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| 1 | Effect of yttrium on the microstructure of a semi-solid A356 Al alloy显示文摘The semi-solid slurry of an A356 Al alloy, which was grain-fined by yttrium, was manufactured by low temperature pouring. The effects of grain-refining on the morphology and the grain size of the primary α phase in the semi-solid A356 Al alloy were researched. The results indicate that the semi-solid A356 Al alloy with particle-like and rosette-like primary α-Al can be prepared by low temperature pouring from a liquid grain-refined A356 alloy. The grain size and particle morphology of primary α-Al in the A356 Al alloy are markedly improved by the addition of 0.5 wt.% Y. The fining mechanism of Y on the morphology and grain size of the primary α-Al in the semi-solid A356 Al alloy was delved. | LIUZheng HU Yongmei | 2008 | Rare Metals2008，27，5： | 23 |
| 2 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 3 | Accurate Analysis of Connectivity and Resilience for a Class of Wireless Sensor Networks显示文摘Increasing attention is being devoted to network security with the extensive application of wireless sensor networks in various fields. Connectivity and resilience are the crucial metrics of network security.We establish precise formulas for obtaining the resilience of a Key predistribution scheme(KPS) obtained from an Orthogonal array(OA). We study the connectivity and resilience of the Broadcast-enhanced key predistribution scheme(BEKPS) based on OAs and improve the existing methods. We also present precise formulas for evaluating the resilience of these schemes based on any number of partitions, completely solving the problem regarding the resilience of this type of BEKPS. We obtain precise formulas for ensuring the connectivity of two partitions under the condition that each pair of trees from different partitions intersects at exactly one node. We present a general approximate formula for evaluating the connectivity of more than two partitions, providing a positive solution to the open problem in Kendall et al.'s paper in ACM Transactions on Sensor Networks(Vol.11,No.1, 2014). Thus, we can conclude that for this type of BEKPS, connectivity increases, whereas resilience remains unchanged as the number of partitions increases. A comparison of the obtained results and the previously reported results reveals the superior performance of the proposed BEKPSs. | PANG Shanqi HU Xianchao GAO Qiang LI Yongmei XIA Yifan | 2020 | Chinese Journal of Electronics2020，29，2： | 5 |
| 4 | Refining mechanism of yttrium on primary α-Al in semi-solid Al alloy显示文摘Semi-solid Al7Si0.3Mg alloy slurry, which is grain-refined by yttrium, is manufactured by low temperature pouring. The effects of grain-refined by yttrium on the morphology and the grain size of the primary α-Al in semi-solid Al7Si0.3Mg alloy are researched. The results indicate that semi-solid Al7Si0.3Mg alloy with particle-like and rosette-like primary α-Al can be prepared by low temperature pouring from liquid Al7Si0.3Mg alloy grain-refined by yttrium. The grain size and particle morphology of primary α-Al in Al7Si0.3Mg alloy are markedly improved by 0.5 wt pct Y. The refining mechanism of Y on the morphology and the grain size of the primary α-Al in semi-solid Al7Si0.3Mg alloy are delved. | Zheng LIU Yongmei HU Xiaomei LIU | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，4： | 5 |
| 5 | Verification of Mutagen Function of Zeocin in Nannochloropsis oceanica Through Transcriptome Analysis显示文摘Zeocin can cause double strand breaks of DNA and thus is frequently used as a selective antibiotic of eukaryotic Sh ble transformants. In non-transformation system, Zeocin may function as a mutagen if not totally lethal. To verify such function of Zeocin, we mutated Nannochloropsis oceanica by increasing the concentration of Zeocin in medium gradually, and isolated a N. oceanica strain(single cell culture) which survived Zeocin up to 10.0μg mL^(-1). The Zeocin-tolerant strain entered the exponential growth phase later and grew slower than the wild strain. Transcriptome profiling showed that the Zeocin-tolerant N. oceanica strain survived Zeocin mainly by adapting(heritable), rather than acclimating(plastic) to Zeocin. Hence mutating N. oceanica with Zeocin was approved effective. Meanwhile, the physiological characteristics of this Zeocin-tolerant strain were demonstrated. As we proposed, N. oceanica tolerated Zeocin by strengthening its protein degradation and antioxidation. The genes controlling cell division and cellular response to stimuli may also have played important roles in the reduction of growth and the tolerance to Zeocin. Our findings evidenced that Zeocin can serve as an appropriate mutagen of microalgae. Creating variations through mutation with Zeocin may help to study the genetic basis of the traits of this monoploidy and asexual microalga, as well as improve its production. | LIN Genmei WANG Yamei GUO Li DING Haiyan HU Yongmei LIANG Sijie ZHANG Zhongyi YANG Guanpin | 2017 | Journal of Ocean University of China2017，16，3： | 5 |
| 6 | Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression:the role of adenosine receptor A2显示文摘Hypoxia is a major characteristic of the tumor microenvironment,and its effects on immune cells are proposed to be important factors for the process of tumor immune escape.It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells.Here we discuss the effects of hypoxia on T-cell survival.Our results showed that hypoxia induced apoptosis of T cells.Adenosine and adenosine receptors(AR)are important to the hypoxia-related signaling pathway.Using AR agonists and antagonists,we demonstrated that hypoxia-induced apoptosis of T cells was mediated by A^(2a)and A^(2b)receptors.Furthermore,we are the first,to our knowledge,to report that hypoxia significantly inhibited the expression of chemokine C receptor 7(CCR7)of T cells via the A^(2)R signal pathway,perhaps representing a mechanism of hypoxia-induced apoptosis of T cells.Collectively,our research demonstrated that hypoxia induces T-cell apoptosis by the A^(2)R signaling pathway partly by suppressing CCR7.Blocking the A^(2)R signaling pathway and/or activation of CCR7 can increase the anti-apoptosis function of T cells and may become a new strategy to improve antitumor potential. | Jintang Sun Yan Zhang Meixiang Yang Yun Zhang Qi Xie Zewu Li Zhaogang Dong Yongmei Yang Biping Deng Alei Feng Weixu Hu Haiting Mao Xun Qu | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 7 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 8 | Effective removal of Cu ( Q )ions from aqueous solution by amino-functionalized magneticnanoparticles 显示文摘 | Hao Yongmei Man Chen Hu Zhongbo | 2010 | Journal of hazardous materials2010，184，123： | 1 |
| 9 | Quality as sessment of Cortex Phellodendri by high-performance liquid chromatography coupled with eleetrospray ionization mass spectrometry显示文摘 | Hu YongMei Su GuangHai Sze S C W | 2010 | Biomed Chromatogr2010，24，4： | 1 |
| 10 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 11 | Tailoring biochar by PHP towards the oxygenated functional groups(OFGs)-rich surface to improve adsorption performance显示文摘In this work,a modification method of H_(3)PO_(4)plus H_(2)O_(2)(PHP)was introduced to targetedly form abundant oxygenated functional groups(OFGs)on biochar,and methylene blue(MB)was employed as a model pollutant for adsorption to reflect the modification performance.Results indicated that parent biochars,especially derived from lower temperatures,substantially underwent oxidative modification by PHP,and OFGs were targetedly produced.Correspondingly,approximately 21.5-fold MB adsorption capacity was achieved by PHP-modified biochar comparing with its parent biochar.To evaluate the compatibility of PHP-modification,coefficient of variation(CV)based on MB adsorption capacity by the biochar from various precursors was calculated,in which the CV of PHP-modified biochars was 0.0038 comparing to0.64 of the corresponding parent biochars.These results suggested that the PHP method displayed the excellent feedstock compatibility on biochar modification.The maximum MB adsorption capacity was454.1 mg/g when the H_(3)PO_(4)and H_(2)O_(2)fraction in PHP were 65.2%and 7.0%;the modification was further intensified by promoting temperature and duration.Besides,average 94.5%H_(3)PO_(4)was recovered after 10-batch modification,implying 1.0 kg H_(3)PO_(4)(85%)in PHP can maximally modify 2.37 kg biochar.Overall,this work offered a novel method to tailor biochar towards OFGs-rich surface for efficient adsorption. | Xinyue Xiong Zhanglin Liu Li Zhao Mei Huang Lichun Dai Dong Tian Jianmei Zou Yongmei Zeng Jinguang Hu Fei Shen | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 12 | Efficacy of gefitinib as a first-line single agent treatment in patients with advanced non-small cell lung cancer显示文摘Objective: To assess the efficacy and toxicity of gefitinib as a single agent treatment in Chinese patients with advanced non-small cell lung cancer (NSCLC). Methods: Forty-five patients with advanced NSCLC were treated with gefitinib at 250 mg daily until the disease progressed or the patient could not tolerate the toxicity. Results: None of the patients achieved a complete response (CR), while 15 patients achieved a partial remission (PR) and 17 experienced a stable disease (SD). Thirteen patients continued to have a progressive disease (PD). The response rate and the disease control rate were 33.3% and 71.1%, respectively. The symptom remission rate was 72.5%, and the median remission time was 8 days. The median survival time was 15.3 months. The median progression-free survival time was 6.0 months. The most common toxicities included rash (53.3%) and diarrhea (33.3%). Dehydration and pruritus of the skin developed in 26.7% and 22.2% of the patients, respectively. Hepatic toxicity occurred in 6.7% of patients and oral ulceration occurred in 4.4% of patients. Conclusion: Single agent treatment with gefitinib is effective against advanced NSCLC, and is well tolerated in Chinese patients. | Yongmei Yin Yiting Geng Xiaodong Li Xiaoli Hu Xiaofeng Chen Wei Li Yongqian Shu | 2009 | Journal of Nanjing Medical University2009，23，6： | 1 |
| 13 | Indoor positioning simulation based on Landmarc system 显示文摘 | Li Xingpeng Hu YongMei Song Jibo | 2008 | The Computer Engineering and Application2008，，27： | 1 |
| 14 | Sophorolipid production from different lipid precursors observed with LC- MS 显示文摘 | Hu Yongmei Ju Lu-Kwang | 2001 | Enzyme and Microbial Technology2001，29，： | 1 |
| 15 | Comprehensive chemical analysis of Venenum Bufonis by using liquid chromatog- raphy/electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Zhijun | 2011 | J Pharm Biomed Anal2011，56，： | 1 |
| 16 | Effects of Cognitive Behavioral Therapy on Insomnia of Maintenance Hemodialysis Patients显示文摘 | Yongmei Hou Peicheng Hu Yanping Liang Zhanyu Mo | 2014 | Cell Biochemistry and Biophysics2014，，： | 1 |
| 17 | Identifi cation of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of eff ective Erxian Decoction(EXD)fraction by liquid chromatography-mass spectrometry显示文摘 | HU Yongmei WANG Yitao Stephen C W Sze | 2010 | Biomed Chromatogr2010，24，： | 1 |
| 18 | Comprehensive chemi- cal analysis of Venenum Bufonis by using liquid chromatography/ electrospray ionization tandem mass spectrometry 显示文摘 | Hu Yongmei Yu Zhiling Yang Z J | 2011 | J Pharm Bi- omed Anal2011，56，： | 1 |
| 19 | High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation显示文摘Elevated temperature could influence the sex differentiation by altering the expression of sex-related genes in fish.However, the underlying mechanisms by which the gene expression is altered remain poorly understood.Here, we aimed to explore the role of DNA methylation in sex differentiation of zebrafish(Danio rerio) in response to elevated temperature.The results showed that high temperature(33℃) exposure of fish from 20 to 30 days post fertilization(dpf), compared to normal temperature(28℃), resulted in male-biased sex ratio and decreased expression of female-related genes including cyp19a1a, sox9b and esr1.Meanwhile, the expressions of DNA methyltransferases dnmt3a1 and dnmt3a2, and the DNA methylation levels in sox9b and esr1 promoter were significantly increased by high temperature, strongly implying that DNA methylation is involved in high temperature-induced masculinization of zebrafish.Co-treatment with 5-aza-2-deoxycytidine(a DNA methylation inhibitor) attenuated the high temperature-induced masculinizing effect, recovered the expression of esr1 and sox9b, suppressed the transcription of dnmt3a1 and dnmt3a2, and decreased the methylation of esr1 and sox9b promoter, further confirming that DNA methylation plays an important role in high temperature-induced masculinization of zebrafish.Furthermore, the methylation of sox9b promoter decreased the enrichment of transcription factor CREB(cAMP-responsive element binding proteins).Overall, these findings suggest that high temperature induce masculinization of zebrafish by down-regulation of femalerelated genes via DNA methylation, providing a new insight in understanding the epigenetic mechanism of thermal-mediated sex differentiation in fish. | Jiangyuan Han Yan Hu Yongmei Qi Cong Yuan Sajid Naeem Dejun Huang | 2021 | Journal of Environmental Sciences2021，33，9： | 1 |
| 20 | TGF-β1-induced expression of Id-1 is associated with tumor progression in gastric cancer显示文摘 | Huiying Ma Ye Wei Yongmei Leng Shichao Li Lingling Gao Heng Hu Long Chen Fei Wang Honglei Xiao Chouwen Zhu Chunmin Liang | 2014 | Medical Oncology2014，，7： | 1 |
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