|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 3 | Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N^(6)-Methyladenosine-Modified Yap Expression显示文摘Circular RNAs take crucial roles in several pathophysiological processes.The regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown.Here,we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion(I/R)remodeling.Knockdown of circ-ZNF609 protects against acute I/R injury and attenuates left ventricle dysfunction after I/R remodeling in vivo.In vitro,circ-ZNF609 regulates cardiomyocyte survival and proliferation via modulating the crosstalk between Hippo-YAP and Akt signaling.Mechanically,N6-methyladenosine-modification is involved in the regulatory role of circ-ZNF609 on YAP.An in-depth study indicates that knockdown of circ-ZNF609 decreases the expression of YTHDF3 and further fine-tuned the accessibility of Yap mRNA to YTHDF1 and YTHDF2 to regulate YAP expression.circ-ZNF609 knockdown represents a promising therapeutic strategy to combat the pathological process of myocardial I/R injury. | Lijun Wang Pujiao Yu Jiaqi Wang Guie Xu Tianhui Wang Jingyi Feng Yihua Bei Jiahong Xu Hongbao Wang Saumya Das Junjie Xiao | 2022 | Research2022，，3： | 3 |
| 4 | A climatic dataset of ocean vertical turbulent mixing coefficient based on real energy sources显示文摘Using data on wind stress, significant height of combined wind waves and swell, potential temperature, salinity and seawater velocity, as well as objectively-analyzed in situ temperature and salinity, we established a global ocean dataset of calculated wind- and tide-induced vertical turbulent mixing coefficients. We then examined energy conservation of ocean vertical mixing from the point of view of ocean wind energy inputs, gravitational potential energy change due to mixing(with and without artificially limiting themixing coefficient), and K-theory vertical turbulent parameterization schemes regardless of energy inputs. Our research showed that calculating the mixing coefficient with average data and artificial limiting the mixing coefficient can cause a remarkable lack of energy conservation, with energy losses of up to 90% and changes in the energy oscillation period. The data also show that wind can introduce a huge amount of energy into the upper layers of the Southern Ocean, and that tidesdo so in regions around underwater mountains. We argue that it is necessary to take wind and tidal energy inputs into account forlong-term ocean climate numerical simulations. We believe that using this ocean vertical turbulent mixing coefficient climatic dataset is a fast and efficient method to maintain the ocean energy balance in ocean modeling research. | ZHANG Yu LIN YiHua HUANG RuiXin | 2014 | Science China Earth Sciences2014，57，10： | 3 |
| 5 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 6 | Blind Particle Filtering Detector over Time-Varying Frequency-Selective and Nonlinear Channels显示文摘 | YU Yihua | 2013 | Chinese Journal of Electronics2013，22，2： | 2 |
| 7 | CAS-FGOALS Datasets for the Two Interglacial Epochs of the Holocene and the Last Interglacial in PMIP4显示文摘Two versions of the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System model(CASFGOALS),version f3-L and g3,are used to simulate the two interglacial epochs of the mid-Holocene and the Last Interglacial in phase 4 of the Paleoclimate Modelling Intercomparison Project(PMIP4),which aims to study the impact of changes in orbital parameters on the Earth’s climate.Following the PMIP4 experimental protocols,four simulations for the mid-Holocene and two simulations for the Last Interglacial have been completed,and all the data,including monthly and daily outputs for the atmospheric,oceanic,land and sea-ice components,have been released on the Earth System Grid Federation(ESGF)node.These datasets contribute to PMIP4 and CMIP6(phase 6 of the Coupled Model Intercomparison Project)by providing the variables necessary for the two interglacial periods.In this paper,the basic information of the CAS-FGOALS models and the protocols for the two interglacials are briefly described,and the datasets are validated using proxy records.Results suggest that the CAS-FGOALS models capture the large-scale changes in the climate system in response to changes in solar insolation during the interglacial epochs,including warming in mid-to-high latitudes,changes in the hydrological cycle,the seasonal variation in the extent of sea ice,and the damping of interannual variabilities in the tropical Pacific.Meanwhile,disagreements within and between the models and the proxy data are also presented.These datasets will help the modeling and the proxy data communities with a better understanding of model performance and biases in paleoclimate simulations. | Weipeng ZHENG Yongqiang YU Yihua LUAN Shuwen ZHAO Bian HE Li DONG Mirong SONG Pengfei LIN and Hailong LIU | 2020 | Advances in Atmospheric Sciences2020，37，10： | 2 |
| 8 | Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5′ processing of mitochondrial nad5 messenger RNA and endosperm development显示文摘Pentatricopeptide repeat(PPR) proteins, composing one of the largest protein families in plants,are involved in RNA binding and regulation of organelle RNA metabolism at the posttranscriptional level. Although several PPR proteins have been implicated in endosperm development in rice(Oryza sativa), the molecular functions of many PPRs remain obscure. Here, we identified a rice endosperm mutant named floury endosperm 18(flo18) with pleiotropic defects in both reproductive and vegetative development.Map-based cloning and complementation tests showed that FLO18 encodes a mitochondriontargeted P-type PPR protein with 15 PPR motifs.Mitochondrial function was disrupted in the flo18 mutant, as evidenced by decreased assembly of Complex I in the mitochondrial electron transport chain and altered mitochondrial morphology. Loss of FLO18 function resulted in defective 5′-end processing of mitochondrial nad5 transcripts encoding subunit 5 of nicotinamide adenine dinucleotide hydrogenase. These results suggested that FLO18 is involved in 5′-end processing of nad5 messenger RNA and plays an important role in mitochondrial function and endosperm development. | Mingzhou Yu Mingming Wu Yulong Ren Yihua Wang Jingfang Li Cailin Lei Yinglun Sun Xiuhao Bao Hongming Wu Hang Yang Tian Pan Yongfei Wang Ruonan Jing Mengyuan Yan Houda Zhang Lei Zhao Zhichao Zhao Xin Zhang Xiuping Guo Zhijun Cheng Bing Yang Ling Jiang Jianmin Wan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 2 |
| 9 | HIV-1 Vif suppresses antiviral immunity by targeting STING显示文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection. | Yu Wang Gui Qian Lingyan Zhu Zhuo Zhao Yinan Liu Wendong Han Xiaokai Zhang Yihua Zhang Tingrong Xiong Hao Zeng Xianghui Yu Xiaofang Yu Xiaoyan Zhang Jianqing Xu Quanming Zou Dapeng Yan | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 10 | Particle filters for maneuvering target tracking problem 显示文摘 | YU Yihua CHENG Qian-sheng | 2006 | Signal Processing2006，86，： | 1 |
| 11 | Macroporous poly(glycidyl meth-acrylate-triallyl isoeyanumte-divinylbenzene) matrix as ananion-exchange resin for protein adsorption显示文摘 | YU Yihua SUN Yah | 1999 | J Chro-matography A1999，855，1： | 1 |
| 12 | MRF parameter estimation by an accelerated method显示文摘 | Yu Yihua Cheng Qiansheng | 2003 | Pattern Recognition Letters2003，24，9： | 1 |
| 13 | Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice显示文摘It is well established that an abnormal tetrahydrofolate(THF)cycle causes the accumulation of hydrogen peroxide(H_(2)O_(2))and leaf senescence,however,the molecular mechanism underlying this relationship remains largely unknown.Here,we reported a novel rice tetrahydrofolate cycle mutant,which exhibited H_(2)O_(2)accumulation and early leaf senescence phenotypes.Map-based cloning revealed that HPA1 encodes a tetrahydrofolate deformylase,and its deficiency led to the accumulation of tetrahydrofolate,5-formyl tetrahydrofolate and 10-formyl tetrahydrofolate,in contrast,a decrease in 5,10-methenyl-tetrahydrofolate.The expression of tetrahydrofolate cycle-associated genes encoding serine hydroxymethyl transferase,glycine decarboxylase and 5-formyl tetrahydrofolate cycloligase was significantly down-regulated.In addition,the accumulation of H_(2)O_(2)in hpa1 was not caused by elevated glycolate oxidation.Proteomics and enzyme activity analyses further revealed that mitochondria oxidative phosphorylation complex I and complex V were differentially expressed in hpa1,which was consistent with the H_(2)O_(2)accumulation in hpa1.In a further feeding assay with exogenous glutathione(GSH),a non-enzymatic antioxidant that consumes H_(2)O_(2),the H_(2)O_(2)accumulation and leaf senescence phenotypes of hpa1 were obviously compensated.Taken together,our findings suggest that the accumulation of H_(2)O_(2)in hpa1 may be mediated by an altered folate status and redox homeostasis,subsequently triggering leaf senescence. | Erhui Xiong Guojun Dong Fei Chen Chen Zhang Shan Li Yanli Zhang Jahidul Islam Shohag Xiaoe Yang Yihua Zhou Qian Qian Limin Wu Yanchun Yu | 2021 | Science China(Life Sciences)2021，64，5： | 1 |
| 14 | Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development显示文摘Most of the reported P-type pentatricopeptide repeat(PPR) proteins play roles in organelle RNA stabilization and splicing. However, P-type PPRs involved in both RNA splicing and editing have rarely been reported, and their underlying mechanism remains largely unknown. Here, we report a rice floury endosperm22(flo22) mutant with delayed amyloplast development in endosperm cells. Map-based cloning and complementation tests demonstrated that FLO22 encodes a mitochondrion-localized P-type PPR protein.Mutation of FLO22 resulting in defective transsplicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. RNA-seq analysis showed that expression levels of many genes involved in starch and sucrose metabolism were significantly down-regulated in the flo22mutant compared with the wild type, whereas genes related to oxidative phosphorylation and the tricarboxylic acid cycle were significantly upregulated. In addition to involvement in splicing as a P-type PPR protein, we found that FLO22 interacted with DYW3, a DYW-type PPR protein, and they may function synergistically in mitochondrial RNA editing. The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi-site editing of mitochondrial messager RNA. | Hang Yang Yunlong Wang Yunlu Tian Xuan Teng Zehui Lv Jie Lei Erchao Duan Hui Dong Xue Yang Yuanyan Zhang Yinglun Sun Xiaoli Chen Xiuhao Bao Rongbo Chen Chuanwei Gu Yipeng Zhang Xiaokang Jiang Wenyu Ma Pengcheng Zhang Yi Ji Yu Zhang Yihua Wang Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，3： | 1 |
| 15 | Particle filter with ant colony optimization for frequency offset estimation in OFDM systems with unknown noise distribution显示文摘 | YU YIHUA ZHENG XUANYUAN | 2011 | Signal Processing2011，91，5： | 1 |
| 16 | A new type of ALSS-the preparation of erosslinked ehitosan resins and its adsorption properties for bilirubin显示文摘 | Yu Yihua He Binglin | 1996 | Reactive and Functional Polymers1996，31，3： | 1 |
| 17 | A novel protein L-cofilin2 identified in Lampetra morii with roles of immune response and cell proliferation promotion显示文摘Cofilin2,an actin-binding protein,is expressed in many eukaryotic cells.It binds to and depolymerizes the actin filaments,and its activity is regulated by phosphorylation,dephosphorylation,and pH[1].Cofilins have been reported to have multiple functions,including cytokinesis,cell locomotion[2],cellular stress responses[3],and pathological situations[4].Under normal conditions,cofilins can regulate the reorganization of actin.Cofilins can also alter the cell function in response to stress conditions through binding with actin.Other functions of cofilins remain to be explored. | Yingying Li Yu Zuo Wenying Zhang Yihua Zhao Qingwei Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 1 |
| 18 | Characterization of three infectious bronchitis virus isolates from China associated with proventriculus in vaccinated chickens显示文摘 | YU LI HANG Yihua LOW S et at | 2001 | Avian Dis2001，45，2： | 1 |
| 19 | Impact of antitumor regimens on the outcomes of cancer patients with COVID-19:a pooled analysis显示文摘Since the outbreak of coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)discovered in December 2019,the disease has emerged as a global pandemic(Shi et al.,2020;World Health Organization,2020).Several studies have shown a higher incidence of COVID-19,as well as related poor outcomes in patients with malignancies as compared with those without them(Liang et al.,2020;Tian et al.,2020). | Haohua LU Yu SHI Kelie CHEN Zhi CHEN Haihong ZHU Yuequn NIU Dajing XIA Yihua WU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 1 |
| 20 | Construction of hierarchical functional nanomaterials for energy conversion and storage显示文摘Hierarchical functional nanomaterials have important applications in the fields of new energy and the environment because of performance advantages based on the coupling and collaboration of multilevel structures.The key to application is the design and control of the mesoscale structures,such as the crystal-facet structure,lattice orientation,defects,and dislocations.In this review,we present the controlled synthesis of novel semiconductor oxide and carbon-based nanocomposites with three-dimensional hierarchical structures by the multiphase-reaction process.We describe several typical reaction processes,such as the gas-phase flame-combustion method,the vapor-phase deposition technique,and the solid-liquid interface reaction process,to investigate the properties of fluid flow,mixing,transport,and chemical reaction.We also study the formation mechanism,structural evolution and control methods for hierarchical nanomaterials by using combined experimental and simulation methods.These well-designed and prepared hierarchical functional materials can be used in energy storage and conversion fields.Valuable information is provided for the structural design and performance control of new functional nanocomposites. | Jianhua Shen Yu Wang Kailun Gu Yihua Zhu Yanjie Hu Chunzhong Li | 2020 | Particuology2020，18，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员