|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coupled modeling and analysis of radiometer effect and residual gas damping on proof mass in purely gravitational orbit显示文摘Spacecrafts free of all but gravitational forces are important in precision navigation,gravity field measurement and basic scientific research.The Inner-formation Flying System,one kind of spacecrafts free of all but gravitational forces,is used for gravitational field measurement with high precision.Restraining the interfering factors on the inner-satellite is one of the keys to gravitational field measurement.Radiometer effect and residual gas damping are both interfering forces on the inner-satellite caused by gas molecules.By analyzing the mechanism of the two forces,a coupled model for radiometer effect and residual gas damping was established,which contained the coupling term and reflected the actual force of gas molecules on the inner-satellite.The simulation results showed the coupling property of radiometer effect and residual gas damping:The actual force of gas molecules is directly proportional to the average pressure in the cavity and the largest cross-sectional area of the inner-satellite,but is inversely proportional to the square root of the average temperature in the cavity. | LIU HongWei WANG ZhaoKui ZHANG YuLin | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 2 | The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes显示文摘 | Juan Chen Zhaokui Cai Meizhu Bai Xiaohua Yu Chao Zhang Changchang Cao Xihao Hu Lei Wang Ruibao Su Di Wang Yingpeng Yao Rong Ye Baidong Hou Yang Yu Shuyang Yu Jinsong Li Yuanchao xue | 2018 | Cell Research2018，28，10： | 4 |
| 3 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 4 | Analysis of length distribution of short DNA fragments induced by ^(7)Li ions using the random-breakage model显示文摘Deoxyribonucleic acid (DNA) is an important bio-macromolecule. DNA double strand breaks (DSBs) are considered to be the most important initial damage responsi- ble for all biological effects induced by ionizing radiation. In this paper the length distribution of DNA fragments induced by 7Li ionizing radiation is fitted with the random breakage model. In this model, the parameter u is the average number of DSBs on every DNA molecule induced by ionizing radia- tion. The fitting result shows that the random breakage model cannot describe the distribution of DNA fragments in lower doses, while the random breakage model is in better accordance with the experimental data in higher doses. It is shown that the length distribution of DNA fragments has random statistical feature in higher doses. In this situation, the random breakage model looks like a model without any parameter since the u has specific physical meaning and can directly be obtained from experimental data. | KONGFuquan ZHAOKui ZHANYong CAOTianguang NIMeinan SUILi CAIMinghui | 2005 | Chinese Science Bulletin2005，50，9： | 2 |
| 5 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 6 | Analysis of residual gas disturbance on the inner satellite of Inner Formation Flying System显示文摘The Inner Formation Flying System(IFFS) consisting of an outer satellite and an inner satellite which is a sphere proof mass freely flying in the shield cavity can construct a pure gravity orbit to precisely detect the earth gravity field.The residual gas in the cavity is a significant disturbance source due to the temperature inhomogeneity and relative motion of the inner satellite.The expressions of the disturbance forces were derived based on the property of rarefied gas,including the radiometer effect and the damping force.According to the current design of IFFS,heat transfer analysis of the cavity and the inner satellite was carried out,and the surface temperature distribution of the cavity and the inner satellite was given.The relative motion of the inner satellite was obtained from the formation control simulation of IFFS.Then the residual gas disturbance was calculated.The disturbance acceleration acting on the inner satellite due to the radiometer effect was on the order of 10-11 ms-2 and the damping acceleration was on the order of 10-15 m s-2. | GU ZhenFeng WANG ZhaoKui ZHANG YuLin | 2012 | Science China(Technological Sciences)2012，55，9： | 1 |
| 7 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 8 | Fe-porphyrin:A redox-related biosensor of hydrogen molecule显示文摘Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so far.Herein,we originally reveal that Fe-porphyrin is a H_(2)-targeted molecule.We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of CO.These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials. | Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He | 2023 | Nano Research2023，16，2： | 1 |
| 9 | A Hardware-in-Loop Simulation System for Fractionated Spacecraft Cluster显示文摘 | An Meiyan Wang Zhaokui Zhang Yulin | 2015 | Journal of Aerospace Science and Technology2015，1，1： | 1 |
| 10 | Surveying Data Processing in the Nonlinear Model Space:Theory and Its Applications显示文摘 | Li Zhaokui | 2000 | Acta Geodetica et Cartographica Sinica2000，13，3： | 1 |
| 11 | Acquirement of pure gravity orbit using precision formation flying technology显示文摘 | WANG ZHAOKUI ZHANG YULIN | 2013 | Acta Astronautica2013，82，1： | 1 |
| 12 | Historical accumulation and environmental risk of nitrogen and phosphorus in sediments of Erhai Lake, Southwest China显示文摘 | Ni Zhaokui Wang Shengrui | 2015 | Ecological Engineering2015，79，： | 1 |
| 13 | Compensation of gravitational attraction disturbance to pure gravity orbit for Inner Formation Flying System显示文摘 | GU ZHENFENG WANG ZHAOKUI ZHANG YULIN | 2012 | Acta Astronautica2012，81，2： | 1 |
| 14 | Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform显示文摘Photothermal nanotheranostics, especially in the near infrared II(NIR-II) region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II light.NIR-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSe_(x) nano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se(x = 0.43). We have also discovered that the as-prepared TeSe_(x) nano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency(77.2%),^(64)Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions. | Xiang Ling Zhaokui Jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He | 2021 | National Science Review2021，8，6： | 0 |
| 15 | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein显示文摘In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis initiation.Mei2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes meiRNA.Previous research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in vivo.However,the underlying mechanisms still remain elusive.We first employed an in vitro crosslinking and immunoprecipitation sequencing(CLIP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 RRM3.We then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro CLIP-seq.These results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)sequence.Furthermore,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis. | Siyuan Shen Yanze jian Zhaokui Cai Fudong Li Mengqi Lv Yongrui Liu Jihui Wu Chuanhai Fu Yunyu Shi | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 16 | Light-emission organic solar cells with MoO_(3):Al interfacial layer-preparation and characterizations显示文摘A light-emitting organic solar cell(LE-OSC)with electroluminescence(EL)and photovoltaic(PV)properties is successfully fabricated by connecting the EL and PV units using a MoO_(3):Al co-evaporation interfacial layer,which has suitable work function and good transmittance.PV and EL units are fabricated based on poly(3-hexylthiophene)(P3HT)-indene-C60 bisadduct(IC60BA)blends,and 4,4′-bis(N-carbazolyl)biphenyl-factris(2-phenylpyridine)iridium(Ir(ppy)3),respectively.The work function and the transmittance of the MoO_(3):Al co-evaporation are measured and adjusted by the ultraviolet photoelectron spectroscopy and the optical spectrophotometer to obtain the better bi-functional device performance.The forward-and reverse-biased current density-voltage characteristics in dark and under illumination are evaluated to better understand the operational mechanism of the LE-OSCs.A maximum luminance of 1550 cd/m^(2)under forward bias and a power conversion efficiency of 0.24%under illumination(100 mW/cm^(2))are achieved in optimized LE-OSCs.The proposed device structure is expected to provide valuable information in the film conditions for understanding the polymer blends internal conditions and meliorating the film qualities. | Xinran LI Yanhui LOU Zhaokui WANG | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 17 | Establishment of a Cluster Physics Research Device显示文摘Carbon cluster beam of MeV C2-C4 has been successfully accelerated on HI-13 tandem accelerator,researches of interaction between these particles and plastic track detector CR-39 has been lead out. Since the mass energy product of analysis magnet on HI-13 tandem accelerator is 200 MeV·Amu, only low energy C2-C4 cluster beam could be deflected and analyzed in the experimental hall. | GUOJi-yu ZHAOKui NIMei-nan WUXiu-kun SUILi KONGFu-quan BAOYi-wen SUShengyong | 2003 | Annual Report of China Institute of Atomic Energy2003，，1： | 0 |
| 18 | 拟南芥ARGNAUTE 1在植物响应激素和胁迫过程中结合染色质并促进基因表达显示文摘文章简介经典的RNA干扰是指真核生物中由小RNA诱发的基因沉默。小RNA由Dicer(一种核糖核酸内切酶)从双链或具茎环结构的前体RNA加工而来,随后被RNA干扰的核心效应蛋白ARGONAUTE(AGO)家族蛋白所结合。通过小RNA与靶序列的碱基互补配对. | 刘畅 辛颖 徐乐 Zhaokui Cai Yuanchao Xue Yong Liu Daoxin Xie Yule Liu 戚益军 | 2019 | 科学新闻2019，0，2： | 0 |
| 19 | Prospects and Challenges显示文摘The future of Sino-Japanese relations is bright,but the two sides should alsolook out for potential problems Japanese Prime Minister Taro Aso paid a visit to China | FENG ZHAOKUI | 2009 | Beijing Review2009，52，19： | 0 |
| 20 | Non-reproducibility of Cross Sections Measured in Dissipative Collisions of ^(19)F+^(93)Nb显示文摘Two independent measurements of excitation functions of the strongly dissipative collision for the same reaction system of 19F+93Nb have been carried out at the China Institute of Atomic Energy, Beijing. In these measurements, the 19F8+ beam was provided by the HI-13 tandem accelerator. The incident beam energies were varied from 102 to 108 MeV in steps of 250 keV. In both measurements the same accelerator | DongYuchuan WangQi TianWendong LiSonglin JiangZhonghe LiZhichang LuXiuqin ZhaoKui FuChangbo LiuJiancheng JiangHua HuGuiqing | 2002 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2002，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员