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| 1 | A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://gffzzfcd63c5b87fd4ae2huwqwwp6cvpv66uuf.ffgz.tsg.suse.edu.cn)显示文摘 | Zhiqiang Li Zhao Zhang Zangdong He Wei Tang Tao Li Zhen Zeng Lin He Yongyong Shi | 2009 | Cell Research2009，19，4： | 122 |
| 2 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 3 | Secondary organic carbon quantification and source apportionment of PM_(10) in Kaifeng, China显示文摘During 2005, the filter samples of ambient PM10 from five sites and the source samples of particulate matter were collected in Kaifeng, Henan Province of China. Nineteen elements, water-soluble ions, total carbon (TC) and organic carbon (OC) contained in samples were analyzed. Seven contributive source types were identified and their contributions to ambient PM10 were estimated by chemical mass balance (CMB) receptor model. Weak associations between the concentrations of organic carbon and element carbon (EC) were observed during the sampling periods, indicating that there was secondary organic aerosol pollution in the urban atmosphere. An indirect method of 'OC/EC minimum ratio' was applied to estimate the concentration of secondary organic carbon (SOC). The results showed that SOC contributed 26.2%, 32.4% and 18.0% of TC in spring, summer-fall and winter, respectively, and the annual average SOC concentration was 7.07 μg/m3, accounting for 5.73% of the total mass in ambient PM10. The carbon species concentrations in ambient PM10 were recalculated by subtracting SOC concentrations from measured concentrations of TC and OC to increase the compatibility of source and receptor measurements for CMB model. | WU Lin FENG Yinchang WU Jianhui ZHU Tan BI Xiaohui HAN Bo YANG Weihong YANG Zhiqiang | 2009 | Journal of Environmental Sciences2009，21，10： | 26 |
| 4 | Dynamic dam-reservoir interaction analysis including effect of reservoir boundary absorption显示文摘Based on the scaled boundary finite-element method, the governing equations for the analysis of dam-reservoir interaction including the reservoir boundary absorption are developed. Coupling with the equation of dam-unbounded foundation interaction, it can effectively carry out the earthquake response analysis of dameservoir-foundation system. The proposed approach has the advantages that the effect of compressibility of reservoir water as well as the energy absorption of reservoir boundary on the earthquake response of arch dams and gravity dams can be efficiently evaluated and higher accuracy can be achieved. In comparison with the methods available in the literature, the computational cost can be reduced to a great extent. It facilitates the application of earthquake response analysis of dam-reservoir-foundation system including reservoir boundary absorption to the engineering practice. | LIN Gao DU JianGuo HU ZhiQiang | 2007 | Science China(Technological Sciences)2007，50，z1： | 23 |
| 5 | Characteristics and recent trends of sulfur dioxide at urban,rural,and background sites in North China:Effectiveness of control measures显示文摘SO 2 measurements made in recent years at sites in Beijing and its surrounding areas are performed to study the variations and trends of surface SO 2 at different types of sites in Northern China.The overall average concentrations of SO 2 are (16.8±13.1) ppb,(14.8±9.4) ppb,and (7.5±4.0) ppb at China Meteorological Administration (CMA,Beijing urban area),Gucheng (GCH,relatively polluted rural area,110 km to the southwest of Beijing urban area),and Shangdianzi (SDZ,clean background area,100 km to the northeast of Beijing urban area),respectively.The SO 2 levels in winter (heating season) are 4-6 folds higher than those in summer.There are highly significant correlations among the daily means of SO 2 at different sites,indicating regional characteristics of SO 2 pollution.Diurnal patterns of surface SO 2 at all sites have a common feature with a daytime peak,which is probably caused by the downward mixing and/or the advection transport of SO 2 -richer air over the North China Plain.The concentrations of SO 2 at CMA and GCH show highly significant downward trends (-4.4 ppb/yr for CMA and -2.4 ppb/yr for GCH),while a less significant trend (-0.3 ppb/yr) is identified in the data from SDZ,reflecting the character of SDZ as a regional atmospheric background site in North China.The SO 2 concentrations of all three sites show a significant decrease from period before to after the control measures for the 2008 Olympic Games,suggesting that the SO 2 pollution control has long-term effectiveness and benefits.In the post-Olympics period,the mean concentrations of SO 2 at CMA,GCH,and SDZ are (14.3±11.0) ppb,(12.1±7.7) ppb,and (7.5±4.0) ppb,respectively,with reductions of 26%,36%,and 13%,respectively,compared to the levels before.Detailed analysis shows that the differences of temperature,relative humidity,wind speed,and wind direction were not the dominant factors for the significant differences of SO 2 between the pre-Olympics and post-Olympics periods.By extracting the data being more representative of local or regional characteristics,a reduction of up to 40% for SO 2 in polluted areas and a reduction of 20% for regional SO 2 are obtained for the effect of control measures implemented for the Olympic Games. | Weili Lin Xiaobin XU Zhiqiang Ma Huarong Zhao Xiwen Liu Ying Wang | 2012 | Journal of Environmental Sciences2012，24，1： | 15 |
| 6 | AtCDC5 regulates the G2 to M transition of the cell cycle and is critical for the function of Arabidopsis shoot apical meristem显示文摘作为一个房间周期管理者, Myb 相关的 CDC5 蛋白质被报导为在酵母和动物的房间周期的 G2 阶段必要,但是很少在植物对它的功能被知道。这里,我们在 Arabidopsisthaliana 报导 CDC5 基因的功能的描述。Arabidopsis CDC5 (AtCDC5 ) 主要与高细胞分裂活动在纸巾被表示,并且在整个胚胎形成的全部过程被表示。AtCDC5 loss-of-functionmutant 是胚胎的致命。以便调查 AtCDC5 体内的函数,我们 AtCDC5 的表达式被 RNA 干扰在减少的 generatedAtCDC5-RNAi 植物。我们发现到 M (G2/M ) 阶段转变的 G2 在 AtCDC5-RNAi 植物被影响,并且 thatendoreduplication 被增加。另外,射击顶端分生组织(SAM ) 的维护功能在 AtCDC5-RNAi 植物被扰乱,在哪个 WUSCHEL (WUS )-CLAVATA (CLV ) 和射击无分裂组织(STM ) 小径被损害。原位杂交分析证明 STM 的表示极大地在 AtCDC5-RNAi 植物的射击顶端细胞被减少。而且, cyclinB1 或 Histone4 被发现当时,在一些这些房间被表示 STMwas 的抄本无法发现。这些结果建议 AtCDC5 为 G2/M 阶段转变是必要的并且可以由控制 STM 和 WUS 的表示调整 SAM 的功能。 | Zhiqiang Lin Kangquan Yin Danling Zhu Zhangliang Chen Hongya Gu Li-Jia Qu | 2007 | Cell Research2007，17，9： | 13 |
| 7 | Geochronology,petrology,and geochemistry of the Yaojiazhuang ultramafic-syenitic complex from the North China Craton显示文摘The Yaojiazhuang ultramafic-syenitic complex is one of the representative Triassic alkaline plutons on the northern margin of the North China Craton(NCC).Based on detailed study of the zircon U-Pb age,petrological,mineralogical,and geochemical data of the complex,the characteristics of the magmas system,the petrogenesis of different rock types,and the nature of the mantle source were discussed to provide new constraints on the origin and tectonic setting of the Triassic alkaline belt.Cumulus ultramafic rocks,clinopyroxene-syenites and syenites are the main rock types of the complex.The zircons from the syenites yielded a U-Pb age of 209 Ma.Diopside-augite,biotite,and sanidine-orthoclase are the major minerals,with subordinate apatite and magnetite.Rocks from the complex are enriched in large ion lithophile elements(LILE)and light rare earth elements(LREE),depleted in high field strength elements(HFSE)and heavy rare earth elements(HREE),and the initial 87Sr/86Sr ranges from 0.7057 to 0.7061 and ε Nd(t)from-9.4 to-11.4.Mineralogy and geochemical data demonstrate that the parent magma of the complex is SiO2-undersaturated ultrapotassic alkaline-peralkaline,and is characterized by high CaO content and fluid compositions(P2O5,CO2,H2O),and by high oxygen fugacity and high temperature.The complex was originated from a phlogopite-clinopyroxenite-rich lithospheric mantle source in the garnet-stable area(> 80 km)that had previously been metasomatized by melts/fluids from altered oceanic crust.The parent magma has been contaminated by little ancient TTG gneisses during magma emplacement.The development of the Yaojiazhuang complex indicates that the northern margin of the NCC has entered into an extensively extensional regime in the Late Triassic. | CHEN Bin NIU XiaoLu WANG ZhiQiang GAO Lin WANG Chao | 2013 | Science China Earth Sciences2013，56，8： | 13 |
| 8 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 9 | Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer显示文摘Recently, considerable attention in the field of cancer therapy has been focused on the mammalian rapamycin target(m TOR), inhibition of which could result in autophagic cell death(ACD). Though novel combination chemotherapy of autophagy inducers with chemotherapeutic agents is extensively investigated, nanomedicine-based combination therapy for ACD remains in infancy. In attempt to actively trigger ACD for synergistic chemotherapy, here we incorporated autophagy inducer rapamycin(RAP) into 7 pep-modified PEG-DSPE polymer micelles(7 pep-M-RAP) to specifically target and efficiently priming ACD of MCF-7 human breast cancer cells with high expression of transferrin receptor(Tf R). Cytotoxic paclitaxel(PTX)-loaded micelle(7 pep-M-PTX) was regarded as chemotherapeutic drug model. We discovered that with superior intracellular uptake in vitro and more tumor accumulation of micelles in vivo, 7 pep-M-RAP exhibited excellent autophagy induction and synergistic antitumor efficacy with 7 pep-M-PTX. Mechanism study further revealed that 7 pep-M-RAP and 7 pep-MPTX used in combination provided enhanced efficacy through induction of both apoptosis-and mitochondria-associated autophagic cell death. Together, our findings suggested that the targeted excess autophagy may provide a rational strategy to improve therapeutic outcome of breast cancer, and simultaneous induction of ACD and apoptosis may be a promising anticancer modality. | Dong Mei Binlong Chen Bing He Haibin Liu Zhiqiang Lin Jialiang Lin Xiaoyan Zhang Ning Sun Libo Zhao Xiaoling Wang Qiang Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 8 |
| 10 | Early Uplift History of the Tibetan Plateau:Records from Paleocurrents and Paleodrainage in the Hoh Xil Basin显示文摘摘要:在领域工作收集的 Paleocurrent 指示物数据被用来在北西藏的高原在 Hoh Xil 盆学习早新生代地区性的 paleodrainage 模式。paleocurrent 方向始新世 Fenghuoshan 组显然证明流动是向北方与一个单向性的疏开模式。这可能在起始的盆免职时期期间反映 Qiangtang 地面的 uplift 并且显示 Tanggula Moutains 在至少作为地志的高地发生了始新世。渐新世 Yaxicuo 组的 Paleoflows 对北方主导地面向然后在它的迟了的免职期间向东流动了。Yaxicuo 组的 paleodrainage 模式的这地区性的可变性被解释从横向的河记录沉积的疏开风格到纵的河系统。渐新世山妨碍了由的 Kunlun 高举,这被推断向北方,到 orogenic 的 paleoflows 和创造的纵的河系统平行系上带子。paleodrainage 模式的时间、空间的变化建议西藏的高原的北边界在早新生代期间位于 Hoh Xil 区域,它的 uplift 整个时间向北进行了。 | YI Haisheng WANG Chengshan SHI Zhiqiang LIN Jinhui ZHU Lidong | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 7 |
| 11 | Response surface modeling-based source contribution analysis and VOC emission control policy assessment in a typical ozone-polluted urban Shunde,China显示文摘To develop a sound ozone(O_3) pollution control strategy,it is important to well understand and characterize the source contribution due to the complex chemical and physical formation processes of O_3.Using the 'Shunde' city as a pilot summer case study,we apply an innovative response surface modeling(RSM) methodology based on the Community Multi-Scale Air Quality(CMAQ) modeling simulations to identify the O_3 regime and provide dynamic analysis of the precursor contributions to effectively assess the O_3 impacts of volatile organic compound(VOC) control strategy.Our results show that Shunde is a typical VOC-limited urban O_3 polluted city.The 'Jiangmen' city,as the main upper wind area during July 2014,its VOCs and nitrogen oxides(NO_x) emissions make up the largest contribution(9.06%).On the contrary,the contribution from local(Shunde) emission is lowest(6.35%) among the seven neighbor regions.The local VOCs industrial source emission has the largest contribution comparing to other precursor emission sectors in Shunde.The results of dynamic source contribution analysis further show that the local NO_x control could slightly increase the ground O_3 under low(10.00%) and medium(40.00%)reduction ratios,while it could start to turn positive to decrease ground O_3 under the high NO_x abatement ratio(75.00%).The real-time assessment of O_3 impacts from VOCs control strategies in Pearl River Delta(PRD) shows that the joint regional VOCs emission control policy will effectively reduce the ground O_3 concentration in Shunde. | Zhiqiang You Yun Zhu Carey Jang Shuxiao Wang Jian Gao Che-Jen Lin Minhui Li Zhenghua Zhu Hao Wei Wenwei Yang | 2017 | Journal of Environmental Sciences2017，29，1： | 7 |
| 12 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 13 | Scaled boundary isogeometric analysis for 2D elastostatics显示文摘A new numerical method,scaled boundary isogeometric analysis(SBIGA)combining the concept of the scaled boundary finite element method(SBFEM)and the isogeometric analysis(IGA),is proposed in this study for 2D elastostatic problems with both homogenous and inhomogeneous essential boundary conditions.Scaled boundary isogeometric transformation is established at a specified scaling center with boundary isogeometric representation identical to the design model imported from CAD system,which can be automatically refined without communication with the original system and keeping geometry invariability.The field variable,that is,displacement,is constructed by the same basis as boundary isogeometric description keeping analytical features in radial direction.A Lagrange multiplier scheme is suggested to impose the inhomogeneous essential boundary conditions.The new proposed method holds the semi-analytical feature inherited from SBFEM,that is,discretization only on boundaries rather than the entire domain,and isogeometric boundary geometry from IGA,which further increases the accuracy of the solution.Numerical examples,including circular cavity in full plane,Timoshenko beam with inhomogenous boundary conditions and infinite plate with circular hole subjected to remotely tension,demonstrate that SBIGA can be applied efficiently to elastostatic problems with various boundary conditions,and powerful in accuracy of solution and less degrees of freedom(DOF)can be achieved in SBIGA than other methods. | LIN Gao ZHANG Yong HU ZhiQiang ZHONG Hong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，2： | 6 |
| 14 | A bio-inspired approach for cognitive radio networks显示文摘The recent increasing interest in cognitive radio networks has motivated the study and development of new approaches capable of coping with the intrinsic challenges of this kind of network,such as dynamic spectrum availability,distributed and heterogeneous network architectures,and soaring complexity.The bio-inspired approaches,with appealing characteristics such as autonomy,adaptation and collective intelligence of collaborative individuals,have been extensively studied.This paper presents a comprehensive survey of bio-inspired approaches for cognitive radio networks,emphasizing their domains of application.Specifically,ant colony optimization and particle warm optimization are further investigated with examples and numerical simulation. | HE ZhiQiang NIU Kai QIU Tao SONG Tao XU WenJun GUO Li LIN JiaRu | 2012 | Chinese Science Bulletin2012，57，28： | 5 |
| 15 | IMF production and symmetry energy in heavy ion collisions near Fermi energy显示文摘The symmetry energy at the time of the production of intermediate mass fragments(IMFs) is studied using experimentally observed IMF multiplicities combined with quantum statistical model calculations(QSM of Hahn and St cker).The ratios of difference in chemical potentials between neutrons and protons relative to the temperature,(μn-μp)/T,and the double ratio temperature,T,were extracted experimentally in the reactions of64,70Zn,64Ni+58,64Ni,112,124Sn,197Au,232Th at 40A MeV.The extracted(μn-μp)/TTscales linearly with δNN,where δNN is the asymmetry parameter,(N-Z)/A,of the emitting source and(μn-μp)/T=(11.1 1.4)δNN0.21 was derived.The experimentally extracted(μn-μp)/T and the double ratio temperatures are compared with those from the QSM calculations.The temperatures-,T,and densities,ρ,extracted from the(μn-μp)/T values agreed with those from the double ratio thermometer which used the yield ratios of d,t,h and α particles.However the two analyses of the differential chemical potential analysis and the initial temperature analysis end up almost identical relation between T and ρ.T=5.25±0.75 MeV is evaluated from the(μn-μp)/Tanalysis,but no density determination was possible.From the extracted T value,the symmetry energy coefficient Esym =14.6±3.5 MeV is determined for the emitting source of T=5.25±0.75 MeV. | WADA Roy HUANG Meirong LIN Weiping LIU Xingquan ZHAO Minghui CHEN Zhiqiang | 2013 | Nuclear Science and Techniques2013，24，5： | 5 |
| 16 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 17 | SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder显示文摘 | Xiaohan Hu Qiang Liu Zhao Zhang Zhiqiang Li Shilin Wang Lin He Yongyong Shi | 2010 | Cell Research2010，20，7： | 5 |
| 18 | Concentration quenching in transparent glass ceramics containing Er^(3+):NaYF_4 nanocrystals显示文摘In this work, we have studied the concentration quenching in transparent glass ceramics containing Er3+:NaYF4 nanocrystals. For different concentrations, the emission spectra and decay curves of the 4I13/2→4I15/2 emission were measured. The Er-concentration dependence of integrated intensity and lifetime of 4I13/2→4I15/2 emission are showed. With the increase of the Er3+ doping concentration, the 1.5 m fluorescence emission first increases, then decreases, and the lifetime falls gradually. With 980 nm excitation, the efficiency of the energy transfer from Er3+ to quenching centers reaches 73.73% for the sample with 4 mol% Er3+. Meanwhile, owing to the relation of fluorescence integrated intensity and Er-concentration, a dipole-dipole quenching mechanism in the framework of a limited diffusion regime has been proved. Using the limited diffusion case, the critical concentration for quenching has been determined from a fitting equation of the lifetime and Er-concentration. The fitting result shows the critical concentration for quenching is higher than the values obtained in Er-doped different glass by an order of magnitude. | HUANG XingYong CHEN DaQin LIN Lin WANG ZheZhe WANG YuanSheng FENG ZhuoHong ZHENG ZhiQiang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，7： | 5 |
| 19 | QTL mapping for grain number per spikelet in wheat using a high-density genetic map显示文摘Grain number per spikelet (GNS) is a key determinant of grain yield in wheat.A recombinant inbred line population comprising 300 lines was developed from a cross between a high GNS variety H461 and Chinese Spring from which the reference genome assembly of bread wheat was obtained.Both parents and the recombinant inbred lines were genotyped using the wheat 55K single nucleotide polymorphism(SNP) array.A high-density genetic map containing 21,197 SNPs was obtained.These markers covered each of the 21 chromosomes with a total linkage distance of 3792.71 c M.Locations of these markers in this linkage map were highly consistent with their physical locations in the genome assembly of Chinese Spring.The two parents and the whole RIL population were assessed for GNS in two consecutive years at two different locations.Based on multi-environment phenotype data and best liner unbiased prediction values,three quantitative trait loci (QTL) for GNS were identified.One of them located on chromosomes 2B and the other two on 2D.Phenotypic variation explained by these loci varied from 3.07%to26.57%.One of these QTL,QGns.sicau-2D-2,was identified in each of all trials conducted.Based on the best linear unbiased prediction values,this locus explained 19.59%–26.57%of phenotypic variation.A KASP(Kompetitive Allele-Specific PCR) marker closely linked with this locus was generated and used to validate the effects of this locus in three different genetic backgrounds.The identified QTL and the KASP marker developed for it will be highly valuable in fine-mapping the locus and in exploiting it for markerassisted selection in wheat breeding programs. | Yu Lin Xiaojun Jiang Haiyan Hu Kunyu Zhou Qing Wang Shifan Yu Xilan Yang Zhiqiang Wang Fangkun Wu Shihang Liu Caixia Li Mei Deng Jian Ma Guangdeng Chen Yuming Wei Youliang Zheng Yaxi Liu | 2021 | The Crop Journal2021，9，5： | 4 |
| 20 | Comparative analysis of peptidoglycan recognition proteins in endoparasitoid wasp Microplitis mediator显示文摘Peptidoglycan 识别蛋白质(PGRP ) 是明确地在很多病原体的表面上认出 peptidoglycans (PGN ) 的天生的有免疫力的受体的一个家庭。这里,我们从 endoparasitoid 黄蜂识别了并且描绘六 PGRP, Microplitis 调停人(MmePGRPs ) 。在 parasitoid 黄蜂理解 PGRP 的角色,我们分析了他们的进化关系和 orthology,表示与克积极、否定的细菌和真菌在不同发展阶段,和 transcriptional 表示追随者感染期间介绍。MmePGRP-S1 显著地响应病原的感染被导致。这提示了我们评估 RNA 干扰的效果调停的基因特定 MmePGRP-S1 击倒。MmePGRP-S1 (iMmePGRP-S1 ) 击倒戏剧性地影响的 wasps’由小球菌 luteus 的幸存追随者挑战,对克积极的细菌在有免疫力的回答显示这特别 PGRP 的参与。这个行动是可能的被使用费小径调停,但是机制尚待坚定。MmePGRP-S1 不在由 iMmePGRP-S1 黄蜂的幸存率显示了的抗真菌的免疫起一个重要作用。这研究在经济地重要的 hymenopteran 种类 M 提供 PGRP 的全面描述。调停人。 | Rui-Juan Wang Zhe Lin Hong Jiang Jiancheng Li Tusar T. Saha Ziyun Lu Zhiqiang Lu Zhen Zou | 2017 | Insect Science2017，24，1： | 4 |
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