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| 1 | Identification of gamyb-4 and Analysis of the Regulatory Role of GAMYB in Rice Anther Development显示文摘In higher plants,male reproductive development is a complex biological process that includes cell division and differentiation,cell to cell communication etc.,while the mechanism underlying plant male reproductive development remains less understood.GAMYB encodes a gibberellins acid(GA) inducible transcription factor that is required for the early anther development in rice(Oryza sativa L.).Here,we report the isolation and characterization of a new allele gamyb-4 with a C base deletion in the second exon(+2308),causing a frame shift and premature translational termination.Histological analysis showed that gamyb-4 developed abnormal enlarged tapetum and could not undergo normal meiosis.To understand the regulatory role of GAMYB,we carried out quantitative reverse transcription-polymerase chain reaction analysis and comparison of microarray data.These results revealed that the expression of TDR(TAPETUM DEGENERATION RETARDATION),a tapetal cell death regulator,was downregulated in gamyb-4 and udt1(undeveloped tapetum1).While the GAMYB expression was not obviously changed in tdr and udt1-1,and no apparent expression fold change of UDT1 in tdr and gamyb-4,suggesting that TDR may act downstream of GAMYB and UDT1,and GAMYB and UDT1 work in parallel to regulate rice early anther development.This work is helpful in understanding the regulatory network in rice anther development. | Zhenhua Liu Wenjie Bao Wanqi Liang Jingyuan Yin Dabing Zhang | 2010 | Journal of Integrative Plant Biology2010，52，7： | 35 |
| 2 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 3 | Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization显示文摘 | Wanglin Lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu Zheng Liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang | 2014 | Nano Research2014，7，6： | 36 |
| 4 | Monolayer Graphene as a Saturable Absorber in a Mode-Locked Laser显示文摘我们证明单层 graphene 的内在的性质允许它当时,为锁模式的纤维激光充当一个更有效的可饱和的吸收器与多层的 graphene 相比。单层 graphene 的吸收能与多层的 graphene,有像皱纹的缺点的 graphene,或 functionalized graphene 相比在更低的刺激紧张被浸透。单层 graphene 有 65.9% 的显著地大的调整深度,而多层的 graphene 的调整深度极大地由于 nonsaturable 吸收被减少并且散布损失。微微秒 ultrafast 激光脉搏(1.23 ps ) 能作为一个可饱和的吸收器用单层 graphene 被产生。由于 ultrafast 松驰时间,更大的调整深度和单层 graphene 的更低的散布损失,它以塑造能力,脉搏稳定性,和产量精力的脉搏比多层的 graphene 更好表现。 | Qiaoliang Bao Han Zhang Zhenhua Ni Yu Wang Lakshminarayana Polavarapu Zexiang Shen Qing-Hua Xu Dingyuan Tang Kian Ping Loh | 2011 | Nano Research2011，4，3： | 25 |
| 5 | Study of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d broiler chickens显示文摘To study the influence of different levels of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d Arbor Acres(AA) broilers, a total of 800 one-day-old healthy broilers were randomly divided into 5 groups with 4 replicates per group and 40 broilers per replicate. Broilers were fed a basic diet(group 1) which acted as the control group, and 4 other groups(2 to 5) were fed the basal diet with B. subtilis added at concentrations of 100, 150, 200 and 250 mg/kg, respectively for 42 days. The results showed as follow: the average daily gain(ADG) of group 4 was significantly higher than(P < 0.05) that of group 1, and the average daily feed intake(ADFI) of group 5 was the highest but the differences between groups were not significant(P > 0.05). The feed to gain ratio(F/G) of all the experimental groups was lower than that of the control and the difference was significant in group 4(P < 0.05). In addition, supplementation of B. subtilis increased the apparent metabolism of crude protein(P > 0.05), crude fat(P > 0.05), dry matter(P > 0.05) and organic matter(P < 0.05). B. subtilis decreased the Escherichia coli and Salmonella populations in the cecum. This shows that adding B. subtilis to the broiler diet can improve the growth performance, increase feed efficiency, regulate serum index and reduce harmful bacteria in the intestinal tract. Based on our study, it could be recommended that addition of B. subtilis at 200 mg/kg could improve the growth performance of broilers. | Zhenhua Gao Haohao Wu Lin Shi Xiaohui Zhang Ran Sheng Fuquan Yin Ravi Gooneratne | 2017 | Animal Nutrition2017，，2： | 23 |
| 6 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 7 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 8 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 9 | Effects of Biochar and Super Absorbent Polymer on Substrate Properties and Water Spinach Growth显示文摘Most previous researches have focused on biochar application in agricultural soils; however, limited information is available concerning the effects of biochar amendment on greenhouse substrate properties. A greenhouse experiment was conducted to investigate effects of wheat straw biochar(0–160 m L L-1) and super absorbent polymer(SAP, 0.8 g L-1) on physical and chemical properties of a substrate based on spent pig litter compost and the growth of water spinach(Ipomoea aquatica Forsk). Total porosity, water-holding capacity, p H and electrical conductivity(EC) of the substrate significantly increased with increasing biochar rates, especially in the substrate without SAP. The values of p H and EC were significantly lower in the substrate with SAP than those without SAP at the high biochar application rates(100–160 m L L-1). The germination rates of water spinach decreased with increasing biochar rates when biochar was added alone(76.9%–83.7%), whereas the rates increased to 83.6%–85.8% when biochar was added in combination with SAP. Growth parameters of water spinach and nutrient uptake by shoots and roots increased with increasing biochar rates and reached the maximum values at the biochar rate of 100 m L L-1. There were significant cubic relationships between the uptake of nutrients(N, P, and K) and biochar rates, both with and without SAP addition. In order to avoid negative effects on plant growth,the biochar application rate should be controlled at an optimal level(100 m L L-1). The SAP addition not only enhanced the positive effects of biochar application on the properties of the substrate, but also inhibited the excessive rise of p H and EC following biochar additions, which led to better plant growth and enhanced nutrient uptakes by water spinach. | FAN Ruqin LUO Jia YAN Shaohua ZHOU Yunlai ZHANG Zhenhua | 2015 | Pedosphere2015，25，5： | 15 |
| 10 | ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds显示文摘 | Yao, Ruifeng Wang, Fei Ming, Zhenhua Du, Xiaoxi Chen, Li Wang, Yupei Zhang, Wenhao Deng, Haiteng Xie, Daoxin | 2017 | Cell Research2017，27，6： | 15 |
| 11 | ^(15)N isotope fractionation in an aquatic food chain:Bellamya aeruginosa(Reeve) as an algal control agent显示文摘15N isotope tracer techniques and ecological modeling were adopted to investigate the fractionation of nitrogen,its uptake and transformation in algae and snail(Bellamya aeruginosa Reeve).Different algal species were found to differ in their uptake of nitrogen isotopes.Microcystis aeruginisa Ktz.demonstrated the greatest 15N accumulation capacity,with the natural variation in isotopic ratio(δ 15N) and the isotope fractionation factor(ε,‰) being the highest among the species investigated.The transformation and utilization of 15N by snails differed depending on the specific algae consumed(highest for Chlorella pyrenoidosa Chick.,lowest for M.aeruginisa).When snails was seeded in the experimental pond,the algae population structure changed significantly,and total algal biomass as well as the concentration of all nitrogen species decreased,causing an increase in water transparency.A model,incorporating several chemical and biological parameters,was developed to predict algal biomass in an aquatic system when snails was present.The data collected during this investigation indicated that the gastropods such as snails could significantly impact biological community and water quality of small water bodies,suggesting a role for biological control of noxious algal blooms associated with eutrophication. | Shiqun Han Shaohua Yan Kaining Chen Zhenhua Zhang Rengel Zed Jianqiu Zhang Wei Song Haiqin Liu | 2010 | Journal of Environmental Sciences2010，22，2： | 14 |
| 12 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 13 | Effects of combined drip irrigation and sub-surface pipe drainage on water and salt transport of saline-alkali soil in Xinjiang, China显示文摘Developing effective irrigation and drainage strategies to improve the quality of saline-alkali soil is vital for enhancing agricultural production and increasing economic returns. In this study, we explored how irrigation and drainage modes (flood irrigation, drip irrigation, and sub-surface pipe drainage under drip irrigation) improve the saline-alkali soil in Xinjiang, China. We aimed to study the transport characteristics of soil water and salt under different irrigation and drainage modes, and analyze the effects of the combination of irrigation and drainage on soil salt leaching, as well as its impacts on the growth of oil sunflower. Our results show that sub-surface pipe drainage under drip irrigation significantly reduced the soil salt content and soil water content at the 0–200 cm soil depth. Under sub-surface pipe drainage combined with drip irrigation, the mean soil salt content was reduced to below 10 g/kg after the second irrigation, and the soil salt content decreased as sub-surface pipe distance decreased. The mean soil salt content of flood irrigation exceeded 25 g/kg, and the mean soil desalination efficiency was 3.28%, which was lower than that of drip irrigation. The mean soil desalination rate under drip irrigation and sub-surface pipe drainage under drip irrigation was 19.30% and 58.12%, respectively. After sub-surface drainage regulation under drip irrigation, the germination percentage of oil sunflower seedlings was increased to more than 50%, which further confirmed that combined drip irrigation and sub-surface pipe drainage is very effective in improving the quality of saline-alkali soil and increasing the productivity of agricultural crops. | HENG Tong LIAO Renkuan WANG Zhenhua WU Wenyong LI Wenhao ZHANG Jinzhu | 2018 | Journal of Arid Land2018，10，6： | 12 |
| 14 | Accumulation and potential sources of heavy metals in soils of the Hetao area,Inner Mongolia,China显示文摘Soil contamination by heavy metals is a problem in agricultural irrigation systems.To assess the accumulation and sources of heavy metals in the Yongji irrigation district of the Hetao area,Inner Mongolia,China,195 soil samples from 39 sites(0–100 cm)were collected,and Zn,Cu,Pb,Cr,and Cd concentrations were analyzed.The mean concentrations were 107.17,32.48,12.31,53.53,and 0.22 mg kg-1,respectively,with no significant differences between soil depths(P>0.05).Concentrations of Zn,Cu,and Cd were higher than the background levels,with moderate accumulation;the contamination factor(CF)values were 1.9,1.7,and 1.9,respectively,and the geoaccumulation index(Igeo)was>0.Concentrations of Pb and Cr were lower than,or close to,the background levels(CF<1,Igeo<0),indicating that they originated from a natural source.The monomial potential ecological risk index(Eri)for Zn,Cu,Pb,and Cr was low;Eri for Cd was 55.73,implying a moderate risk.The grade of potential ecological risk index of the five heavy metals(RI)was low,declining from south to north.The studied soils were contaminated with Zn,Cu,and Cd;principal component(PC)analysis implicated the enrichment of Cd and partial Cu(high loading in PC 2)was related to agricultural activities;Zn and partial Cu,closely associated with PC 3,may have originated from irrigation water from the Yellow River.Future agricultural development should focus on fertilizer and pesticide application and the quality of irrigation water. | Yangchun ZHU Lijin WANG Xueyong ZHAO Jie LIAN Zhenhua ZHANG | 2020 | Pedosphere2020，30，2： | 12 |
| 15 | Influence of climate warming and nitrogen deposition on soil phosphorus composition and phosphorus availability in a temperate grassland,China显示文摘Climate warming and nitrogen(N)deposition change ecosystem processes,structure,and functioning whereas the phosphorus(P)composition and availability directly influence the ecosystem structure under conditions of N deposition.In our study,four treatments were designed,including a control,diurnal warming(DW),N deposition(ND),and combined warming and N deposition(WN).The effects of DW,ND,and WN on P composition were studied by31P nuclear magnetic resonance(31P NMR)spectroscopy in a temperate grassland region of China.The results showed that the N deposition decreased the soil pH and total N(TN)concentration but increased the soil Olsen-P concentration.The solution-state31P NMR analysis showed that the DW,ND and WN treatments slightly decreased the proportion of orthophosphate and increased that of the monoesters.An absence of myo-inositol phosphate in the DW,ND and WN treatments was observed compared with the control.Furthermore,the DW,ND and WN treatments significantly decreased the recovery of soil P in the NaOH–EDTA solution by17%–20%.The principal component analysis found that the soil pH was positively correlated with the P recovery in the NaOH–EDTA solution.Therefore,the decreased soil P recovery in the DW and ND treatments might be caused by an indirect influence on the soil pH.Additionally,the soil moisture content was the key factor limiting the available P.The positive correlation of total carbon(TC)and TN with the soil P composition indicated the influence of climate warming and N deposition on the biological processes in the soil P cycling. | GuangNa ZHANG ZhenHua CHEN AiMing ZHANG LiJun CHEN ZhiJie WU | 2014 | Journal of Arid Land2014，6，2： | 11 |
| 16 | Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy显示文摘A copper-bearing Ti-6AI-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure,antibacterial performance,and cytocompatibility.Characterization of microstructure revealed that the solution treated alloy consisted of α phase,α' phase and(3 phase,while besides these phases,the aged alloy also contained the precipitations of intermetallic Ti_2Cu compound.The solution treated alloy showed better antibacterial performance with increasing the solution temperature.The Cu ions released from Ti—6AI—4V—5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy,and do not induce any cytotoxicity.The optimal heat treatment for Ti-6Al-4V-5Cu alloy was solution treated at 930 C,at which it could exhibit both promising antibacterial performance and no cytotoxicity. | Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra | 2015 | Journal of Materials Science & Technology2015，31，7： | 10 |
| 17 | Impacts of mixed litter decomposition from Robinia pseudoacacia and other tree species on C loss and nutrient release in the Loess Plateau of China显示文摘The productivity of Robinia pseudoacacia(R.p.) pure forest usually declines at the late growth stage,and reforming it into mixed forests could be a promising way to resolve this problem. When choosing a suitable tree species that can be mixed with R.p., the interspecific relationship is an important issue. Therefore, we gathered the autumn litter fall from R.p. and 10 other species from the Loess Plateau of China were mixed in dual species litterbags(R.p.+each other species) and buried them in soil for a 345 days lab decay incubation. We measured the litter mass loss and nutrient contents to determine whether the nutrient release was affected by mixed species litter decomposition. The impacts of mixed litter decomposition on macro-elements release were more obvious than on micro-elements. The litters with similar substrate quality might show variable impacts on nutrients release in mixed decomposition. The C loss and release of nutrient was improved by descending order when R.p. litter was mixed with Hippophae rhamnoides, Ulmus pumila, Populus simonii, Larix principis-rupprechtii and Quercus liaotungensis(Q.l.). But, except for Q.l., only the other species were recommended as suitable mix-plants for R.p. since promoting a high turnover of the nutrient in the litter compartment and a rapid availability for tree. | Xiaoxi Zhang Zengwen Liu Bochao Zhu Yuanhao Bing Nhu Trung Luc Liangzhen Du Zhenhua Zhu | 2016 | Journal of Forestry Research2016，27，3： | 10 |
| 18 | Experimental study on the flow behaviour of water-sand mixtures in fractured rock specimens显示文摘The study of flow behaviour of water-sand mixtures in fractured rocks is of great necessity to understand the producing mechanism and prevention of water inrush and sand gushing accidents.A self-developed seepage test system is used in this paper to conduct laboratory experiments in order to study the influence of the particle size distribution,the void ratio,and the initial mass of Aeolian sand on the flow behavior.It is concluded that the water flow velocity is insensitive to the initial mass of the Aeolian sand but increases with the power exponent in the Talbot formula and the specimen height.The outflow of the Aeolian sand increases with the power exponent in the Talbot formula,the specimen height,and the initial mass of the Aeolian sand.Besides,the outflow of the Aeolian sand changes exponentially with the water flow velocity.Finally,it is found that the fractured specimen has a maximum sand filtration capacity beyond which the outflow of the Aeolian sand significantly increases with the initial mass of the Aeolian sand. | Boyang Zhang Qingyuan He Zhibin Lin Zhenhua Li | 2021 | International Journal of Mining Science and Technology2021，31，3： | 9 |
| 19 | Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging显示文摘Recently,transplantation of allogeneic and autologous cells has been used for regenerative medicine.A critical issue is monitoring migration and homing of transplanted cells,as well as engraftment efficiency and functional capability in vivo.Monitoring of superparamagnetic iron oxide(SPIO) particles by magnetic resonance imaging(MRI) has been used in animal models and clinical settings to track labeled cells.A major limitation of MRI is that the signals do not show biological characteristics of transplanted cells in vivo.Bone marrow mesenchymal stem cells(MSCs) have been extensively investigated for their various therapeutic properties,and exhibit the potential to differentiate into cells of diverse lineages.In this study,cynomolgus monkey MSCs(cMSCs) were labeled with Molday ION Rhodamine-BTM(MIRB),a new SPIO agent,to investigate and characterize the biophysical and MRI properties of labeled cMSCs in vitro and in vivo.The results indicate that MIRB is biocompatible and useful for cMSCs labeling and cell tracking by multimodality imaging.Our method is helpful for detection of transplanted stem cells in vivo,which is required for understanding mechanisms of cell therapy. | REN ZhenHua WANG JiaYin ZOU ChunLin GUAN YunQian ZHANG Yu Alex | 2011 | Science China(Life Sciences)2011，54，11： | 9 |
| 20 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
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