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| 1 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 2 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 3 | Correlations of nonlinear sorption of organic solutes with soil/sediment physicochemical properties 显示文摘 | Kun Yang Lizhong Zhu Baofeng Lou | 2005 | Chemosphere2005，61，： | 1 |
| 4 | Detection of ECTV,MHV and SV in Clean-grade Mice and Rats in East China显示文摘To study the epidemic status of Ectromelia virus( ECTV),Mouse hepatitis virus( MHV) and Sendai virus( SV) in clean-grade experimental mice and rats in East China,30 individuals of ICR and/or C57BL/6 mice and 15 individuals of SD or Wistar rats were purchased from four major experimental animal supply bases in East China. Blood samples were collected by eyeball picking method,and serum was separated. ECTV,MHV and SV serum antibodies in mice were detected using imported commercial ELISA kits. Since rats were not easily infected by MHV and SV,only the ECTV serum antibody was detected in rats. Survey results revealed that clean-grade experimental mice and rats derived from three out of four major experimental animal supply bases were negative in detection,but the positive rates of MHV and SV serum antibody in clean-grade ICR mice in one supply base were 56. 7% and 100. 0%,respectively,while the positive rate of MHV serum antibody in C57BL/6 mice was 100%. Research results showed that most of the commercial experimental mice and rats in major experimental animal supply bases in East China were qualified in detection of above three kinds of diseases,but MHV and SV still existed in individual base,with severe infection status.Thus,active measures must be strengthened to purify mice and rats. Meanwhile,monitoring of mouse and rat diseases must be developed seriously to guarantee the quality of experimental mice and rats,so as to avoid adverse impacts on breeding and use of experimental rats and mice. | Song Hongyan Dong Ronglian Qiu Baofeng Jing Jin Gu Bingquan Shao Yixiang Liu Chun Zhu Shunxing Wu Liucheng | 2017 | Animal Husbandry and Feed Science2017，9，1： | 1 |
| 5 | Modifying the oxygen adsorption properties of YBaCo4O7 by Ca, Al, and Fe doping显示文摘 | Song Wang Haoshan Hao Baofeng Zhu Jianfeng Jia Xing Hu | 2008 | Journal of Materials Science2008，，15： | 1 |
| 6 | Modifying the oxygen absorption properties of YBaCo4O7 by Ca, A1, and Fe doping 显示文摘 | Wang Song Hao Haoshan Zhu Baofeng | 2008 | Journal of Materials Science2008，43，15： | 1 |
| 7 | Systematical analysis of sludge treatment and disposal technologies for carbon footprint reduction显示文摘This study aims to comprehensively analyze the Greenhouse Gases(GHGs)emissions from current sewage sludge treatment and disposal technologies(buildingmaterial,landfill,land spreading,anaerobic digestion,and thermochemical processes)based on the database of Science Citation Index(SCI)and Social Science Citation Index(SSCI)from 1998 to 2020.The general patterns,spatial distribution,and hotspotswere provided by bibliometric analysis.A comparative quantitative analysis based on life cycle assessment(LCA)put forward the current emission situation and the key influencing factors of different technologies.The effective GHG emissions reduction methods were proposed to mitigate climate change.Results showed that incineration or building materials manufacturing of highly dewatered sludge,and land spreading after anaerobic digestion have the best GHG emissions reduction benefits.Biological treatment technologies and thermochemical processes have great potential for reducing GHGs.Enhancement of pretreatment effect,co-digestion,and newtechnologies(e.g.,injection of carbon dioxide,directional acidification)are major approaches to facilitate substitution emissions in sludge anaerobic digestion.The relationship between the quality and efficiency of secondary energy in thermochemical process and GHGs emission still needs further study.Solid sludge products generated by bio-stabilization or thermochemical processes are considered to have a certain carbon sequestration value and can improve the soil environment to control GHG emissions.The findings are useful for future development and processes selection of sludge treatment and disposal facing carbon footprint reduction. | Yingxin Zhao Zhifan Yang Jiaojiao Niu Zihan Du Conti Federica Zhe Zhu Kaichao Yang Yan Li Baofeng Zhao Thomas Helmer Pedersen Chunguang Liu Mutabazi Emmanuel | 2023 | Journal of Environmental Sciences2023，，6： | 1 |
| 8 | Modifying the oxygen adsorption properties of YBaCo4O7 by Ca, Al, and Fe doping显示文摘 | Song Wang Haoshan Hao Baofeng Zhu Jianfeng Jia Xing Hu | 2008 | Journal of Materials Science2008，，15： | 1 |
| 9 | Distributions of polycyclic aromatic hydrocarbons in surface waters, sediments and soils of Hangzhou City, China显示文摘 | Baoliang Chen Xiaodong Xuan Lizhong Zhu Jing Wang Yanzheng Gao Kun Yang Xueyou Shen Baofeng Lou | 2004 | Water Research2004，，16： | 1 |
| 10 | Modifying the oxygen adsorption properties of YBaCo4O7 by Ca, Al, and Fe doping显示文摘 | Song Wang Haoshan Hao Baofeng Zhu Jianfeng Jia Xing Hu | 2008 | Journal of Materials Science2008，，15： | 1 |
| 11 | Novel Chemical Strategy for the Synthesis of RGDCySS Tetrapeptide显示文摘 | XU Baofeng YANG Sen ZHU Jinming MA Yudan ZHAO Gang GUO Yi XU Li | 2014 | Chemical Research in Chinese Universities2014，30，1： | 0 |
| 12 | The Earth Summit Mission-2022:Successful ozone soundings contribute to source identification in the north Mt.Qomolangma region显示文摘As part of“The Earth Summit Mission-2022”during the second Tibetan Plateau Scientific Expedition and Research(STEP)in April and May 2022,we conducted the ozone sounding experiment(an ozonesonde mated to a radiosonde)at Mt.Qomolangma Base Camp(MQBC;86.85°E,28.14°N;5200 m),a location at an extremely high altitude.A total of ten sounding profiles were obtained between April 30 and May 06,2022,of which seven profiles were above35 km in altitude,with a maximum detection altitude up to 39.0 km.This study presents the temporal variation and vertical distributions of atmospheric temperature,humidity,and ozone during the MQBC campaign.The averaged ozone concentration was high(68.3 ppbv)at the surface and then increased smoothly until peaking(~110 ppbv)in the middle troposphere(approximately 10 km),and afterward,the ozone concentration increased rapidly from the upper troposphere to a maximum of~10 ppmv at~30 km.The enhanced ozone concentration in the middle troposphere was associated with the blocking high pressure,and transport from the southern flank of the Himalayas occurred during the campaign period.The average total ozone column was 291.9±21.4 DU for the seven profiles exceeding 35km in altitude.The ozonesonde measurements were also compared with the vertical ozone profiles retrieved from the space-borne ozone products from the Microwave Limb Sounder(MLS)onboard the Aura satellite and the Atmospheric Infrared Sounder(AIRS)onboard the Aqua satellite. | Jinqiang Zhang Chunxiang Ye Yuejian Xuan Zhixuan Bai Weili Lin Dan Li Lingkun Ran Baofeng Jiao YaomingMa Weiqiang Ma Nan Yao Yunshu Zeng Daren Lv Tong Zhu | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 13 | Near-wall topological patterns and flow structures over a simplified Danaus plexippus model显示文摘Studies on the high-lift mechanisms of butterfly gliding flights shed light on the design of the micro air vehicles.The flow field around a simplified Danaus plexippus model is investigated using the hydrogen bubble visualization and the Particle Image Velocimetry(PIV)techniques.There are three near-wall topological patterns with different Angles of Attack(AoAs):the separation bubble,the Leading-Edge Vortex(LEV)and the high Ao As flow.For the separation bubble pattern,two saddles and two foci form in the middle of the model.The features of the LEV pattern are the leading-edge separation lines.The topological characteristics of the separation lines are changed by the interaction between the LEV and the Wing-Tip Vortex(WTV).For the high Ao As flow pattern,four unstable foci are found at the forewing and the hindwing respectively.The angle between the trajectory of the WTV and the model increases with increasing Ao A even though the slope of the WTV angle versus Ao A curve declines at the moderate AoAs. | Yichen ZHU Yuan QU Jinjun WANG Baofeng MA | 2020 | Chinese Journal of Aeronautics2020，33，10： | 0 |
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