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| 1 | Heritable gene-targeting with gRNA/Cas9 in rats显示文摘 | Xinli Hu Nannan Chang Xuelian Wang Fengyun Zhou Xiaohai Zhou Xiaojun Zhu Jing-Wei Xiong | 2013 | Cell Research2013，23，11： | 7 |
| 2 | GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy. | Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 3 | Tangnaikang improves insulin resistance and β-cell apoptosis by ameliorating metabolic inflammation in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE: To investigate the effects of Tangnaikang(TNK), a mixture of five herbal plant extracts,on inflammation-mediated insulin resistance andβ-cell apoptosis in SHR.Cg-Leprcp/NDmcr(SHR-cp)rats.METHODS: Seven-week-old SHR-cp rats were randomly divided into a control(CON) group and a TNK(3.24 g/kg) group. Wistar-Kyoto rats at the same age were used as the normal control group.After 7 weeks of continuous intragastric administration of TNK, the glucose metabolic status and insulin sensitivity of the rats were evaluated by assessing fasting serum glucose(FBG), the oral glucose tolerance test(OGTT), fasting serum insulin(FINS),and the insulin sensitivity index(ISI). Serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP) and adiponectin were measured via enzyme-linked immunosorbent assays.Macrophage infiltration and apoptosis in adipose tissues were detected through F4/80 immunohistochemistry and the terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay. Islet morphology and β-cell apoptosis were investigated using double immunofluorescence staining and the TUNEL assay. The expression of cytokine genes in adipose tissue, the liver, and the pancreas was detected in real-time polymerase chain reaction assays. The expression and phosphorylation levels of insulin signaling-, inflammation-, and β-cell survival-related proteins in the liver and pancreas of SHR-cp rats were detected by western blotting.RESULTS: TNK(3.24 g/kg) treatment significantly decreased body weight, FBG and FINS; improved impaired glucose tolerance; increased the ISI; reduced serum levels of TNF-α, CRP and IL-6; and increased serum adiponectin. The m RNA expression of inflammatory markers was markedly reduced in the liver, pancreas, and adipose tissue. F4/80-and TUNEL-positive cells in adipose tissues were decreased, as was the number of TUNEL-positiveβ-cells. The phosphorylation of c-Jun N-terminal kinase and that of insulin receptor substrate-1 at serines 307 and 1101 was significantly decreased.In the pancreas, the expression of nuclear factor kappa-light chain-enhancer of activated B cells-p65 was significantly decreased, and phosphoinositide3-kinase and IRS-2 were significantly increased.CONCLUSION: TNK was able to improve insulin resistance and β-cell apoptosis in SHR-cp rats, which might be associated with its ability to relieve the overall and local metabolic inflammatory responses observed in SHR-cp rats. | Li Linyi Hisae Yoshitomi Qin Lingling Wu Xinli Zhou Tian Wang Haiyan Jiang Yueying Wei Ying Xu Tunhai Liu Tonghua Gao Ming | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 3 |
| 4 | Heat Treatment Properties of 42CrMo Steel for Bearing Ring of Varisized Shield Tunneling Machine显示文摘The heat treatment properties of 42 CrMo steel for bearing ring of varisized shield tunneling machine were investigated by optical microscope(OM), scanning electron microscope(SEM), transmission electron microscope(TEM),and impact tests. The addition of 0.03 wt% C into 42 CrMo steel can increase the hardness. But it reduces the impact energy by 46 J because of the appearance of coarser carbides in the matrix and the carbides along the austenite grain boundary.The addition of 0.40 wt% Mn into 42 CrMo steel can improve hardenability. However, the toughness of steel is also reduced by 26 J mainly because of the coarsening of carbides and the strengthening of matrix. Both hardenability and toughness of 42 CrMo steel can be improved by adding 1.49 wt% Ni and reducing 0.32 wt% Cr. The depth of hardening layer can be raised to 45 mm, and the impact energy at-20 °C is 120 J. Thus, it is concluded that a good combination of hardness, hardenability, and toughness of 42 CrMo steel can be achieved by alloying with adding some content of C and Ni.Detailed content of C and Ni should be on the requirements of heat treatment properties of steel for bearing ring of varisized shield tunneling machine. | Bo Jiang Leyu Zhou Xinli Wen Chaolei Zhang Yazheng Liu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 3 |
| 5 | Spatio-temporal characteristics and typical patterns of eco-efficiency of cultivated land use in the Yangtze River Economic Belt, China显示文摘Identifying the dynamics of the eco-efficiency of cultivated land use(ECLU)is important to balance food security and environmental protection.The Yangtze River Economic Belt(YREB)is a vital region of national strategic development in China.However,the spatio-temporal characteristics and typical patterns of the ECLU in the YREB remain unclear.This study aims to reveal the spatio-temporal characteristics of the ECLU by using the super-efficiency slack-based measure(SBM)and a spatial autocorrelation model.The typical patterns of the ECLU were classified based on a decision tree algorithm.The results indicate that the overall ECLU increased from 0.78 to 0.87 from 2000 to 2019,dropping sharply in 2003 before rising again.Different reaches had similar trends.The local indicators of spatial association(LISA)cluster reflect that the spatial distributions of high-high and low-low agglomeration varied dramatically among these years.The ECLU was divided into three typical patterns considering the restriction of agrochemicals and water resources(RAW),cultivated land and agrochemicals(RCA),as well as technology(RT).Most cities belonged to the low ECLU category in RT pattern.Fully understanding the spatio-temporal characteristics and classification of the ECLU will provide a reference for decision-makers to improve the ECLU in different regions. | KE Xinli ZHANG Ying ZHOU Ting | 2023 | Journal of Geographical Sciences2023，33，2： | 3 |
| 6 | A full-process intelligent trial system for smart court显示文摘In constructing a smart court,to provide intelligent assistance for achieving more efficient,fair,and explainable trial proceedings,we propose a full-process intelligent trial system(FITS).In the proposed FITS,we introduce essential tasks for constructing a smart court,including information extraction,evidence classification,question generation,dialogue summarization,judgment prediction,and judgment document generation.Specifically,the preliminary work involves extracting elements from legal texts to assist the judge in identifying the gist of the case efficiently.With the extracted attributes,we can justify each piece of evidence’s validity by establishing its consistency across all evidence.During the trial process,we design an automatic questioning robot to assist the judge in presiding over the trial.It consists of a finite state machine representing procedural questioning and a deep learning model for generating factual questions by encoding the context of utterance in a court debate.Furthermore,FITS summarizes the controversy focuses that arise from a court debate in real time,constructed under a multi-task learning framework,and generates a summarized trial transcript in the dialogue inspectional summarization(DIS)module.To support the judge in making a decision,we adopt first-order logic to express legal knowledge and embed it in deep neural networks(DNNs)to predict judgments.Finally,we propose an attentional and counterfactual natural language generation(AC-NLG)to generate the court’s judgment. | Bin WEI Kun KUANG Changlong SUN Jun FENG Yating ZHANG Xinli ZHU Jianghong ZHOU Yinsheng ZHAI Fei WU | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，2： | 2 |
| 7 | Advances and perspectives in catalytic oxidation of hydrocarbons in liquid phase显示文摘This review article summarizes recent advances in catalytic oxidation of hydrocarbons,especially presents two strategies for activation of C-H bonds or molecular oxygen.Based on our own research results,the applications of the two methods in the oxidation of cyclohexane,toluene and ethyl benzene,etc.are introduced,and the perspectives of the two methods are also discussed. | Zhou Lipeng Yang Guanyu Zhang Wei Sun Zhiqiang Gao Jin Miao Hong Chen Chen Ma Hong Li Xiaoqiang Zhang Qiaohong Wang Feng Tong Xinli Xu Jie | 2007 | Progress in Natural Science:Materials International2007，17，9： | 2 |
| 8 | One-pot green procedure for Biginelli reaction catalyzed by novel task-specific room-temperature ionic liquids显示文摘 | FANG Dong LUO Jun ZHOU Xinli | 2007 | Journal of Molecular Catalysis A:Chemical2007，274，12： | 1 |
| 9 | Diversity of Cultivated and Uncultivated Actinobacterial Endophytes in the Stems and Roots of Rice显示文摘 | Xinli Tian Lixiang Cao Hongming Tan Weiqing Han Ming Chen Yuhuan Liu Shining Zhou | 2007 | Microbial Ecology2007，，4： | 1 |
| 10 | Effects of Rainfall Change on Agricultural Non-point Source Pollution in Liangping County显示文摘[Objective] The study aimed to discuss the impact of rainfall change on agricultural non-point source pollution in Liangping County. [Method]Based on daily precipitation data of Liangping from 1955 to 2011,changes of precipitation and frequency of heavy rain in Liangping during a year were analyzed firstly,and then the risk of surface runoff caused by rainfall to agricultural non-point source pollution was studied,finally changing trends of annual average precipitation and frequency during 1955-2011 were discussed using Mann-Kendal method. [Result]Total precipitation of heavy rain in Liangping mainly concentrated from late May to early September,especially in early and middle July as well as early September. Meanwhile,fertilizer and pesticide were applied to main crops in Liangping in the periods above,so agricultural non-point source pollution became more serious. In recent 57 years,annual average precipitation and frequency of heavy rain in Liangping showed an increasing trend respectively, and surface runoff rose with the increase of the precipitation,thereby probably enlarging agricultural pollution area. [Conclusion]The research could provide a theoretical basis and technical support for the control of agricultural non-point source pollution. | Hui Xie Yuling Wang Hanwen Zhang Xinli Mou Nian Zhou | 2013 | Meteorological and Environmental Research2013，4，10： | 1 |
| 11 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 12 | Bronsted acidic ionic liquids and their use as dual solvent - catalysts for Fischer esterifications 显示文摘 | FANG DONG ZHOU XINLI YE ZHIWEN | 2006 | Ind Eng Chem Res2006，45，24： | 1 |
| 13 | Blast responses of shallow-buried prefabricated modular concrete tunnels reinforced by BFRP-steel bars显示文摘This paper reports the anti-blast performance of shallow-buried prefabricated modular tunnel reinforced by basalt fiber-reinforced polymer(BFRP)-steel bars.Three concrete arch members with steel bars and three concrete arch members with BFRP-steel bars were fabricated,with the other arch parameters kept constant.The three identical arches were assembled into an integral structure and then buried in soil for field anti-blast experiments.Through the experiment,the pressure on the vault,the displacement and acceleration of the vault,the strain in the reinforcement bars and the macroscopic damage of the arches under the blast load were determined.To evaluate the damage of the arch tunnel,a residual load-bearing capacity test was conducted on the arch members after the explosion experiment.The experimental results showed that the BFRP-steel bars reinforced concrete arch exhibited a higher load-bearing capacity and more safety redundancy than the steel bars reinforced concrete arch,and that the BFRP-steel bars could inhibit the occurrence of concrete cracks to a certain extent.A comparison between the arches assembled at different positions showed that the prefabricated modular tun-nel can be simplified directly as a two-dimensional arch structure under the blast load for analysis and calculation. | Chengjie Zhao Zexun Tang Peng Wang Jiang Feng Jiannan Zhou Xinli Kong Hansheng Geng Fengnian Jin Hualin Fan | 2022 | Underground Space2022，7，2： | 1 |
| 14 | Freeze-drying of human platelets: influence of intracellular trehalose and extracellular protectants 显示文摘 | Zhou Xinli Zhu Hong Zhang Shaozhi | 2006 | Cryo Letters2006，27，1： | 1 |
| 15 | Gut microbe analysis between hyperthyroid and healthy individuals显示文摘 | Zhou Lei Li Xinli Ahmed Ayaz | 2014 | Curr Microbiol2014，69，： | 1 |
| 16 | A Meta-Analysis of Randomized Controlled Trials Comparing Irinotecan/Platinum with Etoposide/Platinum in Patients with Previously Untreated Extensive-Stage Small Cell Lung Cancer显示文摘 | Jingwei Jiang Xiaohua Liang Xinli Zhou Lizhen Huang Ruofan Huang Zhaohui Chu Qiong Zhan | 2010 | Journal of Thoracic Oncology2010，，6： | 1 |
| 17 | Gefitinib versus docetaxel in previously treated advanced non-small-cell lung cancer: A meta-analysis of randomized controlled trials显示文摘 | Jingwei Jiang Lizhen Huang Xiaohua Liang Xinli Zhou Ruofan Huang Zhaohui Chu Qiong Zhan | 2011 | Acta Oncologica2011，，4： | 1 |
| 18 | Ion compartmentation of leaf cells of Ginkgo biloba and Ailanthus altissima under salt stress显示文摘 | XIA Xinli ZHOU Xiaoyang YIN Weilun | 1999 | ForStud China1999，1，2： | 1 |
| 19 | Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population显示文摘The purpose of this study was to assess the relationship between arterial stiffness,as measured by brachial-ankle pulse wave velocity(baPWV),and the presence of the metabolic syndrome(MS)in a Chinese population.A total of 4,445 subjects were enrolled.The prevalence of MS in our study population was 21.7%,17.2%and 25.6%for the general population,males and females,respectively.With adjustments for age,gender,cigarette smoking,heart rate,total cholesterol,low-density lipoprotein(LDL)cholesterol,and the use of anti-hypertensive drug,the stepwise regression analysis showed that baPWV had a significant relationship with components of MS,including systolic blood pressure(P<0.001),diastolic blood pressure(P<0.001),glucose(P<0.001),highdensity lipoprotein(HDL)cholesterol(P=0.04),and triglycerides(P<0.001),but no relationship with waist circumference(P=0.25).With an increase in the number of the MS components,baPWV increased significantly both in women and men.This study indicated that the MS is indeed a risk factor for arterial stiffness.Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease. | Fang Zhou Haifeng Zhang Wenming Yao Hongbin Mei Dongjie Xu Yanhui Sheng Rong Yang Xiangqing Kong Liansheng Wang Jiangang Zou Zhijian Yang Xinli Li | 2014 | The Journal of Biomedical Research2014，28，4： | 1 |
| 20 | Brain metastases as the first symptom of lung cancer: a clinical study from an Asian medical center显示文摘 | Jia Jin Xinli Zhou Xiaohua Liang Ruofan Huang Zhaohui Chu Jingwei Jiang Qiong Zhan | 2013 | Journal of Cancer Research and Clinical Oncology2013，，3： | 1 |
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