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| 1 | Crustal velocity structure in the Emeishan large igneous province and evidence of the Permian mantle plume activity显示文摘The Emeishan large igneous province(ELIP) in SW China is interpreted to be associated with an ancient mantle plume. Most of the constraints on the role of mantle plume in the generation of the Emeishan flood basalts were provided by geological and geochemical methods, but the geophysical investigation is very limited. In order to better understand the deep structure and features of ELIP, we have studied the crustal velocity structure using the data acquired from the Lijiang-Panzhihua-Qingzhen wide-angle seismic profile. This profile crosses the three sub-zones of the ELIP(the inner, intermediate, and outer zones), divided based on the differential erosion and uplift of the Maokou limestone. The results provided by the active source seismic experiment demonstrate:(1) The average depth of the crystalline basement along the profile is about 2 km.(2) The middle crust in the Inner Zone is characterized by high-velocity anomalies, with the average velocity of 6.2-6.6 km/s, which is about 0.1– 0.2 km/s higher than the normal one. The velocity of the lower crust in the inner zone is 6.9-7.2 km/s, higher than those observed in the intermediate and outer zones(6.7-7.0 km/s). Relatively low velocity anomalies appear in the upper, middle and lower crusts near the junction of the inner zone and intermediate zone, probably due to the effect of the Xiaojiang fault(XJF).(3) The average velocity of the crust is comparatively low on both sides of XJF, especially on the east side, and the average velocity of the consolidated continental crust is also low there. This may suggest that the XJF extends at least down to 40 km deep, even beyond through the crust.(4) The depth to the Moho discontinuity decrease gradually from 47-53 km in the inner zone, via 42-50 km in the intermediate zone to 38-42 km in the outer zone. In the inner zone, the Moho uplifts locally and the(consolidated) crust is characterized by high-velocity anomalies, which are likely related to intensive magma intrusion and underplating associated with melting of plume head. Overall the crustal velocity structure in the study area recorded the imprint left by the Permian Emeishan mantle plume. | XU Tao ZHANG ZhongJie LIU BaoFeng CHEN Yun ZHANG MingHui TIAN XiaoBo XU YiGang TENG JiWen | 2015 | Science China Earth Sciences2015，58，7： | 36 |
| 2 | The P-wave velocity structure of the lithosphere of the North China Craton——Results from the Wendeng-Alxa Left Banner deep seismic sounding profile显示文摘For the first time on the Chinese mainland, long-range wide-angle seismic reflection/refraction profiling technology has been applied to seismic wave phases from different depths and with different attributes within the various blocks of the North China Craton to characterize the structure of the crust and upper mantle lithosphere. By comparative analysis of the seismic wave phase characteristics in each block across a 1500-km-long east-west profile, we have identified conventional Pg, Pci, PmP and Pn phases in the crust, made a clear contrast between PL1 and PL2 waves belonging to two groups of lithospheric-scale phases, and produced a model of crust-mantle velocity structures and tectonic characteristics after one- and two-dimensional calculations and processing. The results show that the thickness of the crust and lithosphere gradually deepens from east to west along the profile. However, at the reflection/refraction interface, seismic waves in each group show obvious localized changes in each block. Also, the depth to the crystalline basement changes greatly, from as much as 7.8 km in the North China fault basin to only about 2 km beneath the Jiaodong Peninsula and Taihang-Lüliang area. The Moho morphology as a whole ranges from shallow in the east to deep in the west, with the deepest point in the Ordos Block at 47 km; in contrast, the North China Plain Block is uplifting. The L1 interface of the lithosphere is observed only to the west of Taihang Mountains, at a relatively slowly changing depth of about 80 km. The L2 interface varies from 75 to 160 km and shows a sharp deepening to the west of Taihang Mountains, forming a mutation belt. | WANG ShuaiJun WANG FuYun ZHANG JianShi JIA ShiXu ZHANG ChengKe ZHAO JinRen LIU BaoFeng | 2014 | Science China Earth Sciences2014，57，9： | 26 |
| 3 | Three-dimensional crustal velocity structure model of the middle-eastern north China Craton (HBCrust1.0)显示文摘Lithosphere thinning and destruction in the middle-eastern North China Craton(NCC), a region susceptible to strong earthquakes, is one of the research hotspots in solid earth science. All 42 seismic wide-angle reflection/refraction profiles have been completed in the middle-eastern NCC. We collect all the 2-D profiling results and perform gridding of the velocity and interface depth data, building a 3-D crustal velocity structure model for the middle-eastern NCC, named HBCrust1.0, by using the Kriging interpolation method. Our result shows that the first-arrival times calculated by HBCust1.0 fit well with the observations. The result demonstrates that the upper crust is the main seismogenic layer, and the brittle-ductile transition occurs at depths near interface C(the interface between upper and lower crust). The depth of interface Moho varies beneath the source area of the Tangshan earthquake, and a low-velocity structure is found to extend from the source area to the lower crust. Based on these observations, it can be inferred that stress accumulation responsible for the Tangshan earthquake may have been closely related to the migration and deformation of the mantle materials. Comparisons of the average velocities of the whole crust, the upper and the lower crust show that the average velocity of the lower crust under the central part of the North China Basin(NCB) in the east of the craton is obviously higher than the regional average. This high-velocity probably results from long-term underplating of the mantle magma. | DUAN YongHong WANG FuYun ZHANG XianKang LIN JiYan LIU Zhi LIU BaoFeng YANG ZhuoXin GUO WenBin WEI YunHao | 2016 | Science China Earth Sciences2016，59，7： | 24 |
| 4 | Atrial remodeling in atrial fibrillation and association between microRNA network and atrial fibrillation显示文摘Atrial fibrillation(AF) remains one of the leading causes of morbidity and mortality in the world which are related to palpitations,fainting,congestive heart failure or stroke.The mechanism for atrial fibrillation has been identified as electrical remodeling,structure remodeling and intracellular calcium handling remodeling.microRNAs(miRNAs) have recently emerged as one of the important factors in regulating gene expression.So far,thousands of miRNA genes have been found in diverse animals with the function of regulating cell death,cell proliferation,haematopoiesis and even participate in the processing of cardiovascular disease.In this review,we summarize the mechanism of AF and the association of microRNAs network with AF.We provide a potential perspective of miRNAs as the therapeutic target for AF. | ZHANG Ying DONG DeLi YANG BaoFeng | 2011 | Science China(Life Sciences)2011，54，12： | 15 |
| 5 | 2-D P-wave velocity structure of lithosphere in the North China tectonic zone: Constraints from the Yancheng-Baotou deep seismic profile显示文摘We obtained the 2-D P-wave velocity structure of the lithosphere in the eastern North China Craton, Shanxi fault subsidence zone, and Yinchuan-Hetao fault subsidence zone by ray tracking technology based on six groups of clearly identified crustal phases and one group of lithospheric interface reflection phases from seismic recording sections of 21 shots along the 1300-km-long Yancheng-Baotou deep seismic wide-angle reflection/refraction profile. The results indicate significant differences between the lithospheric structure east and west of the Taihang Mountains, which is a gravity-gradient zone as well as a zone of abrupt change in lithospheric thickness and a separation zone of different rock components. East of the Taihang Mountains, the Mesozoic and Cenozoic lithospheric structure of the North China Craton has undergone strong reformation and destruction, resulting in the lithosphere thickness decreasing to 70–80 km. The North China Basin has a very thick Cenozoic sedimentary cover and the deepest point of crystalline basement is about 7.0 km, with the crustal thickness decreasing to about 31.0 km. The crystalline basement of the Luxi uplift zone is relatively shallow with a depth of 1.0–2.0 km and crustal thickness of 33.0–35.0 km. The Subei Basin has a thicker Cenozoic sedimentary cover and the bottom of its crystalline basement is at about 5.0–6.0 km with a crustal thickness of 31.0–32.0 km. The Tanlu fault is a deep fracture which cuts the lithosphere with a significant velocity structure difference on either side of the fault. The Tanlu fault plays an important role in the lithospheric destruction in the eastern part of the North China Craton. West of the Taihang Mountains, the crustal thickness increases significantly. The crust thickness beneath the Shanxi fault depression zone is about 46 km, and there is a low-velocity structure with a velocity of less than 6.1 km s?? in the upper part of the middle crust. Combined with other geophysical study results, our data shows that the lithospheric destruction at the Shaanxi-Shanxi fault depression zone and the Yinchuan-Hetao rift surrounding the Ordos block is non-uniform. The lithosphere thickness is about 80–90 km in the Datong-Baotou area, 75–137 km at the Dingxiang-Shenmu region, and about 80–120 km in the Anyang-Yichuan area. The non-uniform lithospheric destruction may be related to the ancient tectonic zone surrounding the Ordos block. This zone experienced multi-period tectonic events in the long-term process of its tectonic evolution and was repeatedly transformed and weakened. The weakening level is related to the interactions with the Ordos block. The continental collision between the Cenozoic India and Eurasia plates and N-E thrusting by the Qinghai Tibet Plateau block is causing further reformation and reduction of the lithosphere. | DUAN YongHong LIU BaoJin ZHAO JinRen LIU BaoFeng ZHANG ChengKe PAN SuZhen LIN JiYan GUO WenBin | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 6 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 7 | Mechanical and Morphological Properties of Highly Dispersed Carbon Nanotubes Reinforced Cement Based Materials显示文摘Stable homogeneous suspensions of multi-walled carbon nanotubes (MWCNTs) were prepared using gum arabic (GA) as dispersant and were incorporated to Portland cement paste. The dispersion was examined by ultraviolet visible spectroscopy (UV-vis), and the concentration measurement shows that the optimum concentration of GA is 0.45 g L-1. The dispersibility of the surface-modified MWCNTs in aqueous solution and cement matrix were investigated by transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS), and the mechanical properties of the composites were investigated. The results show that the addition of the treated nanotubes can improve both the flexural strength and the compressive strength of the Portland cement composite significantly. The flexural strength of the composite increases up to 43.38% with the MWCNT concentration of 0.08% (by weight of cement). The porosity and pore size distribution of the composites were measured by mercury intrusion porosimetry (MIP), and the results indicate that the cement paste doped with MWCNTs obtained lower porosity and concentrated pore size distribution. The morphological structure was analyzed by field emission scanning electron microscopy (FESEM) and EDS. It is shown that MWCNTs act as bridges and networks across cracks and voids, which transfer the load in case of tension, and the interface bond strength between the nanotubes and matrix is very strong. | 王宝民 HAN Yu PAN Baofeng ZHANG Tingting | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，1： | 13 |
| 8 | Study on the velocity structure of the crust in Southwest Yunnan of the north-south seismic belt—Results from the Menghai-Gengma-Lushui deep seismic sounding profile显示文摘Southwest Yunnan, located in the southern segment of the north-south seismic belt, is one of the regions with strong tectonic movement and seismic activity in China. Study on the characteristics of tectonic setting and deep geophysical field in the region is an important issue in basic science. In 2013, we conducted a 600-km-long Menghai-Gengma-Lushui profile of deep seismic wide-angle reflection/refraction and high-resolution seismic refraction in Southwest Yunnan. In this paper, we use 6 groups of clear intracrustal P-wave phases picked from the seismic record sections of 11 shots to build a velocity structure model of basement and 2D crustal P-wave of the region by using finite difference inversion and ray travel time forward fitting technology. The results show that, from south to north, the crust gradually thickens along the profile and its basement shows a significant lateral heterogeneity. In the vicinity of the Nanting River fault, the basement structure shows the character of alternate depressions and uplifts, and the shallowest basement is about 1.0 km. In the vicinity of Tengchong and Lancang, the basement is about 5.0 km deep. The velocity of the middle and lower crust in the region generally increases with the increasing of depth. At the block boundary and beneath the fault tectonic belt, the velocity contours show apparent irregularity and the P-wave velocity changes sharply. In this region, the Moho gradually deepens from south to north with relatively large lateral undulations. The shallowest point of the Moho is located near Menghai at a depth of about 32.0 km. The deepest point of the Moho is located near Tengchong at a depth of about 40.5 km. Between Gengma and Yongde, the Moho shows significantly fast uplifting and depressing with an amplitude of about 4.0 km. Beneath the Nanting River fault, Longling-Ruili fault, Dayingjiang fault and Tengchong volcano, the basement velocity structure, 2D crustal P-wave velocity structure, distribution of average profile velocity and intracrustal interface spreading also show significant changes from the basement to the top of the Moho, indicating that the crustal velocity and medium physical properties beneath the fault tectonic belt are apparently different from the crustal materials on its both sides, which suggests that these faults should be in a certain scale and may extend to the lower crust or the top of the upper mantle. The earthquakes in the region mainly occurred at a depth of 10–20 km, and the seismic activity is related to the intracrustal medium velocity difference and fault belt distribution. The results can serve as the important data of the crust-mantle structure for the analysis of the deep tectonic setting, earthquake precise positioning, seismogenic structure modeling of the seismic activities in Southwest Yunnan, as well as the important reference for the evaluation of seismic hazard and the planning of earthquake disaster mitigation of this region. | WANG ShuaiJun LIU BaoJin ZHANG JianShi LIU BaoFeng DUAN YuLing SONG XiangHui DENG XiaoGuo MA CeJun ZANG YiRan | 2015 | Science China Earth Sciences2015，58，12： | 13 |
| 9 | Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3显示文摘Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective of this study is to determine the effects of emodin on cardiac fibrosis and the underlying molecular mechanisms. Intragastric administration of emodin markedly decreased left ventricular wall thickness in a mouse model of pathological cardiac hypertrophy with excess fibrosis induced by transaortic constriction(TAC) and suppressed activation of cardiac fibroblasts induced by angiotensin II(AngII). Emodin upregulated expression of metastasis associated protein 3(MTA3) and restored the MTA3 expression in the setting of cardiac fibrosis. Moreover, overexpression of MTA3 promoted cardiac fibrosis;in contrast, silence of MTA3 abrogated the inhibitory effect of emodin on fibroblast activation. Our findings unraveled the potential of emodin to alleviate cardiac fibrosis via upregulating MTA3 and highlight the regulatory role of MTA3 in the development of cardiac fibrosis. | Dan Xiao Yue Zhang Rui Wang Yujie Fu Tong Zhou Hongtao Diao Zhixia Wang Yuan Lin Zhange Li Lin Wen Xujuan Kang Philipp Kopylov Dmitri Shchekochikhin Yong Zhang Baofeng Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 11 |
| 10 | Deep structure at northern margin of Tarim Basin显示文摘In this paper, a 2D velocity structure of the crust and the upper mantle of the northern margin of the Tarim Basin (TB) has been obtained by ray tracing and theoretical seismogram calculation under the condition of 2D lateral inhomogeneous medium using the data of seismic wide angle reflection/refraction profile from Baicheng to Da Qaidam crossing the Kuqa Depression (KD) and Tabei Uplift (TU). And along the Baicheng to Da Qaidam profile, 4 of the 10 shot points are located in the northern margin of the TB. The results show that the character of the crust is uniform on the whole between the KD and TU, but the depth of the layers, thickness of the crust and the velocity obviously vary along the profile. Thereinto, the variation of the crust thickness mainly occurs in the middle and lower crust. The Moho has an uplifting trend near the Baicheng shot point in KD and Luntai shot point in TU, and the thickness of the crust reduces to 42 km and 47 km in these two areas, respectively. The transition zone between the KD and TU has a thickest crust, up to 52 km. In this transition zone, there are high velocity anoma-lies in the upper crust, and low velocity anomalies in the lower crust, these velocity anomalies zone is near vertical, and the sediment above them is thicker than the other areas. According to the velocity distributions, the profile can be divided into three sections:KD, TU and transition zone between them. Each section has a special velocity structural feature, the form of the crystalline basement and the relationship between the deep structure and the shallow one. The differences of velocity and tectonic between eastern and western profile in the northern margin of the Tarim Basin (NMTB) may suggest different speed and intensity of the subduction from the Tarim basin to the Tianshan orogenic belt (TOB). | ZHAO JunMeng CHENG HongGang PEI ShunPing LIU HongBing ZHANG JianShi LIU BaoFeng | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 11 | North China sub-craton lithospheric structure elucidated through coal mine blasting显示文摘We present a super-range seismic observation along the >1300-km-long profile passing through the Yinchuan basin and the Ordos block from the blasting point towards the southeast triggered by a large-(dynamite) scale coal blast in the Ningxia Hui Autonomous Region's Helan Mountain (yielded a profile). The seismic wave information from the uppermost mantle reflecting different depths was obtained by the China continental seismic survey. Pn refracted waves from the uppermost mantle were effectively traced up to 500 km and beyond. The stable dynamic and kinematic characteristics of the Pn wave-group indicate that the uppermost mantle below the Ordos block is a gently changing structure with a weak positive gradient. If Pm1, Pm2 waves are considered as the wave groups from the upper mantle, there may be distinct structural strata in the upper-mantle structures with average velocities of 7.70―7.80 km/s and 8.10―8.20 km/s, respectively. Based on the travel-time curve feature of Pm1, Pm2 waves, there may be a certain layer with a reverse velocity between the M1 and M2 interfaces. The depth range indicated by them is about 110―120 km and 200―220 km. These phenomena basically reflect the structural features of the upper-mantle lithosphere in this region. The information obtained may provide meaningful references for surveying North China craton lithospheric structures, as well as under-standing the shapes and structures of different spherical layers within the upper-mantle. | ZHAO JinRen ZHANG XianKang WANG FuYun ZHANG ChengKe ZHANG JianShi LIU BaoFeng PAN SuZhen | 2009 | Chinese Science Bulletin2009，54，4： | 7 |
| 12 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 13 | Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma显示文摘 | Lai Zhiyong Qin Qin Yu Baofeng Xie Jun Gao Ranpeng Zhang Tiantian Li Chunfeng Niu Kai Xu Jun | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 14 | Caveolin proteins: a molecular insight into disease显示文摘 | Hongli Yin Tianyi Liu Ying Zhang Baofeng Yang | 2016 | Frontiers of Medicine2016，10，4： | 6 |
| 15 | Isolation and characterization of mesenchymal stem-like cells from human nucleus pulposus tissue显示文摘Dear Editor,Large numbers of individuals experience low back pain(LBP)during their lifetime[1,2].LBP excruciates approximately 80%aging population and causes significant socio-economic problem[3,4].LBP often originates from the intervertebral disc degeneration(IVDD).The intervertebral disc(IVD)is a specialized biomechanical complex composed of a hyper-hydrated and oligocellular central structure, | SHEN Quan ZHANG Li CHAI BaoFeng MA Xun | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 16 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 17 | HYD-PEP06 suppresses hepatocellular carcinoma metastasis,epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation显示文摘HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anticolorectal carcinoma effects through inhibiting epithelial-mesenchymal transition(EMT).However,whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma(HCC) remained unknown.In this study,HYD-PEP06 inhibited metastasis and EMT but not proliferation in vitro.Cignal finder pathway reporter array and Western blot analysis revealed that HYD-PEP06 suppressed HCCLM3 cell metastasis and EMT by inhibiting the PI3 K/AKT pathway.Moreover,HYD-PEP06 exerted antimetastasis effects in HepG2 cancer stem-like cells(CSCs) via suppressing the WNT/β-catenin signaling pathway.Finally,in HCCLM3 tumor-bearing BALB/c nu/nu nude mice,HYD-PEP06 substantially suppressed tumor growth,lung metastasis and HCC progress.Our results suggest that HYD-PEP06 inhibits the metastasis and EMT of HCC and CSCs as well,and thus has the potential as an agent for HCC treatment. | Wei Tian Jiatong Li Zhuo Wang Tong Zhang Ying Han Yanyan Liu Wenfeng Chu Yu Liu Baofeng Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 5 |
| 18 | Scaling behavior of magnitude clusters in aftershock sequence:An example of the Wenchuan Earthquake,China显示文摘The Gutenberg-Richter and Omori Laws, which are generally used to characterize the temporal distribution of aftershock, failed to reflect the statistic properties of climatic outbreak of aftershock energy. Based on a new concept of magnitude clusters describing the fluctuation of aftershock energy release of the Wenchuan Earthquake, we discovered that the pattern of the continuous high-magnitude aftershock follows a power-law rather than a non-Poisson distribution. This suggests that the after-shocks with high magnitudes are statistically clustered. We then divided the aftershock sequences into three sections and demonstrated that though the probability of strong outbreaks decreased with time, there exists a high possibility of the occurrence of isolated high-magnitude aftershocks in the future. Based on self-organized criticality theory, the mechanisms of the power-law pattern of magnitude clusters are discussed. This discovery may be used to guide future aftershock predication and the associated post-disaster reconstruction. | ZHANG Bin SHI Kai LIU ChunQiong YAO LingKan DI BaoFeng AI NanShan | 2012 | Science China Earth Sciences2012，55，3： | 4 |
| 19 | An extract from the earthworm Eisenia fetida non-specifically inhibits the activity of influenza and adenoviruses显示文摘OBJECTIVE:To test the in vitro antiviral activity of a crudetissueextract(CTE)fromtheearthwormEisenia fetida,determine any effective components in the CTE,andelucidatepossiblemechanismsofaction.METHODS:A CTE was made by homogenizing earthworms,followed by treatment with ammonium sulfate,then thermal denaturation.Inhibition of virus-induced cytopathic effect(CPE) was used to assess antiviral activity.Chromatographic analysis was used to identify effective components in the CTE.RESULTS:The CTE inhibited viral CPE at non-cytotoxic concentrations.Chromatography indicated that antiviral components corresponded to three active peaks indicative of proteases,nucleases and lysozymes.For adenoviruses,reduction in viral activity occurred for 100 μg/mL CTE.The reduction in adenoviral activity for four fractions was 100%,91.8%,86.9%,and 94.7%.For influenza viruses,reduction in viral activity of 100%,86.6%,69.1% and 88.3% was observed for 37 μg/mL CTE.In addition,three active fractions mixture had stronger antiviral activity(98.7% and 96.7%) than three fractions alone.Gel electrophoresis results indicated that nucleases from E.fetida could degrade the genome of influenza viruses and adenoviruses.CONCLUSION:The earthworm CTE displayed non-specific antiviral properties,possibly mediated by a combination of proteases,nucleases and lysozymes.Nucleases likely participate in the antiviral process,and degrade the genome of the virus thereby preventing further replication. | Zhizhen Liu Jianhua Wang Jianlin Zhang Baofeng Yu Bo Niu | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 4 |
| 20 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
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