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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | (N,F)-codoped TiO_2 Nanocrystals as Visible Light-activated Photocatalyst显示文摘(N, F)-codoped anatase TiO2 nanocrystals with active visible light response were prepared by using a simple sol-gel approach. X-ray photoelectron spectroscopy measurements suggested that the substitutional N and F species replaced the lattice oxygen atoms in TiO2 nanocrystals. Such nanocrystals showed strong absorption from 400 to 550 nm, which was mainly induced by nitrogen doping. The phase transformation from anatase to rutile was hindered by fluorine doping at high calcination temperatures, which was verified by XRD patterns. The N2 adsorption-desorption isotherms revealed the absence of mesopores in these nanocrystals. The (N, F)-codoped TiO2 nanocrystals showed satisfying photocatalytic activity on the photo-degradation of methylene blue under visible light. | Yanling Meng Jiansong Chen Ying Wang Hanming Ding Yongkui Shan | 2009 | Journal of Materials Science & Technology2009，25，1： | 3 |
| 4 | Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton显示文摘Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could | Yanling Wang Zhigang Meng Chengzhen Liang Zhaohong Meng Yuan Wang Guoqing Sun Tao Zhu Yongping Cai Sandui Guo Rui Zhang Yi Lin | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
| 5 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 6 | Diagnosis and management of acquired thrombotic thrombocy- topenic purpura in southeast China: a single center experience of 60 cases显示文摘 | Xinping Zhou XingnongYe Yanling Ren Chen Mei Liya Ma Jiansong Huang Weilai Xu Juying Wei Li Ye Wenyuan Mai Wenbin Qian Haitao Meng Jie Jin Hongyan Tong | 2016 | Frontiers of Medicine2016，10，4： | 2 |
| 7 | Prevalence and risk factors of enteral nutrition intolerance in intensive care unit patients: a retrospective study显示文摘Background: Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU patients.Methods: We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression analysis.Results: The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493,P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707,P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456,P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228,P = 0.001) in the ICU patients.Conclusions: FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies. | Kunrong Yu Na Guo Dingding Zhang Ying Xia Yanling Meng Li Weng Bin Du | 2022 | Chinese Medical Journal2022，，15： | 2 |
| 8 | The Study on the Anti-corrosion Performance of NiTi Alloy in Human Body Solution with the Fabricating Processes of Laser Irradiation and PDMS Modification显示文摘This paper presents a new and safe method of fabricating super-hydrophobic surface on NiTi Shape Memory Alloy(SMA),which aims to further improve the corrosion resistance performance and biocompatibility of NiTi SMA.The super-hydrophobic surfaces with Water Contact Angle(WCA)of 155.4°±0.9°and Water Sliding Angle(WSA)of 4.4°±1.1°were obtained by the hybrid of laser irradiation and polydimethylsiloxane(PDMS)modification.The forming mechanism was systematically revealed via Scanming Electron Microscopy(SEM)and X-ray Photoelectron Spectroscopy(XPS).The ant-corrosion of samples was investigated in Simulated Body Fluid(SBF)via the potentiodynamie polarization(PDP)and Electrochemical Impedance Spectroscopy(EIS)tests.PDMS super-hydrophobic coatings showed superior anti-corrosion performance.The Ni ions release experiment was also conducted and the corresponding result demonstrated that the super-hydrophobic samplcs effectively inhibited the rclease of Ni ions both in clctrolyte and SBF Besides,biocompaibility was further analyzed,indicating that the prepared super-hydrophobic surfaces present a huge potential advantage in biocompatibility. | Chengjuan Yang weiran Cao Zhen Yang Meng Wang Xiubing Jing Yanling Tian | 2021 | Journal of Bionic Engineering2021，18，1： | 2 |
| 9 | Anaerobic treatment of wastewater containing methanol in up-flow anaerobic sludge bed (UASB) reactor显示文摘The direct conversion of methanol into methane is the main process in anaerobic treatment of methanol containing wastewater.However,acetic acid can also be produced from methanol theoretically,which may probably result in an abrupt pH drop and deteriorate the anaerobic process.Therefore,it is interesting to know what would really happen in an anaerobic reactor treating methanol wastewater.In this study,an up-flow anaerobic sludge bed(UASB)reactor treating methanol wastewater was operated.The chemical oxygen demand(COD),acetic acid and pH of the effluent were monitored at different loadings and influent alkalinity.The results showed that the anaerobic reactor could be operated steadily at as low as 119 mg/L of influent alkalinity and high organic loading rate with no obvious pH drops.Volatile fatty acids accumulation was not observed even at strong shock loadings.The microorganisms in the sludge at the end of the test became homogeneous in morphology,which were mainly spherical or spheroidal in shape. | Yishan LIN Yanling HE Zhuo MENG Shucheng YANG | 2008 | Frontiers of Environmental Science & Engineering2008，2，2： | 2 |
| 10 | LM-11SL:A Sea-Launched Carrier Rocket for Small Satellites and Its Launch Service显示文摘Following the successful maiden flight of the Long March 11(LM-11) launch vehicle from the Jiuquan Satellite Launch Center in September 2015, the first sea-launched carrier rocket dedicated to provide a launch service for small satellites and their constellations, the Long March 11 Sea Launch(LM-11 SL) has been under development by the China Academy of Launch Vehicle Technology(CALT) and the China Great Wall Industry Corporation(CGWIC). It is planned to commence launch service in 2018. Based on the LM-11, a land-launched four-staged solid launch vehicle which has entered the market and accomplished launch missions for several small satellites in the past 3 years, the newly adopted sea launch technology enables transport and launch of LM-11 SL from maritime ships, providing flexible launch location selection.After inheriting the mature launch vehicle technologies from previous members of the Long March launch vehicle family and adopting a new way of launching from the sea, the LM-11 SL is capable of sending payloads into low Earth orbits with all altitudes and inclinations, from 200 km to 1000 km, from equatorial to sun synchronous, within a shortduration launch campaign. The LM-11 SL provides a flexible, reliable and economical launch service for the global small satellite industry. | SHANG Hui LIU Bo MENG Xiang WU Zhenyu ZHANG Yanling ZHANG Feiting | 2018 | Aerospace China2018，19，2： | 2 |
| 11 | Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade显示文摘 | Ma Jianhui Meng Yan Kwiatkowski David J Chen Xinxin Peng Haiyong Sun Qian Zha Xiaojun Wang Fang Wang Ying Jing Yanling Zhang Shu Chen Rongrong Wang Lianmei Wu Erxi Cai Guifang Malinowska-Kolodziej Izabela Liao Qi Liu Yuqin Zhao Yi Sun | 2010 | Journal of Clinical Investigation2010，，1： | 1 |
| 12 | A highly efficient visible-light-activated photocatalyst based on bismuth-and Sulfur-Codoped TiO显示文摘 | Wang Ying Wang Yan Meng Yanling Ding Hanming Shan Yongkui Zhao Xian Tang Xiaozhen | 2008 | Journal of Physical Chemistry C2008，112，： | 1 |
| 13 | A Molecular Biomarker for Disruption of Crustacean Molting: The N-acetyl-β-glucosaminidase mRNA in the Epidermis of the Fiddler Crab显示文摘 | Yanling Meng Enmin Zou | 2009 | Bulletin of Environmental Contamination and Toxicology2009，，5： | 1 |
| 14 | Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency显示文摘 | Yao Bang Lu Keiko Kobayashi Miharu Ushikai Ayako Tabata Mikio Iijima Meng Xian Li Lei Lei Kotaro Kawabe Satoru Taura Yanling Yang Tze-Tze Liu Szu-Hui Chiang Kwang-Jen Hsiao Yu-Lung Lau Lap-Chee Tsui Dong Hwan Lee Takeyori Saheki | 2005 | Journal of Human Genetics2005，，7： | 1 |
| 15 | 3D printing of conch-like scaffolds for guiding cell migration and directional bone growth显示文摘Regeneration of severe bone defects remains an enormous challenge in clinic.Developing regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome this hurdle.Conch,an interesting creature widely spreading in ocean,has tough spiral shell that can continuously grow along the spiral direction.Herein,inspired by the physiological features of conches,a conch-like(CL)scaffold based onβ-TCP bioceramic material was successfully prepared for guiding directional bone growth via digital light processing(DLP)-based 3D printing.Benefiting from the spiral structure,the CL scaffolds significantly improved cell adhesion,proliferation and osteogenic differentiation in vitro compared to the conventional 3D scaffolds.Particularly,the spiral structure in the scaffolds could efficiently induce cells to migrate from the bottom to the top of the scaffolds,which was like“cells climbing stairs”.Furthermore,the capability of guiding directional bone growth for the CL scaffolds was demonstrated by a special half-embedded femoral defects model in rabbits.The new bone tissue could consecutively grow into the protruded part of the scaffolds along the spiral cavities.This work provides a promising strategy to construct biomimetic biomaterials for guiding directional bone tissue growth,which offers a new treatment concept for severe bone defects,and even limb regeneration. | Boshi Feng Meng Zhang Chen Qin Dong Zhai Yufeng Wang Yanling Zhou Jiang Chang Yufang Zhu Chengtie Wu | 2023 | Bioactive Materials2023，，4： | 1 |
| 16 | Characterization of uncommon portosystemic collateral circulations inpatients with hepatic cirrhosis显示文摘 | Qin Wu Lijun Shen Jindong Chu Xuemei Ma Bo Jin Fanping Meng Jinpin Chen Yanling Wang Libing Wu Jun Han Wenhui Zhang Wei Ma Huaming Wang Hanwei Li | 2015 | Oncology Letters2015，，1： | 1 |
| 17 | Advances in Research of Garlic Virus Diseases显示文摘Garlic virus infection is an important disease which affects garlic production,with the increasing years of planting,harm of virus is serious year by year,which seriously affect yield and quality of garlic.In order to know the garlic virus effectively,the paper reviewed the research situation of several important garlic virus in virus species,origin,distribution,host range,symptom,route of transmission,classification,genome and detection technique and the prevention technology of garlic viruses.At the same time,prospected several important research aspects of garlic virus in the future. | BAI Yanju 1,ZHANG Wei 1,LI Xuezhan 1,SHEN Yu 1,GAO Yanling 1,FAN Guoquan 1,GENG Hongwei 1,and MENG Xianxin 2 1 Virus-free Seeding Research Institute of Heilongjiang Agricultural Sciences,Harbin 150086,China 2 Crop Breeding Institute of Heilongjiang Academy of Agricultural Sciences,Harbin 150086,China | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，2： | 1 |
| 18 | TdIF1:a putative oncogene in NSCLC tumor progression显示文摘TdT-interacting factor 1(TdIF1)is a ubiquitously expressed DNA-and protein-binding protein that directly binds to terminal deoxynucleotidyl transferase(TdT)polymerase.Little is known about the functional role of TdIF1 in cancer cellular signaling,nor has it previously been identified as aberrant in any type of cancer.We report here for the first time that TdIF1 is abundantly expressed in clinical lung cancer patients and that high expression of TdIF1 is associated with poor patient prognosis.We further established that TdIF1 is highly expressed in human non-small cell lung cancer(NSCLC)cell lines compared to a normal lung cell line.shRNA-mediated gene silencing of TdIF1 resulted in the suppression of proliferation and anchorage-independent colony formation of the A549 adenocarcinoma cell line.Moreover,when these TdIF1-silenced cells were used to establish a mouse xenograft model of human NSCLC,tumor size was greatly reduced.These data suggest that TdIF1 is a potent regulator of lung tumor development.Several cell cycle-related and tumor growth signaling pathways,including the p53 and HDAC1/2 pathways,were identified as participating in the TdIF1 signaling network by in silico analysis.Microarray,transcriptome and protein-level analyses validated p53 and HDAC1/2 modulation upon TdIF1 downregulation in an NSCLC cellular model.Moreover,several other cell cycle regulators were affected at the transcript level by TdIF1 silencing,including an increase in CDKN1A/p21 transcripts.Taken together,these results indicate that TdIF1 is a bona fide tumor-promoting factor in NSCLC and a potential target for therapy. | Yujuan Zhang Zhigang Wang Yanqing Huang Muying Ying Yifan Wang Juan Xiong Qi Liu Fan Cao Rakesh Joshi Yanling Liu Derong Xu Meng Zhang Keng Yuan Nanjin Zhou James Koropatnick Weiping Min | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 19 | Stability of traveling wave fronts for nonlocal diffusive systems显示文摘This paper is concerned with stability of traveling wave fronts for nonlocal diffusive system.We adopt L^(1),-weighted,L^(1)-and L^(2)-energy estimates for the perturbation systems,and show that all solutions of the Cauchy problem for the considered systems converge exponentially to traveling wave fronts provided that the initial perturbations around the traveling wave fronts belong to a suitable weighted Sobolev spaces. | Yanling Meng Zhixian Yu Shengqiang Zhang | 2021 | International Journal of Biomathematics2021，14，3： | 0 |
| 20 | MBTIviz: A Visualization System for Research on Psycho-Demographics and Personality显示文摘The increasing interest in exploring the correlation between personal-ity traits and real-life individual characteristics has been driven by the growing popularity of the Myers–Briggs Type Indicator(MBTI)on social media plat-forms.To investigate this correlation,we conduct an analysis on a Myers–Briggs Type Indicator(MBTI)-demographic dataset and present MBTIviz,a visualiza-tion system that enables researchers to conduct a comprehensive and accessible analysis of the correlation between personality and demographic variables such as occupation and nationality.While humanities and computer disciplines provide valuable insights into the behavior of small groups and data analysis,analysing demographic data with personality information poses challenges due to the com-plexity of big data.Additionally,the correlation analysis table commonly used in the humanities does not offer an intuitive representation when examining the relationship between variables.To address these issues,our system provides an integrated view of statistical data that presents all demographic information in a single visual format and a more informative and visually appealing approach to presenting correlation data,facilitating further exploration of the linkages between personality traits and real-life individual characteristics.It also includes machine learning predictive views that help nonexpert users understand their personality traits and provide career predictions based on demographic data.In this paper,we utilize the MBTIviz system to analyse the MBTI-demographic dataset,calcu-lating age,gender,and occupation percentages for each MBTI and studying the correlation between MBTI,occupation,and nationality. | Yutong Yang Xiaoju Dong Xuefei Tian Yanling Zhang Meng Zhou | 2023 | 国际计算机前沿大会会议论文集2023，，1： | 0 |
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