming response to global warming at 1.50℃and 2.00℃,we detected the 1.50℃and 2.00℃warming threshold-crossing time(WTT)above pre-industrial levels globally using the Coupled Model Intercomparison Project phase 6(CMIP6)models.Our findings indicate that the 1.50℃or 2.00℃WTT differs substantially worldwide.The warming rate of land would be approximately 1.35–1.46 times that of the ocean between 60°N–60°S in 2015–2100.Consequently,the land would experience a 1.50℃(2.00℃)warming at least 10–20 yr earlier than the time when the global mean near-surface air temperature reaches 1.50℃(2.00℃)WTT.Meanwhile,the Southern Ocean between 0°and 60°S considerably slows down the global 1.50℃and 2.00℃WTT.In 2040–2060,over 98.70%(77.50%),99.70%(89.30%),99.80%(93.40%),and 100.00%(98.00%)of the land will have warmed by over 1.50℃(2.00℃)under SSP(Shared Socioeconomic Pathway)1–2.6,SSP2-4.5,SSP3-7.0,and SSP5-8.5,respectively.We conclude that regional 1.50℃(2.00℃)WTT should be fully considered,especially in vulnerable high-latitude and high-altitude regions. | MENG Yali DUAN Keqin SHANG Wei SHI Peihong LI Shuangshuang CHENG Ying CHEN Rong ZHANG Zhaopeng | 2023 | Chinese Geographical Science2023，33，6： | 0 |
| 18 | A novel approach to estimate and control denitrification performance in activated sludge systems with respirogram technology显示文摘Respirogram technology has been widely applied for aerobic process, however, the response of respirogram to anoxic denitrification is still unclear. To reveal such response may help to design a new method for the evaluation of the performance of denitrification. The size distribution of flocs measured at different denitrification moments demonstrated a clear expansion of flocs triggered by denitrification, during which higher specific endogenous and quasi-endogenous respiration rates(SOUReand SOURq) were also observed. Furthermore,SOURqincreases exponentially with the specific denitrification rate(SDNR), suggesting that there should be a maximum SDNR in conventional activated sludge systems. Based on these findings, an index Rq/t, defined as the ratio of quasi-endogenous(OURq) to maximum respiration rate(OURt), is proposed to estimate the denitrification capacity that higher Rq/tindicates higher denitrification potential, which can be readily obtained without complex measurement or analysis, and it offers a novel and promising respirogram-based approach for denitrification estimation and control by taking measures to extend anoxic time to maintain its value at a high level within a certain range. | Zhihua Li Yali Zhang Zhenyu Hang Meng Lu Haiguang Wang Xingdong Gao Ruina Zhang | 2022 | Journal of Environmental Sciences2022，34，11： | 0 |
| 19 | A software reliability growth model for component-based software incorporating debugging delay and imperfect debugging显示文摘In view of the problems and the weaknesses of component-based software(CBS) reliability modeling and analysis,and a lack of consideration for real debugging circumstance of integration testing,a CBS reliability process analysis model is proposed incorporating debugging time delay,imperfect debugging and limited debugging resources.CBS integration testing is formulated as a multiqueue multichannel and finite server queuing model(MMFSQM) to illustrate fault detection process(FDP) and fault correction process(FCP).A unified FCP is sketched,given debugging delay,the diversities of faults processing and the limitations of debugging resources.Furthermore,the impacts of imperfect debugging on fault detection and correction are explicitly elaborated,and the expressions of the cumulative number of fault detected and corrected are illustrated.Finally,the results of numerical experiments verify the effectiveness and rationality of the proposed model.By comparison,the proposed model is superior to the other models.The proposed model is closer to real CBS testing process and facilitates software engineer's quantitatively analyzing,measuring and predicting CBS reliability. | 张策 Cui Gang Meng Fanchao Liu Hongwei Bian Yali | 2015 | High Technology Letters2015，21，1： | 0 |
| 20 | 趋化因子受体CCR7诱导的lnc-Dpf3通过抑制HIF-1α介导的糖酵解从而抑制树突状细胞迁移显示文摘文章简介树突状细胞(DC)是一类重要的天然免疫细胞和专制性抗原提呈细胞,在激活机体抗病原体免疫应答及维持自身免疫耐受过程中发挥着关键性的调控作用。DC的体内迁移对于其成熟活化及功能调控至关重要,DC迁移紊乱可导致DC在炎症部位的过度聚集及活化。 | 刘娟 Xiaomin Zhang Kun Chen Yujie Cheng Shuxun Liu Meng Xia Yali Chen Ha Zhu Zhiqing Li 曹雪涛 | 2020 | 科学新闻2020，，2： | 0 |
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