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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis显示文摘Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to DR.In this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were identified.Systematic searches of PUBMED,Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords 'diabetic retinopathy' and 'calcium dobesilate'.The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent angiography.The summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels. | ZHANG XinYuan LIU Wei WU ShanShan JIN JingLong LI WeiHong Wang NingLi | 2015 | Science China(Life Sciences)2015，58，1： | 54 |
| 3 | Altitude dependency of trends of daily climate extremes in southwestern China, 1961-2008显示文摘A total of 12 indices of temperature extremes and 11 indices of precipitation ex-tremes at 111 stations in southwestern China at altitudes of 285-4700 m were examined for the period 1961-2008. Significant correlations of temperature extremes and elevation in-cluded the trends of diurnal temperature range, frost days, ice days, cold night frequency and cold day frequency. Regional trends of growing season length, warm night frequency, coldest night and warmest night displayed a statistically significant positive correlation with altitude. These characteristics indicated the obvious warming with altitude. For precipitation extreme indices, only the trends of consecutive dry days, consecutive wet days, wet day precipitation and the number of heavy precipitation days had significant correlations with increasing alti-tude owing to the complex influence of atmospheric circulation. It also indicated the increased precipitation mainly at higher altitude areas, whereas the increase of extreme precipitation events mainly at lowers altitude. In addition, the clearly local influences are also crucial on climate extremes. The analysis revealed an enhanced sensitivity of climate extremes to ele-vation in southwestern China in the context of recent warming. | Li Zongxing He Yuanqing Theakstone, Wilfred H. Wang Xufeng Zhang Wei Cao Weihong Du Jiankuo Xin Huijuan Chang Li | 2012 | Journal of Geographical Sciences2012，22，3： | 36 |
| 4 | Response of the accumulation of proline in the bodies of Populus euphratica to the change of groundwater level at the lower reaches of Tarim River显示文摘The content of proline in the plant bodies is closely related to the converse-succession-resistant capability of the plants. In this paper, the relationship between the proline accumulation in the bodies of Populus euphratica and the change of groundwater level is analyzed by taking Popu-lus euphratica, the main community-building species of the desert riparian forests along the Tarim River, as the research object. The research results show that the accumulation of proline in the bodies of Populus euphratica is closely related to the change of groundwater level gradient under drought stress, it increases with the drawdown of groundwater level and the increase of moisture stress degree; the accumulation of proline in the bodies of Populus euphratica has two ex-tremely high points at the groundwater depth ranges of 3.64—5.14 m and 9.46—10.16 m. Combining the field investiga-tion and the analysis of the plots, it is considered that the groundwater level of 3.5—4.5 m is rational for the growth of Populus euphratica. The stress groundwater depth for the normal growth and the critical one for the survival of Popu-lus euphratica are below 4.5 m and 9—10 m respectively at the lower reaches of the Tarim River. | Yaning Chen Yapeng Chen Weihong Li Hongfeng Zhang | 2003 | Chinese Science Bulletin2003，48，18： | 31 |
| 5 | Rational groundwater table indicated by the ecophysiological parameters of the vegetation:A case study of ecological restoration in the lower reaches of the Tarim River显示文摘Populus euphratica Oliv 和 Tamarix ramosissima Ldb 的 eco 生理的反应和改编在水版本时期期间被调查。九个典型区域和 45 横断沿着 Tarim 河的更低的活动范围被选择。地下水桌子以及植物表演和脯氨酸,可溶的糖,和植物的内容内长的荷尔蒙(骆驼毛的织物, CTK ) 在叶子被监视并且分析。地下水桌子在不同区域被提起,横断走水路推出程序。生理的压力到 P。euphratica 和 T。ramosissima 在水版本以后被减少了。我们的结果建议在学习区域的地下水桌子在 3.15~4.12 m 留下了,从 9.28~11.06 的脯氨酸内容( mmol/L ),从 224.71~252.16 的可溶的糖内容( mmol/L ),从 3.59~5.01 的 ABA 内容( ng/g FW ),并且从 4.01~4.56 的 CK 内容( ng/g FW ),为最佳生长和 P 的恢复。植物性能参数和水申请的效率显示的 euphratica 最高。在学习区域的地下水桌子在 2.16~3.38 m 留下了,从 12.15~14.17 的脯氨酸内容( mmol/L ),从 154.71~183.16 的可溶的糖内容( mmol/L ),从 2.78~4.86 的 ABA 内容( ng/g FW ),并且从 3.78~4.22 的 CK 内容( ng/g FW ),为最佳生长和 T 的恢复。植物表演参数和水申请的效率显示的 ramosissima 最高。为在学习区域的植被的恢复的合理地下水桌子在 3.15 ~ 3.38 m。 | CHEN Yaning WANG Qiang LI Weihong RUAN Xiao CHEN Yapengr ZHANG Lihua | 2006 | Chinese Science Bulletin2006，51，A01： | 31 |
| 6 | A review of topology optimization for additive manufacturing:Status and challenges显示文摘Topology optimization was developed as an advanced structural design methodology to generate innovative lightweight and high-performance configurations that are difficult to obtain with conventional ideas.Additive manufacturing is an advanced manufacturing technique building asdesigned structures via layer-by-layer joining material,providing an alternative pattern for complex components.The integration of topology optimization and additive manufacturing can make the most of their advantages and potentials,and has wide application prospects in modern manufacturing.This article reviews the main content and applications of the research on the integration of topology optimization and additive manufacturing in recent years,including multi-scale or hierarchical structural optimization design and topology optimization considering additive manufacturing constraints.Meanwhile,some challenges of structural design approaches for additive manufacturing are discussed,such as the performance characterization and scale effects of additively manufactured lattice structures,the anisotropy and fatigue performance of additively manufactured material,and additively manufactured functionally graded material issues,etc.It is shown that in the research of topology optimization for additive manufacturing,the integration of material,structure,process and performance is important to pursue high-performance,multi-functional and lightweight production.This article provides a reference for further related research and aerospace applications. | Jihong ZHU Han ZHOU Chuang WANG Lu ZHOU Shangqin YUAN Weihong ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，1： | 33 |
| 7 | Topology Optimal Design of Material Microstructures Using Strain Energy-based Method显示文摘敏感分析和使用的微观结构的拓扑学优化拉紧基于精力的方法被介绍。与 homogenization 方法相比,基于精力的方法有的紧张更高计算效率和简化编程有利。双凸的编程方法和周界限制计划被用来优化 2D 和 3D 微观结构。数字结果显示基于精力的方法有的紧张象为 orthotropic 材料的 homogenization 方法的一样的有效性。 | Zhang Weihong Wang Fengwen Dai Gaoming Sun Shiping | 2007 | Chinese Journal of Aeronautics2007，20，4： | 21 |
| 8 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 9 | Using strain energy-based prediction of effective elastic properties in topology optimization of material microstructures显示文摘一个其他的紧张精力方法在这篇论文为 orthotropic 材料的有效有弹性的性质的预言被建议。方法在拓扑学优化过程被实现设计细胞的固体。比较研究在紧张精力方法和著名 homogenization 方法之间被做。当同类的边界条件适当地被指定时,数字结果证明两个方法在数字预言和有效有弹性的张肌的敏感分析同意很好。二维并且三维的微观结构被把建议方法与凸的编程的双优化算法相结合为最大的僵硬图案优化。令人满意的结果为许多设计盒子被获得。 | Weihong Zhang Gaoming Dai Fengwen Wang Shiping Sun Hicham Bassir | 2007 | Acta Mechanica Sinica2007，23，1： | 15 |
| 10 | Variations of temperature and precipitation of snowmelt period and its effect on runoff in the mountainous areas of Northwest China显示文摘在西北中国的干旱陆地的水资源主要源于雪和冰河在多山的区域融化水。snowmelt 时期的发作,停止,长度,温度和降水上的学习因此具有为相当分配有限的水资源并且采取科学的水资源管理措施的大意义。用从在时期上的 8 个多山的气象站的每日的吝啬的温度和降水 19602010 在西北中国的干旱陆地,这份报纸分析 snowmelt 时期和它的空间变化的气候变化并且探索流量的敏感到 snowmelt 的长度,温度和降水时期。结果证明当吝啬的结束日期 9.19 天以后移动了时, snowmelt 时期的那吝啬的发作 15.33 天早变了。当那仅仅 10.16 天早在北 Qilian 山移动了时,在南部的 Tianshan 山的 snowmelt 时期的发作 20.01 天早移动了。吝啬的降水和空气温度由 47.3 公里增加了并且 0. | LI Baofu CHEN Yaning CHEN Zhongsheng LI Weihong ZHANG Baohuan | 2013 | Journal of Geographical Sciences2013，23，1： | 14 |
| 11 | Multi-scale design and optimization for solid-lattice hybrid structures and their application to aerospace vehicle components显示文摘By integrating topology optimization and lattice-based optimization,a novel multi-scale design method is proposed to create solid-lattice hybrid structures and thus to improve the mechanical performance as well as reduce the structural weight.To achieve this purpose,a two-step procedure is developed to design and optimize the innovative structures.Initially,the classical topology optimization is utilized to find the optimal material layout and primary load carrying paths.Afterwards,the solid-lattice hybrid structures are reconstructed using the finite element mesh based modeling method.And lattice-based optimization is performed to obtain the optimal crosssection area of the lattice structures.Finally,two typical aerospace structures are optimized to demonstrate the effectiveness of the proposed optimization framework.The numerical results are quite encouraging since the solid-lattice hybrid structures obtained by the presented approach show remarkably improved performance when compared with traditional designs. | Chuang WANG Jihong ZHU Manqiao WU Jie HOU Han ZHOU Lu MENG Chenyang LI Weihong ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，5： | 14 |
| 12 | Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells显示文摘Early detection and treatment of cancer depends on developing highly sensitive and specific methods for targeting cancer cells. To do this, aptamers, which are generated by a novel technique called cell-SELEX (systematic evolution of ligands by exponential enrichment), have been widely applied in cancer cell targeting based on such merits as high target affinity and specificity, small size, minimal immunogenicity, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, quantum dots, silica nanoparticles, and carbon nanomaterials, among others. In this review, we discuss the use of cell-SELEX-based aptamer-nanomaterials conjugates as novel molecular tools for enhanced targeting of cancer cells. | KONG RongMei, CHEN Zhuo, YE Mao, ZHANG XiaoBing & TAN WeiHong State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2011 | Science China Chemistry2011，54，8： | 13 |
| 13 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 14 | Chalcogenide glass photonic integration for improved 2μm optical interconnection显示文摘In this work,on-chip chalcogenide glass photonic integrations with several fundamental photonic building blocks are designed and fabricated based on the As2 S3 platform for improved 2μm optical interconnection,achieving a broadened wavelength bandwidth and improved fabrication tolerance.A 600 nm thick As2 S3 strip waveguide has low propagation loss of 1.447 dB/cm at 2μm.Broadband vertical coupling is realized by a grating coupler with 4.3 dB coupling loss.A Bragg grating filter,power splitter,Mach–Zander interferometer,and mode converter for on-chip mode division multiplexing(MDM)are also reported at 2μm with reliable performances.Finally,a record high MDM optical interconnection capacity of 3×80 Gbps at 2μm is experimentally demonstrated based on the proposed As2 S3 chip,drawing promising prospects for future photonic integration and high-speed interconnection at the 2μm waveband. | WEIHONG SHEN PINGYANG ZENG ZELIN YANG DI XIA JIANGBING DU BIN ZHANG KE XU ZUYUAN HE AND ZHAOHUI LI | 2020 | Photonics Research2020，8，9： | 10 |
| 15 | Cd uptake in rice cultivars treated with organic acids and EDTA显示文摘A pot experiment was conducted to examine the activity of antioxidant enzymes, the content of malondialdehyde (MDA), proline and protein, and Cd uptake in different rice cultivars exposed to Cd (0, 1 and 5 mg/kg) in the presence of organic acids and ethylenediamine tetraacetic acid (EDTA). The results showed the increase in activity of dismutase (SOD), contents of proline and protein but a decline in activities of peroxidase (POD) and catalase (CAT), and MDA content for cultivars Xiushui63 and IIyou527. The resistance to Cd was higher in Xiushui63 than that in IIyou527 under the same Cd treatment. Cadmium contents in grain, straw and roots of both cultivars were markedly reduced in the presence of organic acids and EDTA. Grain Cd contents was the highest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the lowest with EDTA; Cd contents in straw and root were the lowest for plants treated with organic acids, followed by organic acids + 1/2EDTA, and the highest with EDTA treatment when exposed to Cd. | Weihong Xu Yangrui Li Jianping He Qifu Ma Xiaojing Zhang Guiqing Chen Huixian Wang Haibo Zhang | 2010 | Journal of Environmental Sciences2010，22，3： | 9 |
| 16 | Permian integrative stratigraphy and timescale of China显示文摘A series of global major geological and biological events occurred during the Permian Period. Establishing a highresolution stratigraphic and temporal framework is essential to understand their cause-effect relationship. The official International timescale of the Permian System consists of three series(i.e., Cisuralian, Guadalupian and Lopingian in ascending order) and nine stages. In China, the Permian System is composed of three series(Chuanshanian, Yansingian and Lopingian) and eight stages, of which the subdivisions and definitions of the Chuanshanian and Yangsingian series are very different from the Cisuralian and Guadalupian series. The Permian Period spanned ~47 Myr. Its base is defined by the First Appearance Datum(FAD) of the conodont Streptognathodus isolatus at Aidaralash, Kazakhstan with an interpolated absolute age 298.9±0.15 Ma at Usolka, southern Urals, Russia. Its top equals the base of the Triassic System and is defined by the FAD of the conodont Hindeodus parvus at Meishan D section, southeast China with an interpolated absolute age 251.902±0.024 Ma. Thirty-five conodont, 23 fusulinid, 17 radiolarian and 20 ammonoid zones are established for the Permian in China, of which the Guadalupian and Lopingian conodont zones have been served as the standard for international correlation. The Permian δ13 Ccarbtrend indicates that it is characterized by a rapid negative shift of 3–5‰ at the end of the Changhsingian, which can be used for global correlation of the end-Permian mass extinction interval, but δ13 Ccarbrecords from all other intervals may have more or less suffered subsequent diagenetic alteration or represented regional or local signatures only. Permian δ18 Oapatitestudies suggest that an icehouse stage dominated the time interval from the late Carboniferous to Kungurian(late Cisuralian). However, paleoclimate began to ameriolate during the late Kungurian and gradually shifted into a greenhouse-dominated stage during the Guadalupian.The Changhsingian was a relatively cool stage, followed by a globally-recognizable rapid temperature rise of 8–10°C at the very end of the Changhsingian. The87 Sr/86 Sr ratio trend shows that their values at the beginning of the Permian were between 0.70800,then gradually decreased to the late Capitanian minimum 0.70680–0.70690, followed by a persistent increase until the end of the Permian with the value 0.70708. Magenetostratigraphy suggests two distinct stages separated by the Illawarra Reversal in the middle Wordian, of which the lower is the reverse polarity Kiaman Superchron and the upper is the mixed-polarity Illawarra Superchron. The end-Guadalupian(or pre-Lopingian) biological crisis occurred during the late Capitanian, when faunal changeovers of different fossil groups had different paces, but generally experienced a relatively long time from the Jinogondolella altudensis Zone until the earliest Wuchiapingian. The end-Permian mass extinction was a catastrophic event that is best constrained at the Meishan section, which occurred at 251.941±0.037 Ma and persisted no more than 61±48 kyr. After the major pulse at Bed 25, the extinction patterns are displayed differently in different sections. The global end-Guadalupian regression is manifested between the conodont Jinogondolella xuanhanensis and Clarkina dukouensis zones and the endChanghsingian transgression began in the Hindeodus changxingensis-Clarkina zhejiangensis Zone. The Permian Period is also characterized by strong faunal provincialism in general, which resulted in difficulties in inter-continental and inter-regional correlation of both marine and terrestrial systems. | Shuzhong SHEN Hua ZHANG Yichun ZHANG Dongxun YUAN Bo CHEN Weihong HE Lin MU Wei LIN Wenqian WANG Jun CHEN Qiong WU Changqun CAO Yue WANG Xiangdong WANG | 2019 | Science China Earth Sciences2019，62，1： | 9 |
| 17 | Shape optimization of 3D curved slots and its application to the squirrel-cage elastic support design显示文摘The squirrel-cage elastic support is one of the most important components of an aero-engine rotor system.A proper structural design will favor the static and dynamic performances of the system.In view of the deficiency of the current shape optimization techniques,a new mapping approach is proposed to define shape design variables based on the parametric equations of 3D curves and surfaces.It is then applied for the slot shape optimization of a squirrel-cage elastic support.To this end,an automatic design procedure that integrates the Genetic Algorithm (GA) is developed to solve the problem.Two typical examples with different shape constraints are considered.Numerical results provide reasonable optimum designs for the improvement of stiffness and strength of the squirrel-cage elastic support. | WANG Dan,ZHANG WeiHong*,WANG ZhenPei & ZHU JiHong Engineering Simulation and Aerospace Computing,The Key Laboratory of Contemporary Design & Integrated Manufacturing Technology,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 8 |
| 18 | Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin显示文摘 | Xia Ding Feng Yan Phil Yao Zhihong Yang Weihong Wan Xiwei Wang Jing Liu Xinjiao Gao Ariane Abrieu Tongge Zhu Jiancun Zhang Zhen Dou Xuebiao Yao | 2010 | Cell Research2010，20，12： | 8 |
| 19 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 20 | Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity显示文摘The metabolic intermediate of acetaminophen(APAP)can cause severe hepatocyte necrosis,which triggers aberrant immune activation of liver non-parenchymal cells(NPC).Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury(AILI).Interleukin-1 receptor(IL-1R)signaling has been shown to play a critical role in various inflammatory conditions,but its precise role and underlying mechanism in AILI remain debatable.Herein,we show that NLRP3 inflammasome activation of IL-1βis dispensable to AILI,whereas IL-1α,the other ligand of IL-1R1,accounts for hepatic injury by a lethal dose of APAP.Furthermore,Kupffer cells function as a major source of activated IL-1αin the liver,which is activated by damaged hepatocytes through TLR4/MyD88 signaling.Finally,IL-1αis able to chemoattract and activate CD11b^(+)Gr-1^(+) myeloid cells,mostly neutrophils and inflammatory monocytes,to amplify deteriorated inflammation in the lesion.Therefore,this work identifies that MyD88-dependent activation of IL-1αin Kupffer cells plays a central role in the immunopathogenesis of AILI and implicates that IL-1αis a promising therapeutic target for AILI treatment. | Chao Zhang Jin Feng Jun Du Zhiyong Zhuo Shuo Yang Weihong Zhang Weihong Wang Shengyuan Zhang Yoichiro Iwakura Guangxun Meng Yang-Xin Fu Baidong Hou Hong Tang | 2018 | Cellular & Molecular Immunology2018，15，11： | 7 |
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