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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Interactions between water vapor and atmospheric aerosols have key roles in air quality and climate change显示文摘INTRODUCTION Atmospheric aerosols,which are ubiquitous in the planetary boundary layer, have received much attention due to their effects on visibility,climate and human health.Water,a semi-volatile species,is ubiquitous in the atmosphere as well.The interaction between water vapor and aerosols plays a key role in determining the aerosol properties in the atmosphere and therefore has great effects on both air quality (Fig.la and b)and climate change (Fig.lc),which is depicted in Fig.1 as a function of atmospheric relative humidity (RH)and temperature. | Zhijun Wu Jie Chen Yu Wang Yishu Zhu Yuechen Liu Bai Yao Yuanhang Zhang Min Hu | 2018 | National Science Review2018，5，4： | 4 |
| 3 | Compositional and structural study of ash deposits spatially distributed in superheaters of a large biomass-fired CFB boiler显示文摘Recognizing the nature and formation progress of the ash deposits is essential to resolve the deposition problem hindering the wide application of large-scale biomass-fired boilers.Therefore,the ash deposits in the superheaters of a 220 t/h biomass-fired CFB boiler were studied,including the platen(PS),the high-temperature(HTS),the upper and the lower low-temperature superheaters(LTS).The results showed that the deposits in the PSs and HTSs were thin(several millimeters)and compact,consisting of a yellow outer layer and snow-white inner layer near the tube surface.The deposits in the upper LTS appeared to be toughly sintered ceramic,while those in the lower LTS were composed of dispersive coarse ash particles with an unsintered surface.Detailed characterization of the cross-section and the initial layers in the deposits revealed that the dominating compositions in both the PSs and the HTSs were Cl and K(approximately 70%)in the form of KCl.Interestingly,the cross-section of the deposition in the upper LTS exhibited a unique lamellar structure with a major composition of Ca and S.The contents of Ca and Si increased from approximately 10%to approximately 60%in the deposits from the high temperature surfaces to the low temperature ones.It was concluded that the vaporized mineral matter such as KCl played the most important role in the deposition progress in the PS and the HTS.In addition,although the condensation of KCl in the LTSs also happened,the deposition of ash particles played a more important role. | Yishu XU Xiaowei LIU Jiuxin QI Tianpeng ZHANG Minghou XU Fangfang FEI Dingqing LI | 2021 | Frontiers in Energy2021，15，2： | 3 |
| 4 | Much enhanced electromagnetic wave absorbing properties from the synergistic effect of graphene/γ-graphyne heterostructure in both gigahertz and terahertz band ranges显示文摘Exploring advanced electromagnetic wave(EMW)absorbers is one of the most feasible ways to solve the increasing electromagnetic pollution in both military and civil fields.In this work,γ-graphyne(γ-GY)is synthesized by a mechanochemical route using CaC2 and hexabromobenzene(PhBr6).Then three-dimensional(3D)reduced graphene oxide/γ-GY(RGO/GY)heterostructures are prepared through facile solvothermal self-assembly and subsequent thermal reduction.The influences of calcination temperature and the content ofγ-GY of the composite on EMW absorption performance are fully investigated.The minimum reflection loss(RL)value of the RGO/GY composite foam is−71.73 dB at 10.48 GHz with the matching thickness of 3.54 mm,and the effective absorption bandwidth(EAB)less than−10 dB is 7.36 GHz.Moreover,excellent terahertz(THz)absorption property is also obtained at 0.2–1.6 THz.The RL of 84.08 dB is acquired,and the EAB covers 100%of the entire measured bandwidth.In addition,the composite is also a promising anticorrosive EMW absorber.This work provides encouraging findings,which are also instructive for the potential advantages of graphyne-based materials as highly efficient EMW absorbers in both gigahertz and terahertz band ranges. | Zhiwei Zhang Zhuo Li Lun Xia Ruofeng Wang Yishu Cao Zheng Cheng Yi Huang | 2023 | Nano Research2023，16，1： | 2 |
| 5 | Effect of Rapeseed Straw on Growth and Slaughter Performance of Sichuan White Goose显示文摘[Objective] The paper was to study the effects of rapeseed straw on growth and slaughter performance of Sichuan white goose.[Method]Totally 4003-day-old Sichuan white geese were randomly divided into four groups; geese in control group were fed with the fundamental diet; geese in group 1,group 2 and group 3 were fed with the fundamental diet containing 5%,10% and 10% rapeseed straw instead of equal amount of wheat bran,respectively.The body weight and slaughter performance of Sichuan white geese in control group,group 1 and group 2 were determined at 10 weeks of age,while those in group 3 were determined at14 weeks of age.[Result] There was no significant difference in gross weight,slaughter weight,eviscerated weight with giblet,head weight,sole weight,wing weight,neck weight,muscular stomach weight and intestine indexes of 10-week-old white geese between group 1 and control group,and between group 2 and control group( P > 0.05); the live weight slightly decreased.The growth and slaughter performance of 14-week-old Sichuan white geese were significantly higher than that of 10-week-old geese( P < 0.05),with better meat and flavor,but relatively low average daily gain( P < 0.05); there was no significant impact on muscular stomach p H and intestinal p H( P > 0.05).[Conclusion]Substituting partial wheat bran with rapeseed straw can satisfy the diet requirement of Sichuan white geese,but has no significant impact on its growth and slaughter performance( P > 0.05). | Yang Ting Lei Zhengda Zhang Yishu Yu Zhiqiang Wang Dayi | 2017 | Animal Husbandry and Feed Science2017，9，6： | 1 |
| 6 | Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering显示文摘 | Xuebin Chen Fang Zhang Xinhong He Yinsheng Xu Zhiping Yang Li Chen Shaomei Zhou Yishu Yang Zhixiang Zhou Wang Sheng Yi Zeng | 2012 | Injury2012，，： | 1 |
| 7 | Identifi cation of targets and mechanisms for Eleutheroside E in the treatment of cancer显示文摘Eleutheroside E(EE)is a monomer compound isolated from Acanthopanax senticosus,which has functions of antifatigue,antioxidation,and immune regulation.However,the function of EE in inhibiting cancer has rarely been reported.In this study,we used bioinformatics to determine the role and mechanisms of EE in inhibiting breast cancer(BRCA),prostate cancer(PRAD),lung cancer(LUAD),and bladder cancer(BLCA).Finally,the MTT method was used to evaluate the inhibitory effect of EE on breast cancer MDA-MB-231 cells,and the target genes were determined by qRT-PCR.The results showed that the survival rate of MDA-MB-231 cells was reduced by 27.33%after 400μg/mL EE treatment.The results of qRT-PCR showed that EE down-regulated target genes in breast cancer cells,which was consistent with our predicted results.Moreover,our results indicated that EE may have impact on the transcription and translation of BLCA cells by targeting ADCY2,ADCY5 and JUN.In BRCA,we identified three targets for EE.In addition,EE affected DNA repair and the development of BRCA by affecting the expression of RAD51.In LUAD,we identified 9 targets for EE,8 of which were related to DNA repair.EE inhibited PRAD by targeting ADCY8.Our research was the first report on the targets and mechanisms of EE for suppressing cancer combined with clinical data.Our research also provides theoretical support for using EE to suppress cancer. | Deyong Zeng Yi Xiong Yishu Yin Shan Shan Fangyuan Duan Xin Gao Chen Song Mengyao Liu Yingchun Zhang Weihong Lu | 2022 | Journal of Future Foods2022，2，1： | 0 |
| 8 | STUDY ON THE FORMATION OF DEFECTS IN DURALUMIN FORGINGS显示文摘The mechanism of forming defects in 2024. 7075 series aluminium alloy forgings has been studiedby means of metallography. EDAX. SEM etc. The defects are divided into two types by their appearance.needle-shaped and flake-shaped. The mechanism of them forming is discussed. It has been testified that thedefects result from hydrogen or oxide film. The defects can be prevented by controlling the hydrogen contentin the melt and keeping oxide film from involving. | Zhang Shenghua Zhu Xuxia Lin Gaoyong Hu Zehao(Department of Materials Science and Engineering. Central South University ofTechnology, Changsha 410083, China)Deng Dongqiao Yan Wenming Wu Shigao Chen Yishu(Southwest Aluminium Fabrication Plant, Chongq | 1997 | Journal of Central South University1997，9，1： | 0 |
| 9 | Two-dimensional oxide derived from high-temperature liquid metals via bubble templating显示文摘Two-dimensional(2D)oxide can be continuously produced by bubbling oxygen into liquid metals and the harvesting of these oxide relies on the proper choice of dispersion solvents.The mass-production of ligand-free 2D materials from high melting-point metals will not be possible if the limited stability of the traditional dispersion solvents is not circumvented.Herein,liquid tin was used for the first time in the bubbling protocol and 2D tin oxide was obtained in molten salts.The nanosheets were studied with combined microscopic and spectroscopic techniques,and high-density grain boundaries was identified between the sub-5-nm nano-crystallites in the nanosheets.It gives rise to the high performance in electrocatalytic CO_(2) reduction reaction.Density-functional-theory based calculation was applied to achieve a deeper understanding of the relationship between the activity,selectivity,and the grain-boundary features.The molten-salt based protocol could be explored for the synthesis of a library of functional 2D oxides. | Zheng Hu Tingbiao Yuan Hui Li Yishu Qiu Wei Zhou Jiangwei Zhang Yuxin Zhao Shi Hu | 2021 | Nano Research2021，14，12： | 0 |
| 10 | Identifying Vital Nodes in Social Networks Using an Evidential Methodology Combining with High-Order Analysis显示文摘Identifying vital nodes is a basic problem in social network research.The existing theoretical framework mainly focuses on the lowerorder structure of node-based and edge-based relations and often ignores important factors such as interactivity and transitivity between multiple nodes.To identify the vital nodes more accurately,a high-order structure,named as the motif,is introduced in this paper as the basic unit to evaluate the similarity among the node in the complex network.It proposes a notion of high-order degree of nodes in complex network and fused the effect of the high-order structure and the lower-order structure of nodes,using evidence theory to determine the vital nodes more efficiently and accurately.The algorithm was evaluated from the function of network structure.And the SIR model was adopted to examine the spreading influence of the nodes ranked.The results of experiments in different datasets demonstrate that the algorithm designed can identify vital nodes in the social network accurately. | Meng Zhang Guanghui Yan Yishu Wang Ye Lv | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 11 | Effects of Space Flight on Expression of Key Proteins in Rice Leaves显示文摘As a unique form of abiotic stress, the environmental conditions of outer space are expected to induce changes in plant genomes, proteomes and metabolic pathways. However, the effect of outer space conditions on the overall physiology of plants at the protein level has yet to be reported. To investigate the effects of outer space conditions on the growth-and development-related physiological processes and metabolic pathways of rice different stages, the seeds of rice variety DN423 were sent into orbit for 12.5 d aboard the SJ-10 Returning Satellite, and then the seedlings of both treated and control rice were compared at the three-leaf stage(TLS) and tillering stage(TS). In addition to comparing plant growth and reactive oxygen species(ROS) levels, seedling proteomes were also compared using isobaric tags for relative and absolute quantitation(i TRAQ). Space flight increased TLS plant height by 20%, reduced and increased ROS levels of the TLS and TS seedlings, respectively, and affected the expression of 36 and 323 proteins in TLS and TS leaves, respectively. Furthermore, the functions of the differentially abundant proteins were mainly associated with metabolism, energy, and protein synthesis and degradation. These results suggested that the exposure of seeds to outer space conditions affects the subsequent abundance of key signaling proteins, gene expression, and the processes of protein synthesis and degradation, thereby affecting metabolic processes and promoting adaptation to the abiotic stress of outer space. As such, the present study sheds light on the effects of space flight on plants and contributes to a more comprehensive understanding of extraterrestrial biology. | Zeng Deyong Cui Jie Yin Yishu Zhang Meng Shan Shan Gao Xin Zhang Yingchun Sun Yeqing Lu Weihong | 2020 | Rice science2020，27，5： | 0 |
| 12 | Core processing neuron-enabled circuit motifs for neuromorphic computing显示文摘Based on brain-inspired computing frameworks,neuromorphic systems implement large-scale neural networks in hardware.Although rapid advances have been made in the development of artificial neurons and synapses in recent years,further research is beyond these individual components and focuses on neuronal circuit motifs with specialized excitatory-inhibitory(E-I)connectivity patterns.In this study,we demonstrate a core processor that can be used to construct commonly used neuronal circuits.The neuron,featuring an ultracompact physical configuration,integrates a volatile threshold switch with a gate-modulated two-dimensional(2D)MoS2 field-effect channel to process complex E-I spatiotemporal spiking signals.Consequently,basic neuronal circuits are constructed for biorealistic neuromorphic computing.For practical applications,an algorithm-hardware co-design is implemented in a gatecontrolled spiking neural network with substantial performance improvement in human speech separation. | Hanxi Li Jiayang Hu Anzhe Chen Yishu Zhang Chenhao Wang Beiduo Wang Yi Tong Jiachao Zhou Kian Ping Loh Yang Xu Tawfique Hasan Bin Yu | 2023 | InfoMat2023，5，11： | 0 |
| 13 | Photoredox-neutral ring-opening pyridylation of cyclic oximes via phosphoranyl radical-mediated N-O/C-C bond cleavages and sequential radical-radical coupling显示文摘A novel photoredox-neutral ring-opening pyridylation of non-prefunctionalized cyclic oximes has been accomplished through phosphoranyl radical-mediated N-O/C-C bond cleavages followed by radicalradical coupling.This mild acid-,base-,and oxidant-free protocol provides highly site-selective and efficient access to distally pyridylated alkylnitriles,which could be scale-up synthesized and readily converted into skeletally diverse compounds.Notably,the oxidized ground-state photocatalyst generated via the SET oxidation of the highly reducing excited-state photocatalyst by cyanopyridines might initiate the following phosphoranyl radical-mediated deoxygenative process. | Ting Zou Yishu He Rui Liu Yihao Zhang Siping Wei Ji Lu Jun Wang Lin Wang Qiang Fu Dong Yi | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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