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| 1 | 3RISPR-P 2.0: An Improved CRISPR-Cas9 Too For Genome Editing in Plants显示文摘 | Hao Liu Yuduan Ding Yanqing Zhou Wenqi Jin Kabin Xie Ling-Ling Chen | 2017 | Molecular Plant2017，10，3： | 32 |
| 2 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 3 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 4 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 5 | Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway显示文摘OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 pathway.METHODS: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation assay.RESULTS: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and STAT3.CONCLUSION: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis. | Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian Kang Liyuan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 11 |
| 6 | Anti Cervix Cancer Activity of Co-immobilized Tumor Necrosis Factor-α and Interferon-γ显示文摘肿瘤坏死因素一(TNF-alpha ) 并且有强壮的反肿瘤活动的 interferon-7 (IFN-gamma ) arecytokines。他们与 photoactivearylazide-4-azidobenzoic 酸被反应,导致光敏的 TNF-alpha 和 IFN-gamma。红外线(红外) 这些产品的系列在 2127 cm~ 显示出一个叠氮基组的典型吸收(-1) 。Byphoto 固定,这修改 TNF-alpha 和 IFN-gamma 在聚苯乙烯膜上被使不能调动让房间文化准备简历材料。与一台扫描电子显微镜(SEM ) 观察的光敏的 cytokineswas 微形态学。Helacells 的生长和这二 cytokines 的导致的 apoptosis 活动上的禁止的效果被生长曲线,传播电子显微镜(TEM ) 和荧光分析活跃房间 sorter (FACS ) 。结果显示出 IFN-gamma 的那合作固定, TNF-alpha 在 Hela 细胞,直到 82% 的禁止的率,和显然有的 IFN-gamma 的生长上有重要禁止的效果 synergistic 行动。 | Yanqing GUAN Limei HE Shumei CAI Tianhong ZHOU | 2006 | Journal of Materials Science & Technology2006，22，2： | 7 |
| 7 | Liquid crystal integrated metalens with tunable chromatic aberration显示文摘Overcoming chromatic aberrations is a vital concern in imaging systems in order to facilitate fullcolor and hyperspectral imaging.By contrast,large dispersion holds opportunities for spectroscopy and tomography.Combining both functions into a single component will significantly enhance its versatility.A strategy is proposed to delicately integrate two lenses with a static resonant phase and a switchable geometric phase separately.The former is a metasurface lens with a linear phase dispersion.The latter is composed of liquid crystals(LCs)with space-variant orientations with a phase profile that is frequency independent.By this means,a broadband achromatic focusing from 0.9 to 1.4 THz is revealed.When a saturated bias is applied on LCs,the geometric phase modulation vanishes,leaving only the resonant phase of the metalens.Correspondingly,the device changes from achromatic to dispersive.Furthermore,a metadeflector with tunable dispersion is demonstrated to verify the universality of the proposed method.Our work may pave a way toward active metaoptics,promoting various imaging applications. | Zhixiong Shen Shenghang Zhou Xinan Li Shijun Ge Peng Chen Wei Hu Yanqing Lu | 2020 | Advanced Photonics2020，2，3： | 7 |
| 8 | Evaluation of oxygen transfer parameters of fine-bubble aeration system in plug flow aeration tank of wastewater treatment plant显示文摘Knowledge of the oxygen mass transfer of aerators under operational conditions in a full-scale wastewater treatment plant (WWTP) is meaningful for the optimization of WWTP, however, scarce to best of our knowledge. Through analyzing a plug flow aeration tank in the Lucun WWTP, in Wuxi, China, the oxygenation capacity of fine-bubble aerators under process conditions have been measured in- situ using the off-gas method and the non-steady-state method. The off-gas method demonstrated that the aerators in different corridors in the aeration tank of WWTP had significantly different oxygen transfer performance; furthermore, the aerators in the same corridor shared almost equal oxygen transfer performance over the course of a day. Results measured by the two methods showed that the oxygen transfer performance of fine-bubble aerators in the aeration tank decreased dramatically compared with that in the clean water. The loss of oxygen transfer coefficient was over 50% under low-aeration conditions (aeration amount < 0.67 Nm 3 /hr). However, as the aeration amount reached 0.96 Nm 3 /hr, the discrepancy of oxygen transfer between the process condition and clean water was negligible. The analysis also indicated that the non-steady-state and off-gas methods resulted in comparable estimates of oxygen transfer parameters for the aerators under process conditions. | Xiaohong Zhou Yuanyuan Wu Hanchang Shi Yanqing Song | 2013 | Journal of Environmental Sciences2013，25，2： | 6 |
| 9 | Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation显示文摘象 bystin 一样(BYSL ) 基因以前被描绘为参予早胚胎培植的房间粘附编码附件蛋白质。它也涉及 40S ribosomal 子单元生物的续生说并且被发现在很快种胚胎和癌症房间线被表示。以便在癌症房间增长和生长探索 BYSL 的角色,我们把 hepatocellular 癌(HCC ) 用作一个模型。这里,我们报导 BYSL 在 vitro 并且在 vivo 为 HCC 房间生长是关键的。在人的 HCC 标本的 BYSL mRNA 和蛋白质的表示层次显著地与在邻近的非癌的织物看见的那些相比被增加。在 vitro,由短发卡 RNA 的 BYSL 的抑制减少了 HCC 房间增长,导致了 apoptosis 并且部分在 G2/M 阶段逮捕了房间周期。在 vivo,与 BYSL siRNA 对待的 HCC 房间没能在下的培植以后在裸体老鼠形成肿瘤。为了为 BYSL 导致 RNAi 的细胞生长决定细胞的基础,逮捕, BYSL subcellular 本地化在有丝分裂并且分裂期间 HepG2 细胞被检验。BYSL 在 nucleologenesis 期间在多重阶段是在场的,在导出核的 foci (NDF ) 包括, perichromosomal 区域和 prenucleolar 身体(PNB ) 在有丝分裂期间。BYSL 弄空显著地压制了 NDF 和 PNB 形成,并且在有丝分裂以后破坏了 nucleoli 汇编,导致增加的 apoptosis 和到浆液饥饿的 HCC 房间的减少的忍耐。一起拿,我们的研究显示那 upregulated BYSL 表情在 hepatocarcinogenesis 起一个作用。 | Hanzhi Wang Wei Xiao Qinbo Zhou Yun Chen Shuo Yang Jiansong Sheng Yanqing Yin Jia Fan Jiawei Zhou | 2009 | Cell Research2009，19，10： | 5 |
| 10 | Strongly coupled Ag/TiO2 heterojunctions for effective and stable photothermal catalytic reduction of 4-nitrophenol显示文摘 | Ying Gu Yanqing Jiao Xiaoguang Zhou Aiping Wu Bater Buhe Honggang Fu | 2018 | Nano Research2018，11，1： | 5 |
| 11 | Phosphate removal by a La(OH)_(3) loaded magnetic MAPTAC-based cationic hydrogel:Enhanced surface charge density and Donnan membrane effect显示文摘Cationic hydrogels have received great attention to control eutrophication and recycle phosphate.In this study,a type of La(OH)_(3) loaded magnetic MAPTAC-based cationic hydrogel(La(OH)_(3)@MMCH)was developed as a potential adsorbent for enhanced phosphate removal from aqueous environment.La(OH)_(3)@MMCH exhibited high adsorption capacity of 105.72±5.99 mg P/g,and reached equilibrium within 2 hr.La(OH)_(3)@MMCH could perform effectively in a wide pH range from 3.0 to 9.0 and in the presence of coexisting ions(including SO_(4)^(2-),Cl^(-),NO_(3)^(-),HCO_(3)^(-),SiO_(4)^(4-) and HA).The adsorption-desorption experiment indicated that La(OH)_(3)@MMCH could be easily regenerated by using NaOH-NaCl as the desorption agent,and 73.3%adsorption capacity remained after five cycles.Moreover,La(OH)_(3)@MMCH was employed to treat surface water with phosphate concentration of 1.90 mg/L and showed great removal efficiency of 95.21%.Actually,MMCH showed high surface charge density of 34.38-59.38 meq/kg in the pH range from 3.0 to 11.0 and great swelling ratio of 3014.57%within 24 h,indicating that MMCH could produce the enhanced Donnan membrane effect to pre-permeate phosphate.Furthermore,the bifunctional structure of La(OH)_(3)@MMCH enabled it to capture phosphate through electrostatic attraction and ligand exchange.All the results prove that La(OH)_(3)@MMCH is a promising adsorbent for eutrophication control and phosphate recovery. | Yanqing Zhou Yili Wang Shuoxun Dong Haotian Hao Junyi Li Chenyang Liu Xiaolin Li Yao Tong | 2022 | Journal of Environmental Sciences2022，34，3： | 4 |
| 12 | Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex显示文摘The nuclear pore complex(NPC)mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells.Here we report the cryo-electron tomography(cryo-ET)structure of the luminal ring(LR)of the NPC from Xenopus laevis oocyte.The observed key structural features of the LR are independently confirmed by single-particle cryo-electron microscopy(cryo-EM)analysis.The LR comprises eight butterfly-shaped subunits,each containing two symmetric wings.Each wing consists of four elongated,tubular protomers.Within the LR subunit,the eight protomers form a Finger domain,which directly contacts the fusion between the inner and outer nuclear membranes and a Grid domain,which serves as a rigid base for the Finger domain.Two neighboring LR subunits interact with each other through the lateral edges of their wings to constitute a Bumper domain,which displays two major conformations and appears to cushion neighboring NPCs.Our study reveals previously unknown features of the LR and potentially explains the elastic property of the NPC. | Yanqing Zhang Sai Li Chao Zeng Gaoxingyu Huang Xuechen Zhu Qifan Wang Kunpeng Wang Qiang Zhou Chuangye Yan Wusheng Zhang Guangwen Yang Minhao Liu Qinghua Tao Jianlin Lei Yigong Shi | 2020 | Cell Research2020，30，6： | 4 |
| 13 | The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm显示文摘Objective This study aimed to combine tumor abnormal protein(TAP) and high-sensitivity C-reactive protein(hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less than 8 mm, and to provide a reference for clinical screening and diagnosis. Methods Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings, were collected from September 2014 to December 2015. The inclusion criteria were as follows: the patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal patients(n = 26) with uterine fibroids seen during the same period were selected as a control group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined on admission. Results We found that both TAP and hs-CRP levels in the experimental group were higher than those in the control group [(182.95 ± 72.14) μm^2 vs.(133.19 ± 55.18) μm^2, P = 0.019;(7.52 ± 19.03) mg/L vs.(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%, the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was found to be 160.662 μm^2 and that for hs-CRP was 1.07 mg/L. Conclusion For patients suspected of having endometrial cancer with endometrial thickness less than 8 mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new ideas regarding clinical diagnosis and treatment. | Yi Li Ruiqin Yue Dongrui Qin Yanqing Wang Xinling Zhou Xinyong Jing Chuanzhong Wu | 2016 | Oncology and Translational Medicine2016，2，4： | 3 |
| 14 | Dielectr ic barr ier discharge plasma-assisted modification of g-C_(3)N_(4)/Ag_(2)O/TiO_(2)-NRs composite enhanced photoelectrocatalytic activity显示文摘Dielectric barrier discharge(DBD)plasma applied as surface treatment technology was employed for the modification of Ag_(2)O and graphitic carbon nitride(g-C_(3)N_(4))powders.Subsequently,the pretreated powders were sequentially loaded onto TiO_(2)nanorods(TiO_(2)-NRs)via electro-deposition,followed by calcination at N_(2)atmosphere.The results indicated that at the optimal plasma discharge time of 5 min for modification of g-C_(3)N_(4)and Ag_(2)O,photocurrent density of ternary composite was 6 times to bare TiO_(2)-NRs under UV-visible light irradiation.Phenol was degraded by using DBD plasma-modified g-C_(3)N_(4)/Ag_(2)O/TiO_(2)-NRs electrode to analyze the photoelectrocatalytic performance.The removal rate of phenol for g-C_(3)N_(4)-5/Ag_(2)O-5/TiO_(2)-NRs electrode was about 3.07 times to that for TiO_(2)-NRs electrode.During active species scavengers'analysis,superoxide radicals and hydroxyl radicals were the main oxidation active species for pollutants degradation.A possible electron-hole separation and transfer mechanism of ternary composite with high photoelectrocatalytic performance was proposed. | Yupei Long Chenchen Yuan Xiaomin Wang Dongyan Jin Hong Zhou Qiongyin Wang Chenyang Lu Yuqi Chen Yanqing Cong Qi Wang Yi Zhang | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 15 | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis显示文摘The nuclear pore complex(NPC)exhibits structural plasticity and has only been characterized at local resolutions of up to 15 A for the cytoplasmic ring(CR).Here we present a single-particle cryo-electron microscopy(cryo-EM)structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9A,with local resolutions reaching 4.5 A.Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components.The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits,forming a circular scaffold.Within each CR subunit,the Nup358-containing region wraps around the stems of both Y complexes,likely stabilizing the scaffold.Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex.The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC.These previously uncharacterized structural features reveal insights into NPC assembly. | Gaoxingyu Huang Yanqing Zhang Xuechen Zhu Chao Zeng Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2020 | Cell Research2020，30，6： | 2 |
| 16 | Inactivation of food spoilage bacteria by high pressure processing: Evaluation with conventional media and PCR–DGGE analysis显示文摘 | Yanqing Han Xinglian Xu Yun Jiang Guanghong Zhou Xinsheng Sun Baocai Xu | 2010 | Food Research International2010，，6： | 2 |
| 17 | miR-24-3p promotes colon cancer progression by targeting ING1显示文摘Dear Editor,Activation or upregulation of oncogenes and/or loss of function or downregulation of tumour suppressors are central to the processes involved in the transformation from normal colonic mucosa to malignant tumours.Inhibitor of growth 1(ING1)has been functionally linked to cell cycle arrest,apoptosis and chromatin remodelling. | Zhiying Gao Likun Zhou Shiyu Hua Huan Wu Laizhi Luo Libo Li Shuping Wang Yanqing Liu Zhen Zhou Xi Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 18 | Highly efficient P uptake by Fe3O4 loaded amorphous Zr-La (carbonate) oxides: Electrostatic attraction, inner-sphere complexation and oxygen vacancies acceleration effect显示文摘Bimetallic oxides composites have received an increasing attention as promising adsorbents for aqueous phosphate (P) removal in recent years. In this study, a novel magnetic composite MZLCO was prepared by hybridizing amorphous Zr-La (carbonate) oxides (ZLCO) with nano-FeOthrough a one-pot solvothermal method for efficient phosphate adsorption. Our optimum sample of MZLCO-45 exhibited a high Langmuir maximum adsorption capacity of 96.16 mg P/g and performed well even at low phosphate concentration. The phosphate adsorption kinetics by MZLCO-45 fitted well with the pseudo-second-order model, and the adsorption capacity could reach 79% of the ultimate value within the first 60 min. The phosphate adsorption process was highly p H-dependent, and MZLCO-45 performed well over a wide p H range of 2.0-8.0. Moreover, MZLCO-45 showed a strong selectivity to phosphate in the presence of competing ions (Cl^(-), NO_(3)^(-), SO_(4)^(2-), HCO_(3)^(-), Ca^(2+), and Mg^(2+)) and a good reusability using the eluent of Na OH/Na Cl mixture, then 64% adsorption capacity remained after ten recycles. The initial 2.0 mg P/L in municipal wastewater and surface water could be efficiently reduced to below 0.1mg P/L by 0.07 g/L MZLCO-45, and the phosphate removal efficiencies were 95.7% and 96.21%, respectively. Phosphate adsorption mechanisms by MZLCO-45 could be attributed to electrostatic attraction and the inner-sphere complexation via ligand exchange forming Zr/La-O-P, -OH and CO_(3)^(2-)groups on MZLCO-45 surface played important roles in the ligand exchange process. The existence of oxygen vacancies could accelerate the phosphate absorption rate of the MZLCO-45 composites. | Chenyang Liu Yili Wang Xiaolin Li Junyi Li Shuoxun Dong Haotian Hao Yao Tong Yanqing Zhou | 2022 | Journal of Environmental Sciences2022，34，10： | 2 |
| 19 | Spatial Interaction Network Analysis of Crude Oil Trade Relations between Countries along the Belt and Road显示文摘Based on the theories and methods of complex network,crude oil trade flows between countries along the Belt and Road(B&R,hereafter)are inserted into the Geo-space of B&R and form a spatial interaction network which takes the countries as nodes and takes the trade relations as edges.The networked mining and evolution analysis can provide important references for the research on trade relations among the B&R countries and the formulation of trade policy.This paper researches and discusses the construction,statistical analysis,top networks and stability of the crude oil trade network between the B&R countries from 2001 to 2020 from the perspectives of Geo-Computation for Social Sciences(GCSS)and spatial interaction.Firstly,evolutions of out-degree,in-degree,out-strength and in-strength of the top 10 countries in the crude oil trade network are computed and analyzed.Secondly,the top network method is used to explore the evolution characteristics of hierarchical structures.And finally,the sequential evolution characteristics of the crude oil trade network stability are analyzed utilizing the network stability measure method based on the trade relationship autocorrelation function.The analysis results show that Russia has the largest out-degree and out-strength,and China has the largest in-degree and in-strength.The crude oil trade volume of the top 10 import and export networks between 2001—2020 accounts for over 90%of the total trade volume of the crude oil trade network,and the proportion remains relatively stable.However,the stability of the network showed strong fluctuations in 2009,2012 and 2014,which may be closely related to major international events in these years,which could furtherly be used to build a correlation model between network volatility and major events.This paper explores how to construct and analyze the spatial interaction network of crude oil trade and can provide references for trade relations research and trade policy formulation of B&R countries. | Qixin WANG Kun QIN Donghai LIU Gang XU Yanqing XU Yang ZHOU Rui XIAO | 2022 | Journal of Geodesy and Geoinformation Science2022，5，2： | 2 |
| 20 | Removeal of Phenolic Compounds by Electro-Assisted Advanced Process for Wastewater Purification显示文摘 | Wu Zucheng Cong Yanqing Zhou Minghua | 2002 | Korean Journal of Chemical Engineering2002，19，5： | 1 |
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