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| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Endovascular treatment of post-laparoscopic pancreatectomy splenic arteriovenous fistula with splenic vein aneurysm显示文摘Splenic arteriovenous fistulas(SAVFs) with splenic vein aneurysms are extremely rare entities. There have been no prior reports of SAVFs developing after laparoscopic pancreatectomy. Here, we report the first case. A 40-year-old man underwent a laparoscopic, spleen-preserving, distal pancreatectomy for an endocrine neoplasm of the pancreatic tail. Three months after surgery, a computed tomography(CT) scan demonstrated an SAVF with a dilated splenic vein. The SAVF, together with the splenic vein aneurysm, was successfully treated using percutaneous transarterial coil embolization of the splenic artery, including the SAVF and drainage vein. After the endovascular treatment, the patient's recovery was uneventful. He was discharged on postoperative day 6 and continues to be well 3 mo after discharge. An abdominal CT scan performed at his 3-mo follow-up demonstrated complete thrombosis of the splenic vein aneurysm, which had decreased to a 40 mm diameter. This is the first reported case of SAVF following a laparoscopic pancreatectomy and demonstrates the usefulness of endovascular treatment for this type of complication. | Tatsuo Ueda Satoru Murata Akira Yamamoto Jin Tamai Yuko Kobayashi Chiaki Hiranuma Hiroshi Yoshida Shin-ichiro Kumita | 2015 | World Journal of Gastroenterology2015，21，25： | 5 |
| 3 | High Diagnostic Ability of Multiparametric Magnetic Resonance Imaging to Detect Anterior Prostate Cancer Missed by Transrectal 12-Core Biopsy显示文摘 | Yoshinobu Komai Noboru Numao Soichiro Yoshida Yoh Matsuoka Yasukazu Nakanishi Chikako Ishii Fumitaka Koga Kazutaka Saito Hitoshi Masuda Yasuhisa Fujii Satoru Kawakami Kazunori Kihara | 2013 | The Journal of Urology2013，，： | 1 |
| 4 | Synthesis of 12-deoxyroyleanone, cryptoquinone, 11, 14-dihydroxy-8, 11, 13-abietatrien-7-one, and related derivatives from dehydroabietic acid 显示文摘 | Matsushita Yoh-ichi Iwakiri Yoshihisa Yoshida Satoru | 2005 | Tetrahedron Lett2005，46，21： | 1 |
| 5 | Fecal-oral transmission of the cyst form of Blastocystis hominis in rats显示文摘 | Hisao Yoshikawa Kumi Yoshida Ayumi Nakajima Kimie Yamanari Satoru Iwatani Isao Kimata | 2004 | Parasitology Research2004，，6： | 1 |
| 6 | NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer显示文摘 | Argun Akcakanat Tatsuo Kanda Yu Koyama Michitoshi Watanabe Eiji Kimura Yutaka Yoshida Shintarou Komukai Satoru Nakagawa Shoji Odani Hiroshi Fujii Katsuyoshi Hatakeyama | 2004 | Cancer Chemotherapy and Pharmacology2004，，1： | 1 |
| 7 | Initial Experience of Diffusion-weighted Magnetic Resonance Imaging to Assess Therapeutic Response to Induction Chemoradiotherapy Against Muscle-invasive Bladder Cancer显示文摘 | Soichiro Yoshida Fumitaka Koga Satoru Kawakami Chikako Ishii Hiroshi Tanaka Noboru Numao Yasuyuki Sakai Kazutaka Saito Hitoshi Masuda Yasuhisa Fujii Kazunori Kihara | 2010 | Urology2010，，2： | 1 |
| 8 | Drug-Induced Apoptosis by a Matrix Metalloproteinase Inhibitor, SI-27 on Human Malignant Glioma Cell Lines; in vitro Study显示文摘 | Ryuzaburo Kanazawa Daizo Yoshida Hiroshi Takahashi Yuichi Sugisaki Satoru Suzuki Akira Teramoto | 2004 | Journal of Neuro - Oncology (-)2004，，1： | 1 |
| 9 | Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation: II. Induction DHMEQ Treatment Ameliorates Subsequent Alloimmune Responses and Permits Long-Term Islet Allograft Acceptance显示文摘 | Masaaki Watanabe Kenichiro Yamashita Hirofumi Kamachi Daisuke Kuraya Yasuyuki Koshizuka Susumu Shibasaki Yoh Asahi Hitoshi Ono Shin Emoto Masaomi Ogura Tadashi Yoshida Michitaka Ozaki Kazuo Umezawa Michiaki Matsushita Satoru Todo | 2013 | Transplantation Journal2013，，5： | 1 |
| 10 | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis显示文摘 | Naoko Okumura Hitomi Yoshida Yasuko Kitagishi Mutsumi Murakami Yuri Nishimura Satoru Matsuda Michael L. Grossbard | 2012 | Advances in Hematology2012，，： | 1 |
| 11 | Transumbilical Single-incision Laparoscopic Hepatectomy Using Precoagulation and Clipless Technique in a Patient With Combined Hepatocellular-Cholangiocarcinoma: A Case Report显示文摘 | Yoichi Toyama Seiya Yoshida Norimitsu Okui Hiroaki Kitamura Satoru Yanagisawa Katsuhiko Yanaga | 2013 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2013，，： | 1 |
| 12 | Stable cavitation induces increased cytoplasmic calcium in L929 fibroblasts exposed to 1-MHz pulsed ultrasound显示文摘 | Akira Tsukamoto Satoru Higashiyama Kenji Yoshida Yoshiaki Watanabe Katsuko S. Furukawa Takashi Ushida | 2011 | Ultrasonics2011，，8： | 1 |
| 13 | Thermal physiological response to local heating and cooling during sleep显示文摘 | Yu Hibino Shuichi Hokoi Katsuaki Yoshida Satoru Takada Masanori Nakajima Miho Yamate | 2012 | Frontiers of Architectural Research2012，1，1： | 1 |
| 14 | Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer‐initiating cells显示文摘 | Manabu Tatokoro Fumitaka Koga Soichiro Yoshida Satoru Kawakami Yasuhisa Fujii Len Neckers Kazunori Kihara | 2011 | Int J Cancer2011，，4： | 1 |
| 15 | Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-κB signaling pathway显示文摘 | Yukari Suzuki Kazuhiro Ohgami Kenji Shiratori Xue-Hai Jin Iliyana Ilieva Yoshikazu Koyama Kazunaga Yazawa Kazuhiko Yoshida Satoru Kase Shigeaki Ohno | 2005 | Experimental Eye Research2005，，2： | 1 |
| 16 | Discharge height of lightning narrow bipolar events显示文摘 | Wu Ting Dong Wansheng Zhang Yijun Funaki Tsuyoshi Yoshida Satoru Morimoto Takeshi Ushio Tomoo Kawasaki ZenIchiro | 2012 | EN2012，，5： | 1 |
| 17 | Genistein downregulates presenilin 1 and ubiquilin 1 expression显示文摘 | Naoko Okumura Hitomi Yoshida Yuri Nishimura Mutsumi Murakami Yasuko Kitagishi Satoru Matsuda | 2012 | Molecular Medicine Reports2012，，： | 1 |
| 18 | Azumamides a-E:Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale Izuensis显示文摘 | Nakao Yoichi Yoshida Satoru | 2006 | Angewandte Chemie2006，118，： | 1 |
| 19 | Percutaneous Pelvic Perfusion with Extracorporeal Chemofiltration for Advanced Uterine Cervical Carcinoma显示文摘 | Takeshi Maruo Satoru Motoyama Shinya Hamana Shigeki Yoshida Noriyuki Ohara Mineo Yamasaki Yonson Ku | 2008 | Surgical Oncology Clinics of North America2008，，4： | 1 |
| 20 | Effects of Charge Distribution in Thunderstorms on Lightning Propagation Paths in Darwin, Australia显示文摘 | Akita Manabu Yoshida Satoru Nakamura Yoshitaka Morimoto Takeshi Ushio Tomoo Kawasaki Zen Wang Daohong | 2011 | Journal of the Atmospheric Sciences2011，，4： | 1 |
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